Malu Martínez-Chantar
mlmartinez
Malu Martínez-Chantar
PRINCIPAL INVESTIGATOR
Liver Disease Lab
Orcid: 0000-0002-6446-9911
Email: mlmartinez@cicbiogune.es
Phone: 4218 / 944 061 318
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Malu Martinez Chantar has an extensive experience in the study of liver biology, particularly NAFLD, to which she has dedicated all of her professional career. She has a very high-level track of record productivity with publications in a very high-percentage of publications of the 1st decile in the category of Nature, Nature Communications, Cell Metabolism, Hepatology and Gastroenterology. Since 2005, when she initiated her laboratory as a Principal Investigator and got “tenure” at CIC bioGUNE, Spain, her  laboratory work has been continuously financially supported by government and private funding competitive sources, both national and international. Remarkably, she has been co-PI of NIH with Dr. Lu (USC, Keck School of Medicine, Los Angeles, USA) in the field of liver disease. She was one of the partners in an ambitious European project so called HEPADIP Consortium, which was created in response to the topic of the 3rd call for proposals in the EU FP6 Programme. Actually, she is the coordinator of the Traslational Area of the National Institute for the study of Liver and Gastrointestinal Diseases (CIBEREHD) and the Scientific Advisory Board of national and international centers. Finally, she is part of the select multinational group "Women in Hepatology" composed only of women, experts in the field of Hepatology, with representatives from Europe and USA.

She has also held several collaborations with Pharmaceutical companies with 5 resultant patent applications and 4 licensed products. Finally, she has maintained a closed collaboration with the company OWL Metabolomics in the development of OWLiver® Care and OWLiver®, two non-invasive assays for fatty liver screening and for NASH diagnosis.

Latest Publications
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
de Urturi, DS;Buque, X;Porteiro, B;Folgueira, C;Mora, A;Delgado, TC;Prieto-Fernandez, E;Olaizola, P;Gomez-Santos, B;Apodaka-Biguri, M;Gonzalez-Romero, F;Nieva-Zuluaga, A;de Gauna, MR;Goikoetxea-Usandizaga, ...
NATURE COMMUNICATIONS
2022-03-01
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Zabala-Letona, A;Arruabarrena-Aristorena, A;Fernandez-Ruiz, S;Viera, C;Carlevaris, O;Ercilla, A;Mendizabal, I;Martin, T;Macchia, A;Camacho, L;Pujana-Vaquerizo, M;Sanchez-Mosquera, P;Torrano, ...
ONCOGENESIS
2022-02-23
Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy
Ye, H;Chen, CB;Wu, HH;Zheng, K;Martin-Adrados, B;Caparros, E;Frances, R;Nelson, LJ;del Moral, MG;Asensio, I;Vaquero, J;Banares, R;Avila, MA;Andrade, RJ;Lucena, MI;Martinez-Chantar, ML;Reeves, ...
CELL DEATH & DISEASE
2022-02-10
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Lima, ND;Fondevila, MF;Novoa, E;Buque, X;Mercado-Gomez, M;Gallet, S;Gonzalez-Rellan, MJ;Fernandez, U;Loyens, A;Garcia-Vence, M;Chantada-Vazquez, MD;Bravo, SB;Maranon, P;Senra, A;Escudero, A;Leiva, ...
JOURNAL OF HEPATOLOGY
2022-01-01
A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
Guo, FF;Estevez-Vazquez, O;Benede-Ubieto, R;Maya-Miles, D;Zheng, K;Gallego-Duran, R;Rojas, A;Ampuero, J;Romero-Gomez, M;Philip, K;Egbuniwe, IU;Chen, CB;Simon, J;Delgado, TC;Martinez-Chantar, ...
CANCERS
2022-01-01

2021

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Goikoetxea-Usandizaga, N;Serrano-Macia, M;Delgado, TC;Simon, J;Ramos, DF;Barriales, D;Cornide, ME;Jimenez, M;Perez-Redondo, M;Lachiondo-Ortega, S;Rodriguez-Agudo, R;Bizkarguenaga, M;Zalamea, ...
HEPATOLOGY
2021-12-15
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats
Lafoz, E;Camprecios, G;Garcia-Caldero, H;Anton, A;Vilaseca, M;Ruart, M;Guasch, E;Garrabou, G;Delgado, TC;Martinez-Chantar, ML;Garcia-Martinez, R;Gracia-Sancho, J;Hernandez-Gea, V;Garcia-Pagan, ...
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
2021-12-01
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
Serrano-Macia, M;Simon, J;Gonzalez-Rellan, MJ;Azkargorta, M;Goikoetxea-Usandizaga, N;Lopitz-Otsoa, F;De Urturi, DS;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Mercado-Gomez, M;de Juan, VG;Bizkarguenaga, ...
MOLECULAR METABOLISM
2021-11-01
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Gonzalez-Rellan, MJ;Fondevila, MF;Fernandez, U;Rodriguez, A;Varela-Rey, M;Veyrat-Durebex, C;Seoane, S;Bernardo, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bilbao, J;Iglesias, C;Novoa, E;Ameneiro, ...
NATURE COMMUNICATIONS
2021-08-20
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
Lee-Law, PY;Olaizola, P;Caballero-Camino, FJ;Izquierdo-Sanchez, L;Rodrigues, PM;Perugorria, MJ;Azkargorta, M;Elortza, F;Martinez-Chantar, ML;Aspichueta, P;Marzioni, M;Bujanda, L;Drenth, JPH;Banales, ...
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
2021-07-26
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH
Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Fernandez-Ramos, D;de Urturi, DS;Gruskos, JJ;Fernandez-Tussy, P;Lachiondo-Ortega, S;Gonzalez-Recio, I;Rodriguez-Agudo, R;Gutierrez-de-Juan, ...
JOURNAL OF HEPATOLOGY
2021-07-01
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Iruzubieta, P;Goikoetxea-Usandizaga, N;Barbier-Torres, L;Serrano-Macia, M;Fernandez-Ramos, D;Fernandez-Tussy, P;Gutierrez-de-Juan, V;Lachiondo-Ortega, S;Simon, J;Bravo, M;Lopitz-Otsoa, F;Robles, ...
JHEP REPORTS
2021-06-01
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
Gonzalez-Romero, F;Mestre, D;Aurrekoetxea, I;O'Rourke, CJ;Andersen, JB;Woodhoo, A;Tamayo-Caro, M;Varela-Rey, M;Palomo-Irigoyen, M;Gomez-Santos, B;de Urturi, DS;Nunez-Garcia, M;Garcia-Rodriguez, ...
CANCER RESEARCH
2021-06-01
Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma
Colyn, L;Barcena-Varela, M;Alvarez-Sola, G;Latasa, MU;Uriarte, I;Santamaria, E;Herranz, JM;Santos-Laso, A;Arechederra, M;de Gauna, MR;Aspichueta, P;Canale, M;Casadei-Gardini, A;Francesconi, ...
HEPATOLOGY
2021-06-01
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...
CELL DEATH & DISEASE
2021-05-28
Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals
Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;Bruzzone, C;Bizkarguenaga, M;Embade, N;Gil-Redondo, R;Martinez-Chantar, ML;Lopez-Hoyos, ...
COMMUNICATIONS BIOLOGY
2021-04-20
Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease
Martinez-Chantar, ML;Delgado, TC;Beraza, N
FRONTIERS IN IMMUNOLOGY
2021-02-18
Glutamine, fatty liver disease and aging
Simon, J;Martinez-Chantar, ML;Delgado, TC
AGING-US
2021-02-15
Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Lee-Law, PY;Olaizola, P;Caballero-Camino, FJ;Izquierdo-Sanchez, L;Rodrigues, PM;Santos-Laso, A;Azkargorta, M;Elortza, F;Martinez-Chantar, ML;Perugorria, MJ;Aspichueta, P;Marzioni, M;LaRusso, ...
JOURNAL OF HEPATOLOGY
2021-02-01
Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points
Fondevila, MF;Mercado-Gomez, M;Rodriguez, A;Gonzalez-Rellan, MJ;Iruzubieta, P;Valenti, V;Escalada, J;Schwaninger, M;Prevot, V;Dieguez, C;Crespo, J;Fruhbeck, G;Martinez-Chantar, ML;Nogueiras, ...
JOURNAL OF HEPATOLOGY
2021-02-01
Magnesium, Little Known But Possibly Relevant: A Link between NASH and Related Comorbidities
Simon, J;Delgado, TC;Martinez-Cruz, LA;Martinez-Chantar, ML
BIOMEDICINES
2021-02-01
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01
Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii
Fernandez-Rodriguez, C;Oyenarte, I;Conter, C;Gonzalez-Recio, I;Nunez-Franco, R;Gil-Pitarch, C;Quintana, I;Jimenez-Oses, G;Dominici, P;Martinez-Chantar, ML;Astegno, A;Martinez-Cruz, LA
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
2021-01-01

