Publications

2025

Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn's disease
Kioroglou, D; Egia-Mendikute, L; Palazon, A; Acosta, MBD; Rodríguez-Lago, I; Marigorta, UM;
FRONTIERS IN IMMUNOLOGY
2025

Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients
Zamfir-Taranu, A; Löscher, BS; Carbone, F; Hoter, A; Blanco, CE; Bozzarelli, I; Torices, L; Routhiaux, K; Van den Houte, K; Bonfiglio, F; Mayr, G; Corsetti, M; Naim, HY; Franke, A; Tack, J; ...
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2025

Chemoenzymatic Synthesis and Biological Recognition of a Sulfonate Isostere of 6-Sulfo-sialyl Lewisx
Wu, YF; Weber, J; Kimpel, ALM; Unione, L; Uslu, E; de Vries, RP; Boons, GJ;
JACS AU
2025

Extracellular matrix matters: matrix-based bioscaffolds in advancing translational cancer research and targeted therapy
Karamanos, NK; Piperigkou, Z; Gourdoupi, C; Mangani, S; Vivanco, MD;
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
2025

How sensitive are protein hydration shells to electrolyte concentration and protein composition?
Daronkola, HG; Moussa, B; Millet, O; Krenczyk, O; Ortega-Quintanilla, G; Petersen, PB; Verde, AV;
PROTEIN SCIENCE
2025

Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis
Lamas-Paz, A; Hionides-Gutierrez, A; Guo, FF; Jorquera, G; Moran-Blanco, L; Benede-Ubieto, R; Mesquita, M; Estevez-Vazquez, O; Zheng, K; Mazariegos, M; Vazquez-Ogando, E; Blazquez-Lopez, E; ...
JHEP REPORTS
2025

Letter to the Editor: Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF)
Noureddin, M; Truong, E; Mayo, R; Martínez-Arranz, I; Mincholé, I; Banales, JM; Arrese, M; Cusi, K; Arias-Loste, MT; Bruha, R; Romero-Gómez, M; Iruzubieta, P; Aller, R; Ampuero, J; Calleja, ...
HEPATOLOGY
2025

Long, Synthetic Staphylococcus aureus Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition
Osterlid, KE; Sorieul, C; Unione, L; Li, SZ; García-Sepúlveda, C; Carboni, F; Del Bino, L; Berni, F; Arda, A; Overkleeft, HS; van der Marel, GA; Romano, MR; Jiménez-Barbero, J; Adamo, R; Codée, JDC;
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2025

NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity
Lodge, S; Masuda, R; Nitschke, P; Beilby, JP; Hui, J; Hunter, M; Yeap, BB; Millet, O; Wist, J; Nicholson, JK; Holmes, E;
PLOS ONE
2025

Reproducibility of extracellular vesicle research
Crescitelli, R; Falcon-Perez, J; Hendrix, A; Lenassi, M; Minh, LN; Ochiya, T; Hooten, NN; Sandau, U; Théry, C; Nieuwland, R;
JOURNAL OF EXTRACELLULAR VESICLES
2025

TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells
Priego, N; de Pablos-Aragoneses, A; Perea-García, M; Pieri, V; Hernández-Oliver, C; Alvaro-Espinosa, L; Rojas, A; Sánchez, O; Steindl, A; Caleiras, E; García, F; García-Martín, S; Graña-Castro, ...
CANCER DISCOVERY
2025

Proteomic Profiling of Extracellular Vesicles in Inflammatory Bowel Diseases
Baldán-Martín, M; Azkargorta, M; Lapitz, A; Moreno, LO; Iloro, I; Fernández-Tomé, S; Arbelaiz, A; Escobes, I; Marín, AC; Bernardo, D; Bujanda, L; Bañales, JM; Elortza, F; Gisbert, JP; Chaparro, M;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025

