CIC bioGUNE Bilbao | Research | Most Cited Reviews

Most Cited Reviews

Review Article with more than 100 citations where CIC bioGUNE group leader appears as first or senior author.
Listed as number of citation per year based on Web of Science database.

Cancer metabolism: fatty acid oxidation in the limelight

Arkaitz Carracedo

Nature Reviews Cancer

We have revisited the Warburg effect hyoptesis and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment.

S-Adenosylmethionine in liver health, injury, and cancer

José M Mato

Physiological Reviews

Children with inactive mutation of glycine N-methyltransferase (GNMT) have elevated liver transaminases, and Gnmt knockout mice develop liver injury, fibrosis, and HCC. S-adenosyl-l-methionine (SAMe) it is effective as a chemopreventive agent in HCC, in experimental mice, and perhaps in other forms of cancer as well.

Wnt/beta-catenin signalling in prostate cance

Robert Kypta

Nature Reviews Urology

Wnt/β-catenin signalling can be controlled by secreted Wnt antagonists, many of which are downregulated in cancer. Activation of the Wnt/β-catenin pathway has effects on prostate cell proliferation, differentiation and the epithelial-mesenchymal transition, which is thought to regulate the invasive behaviour of tumour cells.

Structure Unifies the Viral Universe

Nicola Abrescia

Annual Review of Biochemistry

Here, we summarize the arguments behind the use of structure for the higher-order classification of viruses. We also reflect on the opportunities for a more concerted effort to provide high-throughput methods to facilitate the large-scale sampling of the virosphere.

Role of S-adenosyl-L-methionine in liver health and injury

José M Mato


Impaired SAMe metabolism, which occurs in patients with mutations of glycine N‐methyltransferase (GNMT), can lead to liver injury. A better understanding of why liver injury occurs when SAMe homeostasis is perturbed and mechanisms of action of pharmacologic doses of SAMe are essential in defining which patients will benefit from its use.

Methionine metabolism and liver disease

José M Mato & Malu Martínez-Chantar

Annual Review of Nutrition

Long-term administration of diets deficiency in choline and methionine may cause hepatocellular carcinoma in animal models, providing evidences of the importance of labile methyl group balance to maintain normal liver function. Treatments with various methionine metabolites in experimental animal models of liver disease show hepatoprotective properties.


José M Mato

Int J Biochem Cell Biol

5'-Methylthioadenosine (MTA) has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous MTA could play a regulatory role in the cell.