Malu Martínez-Chantar
mlmartinez
Malu Martínez-Chantar
PRINCIPAL INVESTIGATOR
Liver Disease Lab
Orcid: 0000-0002-6446-9911
Email: mlmartinez@cicbiogune.es
Phone: 4218 / 944 061 318
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Malu Martinez Chantar has an extensive experience in the study of liver biology, particularly NAFLD, to which she has dedicated all of her professional career. She has a very high-level track of record productivity with publications in a very high-percentage of publications of the 1st decile in the category of Nature, Nature Communications, Cell Metabolism, Hepatology and Gastroenterology. Since 2005, when she initiated her laboratory as a Principal Investigator and got “tenure” at CIC bioGUNE, Spain, her  laboratory work has been continuously financially supported by government and private funding competitive sources, both national and international. Remarkably, she has been co-PI of NIH with Dr. Lu (USC, Keck School of Medicine, Los Angeles, USA) in the field of liver disease. She was one of the partners in an ambitious European project so called HEPADIP Consortium, which was created in response to the topic of the 3rd call for proposals in the EU FP6 Programme. Actually, she is the coordinator of the Traslational Area of the National Institute for the study of Liver and Gastrointestinal Diseases (CIBEREHD) and the Scientific Advisory Board of national and international centers. Finally, she is part of the select multinational group "Women in Hepatology" composed only of women, experts in the field of Hepatology, with representatives from Europe and USA.

She has also held several collaborations with Pharmaceutical companies with 5 resultant patent applications and 4 licensed products. Finally, she has maintained a closed collaboration with the company OWL Metabolomics in the development of OWLiver® Care and OWLiver®, two non-invasive assays for fatty liver screening and for NASH diagnosis.

Latest Publications
NFATc4: New hub in NASH development
Martinez-Chantar, ML;Foti, M
JOURNAL OF HEPATOLOGY
2020-12-01
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020-12-01
The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...
HEPATOLOGY
2020-11-13
Nutraceutical Properties of Polyphenols against Liver Diseases
Simon, J;Casado-Andres, M;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Martinez-Chantar, ML
NUTRIENTS
2020-11-01
Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment
Martinez-Chantar, ML;Avila, MA;Lu, SC
CANCERS
2020-10-01
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitisviaAMPK and mTOR regulation
Fernandez-Ramos, D;Lopitz-Otsoa, F;Delacruz-Villar, L;Bilbao, J;Pagano, M;Mosca, L;Bizkarguenaga, M;Serrano-Macia, M;Azkargorta, M;Iruarrizaga-Lejarreta, M;Sot, J;Tsvirkun, D;van Liempd, SM;Goni, ...
WORLD JOURNAL OF GASTROENTEROLOGY
2020-09-14
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...
CANCERS
2020-09-01
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
Gomez-Santos, B;de Urturi, DS;Nunez-Garcia, M;Gonzalez-Romero, F;Buque, X;Aurrekoetxea, I;de Juan, VG;Gonzalez-Rellan, MJ;Garcia-Monzon, C;Gonzalez-Rodriguez, A;Mosteiro, L;Errazti, G;Mifsut, ...
AGING CELL
2020-07-07
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier-Torres, L;Fortner, KA;Iruzubieta, P;Delgado, TC;Giddings, E;Chen, YDH;Champagne, D;Fernandez-Ramos, D;Mestre, D;Gomez-Santos, B;Varela-Rey, M;de Juan, VG;Fernandez-Tussy, P;Zubiete-Franco, ...
NATURE COMMUNICATIONS
2020-07-03
A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
Macias, RIR;Munoz-Bellvis, L;Sanchez-Martin, A;Arretxe, E;Martinez-Arranz, I;Lapitz, A;Gutierrez, ML;La Casta, A;Alonso, C;Gonzalez, LM;Avila, MA;Martinez-Chantar, ML;Castro, RE;Bujanda, L;Banales, ...
CANCERS
2020-06-01
Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach
Urman, JM;Herranz, JM;Uriarte, I;Rullan, M;Oyon, D;Gonzalez, B;Fernandez-Urien, I;Carrascosa, J;Bolado, F;Zabalza, L;Arechederra, M;Alvarez-Sola, G;Colyn, L;Latasa, MU;Puchades-Carrasco, L;Pineda-Lucena, ...
CANCERS
2020-06-01
GRK2-Dependent HuR Phosphorylation Regulates HIF1 alpha Activation under Hypoxia or Adrenergic Stress
Reglero, C;Lafarga, V;Rivas, V;Albitre, A;Ramos, P;Berciano, SR;Tapia, O;Martinez-Chantar, ML;Mayor, F;Penela, P
CANCERS
2020-05-01
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Simon, J;Nunez-Garcia, M;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gomez-Santos, B;Buque, X;Lopitz-Otsoa, F;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Rodriguez-Agudo, R;Bizkarguenaga, ...
CELL METABOLISM
2020-03-03
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
Palomo-Irigoyen, M;Perez-Andres, E;Iruarrizaga-Lejarreta, M;Barreira-Manrique, A;Tamayo-Caro, M;Vila-Vecilla, L;Moreno-Cugnon, L;Beitia, N;Medrano, D;Fernandez-Ramos, D;Lozano, JJ;Okawa, S;Lavin, ...
JOURNAL OF CLINICAL INVESTIGATION
2020-01-15
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
Simon, J;Ouro, A;Ala-Ibanibo, L;Presa, N;Delgado, TC;Martinez-Chantar, ML
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020-01-01

