Publications

2022

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients
Capelle, CM;Cire, S;Domingues, O;Ernens, I;Hedin, F;Fischer, A;Snoeck, CJ;Ammerlaan, W;Konstantinou, M;Grzyb, K;Skupin, A;Carty, CL;Hilger, C;Gilson, G;Celebic, A;Wilmes, P;Del Sol, A;Kaplan, ...
CELL REPORTS MEDICINE
2022

The effect of calcium-magnesium mixtures in sol-gel coatings on bone tissue regeneration
Cerqueira, A;Garcia-Arnaez, I;Muriach, M;Azkargorta, M;Elortza, F;Izquierdo, R;Romero-Gavilan, F;Gurruchaga, M;Suay, J;Goni, I
BIOMATERIALS SCIENCE
2022

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
Mercado-Gomez, M;Prieto-Fernandez, E;Goikoetxea-Usandizaga, N;Vila-Vecilla, L;Azkargorta, M;Bravo, M;Serrano-Macia, M;Egia-Mendikute, L;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Lee, SY;Gine, AE;Gil-Pitarch, ...
COMMUNICATIONS BIOLOGY
2022

Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum
Nitschke, P;Lodge, S;Hall, D;Schaefer, H;Spraul, M;Embade, N;Millet, O;Holmes, E;Wist, J;Nicholson, JK
ANALYST
2022

Chemometric-assisted cocrystallization: supervised pattern recognition for predicting the formation of new functional cocrystals
Fornari, F;Montisci, F;Bianchi, F;Cocchi, M;Carraro, C;Cavaliere, F;Cozzini, P;Peccati, F;Mazzeo, PP;Riboni, N;Careri, M;Bacchi, A
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
2022

Structural and functional comparison of magnesium transporters throughout evolution
Franken, GAC;Huynen, MA;Martinez-Cruz, LA;Bindels, RJM;de Baaij, JHF
CELLULAR AND MOLECULAR LIFE SCIENCES
2022

Oral Progenitor Cell Line-Derived Small Extracellular Vesicles as a Treatment for Preferential Wound Healing Outcome
Knight, R;Board-Davies, E;Brown, H;Clayton, A;Davis, T;Karatas, B;Burston, J;Tabi, Z;Falcon-Perez, JM;Paisey, S;Stephens, P
STEM CELLS TRANSLATIONAL MEDICINE
2022

Proceedings of workshop: "Neuroglycoproteins in health and disease", INNOGLY cost action
Llop, E;Arda, A;Zacco, E;O'Flaherty, R;Garcia-Ayllon, MS;Aureli, M;Frenkel-Pinter, M;Reis, CA;Greiner-Tollersrud, OK;Cuchillo-Ibanez, I
GLYCOCONJUGATE JOURNAL
2022

Selective Exoenzymatic Labeling of Lipooligosaccharides of Neisseria gonorrhoeae with alpha 2,6-Sialoside Analogues
de Jong, H;Moure, MJ;Hartman, JEM;Bosman, GP;Ong, JY;Bardoel, BW;Boons, GJ;Wosten, MMSM;Wennekes, T
CHEMBIOCHEM
2022

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples
Bordanaba-Florit, G;van Liempd, S;Cabrera, D;Royo, F;Falcon-Perez, JM
METABOLITES
2022

HPLC-(Q)-TOF-MS-Based Study of Plasma Metabolic Profile Differences Associated with Age in Pediatric Population Using an Animal Model
Alboniga, OE;Gonzalez-Mendia, O;Blanco, ME;Alonso, RM
METABOLITES
2022

U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration
Rovira, E;Moreno, B;Razquin, N;Hjerpe, R;Gonzalez-Lopez, M;Barrio, R;de los Mozos, IR;Ule, J;Pastor, F;Blazquez, L;Fortes, P
MOLECULAR THERAPY-NUCLEIC ACIDS
2022

microRNA-based signatures obtained from endometrial fluid identify implantative endometrium
Ibanez-Perez, J;Diaz-Nunez, M;Clos-Garcia, M;Lainz, L;Iglesias, M;Diez-Zapirain, M;Rabanal, A;Barcena, L;Gonzalez, M;Lozano, JJ;Marigorta, UM;Gonzalez, E;Royo, F;Aransay, AM;Subiran, N;Matorras, ...
HUMAN REPRODUCTION
2022

Proteomic evaluation of human osteoblast responses to titanium implants over time
Romero-Gavilan, F;Cerqueira, A;Garcia-Arnaez, I;Azkargorta, M;Elortza, F;Gurruchaga, M;Goni, I;Suay, J
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2022