2020

NFATc4: New hub in NASH development
Martinez-Chantar, ML;Foti, M
JOURNAL OF HEPATOLOGY
2020-12-01
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020-12-01
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis
Claveria-Cabello, A;Colyn, L;Uriarte, I;Latasa, MU;Arechederra, M;Herranz, JM;Alvarez, L;Urman, JM;Martinez-Chantar, ML;Banales, JM;Sangro, B;Rombouts, K;Oyarzabal, J;Marin, JJG;Berasain, C;Avila, ...
CANCERS
2020-12-01
The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...
HEPATOLOGY
2020-11-13
Nutraceutical Properties of Polyphenols against Liver Diseases
Simon, J;Casado-Andres, M;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Martinez-Chantar, ML
NUTRIENTS
2020-11-01
Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment
Martinez-Chantar, ML;Avila, MA;Lu, SC
CANCERS
2020-10-01
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitisviaAMPK and mTOR regulation
Fernandez-Ramos, D;Lopitz-Otsoa, F;Delacruz-Villar, L;Bilbao, J;Pagano, M;Mosca, L;Bizkarguenaga, M;Serrano-Macia, M;Azkargorta, M;Iruarrizaga-Lejarreta, M;Sot, J;Tsvirkun, D;van Liempd, SM;Goni, ...
WORLD JOURNAL OF GASTROENTEROLOGY
2020-09-14
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...
CANCERS
2020-09-01
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
Gomez-Santos, B;de Urturi, DS;Nunez-Garcia, M;Gonzalez-Romero, F;Buque, X;Aurrekoetxea, I;de Juan, VG;Gonzalez-Rellan, MJ;Garcia-Monzon, C;Gonzalez-Rodriguez, A;Mosteiro, L;Errazti, G;Mifsut, ...
AGING CELL
2020-07-07
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier-Torres, L;Fortner, KA;Iruzubieta, P;Delgado, TC;Giddings, E;Chen, YDH;Champagne, D;Fernandez-Ramos, D;Mestre, D;Gomez-Santos, B;Varela-Rey, M;de Juan, VG;Fernandez-Tussy, P;Zubiete-Franco, ...
NATURE COMMUNICATIONS
2020-07-03
A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
Macias, RIR;Munoz-Bellvis, L;Sanchez-Martin, A;Arretxe, E;Martinez-Arranz, I;Lapitz, A;Gutierrez, ML;La Casta, A;Alonso, C;Gonzalez, LM;Avila, MA;Martinez-Chantar, ML;Castro, RE;Bujanda, L;Banales, ...
CANCERS
2020-06-01
Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach
Urman, JM;Herranz, JM;Uriarte, I;Rullan, M;Oyon, D;Gonzalez, B;Fernandez-Urien, I;Carrascosa, J;Bolado, F;Zabalza, L;Arechederra, M;Alvarez-Sola, G;Colyn, L;Latasa, MU;Puchades-Carrasco, L;Pineda-Lucena, ...
CANCERS
2020-06-01
GRK2-Dependent HuR Phosphorylation Regulates HIF1 alpha Activation under Hypoxia or Adrenergic Stress
Reglero, C;Lafarga, V;Rivas, V;Albitre, A;Ramos, P;Berciano, SR;Tapia, O;Martinez-Chantar, ML;Mayor, F;Penela, P
CANCERS
2020-05-01
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Simon, J;Nunez-Garcia, M;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gomez-Santos, B;Buque, X;Lopitz-Otsoa, F;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Rodriguez-Agudo, R;Bizkarguenaga, ...
CELL METABOLISM
2020-03-03
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
Palomo-Irigoyen, M;Perez-Andres, E;Iruarrizaga-Lejarreta, M;Barreira-Manrique, A;Tamayo-Caro, M;Vila-Vecilla, L;Moreno-Cugnon, L;Beitia, N;Medrano, D;Fernandez-Ramos, D;Lozano, JJ;Okawa, S;Lavin, ...
JOURNAL OF CLINICAL INVESTIGATION
2020-01-15
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
Simon, J;Ouro, A;Ala-Ibanibo, L;Presa, N;Delgado, TC;Martinez-Chantar, ML
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020-01-01