2019

Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4
Gimenez-Mascarell, P (Gimenez-Mascarell, Paula); Oyenarte, I (Oyenarte, Iker); Gonzalez-Recio, I (Gonzalez-Recio, Irene); Fernandez-Rodriguez, C (Fernandez-Rodriguez, Carmen); Corral-Rodriguez, ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019-12-01
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis
Lachiondo-Ortega, S (Lachiondo-Ortega, Sofia); Mercado-Gomez, M (Mercado-Gomez, Maria); Serrano-Macia, M (Serrano-Macia, Marina); Lopitz-Otsoa, F (Lopitz-Otsoa, Fernando); Salas-Villalobos, ...
CELLS
2019-12-01
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors-1 alpha and-2 alpha in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets
Cannito, S (Cannito, Stefania)[ 1 ] ; Foglia, B (Foglia, Beatrice); Villano, G (Villano, Gianmarco); Turato, C (Turato, Cristian); Delgado, TC (Delgado, Teresa C.); Morello, E (Morello, Elisabetta); ...
CANCERS
2019-12-01
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernandez-Tussy, P;Fernandez-Ramos, D;Lopitz-Otsoa, F;Simon, J;Barbier-Torres, L;Gomez-Santos, B;Nunez-Garcia, M;Azkargorta, M;Gutierrez-de Juan, V;Serrano-Macia, M;Rodriguez-Agudo, R;Iruzubieta, ...
MOLECULAR METABOLISM
2019-11-01
SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Lopitz-Otsoa, F;Delgado, TC;Lachiondo-Ortega, S;Azkargorta, M;Elortza, F;Rodriguez, MS;Martinez-Chantar, ML
JOURNAL OF VISUALIZED EXPERIMENTS : JOVE
2019-11-01
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
Bailly, AP;Perrin, A;Serrano-Macia, M;Maghames, C;Leidecker, O;Trauchessec, H;Martinez-Chantar, ML;Gartner, A;Xirodimas, DP
CELL REPORTS
2019-10-01
Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy
Lozano, E;Macias, RIR;Monte, MJ;Asensio, M;del Carmen, S;Sanchez-Vicente, L;Alonso-Pena, M;Al-Abdulla, R;Munoz-Garrido, P;Satriano, L;O'Rourke, CJ;Banales, JM;Avila, MA;Martinez-Chantar, ...
HEPATOLOGY
2019-10-01
Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis
Banales, JM;Inarrairaegui, M;Arbelaiz, A;Milkiewicz, P;Muntane, J;Munoz-Bellvis, L;La Casta, A;Gonzalez, LM;Arretxe, E;Alonso, C;Martinez-Arranz, I;Lapitz, A;Santos-Laso, A;Avila, MA;Martinez-Chantar, ...
HEPATOLOGY
2019-08-01
Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis
Reverter, E;Lozano, JJ;Alonso, C;Berzigotti, A;Seijo, S;Turon, F;Baiges, A;Martinez-Chantar, ML;Mato, JM;Martinez-Arranz, I;La Mura, V;Hernandez-Gea, V;Bosch, J;Garcia-Pagan, JC
LIVER INTERNATIONAL
2019-04-01
NEDDylation inhibition as a new potential therapy of nonalcoholic fatty liver disease
Serrano-Macia, M;Azkargorta, M;Simon, J;Otsoa, FL;Delgado, TC;Ramos, DF;de Juan, VG;Varela-Rey, M;Goikoetxea, N;Tussy, PF;Apichueta, P;de Urturi, DS;Buque, X;Iruzubieta, P;Crespo, J;Lu, SC;Mato, ...
JOURNAL OF HEPATOLOGY
2019-04-01
Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD
Ramos, DF;Tussy, PF;Otsoa, FL;Simon, J;Torres, LB;Santos, BG;Nunez, M;Azkargorta, M;de Juan, VG;Serrano-Macia, M;Agudo, RR;Champagne, DG;Iruzubieta, P;Anguita, J;Rincon, M;Elortza, F;Anita, ...
JOURNAL OF HEPATOLOGY
2019-04-01
Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators
Gimenez-Mascarell, P;Gonzalez-Recio, I;Fernandez-Rodriguez, C;Oyenarte, I;Muller, D;Martinez-Chantar, ML;Martinez-Cruz, LA
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019-03-06
Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib
Al-Abdulla, R;Lozano, E;Macias, RIR;Monte, MJ;Briz, O;O'Rourke, CJ;Serrano, MA;Banales, JM;Avila, MA;Martinez-Chantar, ML;Geier, A;Andersen, JB;Marin, JJG
BRITISH JOURNAL OF PHARMACOLOGY
2019-03-01
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
Blokker, BA;Maijo, M;Echeandia, M;Galduroz, M;Patterson, AM;Ten, A;Philo, M;Schungel, R;Gutierrez-de Juan, V;Halilbasic, E;Fuchs, C;Le Gall, G;Milkiewicz, M;Milkiewicz, P;Banales, JM;Rushbrook, ...
HEPATOLOGY
2019-02-01
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
Zubiete-Franco, I;Garcia-Rodriguez, JL;Lopitz-Otsoa, F;Serrano-Macia, M;Simon, J;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gutierrez-de-Juan, V;de Davalillo, SL;Carlevaris, O;Gomez, ...
EBIOMEDICINE
2019-02-01
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
Pabis, M;Popowicz, GM;Stehle, R;Fernandez-Ramos, D;Asami, S;Warner, L;Garcia-Maurino, SM;Schlundt, A;Martinez-Chantar, ML;Diaz-Moreno, I;Sattler, M
NUCLEIC ACIDS RESEARCH
2019-01-25
Plasticity of adult hepatocytes and readjustment of cell fate: a novel dogma in liver disease
Cubero, FJ;Martinez-Chantar, ML
GUT
2019-01-01
Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma
Delgado, TC;Lopitz-Otsoa, F;Martinez-Chantar, ML
JOURNAL OF HEPATOCELLULAR CARCINOMA
2019-01-01
Fine tuning of SIRT1 expression is essential to protect the liver from cholestasis
Blokker, B (Blokker, B.); Maijo, M (Maijo, M.); Philo, M (Philo, M.); Gutierrez, V (Gutierrez, V.); Halilbasic, E (Halilbasic, E.); Fuchs, C (Fuchs, C.); Legall, G (Legall, G.); Milkiewicz, ...
JOURNAL OF HEPATOLOGY
2019-04-01