Decellularization of xenografted tumors provides cell-specific in vitro 3D environment
Iazzolino, G;Mendibil, U;Arnaiz, B;Ruiz-de-Angulo, A;Azkargorta, M;Uribe, KB;Khatami, N;Elortza, F;Olalde, B;Gomez-Vallejo, V;Llop, J;Abarrategi, A
FRONTIERS IN ONCOLOGY
2022

miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma
de la Cruz-Ojeda, P;Schmid, T;Boix, L;Moreno, M;Sapena, V;Praena-Fernandez, JM;Castell, FJ;Falcon-Perez, JM;Reig, M;Brune, B;Gomez-Bravo, MA;Giraldez, A;Bruix, J;Ferrer, MT;Muntane, J
CELLS
2022

Enzymatic bioconversion of beechwood xylan into the antioxidant 2 '-O-alpha-(4-O-methyl-D-glucuronosyl)-xylobiose
Miguez, N;Fernandez-Polo, D;Santos-Moriano, P;Rodriguez-Colinas, B;Poveda, A;Jimenez-Barbero, J;Ballesteros, AO;Plou, FJ
BIOMASS CONVERSION AND BIOREFINERY
2022

Performance of the Use of Genetic Information to Assess the Risk of Colorectal Cancer in the Basque Population
Garcia-Etxebarria, K;Etxart, A;Barrero, M;Nafria, B;Merino, NMS;Romero-Garmendia, I;Franke, A;D'Amato, M;Bujanda, L
CANCERS
2022

Severe pathogenic variants of intestinal sucrase-isomaltase interact avidly with the wild type enzyme and negatively impact its function and trafficking
Husein, DM;Rizk, S;Hoter, A;Wanes, D;D'Amato, M;Naim, HY
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
2022

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...
HEPATOLOGY
2022

Comparison of Genomic Profiling Data with Clinical Parameters: Implications for Breast Cancer Prognosis
Lopez-Ruiz, JA;Mieza, JA;Zabalza, I;Vivanco, MDM
CANCERS
2022

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV-Cell Interaction and Functional Activation of Endothelial Cells
Clos-Sansalvador, M;Garcia, SG;Moron-Font, M;Williams, C;Reichardt, NC;Falcon-Perez, JM;Bayes-Genis, A;Roura, S;Franquesa, M;Monguio-Tortajada, M;Borras, FE
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022

Application of adipose-derived mesenchymal stem cells in an in vivo model of peripheral nerve damage
Gonzalez-Cubero, E;Gonzalez-Fernandez, ML;Rodriguez-Diaz, M;Palomo-Irigoyen, M;Woodhoo, A;Villar-Suarez, V
FRONTIERS IN CELLULAR NEUROSCIENCE
2022

The serotonin receptor 3E variant is a risk factor for female IBS-D
Fritz, N;Berens, S;Dong, YJ;Martinez, C;Schmitteckert, S;Houghton, LA;Goebel-Stengel, M;Wahl, V;Kabisch, M;Gotze, D;D'Amato, M;Zheng, TH;Roth, R;Monnikes, H;Tesarz, J;Engel, F;Gauss, A;Raithel, ...
JOURNAL OF MOLECULAR MEDICINE-JMM
2022

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Penuelas-Haro, I;Espinosa-Sotelo, R;Crosas-Molist, E;Herranz-Iturbide, M;Caballero-Diaz, D;Alay, A;Sole, X;Ramos, E;Serrano, T;Martinez-Chantar, ML;Knaus, UG;Cuezva, JM;Zorzano, A;Bertran, E;Fabregat, ...
HEPATOLOGY
2022

Differential Protein Content between Fresh and Freeze-Dried Plasma Rich in Growth Factors Eye Drops
Anitua, E;Pino, A;Azkargorta, M;Elortza, F;Merayo-Lloves, J;Muruzabal, F
BIOMOLECULES
2022

Extracellular vesicles from thyroid cancer harbor a functional machinery involved in extracellular matrix remodeling
Bravo-Miana, RD;Soler, MF;Ceschin, DG;Royo, F;Negretti-Borga, DM;Azkargorta, M;Elortza, F;Montesinos, MD;Pellizas, CG;Falcon-Perez, JM;Donadio, AC
EUROPEAN JOURNAL OF CELL BIOLOGY
2022

Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation
Lasagni, S;Leonardi, F;Pivetti, A;Di Marco, L;Ravaioli, F;Serenari, M;Gitto, S;Critelli, RM;Milosa, F;Romanzi, A;Mancarella, S;Dituri, F;Riefolo, M;Catellani, B;Magistri, P;Romagnoli, D;Celsa, ...
FRONTIERS IN ONCOLOGY
2022