MicroRNAs in Plasma-Derived Extracellular Vesicles as Non-Invasive Biomarkers for Eosinophilic Esophagitis
Grueso-Navarro, E; Rodríguez-Alcolado, L; Arias-González, L; Aransay, AM; Lozano, JJ; Sidorova, J; Juárez-Tosina, R; González-Cervera, J; Lucendo, AJ; Laserna-Mendieta, EJ;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025

Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
Elurbide, J; Colyn, L; Latasa, MU; Uriarte, I; Mariani, S; Lopez-Pascual, A; Valbuena, E; Castello-Uribe, B; Arnes-Benito, R; Adan-Villaescusa, E; Martinez-Perez, LA; Azkargorta, M; Elortza, ...
GUT
2025

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential
Bellini, C; Atxabal, U; Bosze, S; Dobay, O; Horvath, A; Szigyártó, IC; Beke-Somfai, T; Jiménez-Barbero, J; Puskás, I; Horváti, K;
AGGREGATE
2025

Host-Guest Dynamic Behavior of Melatonin Encapsulated in β-Cyclodextrin Nanosponges
Ferrero, R; Pantaleone, S; Brunella, V; Corno, M; Jiménez-Osés, G; Peccati, F;
ACS OMEGA
2025

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions
Pérez-Castro, MA; Eraña, H; Vidal, E; Charco, JM; Lorenzo, NL; Gonçalves-Anjo, N; Galarza-Ahumada, J; Díaz-Domínguez, CM; Piñeiro, P; González-Miranda, E; Giler, S; Telling, G; Sánchez-Martín, ...
PLOS PATHOGENS
2025

Dual-Mode Immunosensor for Antibody Detection: Harnessing the Versatility of Antibody-Based Nanozymes across Optical and Electrochemical Platforms
Vazquez-Diaz, S; Saa, L; Otaegui, D; Pavlov, V; Palazon, A; Cortajarena, AL;
ANALYTICAL CHEMISTRY
2025

Metabolic Profiling of Brain Tissue and Brain-Derived Extracellular Vesicles in Alzheimer's Disease
Hernandez, P; Rackles, E; Alboniga, OE; Martínez-Lage, P; Camacho, EN; Onaindia, A; Fernandez, M; Talamillo, A; Falcon-Perez, JM;
JOURNAL OF EXTRACELLULAR VESICLES
2025

Growing Hybrid Cuticles: Metallochitins as an Emerging Family of Bioactive Mimics of Chitin
Ashurbekova, K; Alonso-Lerma, B; Ashurbekova, K; Muriqi, A; Barandiaran, L; Jankovic, IS; Modin, E; Santos, JI; Perez-Jimenez, R; Petravic, M; Nolan, M; Knez, M;
ACS APPLIED MATERIALS & INTERFACES
2025

Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis
Kioroglou, D; Peña-Cearra, A; Corraliza, AM; Seoane, I; Castelo, J; Panés, J; Gómez-Irwin, L; Rodríguez-Lago, I; de Zarate, JO; Fuertes, M; Martín-Ruiz, I; Gonzalez, M; Aransay, AM; Salas, A; ...
INFLAMMATORY BOWEL DISEASES
2025

Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients
Martin-Inaraja, M; Romayor, I; de Cámara, AS; Herrera, L; Palacios, A; Villaverde, M; Santos, S; Vesga, MA; Barreña, B; Aransay, AM; Anguita, J; Solorzano, E; Prieto, MB; Matorras, R; Eguizabal, C;
STEM CELL RESEARCH
2025

Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction
Dutta, S; Rana, VS; Backstedt, BT; Shakya, AK; Kitsou, C; Yas, OB; Smith, AA; Ronzetti, MH; Lipman, RM; Araujo-Aris, S; Yang, XL; Rai, G; Lin, YP; Herzberg, O; Pal, U;
MBIO
2025

S-Adenosylmethionine: A Multifaceted Regulator in Cancer Pathogenesis and Therapy
Fernández-Ramos, D; Lopitz-Otsoa, F; Lu, SC; Mato, JM;
CANCERS
2025

Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis
Salgueiro-Toledo, VC; Bertol, J; Gutierrez, C; Serrano-Mestre, JL; Ferrer-Luzon, N; Vázquez-Iniesta, L; Palacios, A; Pasquina-Lemonche, L; Espaillat, A; Lerma, L; Weinrick, B; Lavin, JL; Elortza, ...
ELIFE
2025

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
Merino-Cacho, L; Barroso-Gomila, O; Pozo-Rodríguez, M; Muratore, V; Guinea-Pérez, C; Serrano, A; Pérez, C; Cano-López, S; Urcullu, A; Azkargorta, M; Iloro, I; Galdeano, C; Juárez-Jiménez, J; ...
CELL COMMUNICATION AND SIGNALING
2025

Fructose-induced progression of steatohepatitis involves disrupting aldolase B-AMPK signaling in methionine adenosyltransferase 1A deficient mice
Barbier-Torres, L; Luque-Urbano, M; Chhimwal, J; Robinson, AE; Fernández-Ramos, D; Lopitz-Otsoa, F; Van Eyk, JE; Millet, O; Mato, JM; Lu, SC;
METABOLISM-CLINICAL AND EXPERIMENTAL
2025

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis
de la Torre, RAMG; Vallverdú, J; Xu, ZQ; Ariño, S; Ferrer-Lorente, R; Zanatto, L; Mercado-Gómez, M; Aguilar-Bravo, B; Ruiz-Blázquez, P; Fernandez, MF; Navarro-Gascon, A; Blasco-Roset, A; Sànchez-Fernàndez-de-Landa, ...
NATURE COMMUNICATIONS
2025

Proteomic evaluation of borosilicate hybrid sol-gel coatings with osteogenic, immunomodulatory and antibacterial properties
Romero-Gavilán, F; Cerqueira, A; García-Arnáez, I; Scalschi, L; Vicedo, B; Azkargorta, M; Elortza, F; Izquierdo, R; Gurruchaga, M; Goñi, I; Suay, J;
COLLOIDS AND SURFACES B-BIOINTERFACES
2025

Sucrase Isomaltase Dysfunction Reduces Sucrose Intake in Mice and Humans
Aldiss, P; Torices, L; Ramne, S; Jorgensen, ME; Damato, M; Andersen, MK;
GASTROENTEROLOGY
2025

Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes
Lago-Baameiro, N; Camino, T; Vazquez-Durán, A; Sueiro, A; Couto, I; Santos, F; Baltar, J; Falcón-Pérez, JM; Pardo, M;
JOURNAL OF TRANSLATIONAL MEDICINE
2025

The influence of amniotic membrane proteins on corneal regeneration when delivered directly or using hydrogel platforms
Basasoro, A; Mendicute, J; Rezola, M; Burgos, J; Fernández, M; Esporrín-Ubieto, D; Sonzogni, A; Calderón, M; Calafel, I; Díaz, A; De Souza, J; Aiastui, A; Azkargorta, M; Elortza, F; Vecino, ...
FRONTIERS IN MEDICINE
2025

Impact of loosenins on the enzymatic preparation of cellulose nanocrystals
Jabalera, Y; Dahiya, D; Cencerrado, CDO; Caballero, AJ; Zaldua, N; Eceiza, A; Master, ER; Perez-Jimenez, R;
CARBOHYDRATE POLYMERS
2025

Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination
Lang, JRS; Bernal, A; Wist, J; Egan, S; Bong, SH; Millet, O; Ryan, M; Lee, AC; Hall, D; Nitschke, P; Masuda, R; Imrie, A; Holmes, E; Nicholson, J; Loo, RL;
JOURNAL OF MOLECULAR MEDICINE-JMM
2025