2019

Methionine Adenosyltransferase alpha 1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression
Murray, B;Peng, H;Barbier-Torres, L;Robinson, AE;Li, TWH;Fan, W;Tomasi, ML;Gottlieb, RA;Van Eyk, J;Lu, ZM;Martinez-Chantar, ML;Liangpunsakul, S;Skill, NJ;Mato, JM;Lu, SC
HEPATOLOGY
2019-12-01
Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4
Gimenez-Mascarell, P;Oyenarte, I;Gonzalez-Recio, I;Fernandez-Rodriguez, C;Corral-Rodriguez, MA;Campos-Zarraga, I;Simon, J;Kostantin, E;Hardy, S;Quintana, AD;Lizeaga, MZ;Merino, N;Diercks, T;Blanco, ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019-12-01
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis
Lachiondo-Ortega, S;Mercado-Gomez, M;Serrano-Macia, M;Lopitz-Otsoa, F;Salas-Villalobos, TB;Varela-Rey, M;Delgado, TC;Martinez-Chantar, ML
CELLS
2019-12-01
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors-1 alpha and-2 alpha in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets
Cannito, S;Foglia, B;Villano, G;Turato, C;Delgado, TC;Morello, E;Pin, F;Novo, E;Napione, L;Quarta, S;Ruvoletto, M;Fasolato, S;Zanus, G;Colombatto, S;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bussolino, ...
CANCERS
2019-12-01
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernandez-Tussy, P;Fernandez-Ramos, D;Lopitz-Otsoa, F;Simon, J;Barbier-Torres, L;Gomez-Santos, B;Nunez-Garcia, M;Azkargorta, M;Gutierrez-de Juan, V;Serrano-Macia, M;Rodriguez-Agudo, R;Iruzubieta, ...
MOLECULAR METABOLISM
2019-11-01
SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Lopitz-Otsoa, F;Delgado, TC;Lachiondo-Ortega, S;Azkargorta, M;Elortza, F;Rodriguez, MS;Martinez-Chantar, ML
JOURNAL OF VISUALIZED EXPERIMENTS : JOVE
2019-11-01
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
Bailly, AP;Perrin, A;Serrano-Macia, M;Maghames, C;Leidecker, O;Trauchessec, H;Martinez-Chantar, ML;Gartner, A;Xirodimas, DP
CELL REPORTS
2019-10-01
Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy
Lozano, E;Macias, RIR;Monte, MJ;Asensio, M;del Carmen, S;Sanchez-Vicente, L;Alonso-Pena, M;Al-Abdulla, R;Munoz-Garrido, P;Satriano, L;O'Rourke, CJ;Banales, JM;Avila, MA;Martinez-Chantar, ...
HEPATOLOGY
2019-10-01
Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis
Banales, JM;Inarrairaegui, M;Arbelaiz, A;Milkiewicz, P;Muntane, J;Munoz-Bellvis, L;La Casta, A;Gonzalez, LM;Arretxe, E;Alonso, C;Martinez-Arranz, I;Lapitz, A;Santos-Laso, A;Avila, MA;Martinez-Chantar, ...
HEPATOLOGY
2019-08-01
Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis
Reverter, E;Lozano, JJ;Alonso, C;Berzigotti, A;Seijo, S;Turon, F;Baiges, A;Martinez-Chantar, ML;Mato, JM;Martinez-Arranz, I;La Mura, V;Hernandez-Gea, V;Bosch, J;Garcia-Pagan, JC
LIVER INTERNATIONAL
2019-04-01
NEDDylation inhibition as a new potential therapy of nonalcoholic fatty liver disease
Serrano-Macia, M;Azkargorta, M;Simon, J;Otsoa, FL;Delgado, TC;Ramos, DF;de Juan, VG;Varela-Rey, M;Goikoetxea, N;Tussy, PF;Apichueta, P;de Urturi, DS;Buque, X;Iruzubieta, P;Crespo, J;Lu, SC;Mato, ...
JOURNAL OF HEPATOLOGY
2019-04-01
Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD
Ramos, DF;Tussy, PF;Otsoa, FL;Simon, J;Torres, LB;Santos, BG;Nunez, M;Azkargorta, M;de Juan, VG;Serrano-Macia, M;Agudo, RR;Champagne, DG;Iruzubieta, P;Anguita, J;Rincon, M;Elortza, F;Anita, ...
JOURNAL OF HEPATOLOGY
2019-04-01
Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators
Gimenez-Mascarell, P;Gonzalez-Recio, I;Fernandez-Rodriguez, C;Oyenarte, I;Muller, D;Martinez-Chantar, ML;Martinez-Cruz, LA
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019-03-06
Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib
Al-Abdulla, R;Lozano, E;Macias, RIR;Monte, MJ;Briz, O;O'Rourke, CJ;Serrano, MA;Banales, JM;Avila, MA;Martinez-Chantar, ML;Geier, A;Andersen, JB;Marin, JJG
BRITISH JOURNAL OF PHARMACOLOGY
2019-03-01
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
Blokker, BA;Maijo, M;Echeandia, M;Galduroz, M;Patterson, AM;Ten, A;Philo, M;Schungel, R;Gutierrez-de Juan, V;Halilbasic, E;Fuchs, C;Le Gall, G;Milkiewicz, M;Milkiewicz, P;Banales, JM;Rushbrook, ...
HEPATOLOGY
2019-02-01
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
Zubiete-Franco, I;Garcia-Rodriguez, JL;Lopitz-Otsoa, F;Serrano-Macia, M;Simon, J;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gutierrez-de-Juan, V;de Davalillo, SL;Carlevaris, O;Gomez, ...
EBIOMEDICINE
2019-02-01
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
Pabis, M;Popowicz, GM;Stehle, R;Fernandez-Ramos, D;Asami, S;Warner, L;Garcia-Maurino, SM;Schlundt, A;Martinez-Chantar, ML;Diaz-Moreno, I;Sattler, M
NUCLEIC ACIDS RESEARCH
2019-01-25
Plasticity of adult hepatocytes and readjustment of cell fate: a novel dogma in liver disease
Cubero, FJ;Martinez-Chantar, ML
GUT
2019-01-01
Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma
Delgado, TC;Lopitz-Otsoa, F;Martinez-Chantar, ML
JOURNAL OF HEPATOCELLULAR CARCINOMA
2019-01-01

2018

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans
Cruces-Sande, M;Vila-Bedmar, R;Arcones, AC;Gonzalez-Rodriguez, A;Rada, P;Gutierrez-De-Juan, V;Vargas-Castrillon, J;Iruzubieta, P;Sanchez-Gonzalez, C;Formentini, L;Crespo, J;Garcia-Monzon, C;Martinez-Chantar, ...
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE
2018-12-01
Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice
Nunez-Garcia, M;Gomez-Santos, B;de Urturi, DS;Mestre, D;Gonzalez-Romero, F;Buque, X;Gutierrez-de Juan, V;Martinez-Chantar, ML;Syn, WK;Fresnedo, O;Aspichueta, P
SCIENTIFIC REPORTS
2018-10-02
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Fernandez-Ramos, D;Fernandez-Tussy, P;Lopitz-Otsoa, F;Gutierrez-de-Juan, V;Navasa, N;Barbier-Torres, L;Zubiete-Franco, I;Simon, J;Fernandez, AF;Arbelaiz, A;Aransay, AM;Lavin, JL;Beraza, N;Perugorria, ...
CELL DEATH & DISEASE
2018-09-20
Liver Angiopoietin-2 Is a Key Predictor of De Novo or Recurrent Hepatocellular Cancer After Hepatitis C Virus Direct-Acting Antivirals
Faillaci, F;Marzi, L;Critelli, R;Milosa, F;Schepis, F;Turola, E;Andreani, S;Vandelli, G;Bernabucci, V;Lei, B;D'Ambrosio, F;Bristot, L;Cavalletto, L;Chemello, L;Sighinolfi, P;Manni, P;Maiorana, ...
HEPATOLOGY
2018-09-01
Metabolomic-Based Noninvasive Serum Test to Diagnose Nonalcoholic Steatohepatitis: Results From Discovery and Validation Cohorts
Mayo, R;Crespo, J;Martinez-Arranz, I;Banales, JM;Arias, M;Minchole, I;de la Fuente, RA;Jimenez-Aguero, R;Alonso, C;de Luis, DA;Vitek, L;Stritesky, J;Caballeria, J;Romero-Gomez, M;Martin-Duce, ...
HEPATOLOGY COMMUNICATIONS
2018-07-01
Neddylation, a novel paradigm in liver cancer
Delgado, TC;Barbier-Torres, L;Zubiete-Franco, I;Lopitz-Otsoa, F;Varela-Rey, M;Fernandez-Ramos, D;Martinez-Chantar, ML
TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
2018-06-01
The liver-specific deletion of the respiratory chain inhibitor MCJ attenuates NAFLD progression by enhancing hepatic beta-oxidation
Barbier-Torres, L;Delgado, TC;Iruzubieta, P;Ramos, DF;de Juan, VG;Varela-Rey, M;Tussy, PF;Zubiete-Franco, I;Simon, J;Otsoa, FL;Congregado, DM;Santos, BG;Buque, X;Crespo, J;Lu, SC;Matos, J;Aspichueta, ...
JOURNAL OF HEPATOLOGY
2018-04-01
Involvement of the CREB-E2F2-PPAR axis in non-alcoholic fatty liver disease development and progression to hepatocarcinoma
Congregado, DM;Aurrekoetxea, I;Santos, BG;de Urturi, DS;Nunez, M;Rodriguez, JLG;Gonzalez-Romero, F;Ares, LF;Iglesias, A;Bernales, I;Iruzubieta, P;de Juan, VG;Varela-Rey, M;Olartekoetxea, GE;Gonzalez, ...
JOURNAL OF HEPATOLOGY
2018-04-01
Targeting the NAFLD metabolome and the shaping of precision medicine for patients with NASH
Iruarrizaga-Lejarreta, M;Martinez-Arranz, I;Morrison, MC;Varela-Rey, M;Ramos, DF;Delacruz-Villar, L;Noureddin, M;Martinez-Chantar, ML;Kleemann, R;Alonso, C;Lu, SC;Mato, JM
JOURNAL OF HEPATOLOGY
2018-04-01
During aging osteopontin deficiency increases vulnerability to non-alcoholic fatty liver disease progression and the associated extrahepatic metabolic complications
Santos, BG;Gonzalez-Romero, F;Nunez-Garcia, M;Congregado, DM;de Urturi, DS;de Juan, VG;Martinez-Chantar, ML;Aurrekoetxea, I;Buque, X;Aspichueta, P
JOURNAL OF HEPATOLOGY
2018-04-01
Glutaminase 1 targeting in non-alcoholic steatohepatitis
Simon, J;Nunez, M;Tussy, PF;Barbier-Torres, L;Ramos, DF;Santos, BG;Otsoa, FL;de Juan, VG;Alonso, C;Iruzubieta, P;Liempd, SMV;Castro, A;Varela-Rey, M;Falcon-Perez, J;Villa, E;Crespo, J;Lu, SC;Matos, ...
JOURNAL OF HEPATOLOGY
2018-04-01