2018

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans
Cruces-Sande, M(Cruces-Sande, Marta);Vila-Bedmar, R(Vila-Bedmar, Rock);Arcones, AC(Arcones, Alba C.);Gonzalez-Rodriguez, A(Gonzalez-Rodriguez, Agueda);Rada, P(Rada, Patricia);Gutierrez-De-Juan, ...
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE
2018-12-01
Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice
Nunez-Garcia, M(Nunez-Garcia, Maitane);Gomez-Santos, B(Gomez-Santos, Beatriz);de Urturi, DS(de Urturi, Diego Saenz);Mestre, D(Mestre, Daniela);Gonzalez-Romero, F(Gonzalez-Romero, Francisco);Buque, ...
SCIENTIFIC REPORTS
2018-10-02
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Fernandez-Ramos, D(Fernandez-Ramos, David);Fernandez-Tussy, P(Fernandez-Tussy, Pablo);Lopitz-Otsoa, F(Lopitz-Otsoa, Fernando);Gutierrez-de-Juan, V(Gutierrez-de-Juan, Virginia);Navasa, N(Navasa, ...
CELL DEATH & DISEASE
2018-09-20
Liver Angiopoietin-2 Is a Key Predictor of De Novo or Recurrent Hepatocellular Cancer After Hepatitis C Virus Direct-Acting Antivirals
Faillaci, F(Faillaci, Francesca);Marzi, L(Marzi, Luca);Critelli, R(Critelli, Rosina);Milosa, F(Milosa, Fabiola);Schepis, F(Schepis, Filippo);Turola, E(Turola, Elena);Andreani, S(Andreani, Silvia);Vandelli, ...
HEPATOLOGY
2018-09-01
Metabolomic-Based Noninvasive Serum Test to Diagnose Nonalcoholic Steatohepatitis: Results From Discovery and Validation Cohorts
Mayo, R(Mayo, Rebeca);Crespo, J(Crespo, Javier);Martinez-Arranz, I(Martinez-Arranz, Ibon);Banales, JM(Banales, Jesus M.);Arias, M(Arias, Mayte);Minchole, I(Minchole, Itziar);de la Fuente, RA(Aller ...
HEPATOLOGY COMMUNICATIONS
2018-07-01
Neddylation, a novel paradigm in liver cancer
Delgado, TC(Cardoso Delgado, Teresa);Barbier-Torres, L(Barbier-Torres, Lucia);Zubiete-Franco, I(Zubiete-Franco, Imanol);Lopitz-Otsoa, F(Lopitz-Otsoa, Fernando);Varela-Rey, M(Varela-Rey, Marta);Fernandez-Ramos, ...
TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
2018-06-01
The liver-specific deletion of the respiratory chain inhibitor MCJ attenuates NAFLD progression by enhancing hepatic beta-oxidation
Barbier-Torres, L (Barbier-Torres, L.); Delgado, TC (Delgado, T. C.); Iruzubieta, P (Iruzubieta, P.); Ramos, DF (Ramos, D. F.); de Juan, VG (de Juan, V. G.); Varela-Rey, M (Varela-Rey, M.); ...
JOURNAL OF HEPATOLOGY
2018-04-01
Involvement of the CREB-E2F2-PPAR axis in non-alcoholic fatty liver disease development and progression to hepatocarcinoma
Congregado, DM (Congregado, D. M.); Aurrekoetxea, I (Aurrekoetxea, I.); Santos, BG (Santos, B. G.); de Urturi, DS (de Urturi, D. S.); Nunez, M (Nunez, M.); Rodriguez, JLG (Rodriguez, J. L. G.); ...
JOURNAL OF HEPATOLOGY
2018-04-01
Targeting the NAFLD metabolome and the shaping of precision medicine for patients with NASH
Iruarrizaga-Lejarreta, M (Iruarrizaga-Lejarreta, M.); Martinez-Arranz, I (Martinez-Arranz, I.); Morrison, MC (Morrison, M. C.); Varela-Rey, M (Varela-Rey, M.); Ramos, DF (Ramos, D. F.); Delacruz-Villar, ...
JOURNAL OF HEPATOLOGY
2018-04-01
During aging osteopontin deficiency increases vulnerability to non-alcoholic fatty liver disease progression and the associated extrahepatic metabolic complications
Santos, BG (Santos, B. G.); Gonzalez-Romero, F (Gonzalez-Romero, F.); Nunez-Garcia, M (Nunez-Garcia, M.); Congregado, DM (Congregado, D. M.); de Urturi, DS (de Urturi, D. S.); de Juan, VG (de ...
JOURNAL OF HEPATOLOGY
2018-04-01
Glutaminase 1 targeting in non-alcoholic steatohepatitis
Simon, J (Simon, J.); Nunez, M (Nunez, M.); Tussy, PF (Tussy, P. F.); Barbier-Torres, L (Barbier-Torres, L.); Ramos, DF (Ramos, D. F.); Santos, BG (Santos, B. G.); Otsoa, FL (Otsoa, F. L.); ...
JOURNAL OF HEPATOLOGY
2018-04-01

