2023/12/21

Ana Ruiz-Saenz joins CIC bioGUNE as a Principal Investigator

CIC bioGUNE is excited to announce the recent incorporation of Dr. Ana Ruiz-Saenz as Principal Investigator, leading the Cancer Therapy Resistance Lab (CTRLab). Dr. Ana Ruiz...

2023/12/20

Nanotechnology to understand the behavior of tumors

Researchers from CIC bioGUNE and CIC biomaGUNE collaborated on a study, utilizing SERS technology, uncovering a novel form of interaction between tumor cells and their environment. The study, published in the journal Proceedings of th...

2023/12/18

Donación en apoyo a la investigación contra el cáncer de colon

El laboratorio de Exosomas, liderado por Juan Manuel Falcón, recibe una generosa donación para apoyar en la lucha contra el cáncer colorrectal. Este aporte respalda la búsqueda de métodos no invasivos y marcadores diagnósticos i...

2023/12/14

The Electron Microscopy Platform achieves ISO 9001:2015 accreditation

CIC bioGUNE's Electron Microscopy Platform attains ISO 9001:2015 certification, underscoring a commitment to elevated quality standards. The platform offers a comprehensive range of services, including negative stain analysis, cryoEM,...

2023/12/11

Unai Atxabal Arrasate will defend his PhD thesis on Friday, December 15th

Unai Atxabal Arrasate will defend his PhD thesis entitled "Unravelling molecular recognition events between glycans and proteins using advanced NMR techniques" on...

2023/12/05

La investigadora Leidy Estefanía Zapata obtiene una Ayuda Predoctoral de la Asociación...

La Asociación Contra el Cáncer en Bizkaia entrega más de 1,3 millones de euros en 11 ayudas a la investigación en cáncer. Las ayudas han sido para personas investigadoras que desarrollan su actividad en centros de investigación ...

2023/12/04

Researchers from CIC bioGUNE develop a strategy capable of identifying the cellular...

The E3 ubiquitin ligase enzymes, very important for the functioning of the organism, are responsible for selecting and marking numerous proteins with ubiquitins to send them to the proteasome for degradation or to alter their cellular localization or o...

2023/11/30

La investigadora Sara Bertuzzi recibe los premios a la “Mejor Tesis Doctoral”...

El Grupo Español de Resonancia Magnética Nuclear (GERMN) y el Grupo Especializado de Hidratos de Carbono (GE-HiC), de la Real Sociedad Españo...

2023/11/27

European project ProFFIle facilitates a dynamic meeting between researchers and prion...

ProFFIle consortium researchers and representatives from various patient associations come together during the VII Annual Convention of individuals affected by and professionals in prion diseases, organized by the Spanish Foundation for Prion Diseases ...

2023/11/24

Glycobasque 6: A successful convergence of leading minds in glycoscience

Professionals, experts, and researchers across diverse glycoscience disciplines, encompassing glycobiology, immunology, and carbohydrate chemistry, converge at the 6th edition of Glycobasque. The event, held on November 23rd to 24th, ...

2023/11/20

Scientific impulse in Barcelona at the 'The Future of Personalized Medicine' meeting...

Last Friday, the Barcelona Science Park hosted the conference "The future of personalized medicine" within the Complementary Plan for Biotechnology in Health in Catalonia. With the participation of more than 100 experts in bi...

2023/11/13

Innovative European Project CARES kicks off to revolutionize cancer research

Cancer remains a formidable challenge, with 2 million cancer-related deaths annually and a staggering cost of €100 billion. The European Project CARES kicks off to revolutionize cancer research by envisioning a bold and innovative t...

2023/11/08

CIC bioGUNE se suma a la XXI edición de la Semana de la Ciencia, la Tecnología...

La Semana de la Ciencia, la Tecnología y la Innovación o Zientzia Astea es un evento anual de divulgación científica, organizado por la Universidad del País Vasco (UPV/EHU), con el fin de fomentar la cultura científica y acercar a la sociedad la ...

2023/11/06

New study sheds light on the genetic link between Hemorrhoids, Diverticular Disease,...

Researchers from CIC bioGUNE provide new insights into digestive disease research. The recent study, published in the international journal in gastroenterology and hepatology Gut, provides fresh insights into the genetic correlation b...

2023/10/30

A scientific project coordinated by CIC bioGUNE receives the 'Young Researchers'...

The AstraZeneca Foundation has awarded the VII Young Researchers Awards under the motto “People who change lives”, an initiative that promotes the development and consolidation of young scientific talent in Spain. CIC bioGUNE lead...

2023/10/23

International partnership for the understanding of rare diseases and cognitive disorders...

Researchers from the Liver Disease lab at CIC bioGUNE in collaboration with researchers from Biobizkaia Research Institute, Hipofam Patients Association (Barcelona), McGill University (Montreal), Radboud University (Nijmegen) and Charite (Berlin), conc...

2023/10/17

La Fundación ”la Caixa” impulsa dos proyectos biomédicos de CIC bioGUNE para...

La convocatoria 2023 del nuevo programa CaixaImpulse Innovación ha concedido 3,3 millones de euros a 29 proyectos de investigación biomédica con el objetivo de contribuir a trasladar los resultados de la investigación a la sociedad y al mercado, y ...

2023/10/16

New potential therapeutic target for lung cancer treatment

Researchers from CIC bioGUNE provide new insights into lung cancer research. The recent study, published in the Journal of Clinical Investigation Insight (JCI Insight), sheds light on how Factor inhibiting HIF (FIH), a molecule that c...

2023/10/13

Maria Azparren Angulo will defend her PhD thesis on Friday, October 20th

Maria Azparren Angulo will defend her PhD thesis entitled "Study of the impact of hepatocytes-secreted extracellular vesicles in liver diseases" on Friday, October 20th at 11:00H. Supervisor:

2023/10/11

New gene therapy for treating chronic alcohol-induced liver damage

Researchers from CIC bioGUNE and CIBEREHD have unveiled a promising strategy for addressing alcohol-related liver disease. Their recent study, published in the international Journal Hepatology Reports, sheds light on the role of miR-8...