Characterization of the Regulatory Landscape in Crohn's Disease Reveals microRNA-Associated Alterations that Shape Anti-TNF Response
Cervera-Seco, L; Baldán-Martín, M; Fernández-Tomé, S; Moreno, LO; Lozano, JJ; Aransay, AM; Chaparro, M; Gisbert, JP; Marigorta, UM;
INFLAMMATORY BOWEL DISEASES
2025

Engineered Oxalate Decarboxylase Boosts Activity and Stability for Biological Applications
Dindo, M; Conter, C; Uechi, GI; Pampalone, G; Ruta, L; Pey, AL; Rossi, L; Laurino, P; Magnani, M; Cellini, B;
ACS OMEGA
2025

Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma
Wist, J; Nitschke, P; Conde, R; de Diego, A; Bizkarguenaga, M; Lodge, S; Hall, D; Chai, ZL; Wang, WJ; Kowlessur, S; Cobo, MF; Pompe, N; Schütz, B; Schäfer, H; Spraul, M; Cannet, C; Diercks, ...
ANALYTICAL CHEMISTRY
2025

Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma
Bouvier, C; Gonzalez-Santamarta, M; Profitós-Pelejà, N; Armengol, M; Quinet, G; Alasseur, Q; Ceccato, L; Xolalpa, W; Freire, R; Guillermet-Guibert, J; Reybier, K; Caminade, AM; Beck, HC; Carvalho, ...
CELL DEATH DISCOVERY
2025

Protocol for pull-down capture of ubiquitinated and NEDDylated liver proteins from transgenic biotinylated ubiquitin and NEDD8 mice
Zapata-Pavas, LE; Delgado, TC; Martínez-Chantar, ML;
STAR PROTOCOLS
2025

Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland
Almeida, GMD; Arriaga, I; de Azevedo, BL; Leppänen, M; Abrahao, JS; Andreani, J; Zabeo, D; Ravantti, JJ; Abrescia, NGA; Sundberg, LR;
ELIFE
2025

Harnessing Plasma Biomarkers to Predict Immunotherapy Outcomes in Hepatocellular Carcinoma: The Role of cfDNA, ctDNA, and Cytokines
Vargas-Accarino, E; Higuera, M; Bermúdez-Ramos, M; Soriano-Varela, A; Torrens, M; Pons, M; Aransay, AM; Martín, JE; Rodríguez-Frías, F; Merino, X; Mínguez, B;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025

Embryo-Induced Changes in the Protein Profile of Bovine Oviductal Extracellular Vesicles
Mazzarella, R; Sánchez, J; Fernandez-Fuertes, B; Egido, SG; McDonald, M; Alvarez-Barrientos, A; González, E; Falcón-Pérez, JM; Azkargorta, M; Elortza, F; González, ME; Lonergan, P; Rizos, D;
MOLECULAR & CELLULAR PROTEOMICS
2025

Generation and validation of a novel multitarget small molecule in glioblastoma
Artetxe-Zurutuza, A; Iturrioz-Rodriguez, N; Elizazu, J; Toledano-Pinedo, M; Porro-Pérez, A; De Goñi, I; Elua-Pinin, A; Schäker-Hübner, L; Azkargorta, M; Elortza, F; Iriepa, I; Lòpez-Muñoz, F; ...
CELL DEATH & DISEASE
2025

Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics
Hernandez-Unzueta, I; Telleria-Gonzalez, U; Aransay, AM; Rodriguez, JEM; Sanz, E; Márquez, J;
FRONTIERS IN PHARMACOLOGY
2025

Management of drug-induced liver injury associated with anti-cancer therapy
Vincenzi, B; Yimin, M; Andrade, RJ; Castillo, MM; Akhundova-Unadkat, G; Mato, JM;
FRONTIERS IN PHYSIOLOGY
2025