2017

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Barbier-Torres, L(Barbier-Torres, Lucia);Iruzubieta, P(Iruzubieta, Paula);Fernandez-Ramos, D(Fernandez-Ramos, David);Delgado, TC(Delgado, Teresa C.);Taibo, D(Taibo, Daniel);Guitierrez-de-Juan, ...
NATURE COMMUNICATIONS
2017-12-12
Role of Aramchol in Steatohepatitis and Fibrosis in Mice
Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, Marta);Varela-Rey, M(Varela-Rey, Marta);Fernandez-Ramos, D(Fernandez-Ramos, David);Martinez-Arranz, I(Martinez-Arranz, Ibon);Delgado, TC(Delgado, ...
HEPATOLOGY COMMUNICATIONS
2017-11-01
The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant
Tomas-Cortazar, J(Tomas-Cortazar, Julen);Martin-Ruiz, I(Martin-Ruiz, Itziar);Barriales, D(Barriales, Diego);Pascual-Itoiz, MA(Angel Pascual-Itoiz, Miguel);de Juan, VG(Gutierrez de Juan, Virginia);Caro-Maldonado, ...
SCIENTIFIC REPORTS
2017-09-06
Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study
Critelli, R(Critelli, Rosina);Milosa, F(Milosa, Fabiola);Faillaci, F(Faillaci, Francesca);Condello, R(Condello, Rosario);Turola, E(Turola, Elena);Marzi, L(Marzi, Luca);Lei, B(Lei, Barbara);Dituri, ...
CELL DEATH & DISEASE
2017-08-01
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Martinez-Sanchez, N(Martinez-Sanchez, Noelia);Seoane-Collazo, P(Seoane-Collazo, Patricia);Contreras, C(Contreras, Cristina);Varela, L(Varela, Luis);Villarroya, J(Villarroya, Joan);Rial-Pensado, ...
CELL METABOLISM
2017-07-05
Hepatic p63 regulates steatosis via IKK beta/ER stress
Porteiro, B(Porteiro, Begona);Fondevila, MF(Fondevila, Marcos F.);Delgado, TC(Delgado, Teresa C.);Iglesias, C(Iglesias, Cristina);Imbernon, M(Imbernon, Monica);Iruzubieta, P(Iruzubieta, Paula);Crespo, ...
NATURE COMMUNICATIONS
2017-05-08
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso, C(Alonso, Cristina);Fernandez-Ramos, D(Fernandez-Ramos, David);Varela-Rey, M(Varela-Rey, Marta);Martinez-Arranz, I(Martinez-Arranz, Ibon);Navasa, N(Navasa, Nicolas);Van Liempd, SM(Van ...
GASTROENTEROLOGY
2017-05-01
An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease
De Las Heras, J(De Las Heras, Javier);Aldamiz-Echevarria, L(Aldamiz-Echevarria, Luis);Martinez-Chantar, ML(Martinez-Chantar, Maria-Luz);Delgado, TC(Delgado, Teresa C.)
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
2017-04-01
Prohibitin 1 Suppresses Liver Cancer Tumorigenesis in Mice and Human Hepatocellular and Cholangiocarcinoma Cells
Fan, W(Fan, Wei);Yang, HP(Yang, Heping);Liu, T(Liu, Ting);Wang, JH(Wang, Jiaohong);Li, TWH(Li, Tony W. H.);Mavila, N(Mavila, Nirmala);Tang, YY(Tang, Yuanyuan);Yang, JW(Yang, JinWon);Peng, H(Peng, ...
HEPATOLOGY
2017-04-01
A morphological method for ammonia detection in liver
Gutierrez-de-Juan, V(Gutierrez-de-Juan, Virginia);de Davalillo, SL(Lopez de Davalillo, Sergio);Fernandez-Ramos, D(Fernandez-Ramos, David);Barbier-Torres, L(Barbier-Torres, Lucia);Zubiete-Franco, ...
PLOS ONE
2017-03-20
Deregulated Neddylation in Liver Fibrosis
Zubiete-Franco, I(Zubiete-Franco, Imanol);Fernadez-Tussy, P(Fernandez-Tussy, Pablo);Barbier-Torres, L(Barbier-Torres, Lucia);Simon, J(Simon, Jorge);Fernadez-Ramos, D(Fernandez-Ramos, David);Lopitz-Otsoa, ...
HEPATOLOGY
2017-02-01
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2
Gimenez-Mascarell, P(Gimenez-Mascarell, Paula);Oyenarte, I(Oyenarte, Iker);Hardy, S(Hardy, Serge);Breiderhoff, T(Breiderhoff, Tilman);Stuiver, M(Stuiver, Marchel);Kostantin, E(Kostantin, Elie);Diercks, ...
THE JOURNAL OF BIOLOGICAL CHEMISTRY
2017-01-20
Aramchol reduces established fibrosis in MCD diet animal model
Varela-Rey, M(Varela-Rey, M.);Fernandez-Ramos, D(Fernandez-Ramos, D.);Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, M.);Van Liempd, SM(Van Liempd, S. M.);DelaCruz-Villar, L(delaCruz-Villar, ...
JOURNAL OF HEPATOLOGY
2017-01-01

2016

Stratification and therapeutic potential of PML in metastatic breast cancer
Martin-Martin, N(Martin-Martin, Natalia);Piva, M(Piva, Marco);Urosevic, J(Urosevic, Jelena);Aldaz, P(Aldaz, Paula);Sutherland, JD(Sutherland, James D.);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Arreal, ...
NATURE COMMUNICATIONS
2016-08-01
AISF position paper on liver transplantation and pregnancy Women in Hepatology Group, Italian Association for the Study of the Liver (AISF)
Alisi, Anna; Balsano, Clara; Bernabucci, Veronica; Berzigotti, Annalisa; Brunetto, Maurizia; Bugianesi, Elisabetta; Burra, Patrizia; Calvaruso, Vincenza; Cariani, Elisabetta; Coco, Barbara; ...
DIGESTIVE AND LIVER DISEASE
2016-08-01
Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension
Seijo, S(Seijo, Susana);Lozano, JJ(Jose Lozano, Juan);Alonso, C(Alonso, Cristina);Miquel, R(Miquel, Rosa);Berzigotti, A(Berzigotti, Annalisa);Reverter, E(Reverter, Enric);Turon, F(Turon, Fanny);Martinez-Chantar, ...
LIVER INTERNATIONAL : OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF THE LIVER
2016-07-01
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study
Villa, E(Villa, Erica);Critelli, R(Critelli, Rosina);Lei, B(Lei, Barbara);Marzocchi, G(Marzocchi, Guido);Camma, C(Camma, Calogero);Giannelli, G(Giannelli, Gianluigi);Pontisso, P(Pontisso, Patrizia);Cabibbo, ...
GUT
2016-05-01
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Zubiete-Franco, I(Zubiete-Franco, Imanol);Garcia-Rodriguez, JL(Garcia-Rodriguez, Juan Luis);Martinez-Una, M(Martinez-Una, Maite);Martinez-Lopez, N(Martinez-Lopez, Nuria);Woodhoo, A(Woodhoo, ...
JOURNAL OF HEPATOLOGY
2016-02-01
SERPINB3 UP-REGULATES HYPOXIA INDUCIBLE FACTORS-1ALPHA AND-2ALPHA IN LIVER CANCER CELLS THROUGH DIFFERENT MECHANISMS
Cannito, S(Cannito, S.);Villano, G(Villano, G.);Turato, C(Turato, C.);Morello, E(Morello, E.);Foglia, B(Foglia, B.);Novo, E(Novo, E.);Quarta, S(Quarta, S.);Colombatto, S(Colombatto, S.);Lopitz-Otsoa, ...
JOURNAL OF HEPATOLOGY
2016-01-01