Germline gain-of-function MMP11 variant results in an aggressive form of colorectal cancer
Martin-Morales, L;Manzano, S;Rodrigo-Faus, M;Vicente-Barrueco, A;Lorca, V;Nunez-Moreno, G;Bragado, P;Porras, A;Caldes, T;Garre, P;Gutierrez-Uzquiza, A
INTERNATIONAL JOURNAL OF CANCER
2022

Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin
Bertuzzi, S;Peccati, F;Serna, S;Artschwager, R;Notova, S;Thepaut, M;Jimenez-Oses, G;Fieschi, F;Reichardt, NC;Jimenez-Barbero, J;Arda, A
ACS CENTRAL SCIENCE
2022

ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells
Zheng, ML;Okawa, S;Bravo, M;Chen, F;Martinez-Chantar, ML;Del Sol, A
NUCLEIC ACIDS RESEARCH
2022

Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma
Critelli, RM;Milosa, F;Romanzi, A;Lasagni, S;Marcelli, G;Di Marco, L;Pivetti, A;Schepis, F;Romagnoli, D;Mancarella, S;Dituri, F;Martinez-Chantar, ML;Giannelli, G;Villa, E
ONCOLOGY LETTERS
2022

The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays
Chamorro-Garcia, A;Parolo, C;Ortega, G;Idili, A;Green, J;Ricci, F;Plaxco, KW
CHEMICAL SCIENCE
2022

The use of pharmacological chaperones in rare diseases caused by reduced protein stability
Gil-Martinez, J;Bernardo-Seisdedos, G;Mato, JM;Millet, O
PROTEOMICS
2022

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
Lopez-Alonso, JP;Lazaro, M;Gil-Carton, D;Choi, PH;Tong, L;Valle, M
NATURE COMMUNICATIONS
2022

Stereoselective alpha-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives
Navo, CD;Oroz, P;Mazo, N;Blanco, M;Peregrina, JM;Jimenez-Oses, G
ORGANIC LETTERS
2022

CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets
Caloto, R;Lorenzo-Martin, LF;Quesada, V;Carracedo, A;Bustelo, XR
BIOLOGY-BASEL
2022

Tear proteome profile in eyes with keratoconus after intracorneal ring segment implantation or corneal crosslinking
Goni, N;Martinez-Soroa, I;Ibarrondo, O;Azkargorta, M;Elortza, F;Galarreta, DJ;Acera, A
FRONTIERS IN MEDICINE
2022

Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets
Diaz-Casado, L;Santana, AG;Gomez-Pinto, I;Villacampa, A;Corzana, F;Jimenez-Barbero, J;Gonzalez, C;Asensio, JL
COMMUNICATIONS CHEMISTRY
2022

ALAD Inhibition by Porphobilinogen Rationalizes the Accumulation of ?-Aminolevulinate in Acute Porphyrias br
San Juan, I;Pereira-Ortuzar, T;Cendoya, X;Lain, A;To-Figueras, J;Mateos, B;Planes, FJ;Bernardo-Seisdedos, G;Mato, JM;Millet, O
BIOCHEMISTRY
2022

Fine-tuning of the Hsc70-based Human Protein Disaggregase Machinery by the Distinctive C-terminal Extension of Apg2
Cabrera, Y;Bernardo-Seisdedos, G;Dublang, L;Albesa-Jove, D;Orozco, N;Viguera, AR;Millet, O;Muga, A;Moro, F
JOURNAL OF MOLECULAR BIOLOGY
2022

Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis
Garcia-Arnaez, I;Romero-Gavilan, F;Cerqueira, A;Elortza, F;Azkargorta, M;Munoz, F;Mata, M;de Llano, JJM;Suay, J;Gurruchaga, M;Goni, I
COLLOIDS AND SURFACES B-BIOINTERFACES
2022

A switch from alpha-helical to beta-strand conformation during co-translational protein folding
Agirrezabala, X;Samatova, E;Macher, M;Liutkute, M;Maiti, M;Gil-Carton, D;Novacek, J;Valle, M;Rodnina, MV
EMBO JOURNAL
2022

Implication of Ceramide Kinase/C1P in Cancer Development and Progression
Camacho, L;Ouro, A;Gomez-Larrauri, A;Carracedo, A;Gomez-Munoz, A
CANCERS
2022

J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum
Nitschke, P;Lodge, S;Kimhofer, T;Masuda, R;Bong, SH;Hall, D;Schafer, H;Spraul, M;Pompe, N;Diercks, T;Bernardo-Seisdedos, G;Mato, JM;Millet, O;Susic, D;Henry, A;El-Omar, EM;Holmes, E;Lindon, ...
ANALYTICAL CHEMISTRY
2022

Intestinal Barrier and Permeability in Health, Obesity and NAFLD
Portincasa, P;Bonfrate, L;Khalil, M;De Angelis, M;Calabrese, FM;D'Amato, M;Wang, DQH;Di Ciaula, A
BIOMEDICINES
2022