2023/10/10

CIC bioGUNE hosts EMBL symposium ‘Molecules to Ecosystems’

The symposium centered on sharing and inspiring dialogue across the complete spectrum of molecular biology, spanning from individual molecules to entire ecosystems. The event, held on October 9th, aimed to strengthen ties and highligh...

2023/10/09

Alice Macchia will defend her PhD thesis tomorrow, October 10th

Alice Macchia will defend her PhD thesis entitled "Exploring the impact of transcriptional deregulation of cell communication genes in prostate" tomorrow, October 10th at 15:00H. Supervisors:

2023/10/09

The ‘Plan Complementario de Biotecnología’ participates in BIOSPAIN 2023

BIOSPAIN 2023, one of the largest events in the biotechnology sector in Europe, featured a round table dedicated to the “Plan Complementario de Biotecnología Aplicada a Salud”. New ways to establish public-private alliances and how to create syner...

2023/10/06

CIC bioGUNE successfully concludes the 6th edition of the annual Introductory Week...

CIC bioGUNE, member of BRTA, successfully concluded the 6th edition of the Introductory Week for new doctora...

2023/10/04

The Breast Cancer Run “Marea Rosa” returns to the streets of Bilbao

The "Marea Rosa" prepares its return to Bilbao on October 8th with the eagerly anticipated solidarity race against breast cancer. This annual event is jointly organized by Acambi (Association of Bre...

2023/10/03

CIC bioGUNE launches "CIC bioGUNE Alumni" to boost collaborations and careers

A dynamic international network for scientific collaboration and professional growth between current and past employees. The CIC bioGUNE Alumni is an international and dynamic professional network aiming at sharing personal and professional e...

2023/10/02

El CIC bioGUNE se suma a la Noche Europea de los Investigadores e Investigadoras

La Noche Europea de los Investigadores e Investigadoras es uno de los eventos más importantes en la divulgación científica en Europa, celebrándose anualmente de manera simultánea en 300 ciudades de 30 países del continente. El centro

2023/09/27

CIC bioGUNE welcomes members of the Swiss Embassy and SBHS-Swiss Business Hub Spain

CIC bioGUNE – member of BRTA - had the pleasure of hosting distinguished members of the

2023/09/25

Jesús Jiménez-Barbero, awarded the 'Enrique Moles' National Research Prize in the...

The Ministry of Science and Research has granted this award within the framework of the 2023 National Research Awards, the most prestigious recognitions in Spain in the field of science and research.

2023/09/20

International collaboration teams up for innovative omics technologies integration...

Researchers from CIC bioGUNE in collaboration with researchers from NOVA Medical School (Lisbon) and the Curie Institute (Paris), concluded a three-day practical workshop. The event, held on September 13th to 15th, focused on the appl...

2023/09/19

...

Researchers from CIC bioGUNE participated in the I Glycoforo La Rioja-Hokkaido-Euskadi, organized by the University of La Rioja. The event, held on September 7th and 8th, brought together experts in chemical biomedicine from Spain and...

2023/09/15

CIC bioGUNE hosts the presentation of BRTA's personalized health research agenda

The presentation event of the personalized health research agenda, organized by the Basque Research & Technology Alliance (BRTA), brought together on Wednesday, September 6th, professionals from technological and cooperative research centers within...

2023/09/12

New advances in the analysis of mechanisms during the development of hepatocellular...

Researchers from IDIBELL, CIC bioGUNE and CIBEREHD discover that a protein called NOX4, which was previously thought to cause cell death, can also help tumor growth. The study published in the journal Redox Biology could open the door...

2023/09/11

La travesía de Carlos Bernabéu en apoyo a la porfiria tiene parada en las instalaciones...

Carlos Bernabéu culmina su desafío solidario en apoyo a la Asociación Española de Porfiria tras un extenso viaje en moto por toda Europa. Después de un largo viaje por toda Europa en su moto, Carlos Bernabéu, un joven de Ibi, Alicante, ...

2023/09/05

Ikerbasque researcher from CIC bioGUNE Luca Unione obtains an European ERC Starting Grant

The European Research Council funds talented researchers who are at the beginning of their research career and have the potential to become research leaders. Luca Unione will receive 1.5 million euros over 5 years to conduct research ...

2023/08/10

Discovery of a new mechanism in the development of diabetes

Researchers from CIC bioGUNE, CIBEREHD and CiMUS discover neddylation as a key mechanism in regulating the levels of key proteins in diabetes. The recent study, published in the international journal Cell Metabolism, reveals the criti...

2023/08/04

Researcher Alberto Fernández Tejada obtains his third ERC Proof of Concept grant in a row

The winning project, known as ADJUPROBE, will exploit a lead adjuvant probe as a dual technological tool for the development of next-generation vaccines. The European Research Council allocates funding to explore the commercial potent...

2023/08/01

Key discovery in cellular adaptation to fasting

Researchers at CIC bioGUNE, CIBEREHD and CiMUS discover that the methyl group donor molecule S-adenosylmethionine (SAMe) has proven to be a metabolic sensor in the physiological response to fasting and nutritional stress. The study, w...

2023/07/28

Arkaitz Carracedo and June Ereño-Orbea, from CIC bioGUNE, receive the Leonardo Grant...

The Leonardo Grants, supported by the BBVA Foundation, have received 1,116 applications in their 2023 call, with only 58 being selected. The evaluation of the candidates considered the excellence of the applicant's curriculum and the ...

2023/07/19

Desafío solidario para concienciar sobre el cáncer de mama masculino

Bajo el lema "Porque no estás sola... ni solo", se llevó a cabo la tercera edición del desafío solidario en apoyo a la Asociación de Cáncer de Mama y/o Ginecológico de Bizkaia (ACAMBI), con...

2023/07/11

Rubén Rodríguez Agudo will defend his PhD thesis on Friday, July14th

Rubén Rodríguez Agudo will defend his PhD thesis entitled "Biomarker Discovery and Novel Therapies Using Micro-RNAs: deeper insights into liver physiopathology" on Friday, July14th at 11:30H. Supervisor:

2023/07/10

La investigadora Naroa Goikoetxea recibe el Premio Extraordinario de Doctorado de...

La Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) otorga anualmente el Premio Extraordinario de Doctorado en diversos ámbitos académicos, en reconocimiento a la excelencia y la destacada labor de los doctorandos de esta instituci...

2023/07/04

A carbohydrate sequence capable of folding into a stable secondary structure

CIC bioGUNE participated in a research project, led by the Max Planck Institute of Colloids and Interfaces (MPICI), which has been published in the journal Nature Chemistry. This work opens the door to endow glycans with new propertie...

2023/06/22

La carrera solidaria contra el cáncer de mama tiñó de rosa Barakaldo

La marcha solidaria organizada por la Intervención Solidaria Barakaldo (ISB) reunió cerca de 3.500 personas en apoyo a la lucha contra el cáncer de mama. El pasado domingo 18 de junio, la asociación

2023/06/22

Coffee Time with the Training Committee

Would you like to join us for a coffee with the Training Committee? This exciting new initiative has received a positive response from doctoral candidates in the early years of their PhD. The main objective of this initiative is to foster closer communication ...

2023/06/20

Researchers from CIC bioGUNE reveal structural insights into the immune modulator...

The study, published in the journal Nature Communications, opens the door to the development of effective drug candidates that fully harness the therapeutic potential of Siglec-15. This knowledge will significantly contribute to the development of new ...

2023/06/16

SEMINAR HIGHLIGHT: The Revolutionary Use of Artificial Intelligence in Protein Design...

The integration of AI in protein design and engineering has the potential to revolutionize the challenge approach in chemical synthesis. This technology offers cost advantages and a real impact by accelerating the development and improvement of key ind...

2023/06/15

Researchers from CIC bioGUNE uncover the structure of one of the cellular machineries...

Researchers from CIC bioGUNE, Biofisika Institute, NIH (National Institutes of Health, USA), BSC (Barcelona Supercomputing Center), and ICVV (Institute of Vine and Wine Sciences) have concluded that proteins that need to be recycled coordinate their ow...

2023/06/14

Chiara Bruzzone will defend her PhD thesis tomorrow

Chiara Bruzzone will defend her PhD thesis entitled “NMR-based metabolomics in precision medicine. Application to metabolic syndrome and COVID-19” tomorrow, ...

2023/06/01

Researcher Óscar Millet presents the AKRIBEA project at the 15th RFMF Scientific...

The 15th Scientific Day of the Réseau Francophone de Métabolomique et Fluxomique (RFMF) held in Perpignan, France, showcased groundbreaking research and advancements in the field of metabolo...

2023/05/30

El CIC bioGUNE participa en la jornada de innovación multidisciplinar en medicina...

El Plan Complementario de Biotecnología aplicada a la Salud organiza la jornada “Innovación Multidisciplinar en Medicina Personalizada” con el objetivo de fortalecer y estimular colaboraciones en el marco de la investigación traslaciona...

2023/05/29

Researcher Juan Manuel Falcón honored with the second ISEV2023 Special Achievement Award

The International Society for Extracellular Vesicles (ISEV) has recognized the work in rigor about standardization and metabolomic profiling of extracellular vesicles (EVs) carried out by lead researcher Juan Manuel Falcón. The second ISEV20...

2023/05/26

Tres investigadoras del CIC bioGUNE incluidas entre las 3000 científicas españolas...

El Consejo Superior de Investigaciones Científicas (CSIC) ha publicado esta semana una nueva clasificación

2023/05/25

El investigador Arkaitz Carracedo participa en el primer “Itinerario Contra el...

Organizado por la Asociación Contra el Cáncer de Bizkaia, el evento contó con un amplio programa de actividades y conferencias centradas en la investigación, la nutrición y la prevención del cáncer. Este recorrido se ha desarro...

2023/05/15

Cristina Viera will defend her PhD thesis on Monday

Cristina Viera will defend her PhD thesis entitled “Metabolic control of prostate cancer aggressiveness by the tumor stroma” on Monday, May 22th at 10:30H. Supervisor:

2023/05/12

Researcher Óscar Millet awarded the Hermanos Elhuyar-Hans Goldschmidt Lectureship 2023

The prestigious Hermanos Elhuyar-Hans Goldschmidt Lectureship 2023 has been handed to Dr. Óscar Millet to recognize his research in the field of chemical biology. The Royal Spanish Chemical...

2023/05/11

Mitochondrial activity, a new therapeutic target for alcohol-induced liver disease

Researchers from CIC bioGUNE, CABIMER, CIBEREHD, CIBERDEM and other national and international centres identify that mitochondrial activity associated with alteration of the MCJ protein may be a cause of alcohol-induced liver failure.

2023/05/08

El CIC bioGUNE se une a la iniciativa de la Asociación Española Contra el Cáncer...

Actualmente, el cáncer es el problema sociosanitario más importante del mundo. Se prevé que 1 de cada 2 hombres y 1 de cada 3 mujeres tendrá esta enfermedad a lo largo de su vida.  Además, cada año, alrededor de 100.000 personas son diagnosticadas c...

2023/05/03

Horizon Europe project to combat diet-related diseases through novel monitoring technologies...

The CoDiet project will trial innovative diet-monitoring technologies to improve our understanding of the relationship between the food we eat and common diseases such as heart disease, diabetes, obesity and cancer. A new research project has...

2023/03/20

Potential for personalized dietary treatment of irritable bowel syndrome

A new study, led by researchers at CIC bioGUNE, suggests specific DNA changes may affect the response to carbohydrate-focused diets. Researchers at CIC bioGUNE, a member of the Basque Research & Technology Alliance (BRTA), report that DNA...

2023/03/10

Mikel Pujana Vaquerizo will defend his PhD thesis on March 31th

Mikel Pujana Vaquerizo will defend his PhD thesis entitled “Molecular and biological consequences of targeting polyamine metabolism in prostate cancer” on Friday, March 31th at 15:00H. Supervisor:

2023/03/09

Marcos Javier Gómez Redondo will defend his PhD thesis on March 22th

Marcos Javier Gómez Redondo will defend his PhD thesis entitled “NMR and molecular recognition: The interaction of human galectin-8 and DC-SIGN with natural glycans and glycomimetics” on Wednesday, March 22th at 11:00H. Supervis...