2015

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Feitelson, MA(Feitelson, Mark A.);Arzumanyan, A(Arzumanyan, Alla);Kulathinal, RJ(Kulathinal, Rob J.);Blain, SW(Blain, Stacy W.);Holcombe, RF(Holcombe, Randall F.);Mahajna, J(Mahajna, Jamal);Marino, ...
SEMINARS IN CANCER BIOLOGY
2015-12-01
Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-beta-Dependent Fibrogenesis
Espinosa-Diez, C(Espinosa-Diez, Cristina);Fierro-Fernandez, M(Fierro-Fernandez, Marta);Sanchez-Gomez, F(Sanchez-Gomez, Francisco);Rodriguez-Pascual, F(Rodriguez-Pascual, Fernando);Alique, M(Alique, ...
ANTIOXIDANTS & REDOX SIGNALING
2015-11-10
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1
Barbier-Torres, L(Barbier-Torres, Lucia);Beraza, N(Beraza, Naiara);Fernandez-Tussy, P(Fernandez-Tussy, Pablo);Lopitz-Otsoa, F(Lopitz-Otsoa, Fernando);Fernandez-Ramos, D(Fernandez-Ramos, David);Zubiete-Franco, ...
HEPATOLOGY
2015-10-01
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Gomez-Sanchez, JA(Gomez-Sanchez, Jose A.);Carty, L(Carty, Lucy);Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, Marta);Palomo-Irigoyen, M(Palomo-Irigoyen, Marta);Varela-Rey, M(Varela-Rey, Marta);Griffith, ...
THE JOURNAL OF CELL BIOLOGY
2015-07-06
NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R
Fernandez-Ramos, D(Fernandez-Ramos, David);Martinez-Chantar, ML(Martinez-Chantar, Mara L.)
PANCREATOLOGY : OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION OF PANCREATOLOGY
2015-07-01
Integrative Genomic Signatures Of Hepatocellular Carcinoma Derived from Nonalcoholic Fatty Liver Disease
Frades, I(Frades, Itziar);Andreasson, E(Andreasson, Erik);Mato, JM(Maria Mato, Jose);Alexandersson, E(Alexandersson, Erik);Matthiesen, R(Matthiesen, Rune);Martinez-Chantar, ML(Martinez-Chantar, ...
PLOS ONE
2015-05-20
A METABOLIC DEFINITION OF NASH AND ITS RESOLUTION BY S-ADENOSYLMETHIONINE IN Mat1a KO MICE
Mato, JM(Mato, J. M.);Fernandez-Ramos, D(Fernandez-Ramos, D.);Martinez-Arranz, I(Martinez-Arranz, I.);Mayo, R(Mayo, R.);van Liempd, SC(van Liempd, S. C.);Sann, H(Sann, H.);Platon, J(Platon, ...
JOURNAL OF HEPATOLOGY
2015-04-01
Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease
Benet, M(Benet, Marta);Guzman, C(Guzman, Carla);Pisonero-Vaquero, S(Pisonero-Vaquero, Sandra);Garcia-Mediavilla, MV(Victoria Garcia-Mediavilla, M.);Sanchez-Campos, S(Sanchez-Campos, Sonia);Martinez-Chantar, ...
MOLECULAR PHARMACOLOGY
2015-04-01
HIF2-ALPHA NEDDYLATION AS A SELECTIVE SERPINB3-DEPENDENT MECHANISM LEADING TO ITS INCREASE
Cannito, S(Cannito, S.);Villano, G(Villano, G.);Turato, C(Turato, C.);Morello, E(Morello, E.);Paternostro, C(Paternostro, C.);Quarta, S(Quarta, S.);Colombatto, S(Colombatto, S.);Lopitz-Otsoa, ...
JOURNAL OF HEPATOLOGY
2015-04-01
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease
Martinez-Una, M(Martinez-Una, Maite);Varela-Rey, M(Varela-Rey, Marta);Mestre, D(Mestre, Daniela);Fernandez-Ares, L(Fernandez-Ares, Larraitz);Fresnedo, O(Fresnedo, Olatz);Fernandez-Ramos, D(Fernandez-Ramos, ...
JOURNAL OF HEPATOLOGY
2015-03-01
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
Barbier-Torres, L(Barbier-Torres, Lucia);Delgado, TC(Delgado, Teresa C.);Garcia-Rodriguez, JL(Garcia-Rodriguez, Juan L.);Zubiete-Franco, I(Zubiete-Franco, Imanol);Fernandez-Ramos, D(Fernandez-Ramos, ...
ONCOTARGET
2015-02-10
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernandez-Alyarezl, S(Fernandez-Alyarezl, Sara);Gutierrez-de Juan, V(Gutierrez-de Juan, Virginia);Zubiete-Franco, L(Zubiete-Franco, Lmanol);Barbier-Torres, L(Barbier-Torres, Lucia);Lahoz, A(Lahoz, ...
LABORATORY INVESTIGATION; A JOURNAL OF TECHNICAL METHODS AND PATHOLOGY
2015-02-01
Regulation of Oxidative Stress by Methylation-Controlled J Protein Controls Macrophage Responses to Inflammatory Insults
Navasa, N(Navasa, Nicolas);Martin, I(Martin, Itziar);Iglesias-Pedraz, JM(Iglesias-Pedraz, Juan Manuel);Beraza, N(Beraza, Naiara);Atondo, E(Atondo, Estibaliz);Izadi, H(Izadi, Hooman);Ayaz, F(Ayaz, ...
THE JOURNAL OF INFECTIOUS DISEASES
2015-01-01
The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
Carracedo, A(Carracedo, Arkaitz);Rousseau, D(Rousseau, Deborah);Douris, N(Douris, Nicholas);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Martin-Martin, N(Martin-Martin, Natalia);Weiss, D(Weiss, ...
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2015-01-01
The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?
...
BIOMED RESEARCH INTERNATIONAL
2015-01-01

2014

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
Scheiba, Rafael M.; Ibanez de Opakua, Alain; Diaz-Quintana, Antonio; Cruz-Gallardo, Isabel; Martinez-Cruz, Luis A.; Martinez-Chantar, Maria L.; Blanco, Francisco J.; Diaz-Moreno, Irene
RNA BIOLOGY
2014-10-01
Systems biology for hepatologists.
Mato, Jose M.; Luz Martinez-Chantar, M.; Lu, Shelly C.
HEPATOLOGY
2014-08-01
Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance
Carrasco, Manuel; Rabaneda, Luis G.; Murillo-Carretero, Maribel; Ortega-Martinez, Sylvia; Martinez-Chantar, Maria L.; Woodhoo, Ashwin; Luka, Zigmund; Wagner, Conrad; Lu, Shelly C.; Mato, Jose ...
HIPPOCAMPUS
2014-07-01
Ubiquitin profiling in liver using a transgenic mouse with biotinylated ubiquitin.
Lectez, Benoit; Migotti, Rebekka; Lee, So Young; Ramirez, Juanma; Beraza, Naiara; Mansfield, Bill; Sutherland, James D.; Martinez-Chantar, Maria L.; Dittmar, Gunnar; Mayor, Ugo
JOURNAL OF PROTEOME RESEARCH
2014-06-06
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Garcia-Rodriguez, Juan L.; Barbier-Torres, Lucia; Fernandez-Alvarez, Sara; Gutierrez-de Juan, Virginia; Monte, Maria J.; Halilbasic, Emina; Herranz, Daniel; Alvarez, Luis; Aspichueta, Patricia; ...
HEPATOLOGY
2014-05-01
S-adenosylmethionine levels regulate the schwann cell DNA methylome.
Varela-Rey, Marta; Iruarrizaga-Lejarreta, Marta; Jose Lozano, Juan; Maria Aransay, Ana; Fernandez, Agustin F.; Luis Lavin, Jose; Mosen-Ansorena, David; Berdasco, Maria; Turmaine, Marc; Luka, ...
NEURON
2014-03-05
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells (vol 288, pg 23161, 2013)
Yang, Heping; Zheng, Yuhua; Li, Tony W. H.; Peng, Hui; Fernandez-Ramos, David; Martinez-Chantar, Maria L.; Rojas, Adriana L.; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF BIOLOGICAL CHEMISTRY
2014-01-10

