The scientific and technical staff at the center is expert in providing solutions to a large variety complex scientific problems and questions raised from industry partners, encompassing the diverse number of disciplines and technologies widely used in life sciences and biomedical research. We also implement and develop state-of-the-art biotechnological tools and reagents for research through collaborations or service provision.

Structural determination and quantification of small molecules by RMN

Structural determination and quantification of small molecules by RMN

We are able to study structural determination of samples in solution, of unknown compounds and confirm their structures; ligand-protein complexes study: molecule-molecule interaction analysis, and determination of molecular weights based on diffusion coefficients (DOSY).

  • Small molecules: Structural determination, quantitation by NMR (Ana Poveda and Tammo). We also screen fragment and molecular libraries towards target receptors.

We are expert in the application of modern NMR methods to study the structure of small and medium size molecules in solution, including unknown compounds. Our expertise includes organic molecules, natural products, peptides, saccharides and nucleotides. Our available methodologies permit to deduce or confirm the chemical structures of isolated molecules and to determine the chemical composition of mixtures, as well as the quantification and determination of their molecular weights, based on diffusion coefficients (DOSY NMR). We are also experts in performing detailed ligand-receptor (proteins, nucleic acids) molecular recognition studies.

Label free nLC MS/MS Quantitative Proteomics

Structural determination and quantification of small molecules by RMN

Proteomics platform has incorporated one of the most sophisticated nLC MS/MS systems on market to address high sensitivity, performance and throughput label free quantitative proteomics studies. We can carry out different relative protein quantification projects such as inmunoprecipitations, subproteomes, cell or tissue extracts and biofluids. Besides, thanks to the incorporation of the EVOSEP new chromatographer, we can now tackle studies with large number of samples like the ones required in precision medicine projects.

Post-Translation Modification Study

Proteomics Platform can characterize different post-translational modification by combining diverse sample preparation protocols and acquisition methods. The analysis of endogenous peptides from biofluids (e.g. tear, urine or endometrial fluid) or immunopeptidomes (HLA peptides) is also an area we are paying attention. Finally, thanks to the unprecedented sensitivity the systems achieves, we are currently conducting projects starting from very small amount of sample (e.g. tissue micro-dissections etc.)

Structural determination and quantification of small molecules by RMN

Single Particle quantitative analysis and 3D Electron

The most valuable single particle method based on CryoTEM. We are able to discriminate between EMPTY, FULL and semi-EMPTY particles (AAV, lentivirus, exosomes, nanoparticles) to be used as gene delivery system. The most advanced unsupervised methods of single particle quantitative and qualitative analysis on the market able to provide 3D reconstruction data of the gene delivery system of your choice.

The more advanced single particle quantitative analysis on the market, available at CIC bioGUNE Electron Microscopy Platform, is able to discriminate between empty, full-loaded and semi-empty particles to be used in gene therapy.

Our staff also provides a detailed set-up for your development process.

We are the best partner for set-up of your development process, and control of single particle production for pre-clinical and clinical applications.

Single Particle quantitative analysis and 3D Electron

Experimental Design High Throughput Sequencing (HTS)

  • The Bioinformatics Unit at CIC bioGUNE is expert in the analysis of data obtained from different origins (proteomics, genomics, mRNseq, microbioma, etc.).

    The results are presented in a customized manner, depending on the requirements of the client.


In line with our spirit for solving challenges and fostering collaborations, we are always open to new those scientific and technical challenges that require advanced solutions. For specific needs of not listed technologies or services, please contact our Technology Transfer Manager or get in touch with Technology Platforms of your interest directly.