Depletion of mitochondrial methionine adenosyltransferase alpha 1 triggers mitochondrial dysfunction in alcohol-associated liver disease
Barbier-Torres, L;Murray, B;Yang, JW;Wang, JH;Matsuda, M;Robinson, A;Binek, A;Fan, W;Fernandez-Ramos, D;Lopitz-Otsoa, F;Luque-Urbano, M;Millet, O;Mavila, N;Peng, H;Ramani, K;Gottlieb, R;Sun, ...
NATURE COMMUNICATIONS
2022

Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids
de Gauna, MR;Biancaniello, F;Gonzalez-Romero, F;Rodrigues, PM;Lapitz, A;Gomez-Santos, B;Olaizola, P;Di Matteo, S;Aurrekoetxea, I;Labiano, I;Nieva-Zuluaga, A;Benito-Vicente, A;Perugorria, MJ;Apodaka-Biguri, ...
HEPATOLOGY
2022

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Zabala-Letona, A;Arruabarrena-Aristorena, A;Fernandez-Ruiz, S;Viera, C;Carlevaris, O;Ercilla, A;Mendizabal, I;Martin, T;Macchia, A;Camacho, L;Pujana-Vaquerizo, M;Sanchez-Mosquera, P;Torrano, ...
ONCOGENESIS
2022

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy
Ye, H;Chen, CB;Wu, HH;Zheng, K;Martin-Adrados, B;Caparros, E;Frances, R;Nelson, LJ;del Moral, MG;Asensio, I;Vaquero, J;Banares, R;Avila, MA;Andrade, RJ;Lucena, MI;Martinez-Chantar, ML;Reeves, ...
CELL DEATH & DISEASE
2022

Fostering experimental and computational synergy to modulate hyperinflammation
Potapov, I;Kanneganti, TD;del Sol, A
TRENDS IN IMMUNOLOGY
2022

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
Lozano-Ruiz, B;Tzoumpa, A;Martinez-Cardona, C;Moreno, D;Aransay, AM;Cortazar, AR;Pico, J;Peiro, G;Lozano, J;Zapater, P;Frances, R;Gonzalez-Navajas, JM
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022

Deconvoluting the Directed Evolution Pathway of Engineered Acyltransferase LovD
Garcia-Marquina, G;Nunez-Franco, R;Peccati, F;Tang, Y;Jimenez-Oses, G;Lopez-Gallego, F
CHEMCATCHEM
2022

Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma
Quinet, G;Xolalpa, W;Reyes-Garau, D;Profitos-Peleja, N;Azkargorta, M;Ceccato, L;Gonzalez-Santamarta, M;Marsal, M;Andilla, J;Aillet, F;Bosch, F;Elortza, F;Loza-Alvarez, P;Sola, B;Coux, O;Matthiesen, ...
CANCERS
2022

A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
Guo, FF;Estevez-Vazquez, O;Benede-Ubieto, R;Maya-Miles, D;Zheng, K;Gallego-Duran, R;Rojas, A;Ampuero, J;Romero-Gomez, M;Philip, K;Egbuniwe, IU;Chen, CB;Simon, J;Delgado, TC;Martinez-Chantar, ...
CANCERS
2022

Detailed Transcriptional Landscape of Peripheral Blood Points to Increased Neutrophil Activation in Treatment-Naive Inflammatory Bowel Disease
Juzenas, S;Hubenthal, M;Lindqvist, CM;Kruse, R;Steiert, TA;Degenhardt, F;Schulte, D;Nikolaus, S;Zeissig, S;Bergemalm, D;Almer, S;Hjortswang, H;Bresso, F;Struning, N;Kupcinskas, J;Keller, A;Lieb, ...
JOURNAL OF CROHNS & COLITIS
2022

Hypoxia-induced HIF1 alpha activation regulates small extracellular vesicle release in human embryonic kidney cells
Muniz-Garcia, A;Romero, M;Falcon-Perez, JM;Murray, P;Zorzano, A;Mora, S
SCIENTIFIC REPORTS
2022

Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction
Garcia-Etxebarria, K;Merino, O;Gaite-Reguero, A;Rodrigues, PM;Herrarte, A;Etxart, A;Ellinghaus, D;Alonso-Galan, H;Franke, A;Marigorta, UM;Bujanda, L;D'Amato, M
SCIENTIFIC REPORTS
2022

Pathogenesis of Microscopic Colitis: A Systematic Review
Zabana, Y;Tontini, G;Hultgren-Hornquist, E;Skonieczna-Zydecka, K;Latella, G;Ostvik, AE;Marlicz, W;D'Amato, M;Arias, A;Mielhke, S;Munch, A;Fernandez-Banares, F;Lucendo, AJ
JOURNAL OF CROHNS & COLITIS
2022