2017

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Barbier-Torres, L;Iruzubieta, P;Fernandez-Ramos, D;Delgado, TC;Taibo, D;Guitierrez-de-Juan, V;Varela-Rey, M;Azkargorta, M;Navasa, N;Fernandez-Tussy, P;Zubiete-Franco, I;Simon, J;Lopitz-Otsoa, ...
NATURE COMMUNICATIONS
2017-12-12
Role of Aramchol in Steatohepatitis and Fibrosis in Mice
Iruarrizaga-Lejarreta, M;Varela-Rey, M;Fernandez-Ramos, D;Martinez-Arranz, I;Delgado, TC;Simon, J;Gutierrez-de Juan, V;delaCruz-Villar, L;Azkargorta, M;Lavin, JL;Mayo, R;van Liempd, SM;Aurrekoetxea, ...
HEPATOLOGY COMMUNICATIONS
2017-11-01
The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant
Tomas-Cortazar, J;Martin-Ruiz, I;Barriales, D;Pascual-Itoiz, MA;de Juan, VG;Caro-Maldonado, A;Merino, N;Marina, A;Blanco, FJ;Flores, JM;Sutherland, JD;Barrio, R;Rojas, A;Martinez-Chantar, ML;Carracedo, ...
SCIENTIFIC REPORTS
2017-09-06
Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study
Critelli, R;Milosa, F;Faillaci, F;Condello, R;Turola, E;Marzi, L;Lei, B;Dituri, F;Andreani, S;Sighinolfi, P;Manni, P;Maiorana, A;Caporali, C;di Benedetto, F;Del Buono, M;De Maria, N;Schepis, ...
CELL DEATH & DISEASE
2017-08-01
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Martinez-Sanchez, N(Martinez-Sanchez, Noelia);Seoane-Collazo, P(Seoane-Collazo, Patricia);Contreras, C(Contreras, Cristina);Varela, L(Varela, Luis);Villarroya, J(Villarroya, Joan);Rial-Pensado, ...
CELL METABOLISM
2017-07-05
Hepatic p63 regulates steatosis via IKK beta/ER stress
Porteiro, B;Fondevila, MF;Delgado, TC;Iglesias, C;Imbernon, M;Iruzubieta, P;Crespo, J;Zabala-Letona, A;Ferno, J;Gonzalez-Teran, B;Matesanz, N;Hernandez-Cosido, L;Marcos, M;Tovar, S;Vidal, A;Sanchez-Ceinos, ...
NATURE COMMUNICATIONS
2017-05-08
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso, C;Fernandez-Ramos, D;Varela-Rey, M;Martinez-Arranz, I;Navasa, N;Van Liempd, SM;Trueba, JLL;Mayo, R;Ilisso, CP;de Juan, VG;Iruarrizaga-Lejarreta, M;delaCruz-Villar, L;Minchole, I;Robinson, ...
GASTROENTEROLOGY
2017-05-01
An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease
De Las Heras, J;Aldamiz-Echevarria, L;Martinez-Chantar, ML;Delgado, TC
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
2017-04-01
Prohibitin 1 Suppresses Liver Cancer Tumorigenesis in Mice and Human Hepatocellular and Cholangiocarcinoma Cells
Fan, W;Yang, HP;Liu, T;Wang, JH;Li, TWH;Mavila, N;Tang, YY;Yang, JW;Peng, H;Tu, J;Annamalai, A;Noureddin, M;Krishnan, A;Gores, GJ;Martinez-Chantar, ML;Mato, JM;Lu, SC
HEPATOLOGY
2017-04-01
A morphological method for ammonia detection in liver
Gutierrez-de-Juan, V;de Davalillo, SL;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;Fernandez-Tussy, P;Simon, J;Lopitz-Otsoa, F;de las Heras, J;Iruzubieta, P;Arias-Loste, MT;Villa, ...
PLOS ONE
2017-03-20
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2
Gimenez-Mascarell, P;Oyenarte, I;Hardy, S;Breiderhoff, T;Stuiver, M;Kostantin, E;Diercks, T;Pey, AL;Ereno-Orbea, J;Martinez-Chantar, ML;Khalaf-Nazzal, R;Claverie-Martin, F;Muller, D;Tremblay, ...
THE JOURNAL OF BIOLOGICAL CHEMISTRY
2017-01-20
Aramchol reduces established fibrosis in MCD diet animal model
Varela-Rey, M;Fernandez-Ramos, D;Iruarrizaga-Lejarreta, M;Van Liempd, SM;DelaCruz-Villar, L;de Davalillo, SL;Martin-Ruiz, I;Aurrekoetxea, I;Buque, X;Lavin, JL;Aransay, AM;Hayardeny, L;Alonso, ...
JOURNAL OF HEPATOLOGY
2017-01-01

2016

Stratification and therapeutic potential of PML in metastatic breast cancer
Martin-Martin, N(Martin-Martin, Natalia);Piva, M(Piva, Marco);Urosevic, J(Urosevic, Jelena);Aldaz, P(Aldaz, Paula);Sutherland, JD(Sutherland, James D.);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Arreal, ...
NATURE COMMUNICATIONS
2016-08-01
AISF position paper on liver transplantation and pregnancy Women in Hepatology Group, Italian Association for the Study of the Liver (AISF)
Alisi, Anna; Balsano, Clara; Bernabucci, Veronica; Berzigotti, Annalisa; Brunetto, Maurizia; Bugianesi, Elisabetta; Burra, Patrizia; Calvaruso, Vincenza; Cariani, Elisabetta; Coco, Barbara; ...
DIGESTIVE AND LIVER DISEASE
2016-08-01
Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension
Seijo, S;Lozano, JJ;Alonso, C;Miquel, R;Berzigotti, A;Reverter, E;Turon, F;Martinez-Chantar, ML;Castro, A;Mato, JM;Hernandez-Gea, V;Bosch, J;Garcia-Pagan, JC
LIVER INTERNATIONAL : OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF THE LIVER
2016-07-01
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study
Villa, E;Critelli, R;Lei, B;Marzocchi, G;Camma, C;Giannelli, G;Pontisso, P;Cabibbo, G;Enea, M;Colopi, S;Caporali, C;Pollicino, T;Milosa, F;Karampatou, A;Todesca, P;Bertolini, E;Maccio, L;Martinez-Chantar, ...
GUT
2016-05-01
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Zubiete-Franco, I;Garcia-Rodriguez, JL;Martinez-Una, M;Martinez-Lopez, N;Woodhoo, A;Gutierrez-De Juan, V;Beraza, N;Lage-Medina, S;Andrade, F;Fernandez, ML;Aldamiz-Echevarria, L;Fernandez-Ramos, ...
JOURNAL OF HEPATOLOGY
2016-02-01
SERPINB3 UP-REGULATES HYPOXIA INDUCIBLE FACTORS-1ALPHA AND-2ALPHA IN LIVER CANCER CELLS THROUGH DIFFERENT MECHANISMS
Cannito, S;Villano, G;Turato, C;Morello, E;Foglia, B;Novo, E;Quarta, S;Colombatto, S;Lopitz-Otsoa, F;Cardoso, T;Martinez-Chantar, ML;Pontisso, P;Parola, M
JOURNAL OF HEPATOLOGY
2016-01-01