2023/02/28

Lucía Fadón Padilla will defend her PhD thesis on Thursday

Lucía Fadón Padilla will defend her PhD thesis entitled “Characterization of environment-related endophenotypes in pulmonary hypertension” on Thursday, March 2th at 10:00H. Supervisor:

2023/02/27

Researcher Alberto Fernández Tejada obtains a new ERC Proof of Concept grant.

The project to be funded, known as ADJU-PLATFORM, focuses on the development of a synthetic technology for the production of molecular vaccines in the pre-clinical phase, and assesses their potential for transfer to the market. The Eu...

2023/02/24

CIC bioGUNE celebrates its eighteenth anniversary with more than 1,700 articles published...

More than 500 researchers from over 30 countries have worked at CIC bioGUNE over the last eighteen years, making the centre an international benchmark in cutting-edge research at the interface between structural, molecular and cellular biology.

2023/02/21

Ane Martínez Castillo will defend her PhD thesis on Thursday, February 23th

Ane Martínez Castillo will defend her PhD thesis entitled “Structural study of flavivirus immunomodulator proteins from Aedes Aegypty salivary glands” on Thursday, February 23th at 11:00H. Supervisor:

2023/02/15

Financiación de 1,2 millones de euros de la Asociación Española Contra el Cáncer...

Buenas noticias en el marco del Día Internacional Contra el Cáncer Infantil. La Asociación Española Contra el Cáncer, a través de sus Programas de Ayuda, ha concedido 1,2 mil...

2023/02/13

Marina Serrano Maciá will defend her PhD thesis Friday, February 17th

Marina Serrano Maciá will defend her PhD thesis entitled “NEDDylation, a versatile mechanism involved in liver disease and COVID-19” Friday, February 17th at 12:00H. Supervisor:

2023/02/09

Galapagos y la Fundación EMQ conceden la primera beca de investigación para investigar...

La galardonada ha sido Beatriz Mateos, investigadora predoctoral becada por la Fundación ONCE en el en el Centro de Investigación Cooperativa en Biociencias – CIC bioGUNE por el proyecto “Preclinical IBD: spatial context in intestinal samples...

2023/01/30

Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid...

Ainara Cano 1,2,†, Mercedes Vazquez-Chantada 2,3,†,‡, Javier Conde-Vancells 3, Aintzane Gonzalez-Lahera 4,5, David Mosen-Ansorena

2023/01/26

Premio Fronteras del Conocimiento Concedido a David Baker, Demis Hassabis y John Jumper

Sus aportaciones en el estudio y diseño de proteínas a través de la Inteligencia Artificial para acelerar el desarrollo de nuevos tratamientos contra múltiples enfermedades. El

2023/01/12

CIC bioGUNE researchers describe the presence of a tick molecular receptor able to...

The information could be used in the future to generate measures that disable this signalling pathway essential for tick survival, and could therefore be used as a control measure for these parasites and the diseases they transmit. Th...

2022/12/21

How damaged cells inhibit muscle regeneration over lifetime

Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the ...

2022/12/20

Gabriel Soares Guerra will defend his PhD thesis Thursday, December 22th

Gabriel Soares Guerra will defend his PhD thesis entitled “Vaccine and structural Studies of Schmallenberg virus” Thursday, December 22th at 12:00H. Supervis...

2022/12/16

Jone Ibáñez Pérez will defend her PhD thesis Tuesday, December 20th

Jone Ibáñez Pérez will defend her PhD thesis entitled “Free and extracelular vesicle-associated microRNAs from endometrial fluid as non-inva...

2022/12/15

CIC bioGUNE researchers develop a new transgenic mouse that faithfully reproduces...

The work provides the scientific community with a new tool for the study of the most frequent prion diseases in humans and the most difficult to get to grips with because their cause is completely unknown and because they are very rare.

2022/12/15

Sara Bertuzzi will defend her PhD thesis Friday, December 16th

Sara Bertuzzi will defend her PhD thesis entitled “Lectin-Glycan Interactions: new NMR insights on the role of dynamics and presentation by using sta...

2022/12/14

Orhi Barroso Gomila will defend his PhD thesis Thursday, December 15th

Orhi Barroso Gomila will defend his PhD thesis entitled “Development of biotin-based strategies to dissect the ubiquitin” Thursday, December 15th at 11:00H. ...

2022/12/13

7 PhD Open Positions “la Caixa” Doctoral INPhINIT Incoming Fellowship Programme 2023

The doctoral fellowship programme INPhINIT “la Caixa” 2023 grants fellowships for talented early-stage researchers of any nationality to pursue their PhD studies in Spain or Portugal. This fellowships programme is aimed at support...

2022/12/12

Paula Oroz Mateo will defend her PhD thesis tomorrow, December 13th

Paula Oroz Mateo will defend her PhD thesis entitled “Adiciones 1,4-Conjugadas a Deshidroalaninas Quirales para la Síntesis de Aminoácidos no Naturales” tomorrow Tuesday, December 13th at 11:00H. Supervisor:

2022/12/08

2022 Introductory Week at CIC bioGUNE

5th edition of the CIC bioGUNE Introductory Week To get new doctoral candidates familiarized with the research environment of CIC bioGUNE and its facilities, as well as to get to know each other, CIC bioGUNE organized the 5th edition of the I...

2022/11/25

New therapeutic approach to treat paracetamol-induced fulminant liver damage

Researchers from CIC bioGUNE, CIBEREHD and New York University discover that altered magnesium levels in the liver may be a cause of liver failure due to high-dose paracetamol ingestion. Use of RNA interference technology opens new th...

2022/11/11

Carlos Miguel Díaz Domínguez will defend his PhD thesis Friday, November 18th

Carlos Miguel Díaz Domínguez will defend his PhD thesis entitled “Estudio de la diversidad de variantes polimórficas de las proteínas del prion de cérvidos, su capacid...