2013

Excess S-adenosylmethionine Reroutes Phosphatidylethanolamine Towards Phosphatidylcholine and Triglyceride Synthesis
Martinez-Una, Maite; Varela-Rey, Marta; Cano, Ainara; Fernandez-Ares, Larraitz; Beraza, Naiara; Aurrekoetxea, Igor; Martinez-Arranz, Ibon; Garcia-Rodriguez, Juan L.; Buque, Xabier; Mestre, Daniela; ...
HEPATOLOGY
2013-10-01
Methionine Adenosyltransferase 2B, HuR, and Sirtuin 1 Protein Cross-talk Impacts on the Effect of Resveratrol on Apoptosis and Growth in Liver Cancer Cells
Yang, Heping; Zheng, Yuhua; Li, Tony W. H.; Peng, Hui; Fernandez-Ramos, David; Martinez-Chantar, Maria L.; Rojas, Adriana L.; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF BIOLOGICAL CHEMISTRY
2013-08-09
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma
Huidobro, Covadonga; Torano, Estela G.; Fernandez, Agustin F.; Urdinguio, Rocio G.; Rodriguez, Ramon M.; Ferrero, Cecilia; Martinez-Camblor, Pablo; Boix, Loreto; Bruix, Jordi; Luis Garcia-Rodriguez, ...
JOURNAL OF MOLECULAR MEDICINE-JMM
2013-08-01
Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension
Seijo, Susana; Jose Lozano, Juan; Alonso, Cristina; Reverter, Enric; Miquel, Rosa; Abraldes, Juan G.; Luz Martinez-Chantar, Maria; Garcia-Criado, Angeles; Berzigotti, Annalisa; Castro, Azucena; ...
AMERICAN JOURNAL OF GASTROENTEROLOGY
2013-06-01
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPAR alpha; and repressed by C/EBP alpha: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease
Guzman, Carla; Benet, Marta; Pisonero-Vaquero, Sandra; Moya, Marta; Victoria Garcia-Mediavilla, M.; Luz Martinez-Chantar, M.; Gonzalez-Gallego, Javier; Vicente Castell, Jose; Sanchez-Campos, ...
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
2013-04-01
Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease
Vazquez-Chantada, Mercedes; Gonzalez-Lahera, Aintzane; Martinez-Arranz, Ibon; Garcia-Monzon, Carmelo; Regueiro, Manuela M.; Garcia-Rodriguez, Juan L.; Schlangen, Karin A.; Mendibil, Inaki; Rodriguez-Ezpeleta, ...
HEPATOLOGY
2013-02-01

2012

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
Woodhoo, Ashwin; Iruarrizaga-Lejarreta, Marta; Beraza, Naiara; Garcia-Rodriguez, Juan L.; Embade, Nieves; Fernandez-Ramos, David; Martinez-Lopez, Nuria; Gutierrez-De Juan, Virginia; Arteta, ...
HEPATOLOGY
2012-11-01
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
von Montfort, Claudia; Matias, Nuria; Fernandez, Anna; Fucho, Raquel; Conde de la Rosa, Laura; Luz Martinez-Chantar, Maria; Mato, Jose M.; Machida, Keigo; Tsukamoto, Hidekazu; Murphy, Michael ...
JOURNAL OF HEPATOLOGY
2012-10-01
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1
Martinez-Lopez, Nuria; Garcia-Rodriguez, Juan L.; Varela-Rey, Marta; Gutierrez, Virginia; Fernandez-Ramos, David; Beraza, Naiara; Aransay, Ana M.; Schlangen, Karin; Jose Lozano, Juan; Aspichueta, ...
GASTROENTEROLOGY
2012-09-01
Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase
Gomez-Santos, Laura; Luka, Zigmund; Wagner, Conrad; Fernandez-Alvarez, Sara; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.; Beraza, Naiara
HEPATOLOGY
2012-08-01
The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development
Iruarrizaga-Lejarreta, Marta; Varela-Rey, Marta; Jose Lozano, Juan; Fernandez-Ramos, David; Rodriguez-Ezpeleta, Naiara; Embade, Nieves; Lu, Shelly C.; van der Kraan, Peter M.; Davidson, Esmeralda ...
JOURNAL OF NEUROSCIENCE
2012-04-04
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Embade, Nieves; Fernandez-Ramos, David; Varela-Rey, Marta; Beraza, Naiara; Sini, Marcella; Gutierrez de Juan, Virginia; Woodhoo, Ashwin; Martinez-Lopez, Nuria; Rodriguez-Iruretagoyena, Begona; ...
HEPATOLOGY
2012-04-01
Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression
Barr, J.; Caballeria, J.; Martinez-Arranz, I.; Dominguez-Diez, A.; Alonso, C.; Muntane, J.; Perez-Cormenzana, M.; Garcia-Monzon, C.; Mayo, R.; Martin-Duce, A.; Romero-Gomez, M.; Lo Iacono, O.; ...
JOURNAL OF PROTEOME RESEARCH
2012-04-01
Biphasic adaptative responses in VLDL metabolism and lipoprotein homeostasis during Gram-negative endotoxemia
Bartolome, Nerea; Aspichueta, Patricia; Martinez, Maria J.; Vazquez-Chantada, Mercedes; Martinez-Chantar, Maria L.; Ochoa, Begona; Chico, Yolanda
INNATE IMMUNITY
2012-02-01