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine
Plou, J;Valera, PS;Garcia, I;de Albuquerque, CDL;Carracedo, A;Liz-Marzan, LM
ACS PHOTONICS
2022

Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging
Carregal-Romero, S;Miguel-Coello, AB;Martinez-Parra, L;Marti-Mateo, Y;Hernansanz-Agustin, P;Fernandez-Afonso, Y;Plaza-Garcia, S;Gutierrez, L;Munoz-Hernandez, MD;Carrillo-Romero, J;Pinol-Cancer, ...
SMALL
2022

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View
Unione, L;Moure, MJ;Lenza, MP;Oyenarte, I;Ereno-Orbea, J;Arda, A;Jimenez-Barbero, J
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2022

A Computational Perspective on Molecular Recognition by Galectins
Nunez-Franco, R;Peccati, F;Jimenez-Oses, G
CURRENT MEDICINAL CHEMISTRY
2022

Prof. Jesus Jimenez-Barbero: Disentangling Molecular Recognition of Carbohydrates
Franconetti, A;Angulo, J
CURRENT MEDICINAL CHEMISTRY
2022

Description of the first Spanish case of Gerstmann-Straussler-Scheinker disease with A117V variant: clinical, histopathological and biochemical characterization
Erana, H;San Millan, B;Diaz-Dominguez, CM;Charco, JM;Rodriguez, R;Vieitez, I;Pereda, A;Yanez, R;Geijo, M;Navarro, C;de Nanclares, GP;Teijeira, S;Castilla, J
JOURNAL OF NEUROLOGY
2022

Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
Martinez-Arranz, I;Bruzzone, C;Noureddin, M;Gil-Redondo, R;Minchole, I;Bizkarguenaga, M;Arretxe, E;Iruarrizaga-Lejarreta, M;Fernandez-Ramos, D;Lopitz-Otsoa, F;Mayo, R;Embade, N;Newberry, E;Mittendorf, ...
HEPATOLOGY
2022

Angiocrine polyamine production regulates adiposity
Monelli, E;Villacampa, P;Zabala-Letona, A;Martinez-Romero, A;Llena, J;Beiroa, D;Gouveia, L;Chivite, I;Zagmutt, S;Gama-Perez, P;Osorio-Conles, O;Muixi, L;Martinez-Gonzalez, A;Castillo, SD;Martin-Martin, ...
NATURE METABOLISM
2022

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
de Urturi, DS;Buque, X;Porteiro, B;Folgueira, C;Mora, A;Delgado, TC;Prieto-Fernandez, E;Olaizola, P;Gomez-Santos, B;Apodaka-Biguri, M;Gonzalez-Romero, F;Nieva-Zuluaga, A;de Gauna, MR;Goikoetxea-Usandizaga, ...
NATURE COMMUNICATIONS
2022

Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE
Garcia-Alija, M;Du, JJ;Ordonez, I;Diz-Vallenilla, A;Moraleda-Montoya, A;Sultana, N;Huynh, CG;Li, C;Donahue, TC;Wang, LX;Trastoy, B;Sundberg, EJ;Guerin, ME
NATURE COMMUNICATIONS
2022

Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases
Trastoy, B;Du, JJ;Garcia-Alija, M;Li, C;Klontz, EH;Wang, LX;Sundberg, EJ;Guerin, ME
CURRENT OPINION IN STRUCTURAL BIOLOGY
2022

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15
Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022

Potential Tear Biomarkers for the Diagnosis of Parkinson's Disease-A Pilot Study
Acera, A;Gomez-Esteban, JC;Murueta-Goyena, A;Galdos, M;Azkargorta, M;Elortza, F;Ruzafa, N;Ibarrondo, O;Pereiro, X;Vecino, E
PROTEOMES
2022

A Three-Protein Panel to Support the Diagnosis of Sepsis in Children
Pilar-Orive, FJ;Astigarraga, I;Azkargorta, M;Elortza, F;Garcia-Obregon, S
JOURNAL OF CLINICAL MEDICINE
2022

HIF-1 alpha inhibitor PX-478 preserves pancreatic. cell function in diabetes
Ilegems, E;Bryzgalova, G;Correia, J;Yesildag, B;Berra, E;Ruas, JL;Pereira, TS;Berggren, PO
SCIENCE TRANSLATIONAL MEDICINE
2022

Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing
Heras, KL;Royo, F;Garcia-Vallicrosa, C;Igartua, M;Santos-Vizcaino, E;Falcon-Perez, JM;Hernandez, RM
STEM CELL RESEARCH & THERAPY
2022

Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity
Auzmendi-Iriarte, J;Otaegi-Ugartemendia, M;Carrasco-Garcia, E;Azkargorta, M;Diaz, A;Saenz-Antonanzas, A;Andermatten, JA;Garcia-Puga, M;Garcia, I;Elua-Pinin, A;Ruiz, I;Sampron, N;Elortza, F;Cuervo, ...
CANCER RESEARCH
2022

Triplet photodynamic and up-conversion luminescence in donor-acceptor dyads with slip-stacked vs. co-facial arrangement
Yun, YJ;Peccati, F;Wiederrecht, GP;Gosztola, DJ;Diroll, BT;Jimenez-Oses, G;Ayitou, AJL
JOURNAL OF MATERIALS CHEMISTRY C
2022

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
Araujo, AM;Abaurrea, A;Azcoaga, P;Lopez-Velazco, JI;Manzano, S;Rodriguez, J;Rezola, R;Egia-Mendikute, L;Valdes-Mora, F;Flores, JM;Jenkins, L;Pulido, L;Osorio-Querejeta, I;Fernandez-Nogueira, ...
JOURNAL OF CLINICAL INVESTIGATION
2022

A starch- and sucrose-reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro-RNA levels
Nilholm, C;Manoharan, L;Roth, B;D'Amato, M;Ohlsson, B
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
2022

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart
Aiestaran-Zelaia, I;Sanchez-Guisado, MJ;Villar-Fernandez, M;Azkargorta, M;Fadon-Padilla, L;Fernandez-Pelayo, U;Perez-Rodriguez, D;Ramos-Cabrer, P;Spinazzola, A;Elortza, F;Ruiz-Cabello, J;Holt, IJ
SCIENTIFIC REPORTS
2022

Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of l-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease
Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V
FOOD & FUNCTION
2022

Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling
Coelho, H;de las Rivas, M;Grosso, AS;Diniz, A;Soares, CO;Francisco, RA;Dias, JS;Companon, I;Sun, LB;Narimatsu, Y;Vakhrushev, SY;Clausen, H;Cabrita, EJ;Jimenez-Barbero, J;Corzana, F;Hurtado-Guerrero, ...
JACS AU
2022

High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
Aldaz, P;Martin-Martin, N;Saenz-Antonanzas, A;Carrasco-Garcia, E;Alvarez-Satta, M;Elua-Pinin, A;Pollard, SM;Lawrie, CH;Moreno-Valladares, M;Sampron, N;Hench, J;Lovell-Badge, R;Carracedo, A;Matheu, A
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022

A Starch- and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin: A Randomized Controlled Study
Roth, B;Myllyvainio, J;D'Amato, M;Larsson, E;Ohlsson, B
NUTRIENTS
2022

HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
Assoni, G;La Pietra, V;Digilio, R;Ciani, C;Licata, NV;Micaelli, M;Facen, E;Tomaszewska, W;Cerofolini, L;Perez-Rafols, A;Rey, MV;Fragai, M;Woodhoo, A;Marinelli, L;Arosio, D;Bonomo, I;Provenzani, ...
ADVANCED DRUG DELIVERY REVIEWS
2022

Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
Ferhati, X;Jimenez-Moreno, E;Hoyt, EA;Salluce, G;Cabeza-Cabrerizo, M;Navo, CD;Companon, I;Akkapeddi, P;Matos, MJ;Salaverri, N;Garrido, P;Martinez, A;Laserna, V;Murray, TV;Jimenez-Oses, G;Ravn, ...
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2022

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants
Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A
FRONTIERS IN IMMUNOLOGY
2022

Coding and non-coding co-expression network analysis identifies key modules and driver genes associated with precursor lesions of gastric cancer
Lario, S;Ramirez-Lazaro, MJ;Brunet-Vega, A;Vila-Casadesus, M;Aransay, AM;Lozano, JJ;Calvet, X
GENOMICS
2022

Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection
Masuda, R;Lodge, S;Whiley, L;Gray, N;Lawler, N;Nitschke, P;Bong, SH;Kimhofer, T;Loo, RL;Boughton, B;Zeng, AX;Hall, D;Schaefer, H;Spraul, M;Dwivedi, G;Yeap, BB;Diercks, T;Bernardo-Seisdedos, ...
ANALYTICAL CHEMISTRY
2022

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodriguez-Agudo, R;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Fernandez-Tussy, P;Fernandez-Ramos, D;Lachiondo-Ortega, S;Gonzalez-Recio, I;Gil-Pitarch, C;Mercado-Gomez, M;Moran, L;Bizkarguenaga, ...
ANTIOXIDANTS
2022