2022/11/07

CIC bioGUNE, recognized with the "Severo Ochoa Center of Excellence" distinction...

The accreditation is the highest recognition for a research center in Spain. The evaluation process has been carried out by an international scientific committee constituted by scientists of recognized prestige and impact

2022/10/24

Julia San Millán will defend her PhD thesis on Thursday, October 27th

Julia San Millán will defend her PhD thesis entitled “Analysis of the essentiality of phosphatidylserine decarboxylase in endocrine resistant breast cancer cells” Thursday, October 27th at 16:00H. Supervisor: 

2022/10/19

Nicanor Zalba Olaizola will defend his PhD thesis Monday, October 24th

Nicanor Zalba Olaizola will defend his PhD thesis entitled “On the effect of cosolutes and crowders in the stability and kinetic properties of proteins” Monday, October 24th at 12:00H. Supervisor: 

2022/10/18

Irene González Recio will defend her PhD thesis Monday, October 24th

Irene González Recio will defend her PhD thesis entitled “Unveiling magnesium homeostasis in liver diseases” Monday, October 24th at 12:00H. Supervisor: 

2022/10/17

Oscar Millet Galardonado con el Premio Bilateral Hispano-Alemán Hermanos Elhuyar...

La Sociedad Alemana de Química junto con la Real Sociedad Española de Química reconocen con el premio Bilateral Hispano-Alemán Hermanos Elhuyar – Hans Goldschmidt 2022 a Óscar Millet, Investigador ...

2022/10/17

Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition...

A collaborative research from the Chemical Glycobiology and Computational Chemistry Labs at CIC bioGUNE, together with the Glycotechnology Group at

2022/10/10

The solidarity race against breast cancer has dyed Bilbao pink again with the “Marea...

After two appointments canceled due to the pandemic, the seventh edition of the “Pink Tide” was held on Sunday 9th October. Organized annually by Acambi, (the Biscay Breast and Gynecological Cancer Association), its aim is to make this disease vis...

2022/10/10

Bilbao acoge el quinto congreso internacional de metabolismo y cáncer

Este evento científico recupera la presencialidad con su ya tradicional reunión en Bilbao. El congreso, organizado por la Asociación Europea de investigación en cáncer (EACR) y coordinado por CIC bioGUNE, cuenta con casi una déc...

2022/10/07

Arkaitz Carracedo, galardonado con el Premio Nacional de Investigación para jóvenes...

El Ministerio de Ciencia e Investigación ha concedido hoy este reconocimiento en el marco de los Premios Nacionales de Investigación 2022, que son el galardón más importante de España en el ámbito de la ciencia e investigación.

2022/10/04

Jon Imanol Quintana will defend his PhD thesis tomorrow, October 5.

Jon Imanol Quintana will defend his PhD thesis entitled “NMR and molecular recognition: The interaction of human galectin-4 with the histo blood group antigens and...

2022/10/03

The U.S. Alzheimer Association funds CIC bioGUNE research aimed at identifying a...

The study, which will run for the next three years, advances the hypothesis that the metabolome of central nervous system-derived exosomes could be a highly valuable tool for discovering new biomarkers of Alzheimer’s disease. The research wil...

2022/09/23

Breast Cancer Solidarity Run-Bilbao 2022

The run against breast cancer organized every year for ACAMBI will take place next October 9th 2022. More than 7,000 people have already got their T-shirt. The presentation of ...

2022/09/07

A CIC bioGUNE study reveals the liver to be a target organ for SARS-CoV-2 infection

Steatosis increases vulnerability to infection by SARS-CoV-2. Metformin, a treatment for hyperglycaemia in patients with type 2 diabetes, reduces infection of human hepatocytes by the SARS-CoV-2 pseudovirus. The study has been published...

2022/08/22

DNA changes behind irritable bowel syndrome (IBS): state-of-the-art

Publication in Nature Reviews Gastroenterology and Hepatology by researchers at CIC bioGUNE Irritable bowel syndrome is a common condition characterized by recurrent abdominal pain, constipation and diarrhea without an apparent underlying org...

2022/07/26

Miguel Tamayo will defend his PhD thesis today, July 26.

Miguel Tamayo will defend his PhD thesis entitled “Neddylation in Schwann cell myelination” Today, Tuesday, July 26 at 11:00H. Supervisor: Ashwin Woodhoo

2022/07/19

The SPIDVAC consortium, of which CIC bioGUNE is a member, awarded EUR 5 million to...

Thirteen European and African research centers will develop innovative vaccines against African horse sickness, peste des petits ruminants and foot-and-mouth disease. The consortium members will evaluate the capabilities of vaccines i...

2022/07/12

CIC bioGUNE research breaks new ground in the use of natural products containing...

The work, published in the journal Nature Chemistry, will allow the use of natural products that until now have been discarded due to their toxicity. Ortho-quinones are highly reactive substances that can be delivered to tumour tissue...

2022/06/16

Arkaitz Carracedo y Fàtima Crispi, ganadores de los Premios a la Investigación...

En esta cuarta edición, los premios reconocen investigaciones en cáncer y en medicina materno-fetal que ahondan en la importancia de la alimentación y la nutrición en la prevención y el tratamiento de enfermedades. Los investigadores premiados rec...

2022/06/06

Arkaitz Carracedo and Isabel Mendizabal receive support from the CRIS Research Programme

After a thorough selection process, CRIS Against Cancer has identified 17 outstanding researchers, 10 women and 7 men, to develop improved therapies for cancer patients. CRIS Research Programmes provide resources, means and stability ...

2022/05/31

Teresa Cardoso Delgado consigue un reconocimiento en la categoria “Rising Star...

El pasado 26 de mayo la Fundación Española para el Estudio del Hígado (FEEH) y Asociación Española para el Estudio del Hígado (AEEH) ha otorgado a

2022/05/25

Researcher Alberto Fernández Tejada awarded ERC Proof of Concept grant

The European Research Council makes funds available to explore the commercial potential of research work The European Research Council (ERC) has awarded a Proof of Concept grant to Alberto Fernández Tejada, an

2022/04/28

Virginia Berasategi donates 7,414 euros to the laboratory of Arkaitz Carracedo for...