2011

Methionine Adenosyltransferase 1A Gene Deletion Disrupts Hepatic Very Low-Density Lipoprotein Assembly in Mice
Cano, Ainara; Buque, Xabier; Martinez-Una, Maite; Aurrekoetxea, Igor; Menor, Ariane; Garcia-Rodriguez, Juan L.; Lu, Shelly C.; Luz Martinez-Chantar, M.; Mato, Jose M.; Ochoa, Begona; Aspichueta, ...
HEPATOLOGY
2011-12-01
HIGH-FREQUENCY ULTRASOUND IMAGING FOR LONGITUDINAL EVALUATION OF NON-ALCOHOLIC FATTY LIVER DISEASE PROGRESSION IN MICE
Fernandez-Dominguez, Itziar; Javier Echevarria-Uraga, J.; Gomez, Nieves; Luka, Zigmund; Wagner, Conrad; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.; Rodriguez-Cuesta, Juan
ULTRASOUND IN MEDICINE AND BIOLOGY
2011-07-01
Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration
Varela-Rey, Marta; Beraza, Naiara; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.
EXPERIMENTAL BIOLOGY AND MEDICINE
2011-04-01
S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes
Yamaji, Sachie; Droggiti, Anna; Lu, Shelly C.; Martinez-Chantar, Maria L.; Warner, Anne; Varela-Rey, Marta
EUROPEAN JOURNAL OF CELL BIOLOGY
2011-04-01

2010

Liver-Specific Deletion of Prohibitin 1 Results in Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice
Ko, Kwang Suk; Tomasi, Maria Lauda; Iglesias-Ara, Ainhoa; French, Barbara A.; French, Samuel W.; Romani, Komal; Jose Lozano, Juan; Oh, Pilsoo; He, Lina; Stiles, Bangyan L.; Li, Tony W. H.; Yang, ...
HEPATOLOGY
2010-12-01
Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma from Nonalcoholic Steatohepatitis
Martinez-Lopez, Nuria; Varela-Rey, Marta; Fernandez-Ramos, David; Woodhoo, Ashwin; Vazquez-Chantada, Mercedes; Embade, Nieves; Espinosa-Hevia, Luis; Javier Bustamante, Francisco; Parada, Luis ...
HEPATOLOGY
2010-11-01
Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease
Barr, Jonathan; Vazquez-Chantada, Mercedes; Alonso, Cristina; Perez-Cormenzana, Miriam; Mayo, Rebeca; Galan, Asier; Caballeria, Juan; Martin-Duce, Antonio; Tran, Albert; Wagner, Conrad; Luka, ...
JOURNAL OF PROTEOME RESEARCH
2010-09-01
The N-terminal domain of the enzyme I is a monomeric well-folded protein with a low conformational stability and residual structure in the unfolded state
Romero-Beviar, Manuel; Martinez-Rodriguez, Sergio; Prieto, Jesus; Goormaghtigh, Erik; Ariz, Usue; de la Luz Martinez-Chantar, Maria; Gomez, Javier; Neira, Jose L.
PROTEIN ENGINEERING DESIGN & SELECTION
2010-09-01
Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
...
GASTROENTEROLOGY
2010-08-01
Fatty Liver and Fibrosis in Glycine N-Methyltransferase Knockout Mice Is Prevented by Nicotinamide
Varela-Rey, Marta; Martinez-Lopez, Nuria; Fernandez-Ramos, David; Embade, Nieves; Calvisi, Diego F.; Woodhoo, Aswhin; Rodriguez, Juan; Fraga, Mario F.; Julve, Josep; Rodriguez-Millan, Elisabeth; ...
HEPATOLOGY
2010-07-01
HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis
Vazquez-Chantada, Mercedes; Fernandez-Ramos, David; Embade, Nieves; Martinez-Lopez, Nuria; Varela-Rey, Marta; Woodhoo, Ashwin; Luka, Zigmund; Wagner, Conrad; Anglim, Paul P.; Finnell, Richard ...
GASTROENTEROLOGY
2010-05-01
Non-alcoholic fatty liver disease proteomics
Rodriguez-Suarez, Eva; Duce, Antonio M.; Caballeria, Juan; Martinez Arrieta, Felix; Fernandez, Estefania; Gomara, Carolina; Alkorta, Nere; Ariz, Usue; Luz Martinez-Chantar, M.; Lu, Shelly C.; ...
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01
The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice
Martinez-Chantar, M. L.; Lu, S. C.; Mato, J. M.; Luka, Z.; Wagner, C.; French, B. A.; French, S. W.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
2010-04-01
Binding of S-Methyl-5 '-Thioadenosine and S-Adenosyl-L-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair
Lucas, Maria; Antonio Encinar, Jose; Astigarraga Arribas, Egoitz; Oyenarte, Iker; Gomez Garcia, Inmaculada; Kortazar, Danel; Fernandez, Jose A.; Mato, Jose M.; Luz Martinez-Chantar, Maria; Alfonso ...
JOURNAL OF MOLECULAR BIOLOGY
2010-02-26

2009

Purification, crystallization and preliminary crystallographic analysis of protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homologue of gamma-AMPK
Gomez Garcia, Inmaculada; Kortazar, Danel; Oyenarte, Iker; Maria Mato, Jose; Luz Martinez-Chantar, Maria; Alfonso Martinez-Cruz, Luis
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2009-08-01
Impaired Liver Regeneration in Mice Lacking Glycine N-Methyltransferase
Varela-Rey, Marta; Fernandez-Ramos, David; Martinez-Lopez, Nuria; Embade, Nieves; Gomez-Santos, Laura; Beraza, Naiara; Vazquez-Chantada, Mercedes; Rodriguez, Juan; Luka, Zigmund; Wagner, Conrad; ...
HEPATOLOGY
2009-08-01
Phenotypic Differences Between Two Gnmt-/- Mouse Models for Hepatocellular Carcinoma Reply
Luka, Zigmund; Luz Martinez-Chantar, M.; Lu, Shelly C.; Wager, Conrad; Mato, Jose M.
HEPATOLOGY
2009-06-01
Non-alcoholic steatohepatitis and animal models: Understanding the human disease
Varela-Rey, Marta; Embade, Nieves; Ariz, Usue; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, M. Luz
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2009-05-01
The CBS Domain Protein MJ0729 of Methanocaldococcus jannaschii Is a Thermostable Protein with a pH-Dependent Self-Oligomerization
Alfonso Martinez-Cruz, Luis; Encinar, Jose A.; Kortazar, Danel; Prieto, Jesus; Gomez, Javier; Fernandez-Millan, Pablo; Lucas, Maria; Astigarraga Arribas, Egoitz; Andres Fernandez, Jose; Luz ...
BIOCHEMISTRY
2009-03-31
S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis
Tomasi, Maria Lauda; Iglesias-Ara, Ainhoa; Yang, Heping; Ramani, Komal; Feo, Francesco; Pascale, Maria Rosa; Luz Martinez-Chantar, M.; Mato, Jose M.; Lu, Shelly C.
GASTROENTEROLOGY
2009-03-01
Evidence for LKB1/AMP-Activated Protein Kinase/Endothelial Nitric Oxide Synthase Cascade Regulated by Hepatocyte Growth Factor, S-Adenosylmethionine, and Nitric Oxide in Hepatocyte Proliferation
Vazquez-Chantada, Mercedes; Ariz, Usue; Varela-Rey, Marta; Embade, Nieves; Martinez-Lopez, Nuria; Fernandez-Ramos, David; Gomez-Santos, Laura; Lamas, Santiago; Lu, Shelly C.; Luz Martinez-Chantar, ...
HEPATOLOGY
2009-02-01
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
Lara, E.; Mai, A.; Calvanese, V.; Altucci, L.; Lopez-Nieva, P.; Martinez-Chantar, M. L.; Varela-Rey, M.; Rotili, D.; Nebbioso, A.; Ropero, S.; Montoya, G.; Oyarzabal, J.; Velasco, S.; Serrano, ...
ONCOGENE
2009-02-01