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis
Vegas-Suarez, S;Simon, J;Martinez-Chantar, ML;Moratalla, R
FRONTIERS IN PHYSIOLOGY
2022

Applicability of polygenic risk scores in endometriosis clinical presentation
Svensson, A;Garcia-Etxebarria, K;Akesson, A;Borgfeldt, C;Roth, B;Ek, M;D'Amato, M;Ohlsson, B
BMC WOMENS HEALTH
2022

Reproducibility of extracellular vesicle research
Nieuwland, R;Siljander, PRM;Falcon-Perez, JM;Witwer, KW
EUROPEAN JOURNAL OF CELL BIOLOGY
2022

Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
Lachiondo-Ortega, S;Delgado, TC;Banos-Jaime, B;Velazquez-Cruz, A;Diaz-Moreno, I;Martinez-Chantar, ML
CANCERS
2022

Editorial: 17th Spanish Society for Developmental Biology Meeting: New Trends in Developmental Biology
Araujo, SJ;Barrio, R
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2022

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study
Berens, S;Dong, YJ;Fritz, N;Walstab, J;D'Amato, M;Zheng, TH;Wahl, V;Boekstegers, F;Bermejo, JL;Martinez, C;Schmitteckert, S;Clevers, E;Engel, F;Gauss, A;Herzog, W;Spiller, R;Goebel-Stengel, ...
WORLD JOURNAL OF GASTROENTEROLOGY
2022

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods
Stagnoli, S;Peccati, F;Connell, SR;Martinez-Castillo, A;Charro, D;Millet, O;Bruzzone, C;Palazon, A;Arda, A;Jimenez-Barbero, J;Ereno-Orbea, J;Abrescia, NGA;Jimenez-Oses, G
FRONTIERS IN MICROBIOLOGY
2022

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Ladewig, E;Michelini, F;Jhaveri, K;Castel, P;Carmona, J;Fairchild, L;Zuniga, AG;Arruabarrena-Aristorena, A;Cocco, E;Blawski, R;Kittane, S;Zhang, YH;Sallaku, M;Baldino, L;Hristidis, V;Chandarlapaty, ...
CANCER RESEARCH
2022

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
Ballesteros, U;Etxaniz, A;Iriondo, MN;Varela, YR;Lazaro, M;Viguera, AR;Montes, LR;Valle, M;Goni, FM;Alonso, A
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2022

Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair
Echave, MC;Erezuma, I;Golafshan, N;Castilho, M;Kadumudi, FB;Pimenta-Lopes, C;Ventura, F;Pujol, A;Jimenez, JJ;Camara, JA;Hernaez-Moya, R;Iturriaga, L;Del Burgo, LS;Iloro, I;Azkargorta, M;Elortza, ...
BIOMATERIALS ADVANCES
2022

Complex effects of Mg-biomaterials on the osteoblast cell machinery: A proteomic study
Cerqueira, A;Garcia-Arnaez, I;Romero-Gavilan, F;Azkargorta, M;Elortza, F;de Llanos, JJM;Carda, C;Gurruchaga, M;Goni, I;Suay, J
BIOMATERIALS ADVANCES
2022

Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages
Hu, YZ;Jiang, YW;Behnan, J;Ribeiro, MM;Kalantzi, C;Zhang, MD;Lou, DH;Haring, M;Sharma, N;Okawa, S;Del Sol, A;Adameyko, I;Svensson, M;Persson, O;Ernfors, P
SCIENCE ADVANCES
2022

Introducing the Catalytic Amination of Silanes via Nitrene Insertion
Rodriguez, AM;Perez-Ruiz, J;Molina, F;Poveda, A;Perez-Soto, R;Maseras, F;Diaz-Requejo, MM;Perez, PJ
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2022

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming
Colyn, L;Alvarez-Sola, G;Latasa, MU;Uriarte, I;Herranz, JM;Arechederra, M;Vlachogiannis, G;Rae, C;Pineda-Lucena, A;Casadei-Gardini, A;Pedica, F;Aldrighetti, L;Lopez-Lopez, A;Lopez-Gonzalvez, ...
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2022

A Comprehensive Metabolomics Analysis of Fecal Samples from Advanced Adenoma and Colorectal Cancer Patients
Telleria, O;Alboniga, OE;Clos-Garcia, M;Nafria-Jimenez, B;Cubiella, J;Bujanda, L;Falcon-Perez, JM
METABOLITES
2022

Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination
Dunsmore, L;Navo, CD;Becher, J;de Montes, EG;Guerreiro, A;Hoyt, E;Brown, L;Zelenay, V;Mikutis, S;Cooper, J;Barbieri, I;Lawrinowitz, S;Siouve, E;Martin, E;Ruivo, PR;Rodrigues, T;da Cruz, FP;Werz, ...
NATURE CHEMISTRY
2022

Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer
Arruabarrena-Aristorena, A;Toska, E
FRONTIERS IN ONCOLOGY
2022

Synthesis of beta(2,2)-Amino Acids by Stereoselective Alkylation of Isoserine Derivatives Followed by Nucleophilic Ring Opening of Quaternary Sulfamidates
Tovillas, P;Navo, CD;Oroz, P;Avenoza, A;Corzana, F;Zurbano, MM;Jimenez-Oses, G;Busto, JH;Peregrina, JM
JOURNAL OF ORGANIC CHEMISTRY
2022

Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
Istrate, A;Geeson, MB;Navo, CD;Sousa, BB;Marques, MC;Taylor, RJ;Journeaux, T;Oehler, SR;Mortensen, MR;Deery, MJ;Bond, AD;Corzana, F;Jimenez-Oses, G;Bernardes, GJL
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2022

Immunogenicity of Mycobacterial Extracellular Vesicles Isolated From Host-Related Conditions Informs About Tuberculosis Disease Status
Schirmer, S;Rauh, L;Alebouyeh, S;Delgado-Velandia, M;Salgueiro, VC;Lerma, L;Serrano-Mestre, JL;Azkargorta, M;Elortza, F;Lavin, JL;Garcia, MJ;Fernandez, MTT;Gola, S;Prados-Rosales, R
FRONTIERS IN MICROBIOLOGY
2022

Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
Parra-Perez, AM;Perez-Jimenez, A;Gris-Cardenas, I;Bonel-Perez, GC;Carrasco-Diaz, LM;Mokhtari, K;Garcia-Salguero, L;Lupianez, JA;Rufino-Palomares, EE
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022

Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces
Lete, MG;Franconetti, A;Delgado, S;Jimenez-Barbero, J;Arda, A
PHARMACEUTICALS
2022

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients
Serrano-Macia, M;Lachiondo-Ortega, S;Iruzubieta, P;Goikoetxea-Usandizaga, N;Bosch, A;Egia-Mendikute, L;Jimenez-Lasheras, B;Azkargorta, M;Elortza, F;Martinez-Redondo, D;Castro, B;Lozano, JJ;Nogueiras, ...
CELL DEATH DISCOVERY
2022

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Davidson, SM;Schmidt, DR;Heyman, JE;'Brien, JPO;Liu, AC;Israelsen, WJ;Dayton, TL;Sehgal, R;Bronson, RT;Freinkman, E;Mak, HH;Fanelli, GN;Malstrom, S;Bellinger, G;Carracedo, A;Pandolfi, PP;Courtney, ...
CANCER RESEARCH
2022

Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif
Desire, J;Foucart, Q;Poveda, A;Gourlaouen, G;Shimadate, Y;Kise, M;Proceviat, C;Ashmus, R;Vocadlo, DJ;Jimenez-Barbero, J;Kato, A;Bleriot, Y
CARBOHYDRATE RESEARCH
2022

High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP)
Anitua, E;Pino, A;Azkargorta, M;Elortza, F;Prado, R
BIOMOLECULES
2022

Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis
Holst, LM;Halfvarson, J;Carlson, M;Hedin, C;Kruse, R;Lindqvist, CM;Bergemalm, D;Almer, S;Bresso, F;Lundstrom, ML;Repsilber, D;D'Amato, M;Keita, A;Hjortswang, H;Soderholm, J;Sundin, J;Tornblom, ...
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
2022

Targeting cyclin M4 as a new therapeutical approach to treat alcoholic liver disease
Gonzalez-Recio, I;Goikoetxea, N;Agudo, RR;Espinosa, JS;Serrano-Macia, M;Azkargorta, M;Elortza, F;Diaz-Moreno, I;Diaz-Quintana, A;Schaeper, U;Bataller, R;Avila, MA;Martinez-Cruz, LA;Martinez-Chantar, ...
JOURNAL OF HEPATOLOGY
2022

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis
Fondevila, MF;Fernandez, U;Heras, V;Parracho, T;Gonzalez-Rellan, MJ;Novoa, E;Porteiro, B;Alonso, C;Mayo, R;Lima, ND;Iglesias, C;Filliol, AA;Senra, A;Delgado, TC;Woodhoo, A;Herrero, L;Serra, ...
JOURNAL OF HEPATOLOGY
2022

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies
Camilleri, M;Zhernakova, A;Bozzarelli, S;D'Amato, M
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
2022

Insights into Domain Organization and Regulatory Mechanism of Cystathionine Beta-Synthase from Toxoplasma gondii
Conter, C;Fruncillo, S;Favretto, F;Fernandez-Rodriguez, C;Dominici, P;Martinez-Cruz, LA;Astegno, A
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022