2015

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Feitelson, MA;Arzumanyan, A;Kulathinal, RJ;Blain, SW;Holcombe, RF;Mahajna, J;Marino, M;Martinez-Chantar, ML;Nawroth, R;Sanchez-Garcia, I;Sharma, D;Saxena, NK;Singh, N;Vlachostergios, PJ;Guo, ...
SEMINARS IN CANCER BIOLOGY
2015-12-01
Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-beta-Dependent Fibrogenesis
Espinosa-Diez, C;Fierro-Fernandez, M;Sanchez-Gomez, F;Rodriguez-Pascual, F;Alique, M;Ruiz-Ortega, M;Beraza, N;Martinez-Chantar, ML;Fernandez-Hernando, C;Lamas, S
ANTIOXIDANTS & REDOX SIGNALING
2015-11-10
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1
Barbier-Torres, L;Beraza, N;Fernandez-Tussy, P;Lopitz-Otsoa, F;Fernandez-Ramos, D;Zubiete-Franco, I;Varela-Rey, M;Delgado, TC;Gutierrez, V;Anguita, J;Pares, A;Banales, JM;Villa, E;Caballeria, ...
HEPATOLOGY
2015-10-01
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Gomez-Sanchez, JA;Carty, L;Iruarrizaga-Lejarreta, M;Palomo-Irigoyen, M;Varela-Rey, M;Griffith, M;Hantke, J;Macias-Camara, N;Azkargorta, M;Aurrekoetxea, I;De Juan, VG;Jefferies, HBJ;Aspichueta, ...
THE JOURNAL OF CELL BIOLOGY
2015-07-06
NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R
Fernandez-Ramos, D;Martinez-Chantar, ML
PANCREATOLOGY : OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION OF PANCREATOLOGY
2015-07-01
Integrative Genomic Signatures Of Hepatocellular Carcinoma Derived from Nonalcoholic Fatty Liver Disease
Frades, I;Andreasson, E;Mato, JM;Alexandersson, E;Matthiesen, R;Martinez-Chantar, ML
PLOS ONE
2015-05-20
A METABOLIC DEFINITION OF NASH AND ITS RESOLUTION BY S-ADENOSYLMETHIONINE IN Mat1a KO MICE
Mato, JM;Fernandez-Ramos, D;Martinez-Arranz, I;Mayo, R;van Liempd, SC;Sann, H;Platon, J;Noureddin, M;Aspichueta, P;Alonso, C;Martinez-Chantar, ML;Lu, SC
JOURNAL OF HEPATOLOGY
2015-04-01
Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease
Benet, M;Guzman, C;Pisonero-Vaquero, S;Garcia-Mediavilla, MV;Sanchez-Campos, S;Martinez-Chantar, ML;Donato, MT;Castell, JV;Jover, R
MOLECULAR PHARMACOLOGY
2015-04-01
HIF2-ALPHA NEDDYLATION AS A SELECTIVE SERPINB3-DEPENDENT MECHANISM LEADING TO ITS INCREASE
Cannito, S(Cannito, S.);Villano, G(Villano, G.);Turato, C(Turato, C.);Morello, E(Morello, E.);Paternostro, C(Paternostro, C.);Quarta, S(Quarta, S.);Colombatto, S(Colombatto, S.);Lopitz-Otsoa, ...
JOURNAL OF HEPATOLOGY
2015-04-01
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease
Martinez-Una, M;Varela-Rey, M;Mestre, D;Fernandez-Ares, L;Fresnedo, O;Fernandez-Ramos, D;Gutierrez-De Juan, V;Martin-Guerrero, I;Garcia-Orad, A;Luka, Z;Wagner, C;Lu, SC;Garcia-Monzon, C;Finnell, ...
JOURNAL OF HEPATOLOGY
2015-03-01
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
Barbier-Torres, L;Delgado, TC;Garcia-Rodriguez, JL;Zubiete-Franco, I;Fernandez-Ramos, D;Buque, X;Cano, A;Gutierrez-de Juan, V;Fernandez-Dominguez, I;Lopitz-Otsoa, F;Fernandez-Tussy, P;Boix, ...
ONCOTARGET
2015-02-10
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernandez-Alyarezl, S;Gutierrez-de Juan, V;Zubiete-Franco, L;Barbier-Torres, L;Lahoz, A;Pares, A;Luka, Z;Wagner, C;Lu, SC;Mato, JM;Martinez-Chantar, ML;Beraza, N
LABORATORY INVESTIGATION; A JOURNAL OF TECHNICAL METHODS AND PATHOLOGY
2015-02-01
Regulation of Oxidative Stress by Methylation-Controlled J Protein Controls Macrophage Responses to Inflammatory Insults
Navasa, N;Martin, I;Iglesias-Pedraz, JM;Beraza, N;Atondo, E;Izadi, H;Ayaz, F;Fernandez-Alvarez, S;Hatle, K;Som, A;Dienz, O;Osborne, BA;Martinez-Chantar, ML;Rincon, M;Anguita, J
THE JOURNAL OF INFECTIOUS DISEASES
2015-01-01
The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
Carracedo, A;Rousseau, D;Douris, N;Fernandez-Ruiz, S;Martin-Martin, N;Weiss, D;Webster, K;Adams, AC;Vazquez-Chantada, M;Martinez-Chantar, ML;Anty, R;Tran, A;Maratos-Flier, E;Gual, P;Pandolfi, ...
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2015-01-01
The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?
Iruzubieta, P;Arias-Loste, MT;Barbier-Torres, L;Martinez-Chantar, ML;Crespo, J
BIOMED RESEARCH INTERNATIONAL
2015-01-01

2014

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
Scheiba, RM;de Opakua, AI;Diaz-Quintana, A;Cruz-Gallardo, I;Martinez-Cruz, LA;Martinez-Chantar, ML;Blanco, FJ;Diaz-Moreno, I
RNA BIOLOGY
2014-10-01
Systems Biology for Hepatologists
Mato, JM;Martinez-Chantar, ML;Lu, SC
HEPATOLOGY
2014-08-01
Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance
Carrasco, M;Rabaneda, LG;Murillo-Carretero, M;Ortega-Martinez, S;Martinez-Chantar, ML;Woodhoo, A;Luka, Z;Wagner, C;Lu, SC;Mato, JM;Mico, JA;Castro, C
HIPPOCAMPUS
2014-07-01
Ubiquitin Profiling in Liver Using a Transgenic Mouse with Biotinylated Ubiquitin
Lectez, B;Migotti, R;Lee, SY;Ramirez, J;Beraza, N;Mansfield, B;Sutherland, JD;Martinez-Chantar, ML;Dittmar, G;Mayor, U
JOURNAL OF PROTEOME RESEARCH
2014-06-01
SIRT1 Controls Liver Regeneration by Regulating Bile Acid Metabolism Through Farnesoid X Receptor and Mammalian Target of Rapamycin Signaling
Garcia-Rodriguez, JL;Barbier-Torres, L;Fernandez-Alvarez, S;Gutierrez-de Juan, V;Monte, MJ;Halilbasic, E;Herranz, D;Alvarez, L;Aspichueta, P;Marin, JJG;Trauner, M;Mato, JM;Serrano, M;Beraza, ...
HEPATOLOGY
2014-05-01
S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome
Varela-Rey, M;Iruarrizaga-Lejarreta, M;Lozano, JJ;Aransay, AM;Fernandez, AF;Lavin, JL;Mosen-Ansorena, D;Berdasco, M;Turmaine, M;Luka, Z;Wagner, C;Lu, SC;Esteller, M;Mirsky, R;Jessen, KR;Fraga, ...
NEURON
2014-03-05
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells (vol 288, pg 23161, 2013)
Yang, Heping; Zheng, Yuhua; Li, Tony W. H.; Peng, Hui; Fernandez-Ramos, David; Martinez-Chantar, Maria L.; Rojas, Adriana L.; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF BIOLOGICAL CHEMISTRY
2014-01-10