The triathlete has taken part in the "Rare but not invisible" fund-raising initiative promoting 7,500 kilometres of solidarity. The triathlete Virginia Berasategi has donated 7,414 euros to CIC bioGUNE for research into rare diseases. The don...

2022/03/28

Nonalcoholic fatty liver disease subtypes exhibit distinctive cardiovascular risk profiles

Nonalcoholic fatty liver disease (NAFLD), a disease affecting approximately one-quarter of the world’s adult population, reflects dysfunctional hepatic lipid metabolism. An international team of researchers, led by

2022/03/25

Ariane Schaub Clerigué will defend her PhD thesis today, March 25rd

Ariane Schaub Clerigué will defend her PhD thesis entitled “PGC1⍺-driven transcriptional control of the cell secretome in prostate cancer: molecular and biological analysis” Today, Friday, March 25 at 15:00H. Supervisor:

2022/03/22

CIC bioGUNE y Tekniker renuevan su compromiso de colaboración en el campo de la...

CIC bioGUNE y el centro tecnológico Tekniker renuevan su compromiso de colaboración apostando por el desarrollo de tecnología para su aplicación al campo de la biomedicina. CIC bioGUNE y

2022/03/14

A study identifies obesity-regulating molecular communication guided by blood vessels

Blood vessels seen to be key players in the development of obesity. Research has revealed a mechanism through which fat cells are instructed by cells in blood vessels. The study, co-led by Drs Mariona Graupera and Arkaitz Carracedo, has...

2022/03/01

Discovered a new molecular interaction mechanism for SARS-Cov2

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids The virus causing the current COVID-19 pandemic is the SARS-CoV-2. Soon after the pandemic outbreak in 2019, the ACE-2 protein, which is present on some of our cells´ s...

2022/02/07

Carmen Fernández will defend her PhD thesis this Thursday, February 10th

Carmen Fernández will defend her PhD thesis entitled “Novel surface engineering approaches for protein crystallization and structural insights into the enzymes of reverse transsulfuration from the human pathogens Toxoplasma gondii ...

2022/02/07

El investigador Asís Palazón obtiene la ayuda ERC Proof of Concept

El Consejo Europeo de Investigación destina financiación a explorar el potencial comercial de trabajos de investigación. El Consejo Europeo de Investigación (European R...

2022/02/02

Atlas Molecular Pharma closes a EUR 3 million round of funding to advance clinical...

SPRI becomes a shareholder of the company, a spin-off of CIC bioGUNE, together with the asset management company Inveready and the Centre for the Development of Industrial Technology (CDTI), among other investors. Atlas develops pharm...

2021/12/22

Experimental and computational synergy – Promising COVID-19 result in immunology

An international collaboration between researchers from, the Centre for Cooperative Research in Biosciences (CIC bioGUNE, Bilbao), the Luxembourg Centre for Systems Biomedicine (LCSB) and the Department of Immunology of St Jude Children’s Research Hospital (...

2021/12/16

Diego Barriales will defend his PhD thesis on Monday, December 20th

Diego Barriales will defend his PhD thesis entitled “PLASTICITY OF MACROPHAGE RESPONSES TO ACTIVATING FACTORS” on Monday, December 20th,  at 11.00 am. ...

2021/12/13

Saray Sánchez will defend her PhD thesis today, December 13th

Saray Sánchez will defend her PhD thesis entitled “Antibody-mediated inhibition of Wnt-11 in prostate cancer” today, December 13th,  at 11.00 am. S...

2021/12/09

Bowel habits written in the DNA: new clues for irritable bowel syndrome

In a large-scale study published in Cell Genomics, researchers studied the DNA of more than 160,000 people who provided information on the frequency of their bowel movements. Genetic profiles and specific genes were identified, which influence bowel ha...

2021/11/29

Cristina Risueño will defend her PhD thesis on Wednesday, December 1st

Cristina Risueño will defend her PhD thesis entitled “Modulating the conformational plasticity of tetraspsanin CD81 by ligand-binders and its implication in cellular and viral processes” on Wednesday, December 1st,  at 11.00...

2021/11/25

Lucia Maio will defend her PhD thesis on November 26th

Lucia Maio will defend her PhD thesis entitled “Designed metallo-tags for probing natural systems” tomorrow November 26th, at 11.30 am. Supervisors: ...

2021/11/23

Early-stage researchers receive training to develop innovative antibacterial vaccines

CIC bioGUNE is hosting the congress of the BactiVax Project, a European training network funded by the European Commission. The BactiVax project brings together 14 world-class experts in vaccinology from 8 European countries to invest...

2021/11/18

SUMO-ID: a new tool to study the consequences of protein modifications by the ubiquitin...

Posttranslational modifications (PTM) by the members of the ubiquitin/ubiquitin-like (Ub/UbL) family are essential for cell survival and the proper function of the organism. Cell signalling drives conserved enzymatic pathways to add Ub/UbLs to other proteins,&...

2021/11/05

Large-scale genetic study reveals new clues for the shared origins of irritable bowel...

The study, co-led by researchers from CIC bioGUNE, has analysed genetic data from over 50,000 patients. The research highlights the close relationship between brain and gut health and paves the way for the development of new treatments.

2021/10/28

La investigadora de CIC bioGUNE Malu Martínez Chantar galardonada como “investigadora...

El pasado 25 de octubre, La Fundación Ikerbasque y el Departamento de Educación del Go...

2021/10/20

Race Against Breast Cancer 2021

On Sunday 17th October the annual ACAMBI (Asociación de Cáncer de Mama y/o Ginecológico de Bizkaia) run filled the streets of Bilbao with thousands of pink T-shirts, add...

2021/10/14

Genetic defects and carbohydrate malabsorption lurking behind irritable bowel syndrome

A new study, led by researchers at CIC bioGUNE, suggests genetic defects in carbohydrates digestion may be (mis)diagnosed as IBS in some patients. Researchers at CIC bioGUNE, a member of the Basque Research & Technology Alliance (BRTA), r...