Relevance of transportome among the mechanisms of chemoresistance in hepatoblastoma
Cives-Losada, C; Asensio, M; Briz, O; Chinchilla-Tábora, LM; Barranco, MM; del Río-Alvarez, A; Martinez-Chantar, ML; Avila, MA; Cairo, S; Armengol, C; Marin, JJG; Macias, RIR;
BIOCHEMICAL PHARMACOLOGY
2025

Preclinical Protein Signatures of Crohn's Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts
Grännö, O; Bergemalm, D; Salomon, B; Lindqvist, CM; Hedin, CRH; Carlson, M; Dannenberg, K; Andersson, E; Keita, Å; Magnusson, MK; Eriksson, C; Lanka, V; Magnusson, PKE; DAmato, M; Öhman, L; ...
GASTROENTEROLOGY
2025

Enhanced Standard Operating Procedures for 31P NMR-Based Metabolomics in Tissue Extracts
Martin-Ramos, S; Bilbao, J; Diercks, T; Mato, JM; Bernardo-Seisdedos, G; Millet, O;
JACS AU
2025

Syndecan-3 positively regulates the pro-inflammatory function of macrophages
Lee, SY; Prieto-Fernández, E; Egia-Mendikute, L; Antonaña-Vildosola, A; Velasco-Beltrán, P; Bosch, A; Jimenez-Lasheras, B; de Blas, A; de Durana, JED; Valdaliso-Díez, E; Bozal-Basterra, L; Ercilla, ...
CELLULAR AND MOLECULAR LIFE SCIENCES
2025

ADCC: the rock band led by therapeutic antibodies, tumor and immune cells
Vincken, R; Armendariz-Martínez, U; Ruiz-Sáenz, A;
FRONTIERS IN IMMUNOLOGY
2025

Multi-omic integration sets the path for early prevention strategies on healthy individuals
Kioroglou, D; Gil-Redondo, R; Embade, N; Bizkarguenaga, M; Conde, R; Millet, O; Mato, JM; Marigorta, UM;
NPJ GENOMIC MEDICINE
2025

Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study
Izagirre, A; Sarasqueta, C; Flores-Arriaga, J; Aso, MC; Pérez, MP; Tack, J; Huang, IH; Sperber, AD; Palsson, OS; Bangdiwala, SI; DAmato, M; Lanas, A; Lobo, B; Alonso-Cotoner, C; Santos, J; Bujanda, ...
AMERICAN JOURNAL OF GASTROENTEROLOGY
2025

Deep Learning-Based Classification of SOX2 Expression in Breast Cancer
Perez-Herrera, LV; García-González, MJ; Vivanco, MD; Oliver, IM; Lopez-Linares, K; Chen, YW; Tanaka, S; Howlett, RJ; Jain, LC;
INNOVATION IN MEDICINE AND HEALTHCARE, KES-INMED 2024
2025

Controlling Glycan Folding with Ionic Functional Groups
Yadav, N; Poveda, A; Mena, YV; Rosenthal, M; Ogawa, Y; Jiménez-Barbero, J; Delbianco, M;
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2025

pH-antenna residues trigger a large-scale conformational change in the large extracellular loop domain of the CD81 human receptor
Risueño, C; Carbajo, I; Charro, D; Abrescia, NGA; Coluzza, I;
JOURNAL OF CHEMICAL PHYSICS
2025

Bis-CF3-bipyridine Ligands for the Iridium-Catalyzed Borylation of N-Methylamides
Marcos-Atanes, D; Jiménez-Osés, G; Mascareñas, JL;
ACS CATALYSIS
2025

From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions
Keskitalo, S; Seppänen, MRJ; del Sol, A; Varjosalo, M;
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2025

Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum
Sousa, A; Oliveira, N; Conde, R; Morais, E; Amaral, AP; Embade, N; Millet, O; Verde, I;
MOLECULES
2025

Friends to remember: innate immune memory regulation by the microbiota
Pellon, A; Palacios, A; Abecia, L; Rodríguez, H; Anguita, J;
TRENDS IN MICROBIOLOGY
2025