2013

Excess S-adenosylmethionine Reroutes Phosphatidylethanolamine Towards Phosphatidylcholine and Triglyceride Synthesis
Martinez-Una, M;Varela-Rey, M;Cano, A;Fernandez-Ares, L;Beraza, N;Aurrekoetxea, I;Martinez-Arranz, I;Garcia-Rodriguez, JL;Buque, X;Mestre, D;Luka, Z;Wagner, C;Alonso, C;Finnell, RH;Lu, SC;Martinez-Chantar, ...
HEPATOLOGY
2013-10-01
Methionine Adenosyltransferase 2B, HuR, and Sirtuin 1 Protein Cross-talk Impacts on the Effect of Resveratrol on Apoptosis and Growth in Liver Cancer Cells
Yang, HP;Zheng, YH;Li, TWH;Peng, H;Fernandez-Ramos, D;Martinez-Chantar, ML;Rojas, AL;Mato, JM;Lu, SC
JOURNAL OF BIOLOGICAL CHEMISTRY
2013-08-09
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma
Huidobro, C;Torano, EG;Fernandez, AF;Urdinguio, RG;Rodriguez, RM;Ferrero, C;Martinez-Camblor, P;Boix, L;Bruix, J;Garcia-Rodriguez, JL;Varela-Rey, M;Mato, JM;Martinez-Chantar, ML;Fraga, MF
JOURNAL OF MOLECULAR MEDICINE-JMM
2013-08-01
Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension
Seijo, S;Lozano, JJ;Alonso, C;Reverter, E;Miquel, R;Abraldes, JG;Martinez-Chantar, ML;Garcia-Criado, A;Berzigotti, A;Castro, A;Mato, JM;Bosch, J;Garcia-Pagan, JC
AMERICAN JOURNAL OF GASTROENTEROLOGY
2013-06-01
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPAR alpha; and repressed by C/EBP alpha: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease
Guzman, Carla; Benet, Marta; Pisonero-Vaquero, Sandra; Moya, Marta; Victoria Garcia-Mediavilla, M.; Luz Martinez-Chantar, M.; Gonzalez-Gallego, Javier; Vicente Castell, Jose; Sanchez-Campos, ...
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
2013-04-01
Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease
Vazquez-Chantada, M;Gonzalez-Lahera, A;Martinez-Arranz, I;Garcia-Monzon, C;Regueiro, MM;Garcia-Rodriguez, JL;Schlangen, KA;Mendibil, I;Rodriguez-Ezpeleta, N;Lozano, JJ;Banasik, K;Justesen, JM;Joergensen, ...
HEPATOLOGY
2013-02-01

2012

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
Woodhoo, A;Iruarrizaga-Lejarreta, M;Beraza, N;Garcia-Rodriguez, JL;Embade, N;Fernandez-Ramos, D;Martinez-Lopez, N;Gutierrez-De Juan, V;Arteta, B;Caballeria, J;Lu, SC;Mato, JM;Varela-Rey, M;Martinez-Chantar, ...
HEPATOLOGY
2012-11-01
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
von Montfort, C;Matias, N;Fernandez, A;Fucho, R;de la Rosa, LC;Martinez-Chantar, ML;Mato, JM;Machida, K;Tsukamoto, H;Murphy, MP;Mansouri, A;Koplowitz, N;Garcia-Ruiz, C;Fernandez-Checa, JC
JOURNAL OF HEPATOLOGY
2012-10-01
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1
Martinez-Lopez, N;Garcia-Rodriguez, JL;Varela-Rey, M;Gutierrez, V;Fernandez-Ramos, D;Beraza, N;Aransay, AM;Schlangen, K;Lozano, JJ;Aspichueta, P;Luka, Z;Wagner, C;Evert, M;Calvisi, DF;Lu, SC;Mato, ...
GASTROENTEROLOGY
2012-09-01
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase
Gomez-Santos, L;Luka, Z;Wagner, C;Fernandez-Alvarez, S;Lu, SC;Mato, JM;Martinez-Chantar, ML;Beraza, N
HEPATOLOGY
2012-08-01
The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development
Iruarrizaga-Lejarreta, M;Varela-Rey, M;Lozano, JJ;Fernandez-Ramos, D;Rodriguez-Ezpeleta, N;Embade, N;Lu, SC;van der Kraan, PM;Davidson, ENB;Gorospe, M;Mirsky, R;Jessen, KR;Aransay, AM;Mato, ...
JOURNAL OF NEUROSCIENCE
2012-04-04
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Embade, N;Fernandez-Ramos, D;Varela-Rey, M;Beraza, N;Sini, M;de Juan, VG;Woodhoo, A;Martinez-Lopez, N;Rodriguez-Iruretagoyena, B;Bustamante, FJ;de la Hoz, AB;Carracedo, A;Xirodimas, DP;Rodriguez, ...
HEPATOLOGY
2012-04-01
Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression
Barr, J;Caballeria, J;Martinez-Arranz, I;Dominguez-Diez, A;Alonso, C;Muntane, J;Perez-Cormenzana, M;Garcia-Monzon, C;Mayo, R;Martin-Duce, A;Romero-Gomez, M;Lo Iacono, O;Tordjman, J;Andrade, ...
JOURNAL OF PROTEOME RESEARCH
2012-04-01
Biphasic adaptative responses in VLDL metabolism and lipoprotein homeostasis during Gram-negative endotoxemia
Bartolome, N;Aspichueta, P;Martinez, MJ;Vazquez-Chantada, M;Martinez-Chantar, ML;Ochoa, B;Chico, Y
INNATE IMMUNITY
2012-02-01

2011

Methionine Adenosyltransferase 1A Gene Deletion Disrupts Hepatic Very Low-Density Lipoprotein Assembly in Mice
Cano, A;Buque, X;Martinez-Una, M;Aurrekoetxea, I;Menor, A;Garcia-Rodriguez, JL;Lu, SC;Martinez-Chantar, ML;Mato, JM;Ochoa, B;Aspichueta, P
HEPATOLOGY
2011-12-01
HIGH-FREQUENCY ULTRASOUND IMAGING FOR LONGITUDINAL EVALUATION OF NON-ALCOHOLIC FATTY LIVER DISEASE PROGRESSION IN MICE
Fernandez-Dominguez, I;Echevarria-Uraga, JJ;Gomez, N;Luka, Z;Wagner, C;Lu, SC;Mato, JM;Martinez-Chantar, ML;Rodriguez-Cuesta, J
ULTRASOUND IN MEDICINE AND BIOLOGY
2011-07-01
Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration
Varela-Rey, M;Beraza, N;Lu, SC;Mato, JM;Martinez-Chantar, ML
EXPERIMENTAL BIOLOGY AND MEDICINE
2011-04-01
S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes
Yamaji, S;Droggiti, A;Lu, SC;Martinez-Chantar, ML;Warner, A;Varela-Rey, M
EUROPEAN JOURNAL OF CELL BIOLOGY
2011-04-01

