Malu Martínez-Chantar
Malu Martínez-Chantar
Liver Disease Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Malu Martínez-Chantar is an independent Group Leader at CIC bioGUNE, has published more than 80 publications in prestigious journals, and has established a high number of collaborations with important research groups in the fi eld of liver health and injury all over the world. Moreover, she has been co-PI of four NIH with Dr. Lu (USC, Keck School of Medicine USC, Los Angeles, USA) in the fi eld of liver disease. She was one of the partners in an ambitious European project so called HEPADIP Consortium, which was created in response to the topic of the 3rd call for proposals in the EU FP6 Programme. Actually, she is the coordinator of the Traslational Area of the National Institute for the study of Liver and Gastrointestinal Diseases (CIBEREHD) and the group is part of the Cholestasis and Metabolic Disorders Program. In this respect, she is member of the Scientifi c Advisory Board of the C3M Inserm Nice and the biopharmaceutical company Mitotherapeutix, Connecticut, USA.

Lastest Publications














During 2015-2018 Liver Disease Lab (LDL) has published 35 peer reviewed articles, 18 of them in the first Decil (Nature Communicaton, Cell Metab, Nature, Hepatology, Gut, Gastroenterology etc) and  eleven of them  in the first quartile with an average impact factor of 9. We have been successful obtaining funding from different national and internationals agencies such as the Ministry of Economy Science and Competitiveness, Carlos III Health Institute, Foundations, crowdfunding and international projects derived from NIH. The visibility of our research group in the liver field has been intensified through an extensive participation in different national and international networks such as Ciberehd (Carlos III Health Institute), Women in Hepatology (International Consortium) and different European COST actions PROTEOSTASIS, TRANSAUTOPHAGY and MITOEAGLE.

Tutoring is an important factor in LDL and along these three years, nine PhD theses, 4 master's  and multiple undergraduate and technician students have been  trained. The co-direction of PhD students with different agencies like hospitals and technology centers has been of special relevance, contributing to enrich our research vision.

Regarding the research lines carried out in the LDL, we have generated three new areas of knowledge in this period of time, two of them practically unexplored, which have led us to be Cover Page of Hepatology in 2017 and to reach high impact journals such as Nature Communications, Gut or Cell Metabolism among others. These areas open new ways of knowledge in the liver field regarding metabolism, physiology and disease. These areas are a) post-translational modifications mainly NEDDylation b) Mitochondrial activity c) microRNAS and d) Magnesium metabolism.  In all of them, we have developed new biological tools, preclinical animal models and new therapeutic approaches that have ended in the generation of patents and the development of a robust translational research.

In fact, one of the relevant points during 2015 -2018 of LDL has been the transfer of our knowledge to biomedical and pharmaceuticals companies. We have generated three patents, all of them licensed and other two under development. Importantly, we have promoted the generation of Mitotherapeutix LLC (USA), a biopharmaceutical company that develops products for treatment of degenerative liver disorders, based on our R&D, with a first product in Phase I Clinical Trial and another molecule under development. We have also participated in the OWL Liver and OWL Test, the first test for non-invasive diagnose of NAFLD, currently commercialized.  We have actively collaborated with international companies such as Takeda Pharmaceutical and AGIOS in preclinical trials of their drugs and we have formal initiatives to transfer our R&D to important pharmaceutical companies. Regarding Basque Health cluster we have generated and consolidate initiatives with technological Engineers Centers (bioGUNE / TEKNIKER) with the aim to validate a candidate molecule as a predictive circulating marker of liver injury developing a promising low-cost effective Point-Of-Care technology to facilitate diagnosis and monitoring solutions in primary healthcare centers, pharmaceutical industry and for consumers
Therefore, in these three years we have generated knowledge, an extensive network of collaborations and we have proven preclinical models and transfer our R&D to national and international pharmaceutical companies.

Lastest Publications

Methionine Adenosyltransferase alpha 1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

Murray, B;Peng, H;Barbier-Torres, L;Robinson, AE;Li, TWH;Fan, W;Tomasi, ML;Gottlieb, RA;Van Eyk, J;Lu, ZM;Mart?nez-Chantar, ML;Liangpunsakul, S;Skill, NJ;Mato, JM;Lu, SC

Hepatology (Baltimore, Md.)


miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

Fernandez-Tussy, P;Fernandez-Ramos, D;Lopitz-Otsoa, F;Simon, J;Barbier-Torres, L;Gomez-Santos, B;Nunez-Garcia, M;Azkargorta, M;Gutierrez-de Juan, V;Serrano-Macia, M;Rodriguez-Agudo, R;Iruzubieta, ...



SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Lopitz-Otsoa, F;Delgado, TC;Lachiondo-Ortega, S;Azkargorta, M;Elortza, F;Rodriguez, MS;Martinez-Chantar, ML

Journal of visualized experiments : JoVE


Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations

Seker, M;Fernandez-Rodriguez, C;Martinez-Cruz, LA;Muller, D



The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Bailly, AP;Perrin, A;Serrano-Macia, M;Maghames, C;Leidecker, O;Trauchessec, H;Martinez-Chantar, ML;Gartner, A;Xirodimas, DP



Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy

Lozano, E;Macias, RIR;Monte, MJ;Asensio, M;del Carmen, S;Sanchez-Vicente, L;Alonso-Pena, M;Al-Abdulla, R;Munoz-Garrido, P;Satriano, L;O'Rourke, CJ;Banales, JM;Avila, MA;Martinez-Chantar, ...



Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Banales, JM;Inarrairaegui, M;Arbelaiz, A;Milkiewicz, P;Muntane, J;Munoz-Bellvis, L;La Casta, A;Gonzalez, LM;Arretxe, E;Alonso, C;Martinez-Arranz, I;Lapitz, A;Santos-Laso, A;Avila, MA;Martinez-Chantar, ...



Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis

Reverter, E;Lozano, JJ;Alonso, C;Berzigotti, A;Seijo, S;Turon, F;Baiges, A;Martinez-Chantar, ML;Mato, JM;Martinez-Arranz, I;La Mura, V;Hernandez-Gea, V;Bosch, J;Garcia-Pagan, JC



NEDDylation inhibition as a new potential therapy of nonalcoholic fatty liver disease

Serrano-Macia, M;Azkargorta, M;Simon, J;Otsoa, FL;Delgado, TC;Ramos, DF;de Juan, VG;Varela-Rey, M;Goikoetxea, N;Tussy, PF;Apichueta, P;de Urturi, DS;Buque, X;Iruzubieta, P;Crespo, J;Lu, SC;Mato, ...



Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD

Ramos, DF;Tussy, PF;Otsoa, FL;Simon, J;Torres, LB;Santos, BG;Nunez, M;Azkargorta, M;de Juan, VG;Serrano-Macia, M;Agudo, RR;Champagne, DG;Iruzubieta, P;Anguita, J;Rincon, M;Elortza, F;Anita, ...