Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

Juan Manuel Falcón

Exosomal membrane proteins as interesting tool to express nonexosomal proteins into exosomes with therapeutic purposes.

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

José M Mato

We identified specific panels of markers that could distinguish patients with NASH from patients with simple steatosis for each subtype of NAFLD.

Sox2 promotes tamoxifen resistance in breast cancer cells

María Vivanco

Development of tamoxifen resistance is driven by Sox2‐dependent activation of Wnt signalling in cancer stem/progenitor cells.

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MiRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments

Ana M Aransay

Stand-alone version of the miRanalyzer that is based on a local and easily customized database is also available at https://bioinfo5.ugr.es/srnatoolbox/

MiRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments

Ana M Aransay

The web tool provides a comprehensive overview of microRNA analysis.

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

José M Mato

Methylation of RASSF1 and SOCS2 promoters and the binding of trimethylated lysine 27 in histone 3 to these 2 genes was increased in Hepatocellular Cacinomas from GNMT-KO mice

Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression

José M Mato

BMI-dependent serum metabolic profile may be able to reliably distinguish NASH from steatosis patients, have significant implications for the development of NASH biomarkers.

Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex

Mikel Valle

The structure of the DNA complex is consistent with that of the complex of four separate core domains and response element fragments solved by x-ray crystallography and contacts identified by NMR

Structure of ratcheted ribosomes with tRNAs in hybrid states

Mikel Valle

During protein synthesis, the displacement of the A-site tRNA on the 50S subunit is passive and is induced by the 30S subunit rotation, catalyzed by elongation factor G.

Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease

José M Mato

Metabolic phenotyping approach may have a future role as a supplement for clinical decision making in NAFLD and in the adaption to more individualized treatment protocols.