2010

Liver-Specific Deletion of Prohibitin 1 Results in Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice
Ko, KS;Tomasi, ML;Iglesias-Ara, A;French, BA;French, SW;Romani, K;Lozano, JJ;Oh, P;He, L;Stiles, BL;Li, TWH;Yang, HP;Martinez-Chantar, ML;Mato, JM;Lu, SC
HEPATOLOGY
2010-12-01
Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma from Nonalcoholic Steatohepatitis
Martinez-Lopez, N;Varela-Rey, M;Fernandez-Ramos, D;Woodhoo, A;Vazquez-Chantada, M;Embade, N;Espinosa-Hevia, L;Bustamante, FJ;Parada, LA;Rodriguez, MS;Lu, SC;Mato, JM;Martinez-Chantar, ML
HEPATOLOGY
2010-11-01
Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease
Barr, J;Vazquez-Chantada, M;Alonso, C;Perez-Cormenzana, M;Mayo, R;Galan, A;Caballeria, J;Martin-Duce, A;Tran, A;Wagner, C;Luka, Z;Lu, SC;Castro, A;Le Marchand-Brustel, Y;Martinez-Chantar, ML;Veyrie, ...
JOURNAL OF PROTEOME RESEARCH
2010-09-01
Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
Dushay, J;Chui, PC;Gopalakrishnan, GS;Varela-Rey, M;Crawley, M;Fisher, FM;Badman, MK;Martinez-Chantar, ML;Maratos-Flier, E
GASTROENTEROLOGY
2010-08-01
Fatty Liver and Fibrosis in Glycine N-Methyltransferase Knockout Mice Is Prevented by Nicotinamide
Varela-Rey, M;Martinez-Lopez, N;Fernandez-Ramos, D;Embade, N;Calvisi, DF;Woodhoo, A;Rodriguez, J;Fraga, MF;Julve, J;Rodriguez-Millan, E;Frades, I;Torres, L;Luka, Z;Wagner, C;Esteller, M;Lu, ...
HEPATOLOGY
2010-07-01
HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis
Vazquez-Chantada, M;Fernandez-Ramos, D;Embade, N;Martinez-Lopez, N;Varela-Rey, M;Woodhoo, A;Luka, Z;Wagner, C;Anglim, PP;Finnell, RH;Caballeria, J;Laird-Offringa, IA;Gorospe, M;Lu, SC;Mato, ...
GASTROENTEROLOGY
2010-05-01
Non-alcoholic fatty liver disease proteomics
Rodriguez-Suarez, E;Duce, AM;Caballeria, J;Arrieta, FM;Fernandez, E;Gomara, C;Alkorta, N;Ariz, U;Martinez-Chantar, ML;Lu, SC;Elortza, F;Mato, JM
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01
The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice
Martinez-Chantar, ML;Lu, SC;Mato, JM;Luka, Z;Wagner, C;French, BA;French, SW
EXPERIMENTAL AND MOLECULAR PATHOLOGY
2010-04-01
Binding of S-Methyl-5 '-Thioadenosine and S-Adenosyl-L-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair
Lucas, M;Encinar, JA;Arribas, EA;Oyenarte, I;Garcia, IG;Kortazar, D;Fernandez, JA;Mato, JM;Martinez-Chantar, ML;Martinez-Cruz, LA
JOURNAL OF MOLECULAR BIOLOGY
2010-02-26

2009

Purification, crystallization and preliminary crystallographic analysis of protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homologue of gamma-AMPK
Garcia, IG;Kortazar, D;Oyenarte, I;Mato, JM;Martinez-Chantar, ML;Martinez-Cruz, LA
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2009-08-01
Impaired Liver Regeneration in Mice Lacking Glycine N-Methyltransferase
Varela-Rey, M;Fernandez-Ramos, D;Martinez-Lopez, N;Embade, N;Gomez-Santos, L;Beraza, N;Vazquez-Chantada, M;Rodriguez, J;Luka, Z;Wagner, C;Lu, SC;Martinez-Chantar, ML;Mato, JM
HEPATOLOGY
2009-08-01
Phenotypic Differences Between Two Gnmt-/- Mouse Models for Hepatocellular Carcinoma Reply
Luka, Z;Martinez-Chantar, ML;Lu, SC;Wager, C;Mato, JM
HEPATOLOGY
2009-06-01
Non-alcoholic steatohepatitis and animal models: Understanding the human disease
Varela-Rey, M;Embade, N;Ariz, U;Lu, SC;Mato, JM;Martinez-Chantar, ML
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2009-05-01
The CBS Domain Protein MJ0729 of Methanocaldococcus jannaschii Is a Thermostable Protein with a pH-Dependent Self-Oligomerization
Martinez-Cruz, LA;Encinar, JA;Kortazar, D;Prieto, J;Gomez, J;Fernandez-Millan, P;Lucas, M;Arribas, EA;Fernandez, JA;Martinez-Chantar, ML;Mato, JM;Neira, JL
BIOCHEMISTRY
2009-03-31
S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis
Tomasi, ML;Iglesias-Ara, A;Yang, HP;Ramani, K;Feo, F;Pascale, MR;Martinez-Chantar, ML;Mato, JM;Lu, SC
GASTROENTEROLOGY
2009-03-01
Evidence for LKB1/AMP-Activated Protein Kinase/Endothelial Nitric Oxide Synthase Cascade Regulated by Hepatocyte Growth Factor, S-Adenosylmethionine, and Nitric Oxide in Hepatocyte Proliferation
Vazquez-Chantada, M;Ariz, U;Varela-Rey, M;Embade, N;Martinez-Lopez, N;Fernandez-Ramos, D;Gomez-Santos, L;Lamas, S;Lu, SC;Martinez-Chantar, ML;Mato, JM
HEPATOLOGY
2009-02-01
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
Lara, E;Mai, A;Calvanese, V;Altucci, L;Lopez-Nieva, P;Martinez-Chantar, ML;Varela-Rey, M;Rotili, D;Nebbioso, A;Ropero, S;Montoya, G;Oyarzabal, J;Velasco, S;Serrano, M;Witt, M;Villar-Garea, A;Inhof, ...
ONCOGENE
2009-02-01

2008

Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100
Lucas, M;Kortazar, D;Astigarraga, E;Fernandez, JA;Mato, JM;Martinez-Chantar, ML;Martinez-Cruz, LA
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2008-10-01
S-adenosylmethionine and proliferation: new pathways, new targets
Martinez-Lopez, N;Varela-Rey, M;Ariz, U;Embade, N;Vazquez-Chantada, M;Fernandez-Ramos, D;Gomez-Santos, L;Lu, SC;Mato, JM;Martinez-Chantar, ML
BIOCHEMICAL SOCIETY TRANSACTIONS
2008-10-01
Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii
Fernandez-Millan, P;Kortazar, D;Lucas, M;Martinez-Chantar, ML;Astigarraga, E;Fernandez, JA;Sabas, O;Albert, A;Mato, JM;Martinez-Cruz, LA
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
2008-07-01
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Martinez-Chantar, ML;Vazquez-Chantada, M;Ariz, U;Martinez, N;Varela, M;Luka, Z;Capdevila, A;Rodriguez, J;Aransay, AM;Matthiesen, R;Yang, H;Calvisi, DF;Esteller, M;Fraga, M;Lu, SC;Wagner, C;Mato, ...
HEPATOLOGY
2008-04-01
Methionine metabolism and liver disease
Mato, JM;Martinez-Chantar, ML;Lu, SC
ANNUAL REVIEW OF NUTRITION
2008-01-01