2021/10/05

OSASUNBERRI, una iniciativa colaborativa de innovación e inversión en la industria...

OSASUNBERRI, una iniciativa colaborativa interregional de innovación e inversión en la industria de la salud Km 0, que tiene como objetivos aunar esfuerzos, crear sinergias y reforzar...

2021/10/04

ACAMBI run again in Bilbao!

The run against breast cancer organized every year for ACAMBI will take place next October 17th 2021. Due to the pandemic, the format will be different, special, but the inspira...

2021/09/30

Therapeutic protein silencing reduces the likelihood of liver failure in older transplant...

Hepatic ischaemia-reperfusion injury is the leading cause of early organ failure after transplant. MCJ protein silencing emerges as a new therapy to prevent liver failure after ischaemia-reperfusion in models of metabolic syndrome and ageing.

2021/09/17

Miguel Ángel Pérez will defend his PhD thesis TOMORROW, September 17th

Miguel Ángel Pérez will defend his PhD thesis entitled “Generación de distintas cepas de priones recombinantes como herramienta para el estudio del malplegamiento espontáneo en las enfermedades priónicas” TOMORROW, September ...

2021/09/06

Rebeca Cuesta will defend her PhD thesis on Thursday, September 9

Rebeca Cuesta will defend her PhD thesis entitled “Structural studies of filamentous plant viruses by cryo-electron microscopy and cryo-electron tomography” on Thursday, September 9th,  at 11.00 am. Supervisors

2021/08/17

Un estudio metabolómico a gran escala permite diagnosticar el Síndrome Metabólico...

El estudio llevado a cabo por investigadores de CIC bioGUNE, publicado en la revista Cardiovascular Diabetology, ha analizado el metaboloma de la orina de más de 11.000 individuos. (Bilbao, 17 de agosto de 2021). Investigado...

2021/07/14

large-scale genetic study links carbohydrate malabsorption to irritable bowel syndrome

The study, coordinated by researchers at CIC bioGUNE and published in the journal Gastroenterology, has analysed the DNA of over 100,000 individuals. A diet low in specific carbohydrates may potentially be beneficial for certain patie...

2021/07/12

CIC bioGUNE, ONCE Foundation and Ikerbasque sign an agreement to promote the research...

The successful candidates will conduct their research at CIC bioGUNE. The aim of the collaboration agreement is to improve equal opportunity, universal accessibility, inclusion and non-discrimination of people ...

2021/07/06

Revisiting the role of Extracellular Vesicles secreted by hepatocytes in drug-induced...

Idiosyncratic drug-induced liver injury (DILI) constitutes a multi-layered challenge that spans the life of the drug from pre-clinical development to clinical trials and post-marketing. Many of the factors that could be behind the mechanism of DILI has been r...

2021/07/01

New key mechanism in the development of non-alcoholic fatty liver disease identified

Alterations in neddylation have been shown to be involved in some liver diseases such as liver cancer, fibrosis and cirrhosis, and now in the development of non-alcoholic fatty liver disease. Pharmacological inhibition of the neddylation proces...

2021/06/25

María Pía Lenza will defend her PhD thesis on Monday, June 28th

María Pía Lenza will defend her PhD thesis entitled “Deciphering the recognition features of glycans by human lectins at the molecular level” on Monday, June 28th,  at 11...

2021/06/18

Technologies for the analysis of single extracellular vesicles

Single-vesicle imaging and analysis methodologies focus attention towards exosomes research. Recent advances in the single-vesicle analysis have facilitated their application in medical diagnosis and therapies. The Exosomes Laboratory and Met...

2021/06/11

DNA changes behind Microscopic Colitis

Spotlight on microscopic colitis research at CIC bioGUNE: publication in Nature Reviews Disease Primers and prize for best basic science communication at the Spanish Society of Gastroenterology (AEG). Microscopic colitis (MC) is a relatively ...

2021/06/09

CIC bioGUNE researchers describe a new microRNA determinant of response to sorafenib...

Identification of the miR-518d-5p molecule in blood is associated with increased resistance to sorafenib treatment and reduced overall survival in patients with hepatocellular carcinoma. Inhibition of this molecule by genomic approach...

2021/06/07

José Daniel Martínez Ordóñez will defend his PhD thesis thisTuesday, June 8th

José Daniel Martínez Ordóñez will defend his PhD thesis entitled “Novel ligand-based 19F-NMR and computational approaches for studying sugar-lectin molecular re...

2021/06/04

El Departamento de Eduación e Ikerbasque reconocen a Malu Martínez Chantar como...

El objetivo de la iniciativa es visibilizar a las mujeres investigadoras de Euskadi para que sirvan de ejemplo e inspiración a las nuevas generaciones de investigadoras. (Bilbao, 4 de junio de 2021).  El

2021/05/31

New miniature organ to understand human pancreas development

Understanding human pancreas during development The pancreas is a little organ behind the stomach and has two main functions – digestion and blood sugar regulation. How the human pancreas develops has been relatively unexplored for...

2021/05/28

Rafael López Moreno will defend his PhD Thesis Today, May28th

Rafael López Moreno will defend his PhD Thesis entitled “Estudio de la diversidad y estabilidad de diferentes priones recombinantes infecciosos para dilucidar los mec...

2021/05/19

PIPgen: a new Innovative Training Network to put PI3K/PTEN related diseases under...

The PIPgen Training Programme seeks to train the next generation of PI3K/PTEN experts and envisions to empower PI3K/PTEN related disease research in Europe towards clinical translation.

2021/04/27

Inhibition of a mitochondrial protein, a new therapeutic target for cholestatic liver...

The presence of this protein slows down the activity of the mitochondria, decreasing their ability to eliminate toxic substances such as certain bile acids. The research, conducted by CIC bioGUNE and the University Hospital Marqués d...

2021/04/23

Large-scale genetic study sheds light on the causes of hemorrhoids (piles)

Hemorrhoidal disease (commonly referred to as hemorrhoids) affects a large portion of the population, for reasons that are mostly unknown. New research from an international collaboration identifies pathophysiological mechanisms by studying the DNA of ...