2008

Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100
Lucas, Maria; Kortazar, Danel; Astigarraga, Egoitz; Fernandez, Jose A.; Mato, Jose M.; Martinez-Chantar, Maria Luz; Martinez-Cruz, Luis Alfonso
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2008-10-01
S-adenosylmethionine and proliferation: new pathways, new targets
Martinez-Lopez, Nuria; Varela-Rey, Marta; Ariz, Usue; Embade, Nieves; Vazquez-Chantada, Mercedes; Fernandez-Ramos, David; Gomez-Santos, Laura; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, ...
BIOCHEMICAL SOCIETY TRANSACTIONS
2008-10-01
Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii
Fernandez-Millan, Pablo; Kortazar, Danel; Lucas, Maria; Martinez-Chantar, Maria Luz; Astigarraga, Egoitz; Fernandez, Jose Andres; Sabas, Olatz; Albert, Armando; Mato, Jose M.; Martinez-Cruz, ...
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
2008-07-01
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Martinez-Chantar, M. Luz; Vazquez-Chantada, Mercedes; Ariz, Usue; Martinez, Nuria; Varela, Marta; Luka, Zigmund; Capdevila, Antonieta; Rodriguez, Juan; Aransay, Ana M.; Matthiesen, Rune; Yang, ...
HEPATOLOGY
2008-04-01
Methionine metabolism and liver disease
Mato, Jose M.; Martinez-Chantar, M. Luz; Lu, Shelly C.
ANNUAL REVIEW OF NUTRITION
2008-01-01

2007

Identification of a gene-pathway associated with non-alcoholic steatohepatitis
Rubio, Angel; Guruceaga, Elizabeth; Vazquez-Chantada, Mercedes; Sandoval, Juan; Martinez-Cruz, L. Alfonso; Segura, Victor; Sevilla, Jose L.; Podhorski, Adam; Corrales, Fernando J.; Torres, Luis; ...
JOURNAL OF HEPATOLOGY
2007-04-01

2006

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
Lu, Shelly C.; Martinez-Chantar, M. Luz; Mato, Jose M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2006-10-01
Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
Rodriguez, Jose L.; Sandoval, Juan; Serviddio, Gaetano; Sastre, Juan; Morante, Maria; Perrell, Maria-Giulia; Martinez-Chantar, Maria L.; Vina, Jose; Vina, Juan R.; Mato, Jose M.; Avila, Matias ...
BIOCHEMICAL JOURNAL
2006-09-15
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase
Martinez-Chantar, Maria L.; Vazquez-Chantada, Mercedes; Garnacho, Marta; Latasa, M. Ujue; Varela-Rey, Marta; Dotor, Javier; Santamaria, Monica; Martinez-Cruz, Luis A.; Parada, Luis A.; Lu, Shelly ...
GASTROENTEROLOGY
2006-07-01
Latest Publications

NFATc4: New hub in NASH development

Martinez-Chantar, ML;Foti, M

JOURNAL OF HEPATOLOGY

2020-12-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...

HEPATOLOGY

2020-11-13

Nutraceutical Properties of Polyphenols against Liver Diseases

Simon, J;Casado-Andres, M;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Martinez-Chantar, ML

NUTRIENTS

2020-11-01

Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment

Martinez-Chantar, ML;Avila, MA;Lu, SC

CANCERS

2020-10-01

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitisviaAMPK and mTOR regulation

Fernandez-Ramos, D;Lopitz-Otsoa, F;Delacruz-Villar, L;Bilbao, J;Pagano, M;Mosca, L;Bizkarguenaga, M;Serrano-Macia, M;Azkargorta, M;Iruarrizaga-Lejarreta, M;Sot, J;Tsvirkun, D;van Liempd, SM;Goni, ...

WORLD JOURNAL OF GASTROENTEROLOGY

2020-09-14

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...

CANCERS

2020-09-01

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease

Gomez-Santos, B;de Urturi, DS;Nunez-Garcia, M;Gonzalez-Romero, F;Buque, X;Aurrekoetxea, I;de Juan, VG;Gonzalez-Rellan, MJ;Garcia-Monzon, C;Gonzalez-Rodriguez, A;Mosteiro, L;Errazti, G;Mifsut, ...

AGING CELL

2020-07-07

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Barbier-Torres, L;Fortner, KA;Iruzubieta, P;Delgado, TC;Giddings, E;Chen, YDH;Champagne, D;Fernandez-Ramos, D;Mestre, D;Gomez-Santos, B;Varela-Rey, M;de Juan, VG;Fernandez-Tussy, P;Zubiete-Franco, ...

NATURE COMMUNICATIONS

2020-07-03

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

Macias, RIR;Munoz-Bellvis, L;Sanchez-Martin, A;Arretxe, E;Martinez-Arranz, I;Lapitz, A;Gutierrez, ML;La Casta, A;Alonso, C;Gonzalez, LM;Avila, MA;Martinez-Chantar, ML;Castro, RE;Bujanda, L;Banales, ...

CANCERS

2020-06-01