2007

Identification of a gene-pathway associated with non-alcoholic steatohepatitis
Rubio, A;Guruceaga, E;Vazquez-Chantada, M;Sandoval, J;Martinez-Cruz, LA;Segura, V;Sevilla, JL;Podhorski, A;Corrales, FJ;Torres, L;Rodriguez, M;Aillet, F;Ariz, U;Arrieta, FM;Caballeria, J;Martin-Duce, ...
JOURNAL OF HEPATOLOGY
2007-04-01

2006

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
Lu, SC;Martinez-Chantar, ML;Mato, JM
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2006-10-01
Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
Rodriguez, JL;Sandoval, J;Serviddio, G;Sastre, J;Morante, M;Perrell, MG;Martinez-Chantar, ML;Vina, J;Vina, JR;Mato, JM;Avila, MA;Franco, L;Lopez-Rodas, G;Torres, L
BIOCHEMICAL JOURNAL
2006-09-15
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase
Martinez-Chantar, ML;Vazquez-Chantada, M;Garnacho, M;Latasa, MU;Varela-Rey, M;Dotor, J;Santamaria, M;Martinez-Cruz, LA;Parada, LA;Lu, SC;Mato, JM
GASTROENTEROLOGY
2006-07-01

During 2015-2018 Liver Disease Lab (LDL) has published 35 peer reviewed articles, 18 of them in the first Decil (Nature Communicaton, Cell Metab, Nature, Hepatology, Gut, Gastroenterology etc) and  eleven of them  in the first quartile with an average impact factor of 9. We have been successful obtaining funding from different national and internationals agencies such as the Ministry of Economy Science and Competitiveness, Carlos III Health Institute, Foundations, crowdfunding and international projects derived from NIH. The visibility of our research group in the liver field has been intensified through an extensive participation in different national and international networks such as Ciberehd (Carlos III Health Institute), Women in Hepatology (International Consortium) and different European COST actions PROTEOSTASIS, TRANSAUTOPHAGY and MITOEAGLE.

Tutoring is an important factor in LDL and along these three years, nine PhD theses, 4 master's  and multiple undergraduate and technician students have been  trained. The co-direction of PhD students with different agencies like hospitals and technology centers has been of special relevance, contributing to enrich our research vision.

Regarding the research lines carried out in the LDL, we have generated three new areas of knowledge in this period of time, two of them practically unexplored, which have led us to be Cover Page of Hepatology in 2017 and to reach high impact journals such as Nature Communications, Gut or Cell Metabolism among others. These areas open new ways of knowledge in the liver field regarding metabolism, physiology and disease. These areas are a) post-translational modifications mainly NEDDylation b) Mitochondrial activity c) microRNAS and d) Magnesium metabolism.  In all of them, we have developed new biological tools, preclinical animal models and new therapeutic approaches that have ended in the generation of patents and the development of a robust translational research.

In fact, one of the relevant points during 2015 -2018 of LDL has been the transfer of our knowledge to biomedical and pharmaceuticals companies. We have generated three patents, all of them licensed and other two under development. Importantly, we have promoted the generation of Mitotherapeutix LLC (USA), a biopharmaceutical company that develops products for treatment of degenerative liver disorders, based on our R&D, with a first product in Phase I Clinical Trial and another molecule under development. We have also participated in the OWL Liver and OWL Test, the first test for non-invasive diagnose of NAFLD, currently commercialized.  We have actively collaborated with international companies such as Takeda Pharmaceutical and AGIOS in preclinical trials of their drugs and we have formal initiatives to transfer our R&D to important pharmaceutical companies. Regarding Basque Health cluster we have generated and consolidate initiatives with technological Engineers Centers (bioGUNE / TEKNIKER) with the aim to validate a candidate molecule as a predictive circulating marker of liver injury developing a promising low-cost effective Point-Of-Care technology to facilitate diagnosis and monitoring solutions in primary healthcare centers, pharmaceutical industry and for consumers
Therefore, in these three years we have generated knowledge, an extensive network of collaborations and we have proven preclinical models and transfer our R&D to national and international pharmaceutical companies.

Latest Publications

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

de Urturi, DS;Buque, X;Porteiro, B;Folgueira, C;Mora, A;Delgado, TC;Prieto-Fernandez, E;Olaizola, P;Gomez-Santos, B;Apodaka-Biguri, M;Gonzalez-Romero, F;Nieva-Zuluaga, A;de Gauna, MR;Goikoetxea-Usandizaga, ...

NATURE COMMUNICATIONS

2022-03-01

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Zabala-Letona, A;Arruabarrena-Aristorena, A;Fernandez-Ruiz, S;Viera, C;Carlevaris, O;Ercilla, A;Mendizabal, I;Martin, T;Macchia, A;Camacho, L;Pujana-Vaquerizo, M;Sanchez-Mosquera, P;Torrano, ...

ONCOGENESIS

2022-02-23

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy

Ye, H;Chen, CB;Wu, HH;Zheng, K;Martin-Adrados, B;Caparros, E;Frances, R;Nelson, LJ;del Moral, MG;Asensio, I;Vaquero, J;Banares, R;Avila, MA;Andrade, RJ;Lucena, MI;Martinez-Chantar, ML;Reeves, ...

CELL DEATH & DISEASE

2022-02-10

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Lima, ND;Fondevila, MF;Novoa, E;Buque, X;Mercado-Gomez, M;Gallet, S;Gonzalez-Rellan, MJ;Fernandez, U;Loyens, A;Garcia-Vence, M;Chantada-Vazquez, MD;Bravo, SB;Maranon, P;Senra, A;Escudero, A;Leiva, ...

JOURNAL OF HEPATOLOGY

2022-01-01

A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Guo, FF;Estevez-Vazquez, O;Benede-Ubieto, R;Maya-Miles, D;Zheng, K;Gallego-Duran, R;Rojas, A;Ampuero, J;Romero-Gomez, M;Philip, K;Egbuniwe, IU;Chen, CB;Simon, J;Delgado, TC;Martinez-Chantar, ...

CANCERS

2022-01-01

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Goikoetxea-Usandizaga, N;Serrano-Macia, M;Delgado, TC;Simon, J;Ramos, DF;Barriales, D;Cornide, ME;Jimenez, M;Perez-Redondo, M;Lachiondo-Ortega, S;Rodriguez-Agudo, R;Bizkarguenaga, M;Zalamea, ...

HEPATOLOGY

2021-12-15

Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats

Lafoz, E;Camprecios, G;Garcia-Caldero, H;Anton, A;Vilaseca, M;Ruart, M;Guasch, E;Garrabou, G;Delgado, TC;Martinez-Chantar, ML;Garcia-Martinez, R;Gracia-Sancho, J;Hernandez-Gea, V;Garcia-Pagan, ...

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

2021-12-01

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Serrano-Macia, M;Simon, J;Gonzalez-Rellan, MJ;Azkargorta, M;Goikoetxea-Usandizaga, N;Lopitz-Otsoa, F;De Urturi, DS;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Mercado-Gomez, M;de Juan, VG;Bizkarguenaga, ...

MOLECULAR METABOLISM

2021-11-01

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan, MJ;Fondevila, MF;Fernandez, U;Rodriguez, A;Varela-Rey, M;Veyrat-Durebex, C;Seoane, S;Bernardo, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bilbao, J;Iglesias, C;Novoa, E;Ameneiro, ...

NATURE COMMUNICATIONS

2021-08-20

Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease

Lee-Law, PY;Olaizola, P;Caballero-Camino, FJ;Izquierdo-Sanchez, L;Rodrigues, PM;Perugorria, MJ;Azkargorta, M;Elortza, F;Martinez-Chantar, ML;Aspichueta, P;Marzioni, M;Bujanda, L;Drenth, JPH;Banales, ...

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL

2021-07-26