2021/04/22

The Spanish Royal Society of Chemistry awards the Young Researcher Prize 2021 to...

Both scientists have been awarded in the "Group Leader" category, achieving for BRTA centers two of the four prizes awarded in this category. (Vitoria-Gasteiz/Bilbao, 22 April 2021). 

2021/04/15

BIOLAN y CIC bioGUNE desarrollarán conjuntamente un test ELISA para la detección...

Esta actuación de colaboración se enmarca en un acuerdo más amplio alcanzado entre CIC bioGUNE y BIOLAN en áreas encaminadas al diagnóstico de enfermedades y otras aplicaciones para la salud. (Bilbao, 15 de abril de 2021)

2021/03/12

A computational guide to lead cells down desired differentiation paths

A novel computer-guided design tool predicts combinations of transcription factors for more effective engineering of cell types with potential use in cell therapies and tissue modeling. (Bilbao, 12 March 2021). There is a gre...

2021/03/11

The Abrescia Lab has recently published two new book-chapters on virus evolution...

VOLUME 1 – The Virus as a Concept – Fundamentals of Virology Evolution Steered by Structure

2021/03/02

Alterations in serum magnesium levels are presented as a new risk factor in liver disease

Liver disease patients presented altered serum magnesium levels and significantly elevated expression of the CNNM4 protein, a modulator of this cation in the liver. Targeted regulation of CNNM4 by GalNac-siRNA technology developed by Silence Th...

2021/02/23

CIC bioGUNE researchers develop a protein capable of catalysing a chemical reaction...

The work, published in the journal Nature Chemistry, describes a zinc-binding protein which accelerates the reaction rate to levels higher than those of natural enzymes. The research shows, for the first time, that proteins containing...

2021/02/16

A new method to find modulators of the immune response to COVID-19

The recent paper, published in Science Advances by the Computational Biology Laboratory at CICbioGUNE, member of the Basque Research & Technology Alliance BRTA and at Luxembourg Centre for Systems Biomedicine (LCSB) in Luxemburg, describes a new me...

2021/02/10

Nuestras científicas para Día Internacional de la Mujer y la Niña en la Ciencia

El 11 de febrero de cada año, se celebra el Día Internacional de la Mujer y la Niña en la Ciencia proclamado por la ONU en el año 2015. El objetivo principal de este día tan especial es lograr una mayor participación e inclusión de las ...

2021/02/01

Genome Analysis Platform at CIC BIOGUNE, 10x Genomics and Bonsai Lab are Sponsoring...

We are pleased to announce the 10x Genomics Single Cell Grant Program. This award offers important discounts on 10x Genomics reagents, library preparation, and bioinformatics support for “Chromium Single Cell 3’ Gene Expression”...

2020/12/01

9 PhD Open Positions “la Caixa” Doctoral INPhINIT Incoming Fellowship Programme 2021

The doctoral fellowship programme INPhINIT “la Caixa” 2021 is devoted to attracting talented Early-Stage Researchers—of any nationality—who wish to pursue doctoral studies in research centres accredited with the Spanish Seal o...

2020/12/01

Iskander Aurrekoetxea will defend his PhD Thesis this Thursday, December 3rd

Iskander Aurrekoetxea will defend his PhD Thesis entitled “Pharmacological inhibition of Sox2 transcription factor-mediated tamoxifen resistance in breast cance...

2020/11/24

17th Meeting of the Spanish Society for Developmental Biology

For the 18th to the 20th of November 2020, the “17th Meeting of the Spanish Society for Developmental Biology” took place in virtual format, organized by CIC bioGUNE, the University of the Basque Country and the University of Cant...

2020/11/18

Sandra García Martínez will defend her PhD Thesis November 20th

Sandra García Martínez will defend her PhD Thesis entitled “Estudio de la uroporfirina I como alternativa terapéutica frente a las encefalopatías espongiformes transmisibles” this Friday, November 20th, at 12.00H. Sup...

2020/11/18

Leire Arreal López will defend her PhD on November 23rd

Leire Arreal López will defend her PhD Thesis entitled “Characterization of the biological and molecular activity of PML in breast cancer” next Monday, November 23rd, at 15.30H. Supervisors:

2020/11/04

La Diputación Foral de Bizkaia declara como actividades prioritarias a efectos de...

El desarrollo y validación de tests serológicos escalables para la identificación de individuos seropositivos frente a la COVID-19 y el desarrollo de herramientas para el diagnóstico serológico de la población general frente al SARS-CoV-2 son los...

2020/11/03

CIC bioGUNE conducts an in-depth study of the mechanism of action of Men A vaccines...

The article, published in the journal of the United States Academy of Sciences, has succeeded in deducing the minimal polysaccharide fragment (epitope) that effectively binds to a bactericidal monoclonal antibody. The work provides th...

2020/10/21

Los pacientes con obesidad e hígado graso con inflamación presentan un mayor riesgo...

En estos pacientes se identifica una expresión significativamente elevada de ACE2, el receptor celular del SARS-CoV-2, y de Tmprss2, la proteasa que favorece la unión de la membrana del virus con la membrana de la célula. El estudi...

2020/10/13

35 aniversario del Parque Científico y Tecnológico de Bizkaia

El Parque Científico y Tecnológico de Bizkaia cumple 35 años como referente de innovación y atracción de talento. Forma parte de la Red de Parques Tecnológicos de Euskadi, un ecosistema de talento y conocimiento que concentra la apuesta por dar a la inno...

2020/10/08

Carrera contra el Cáncer de Mama 2020

El pasado 29 de septiembre ACAMBI presentó en Bilbao lo que este año será una carrera diferente, porque 2020 es un año diferente. La vicepresidenta de la Asociación, Ana Cascajo, junto...

2020/10/01

Charles Williams will defend his PhD thesis on October 7th

Charles Williams will defend his PhD thesis entitled “Glycoengineering of Extracellular Vesicles” next Wednesday, October 7th,  at 12.00 am. Supervisors:

2020/09/30

Carlos López Robles will defend his PhD Thesis on October 2th

Carlos López Robles will defend his PhD Thesis entitled “Mechanism for escpe-1-mediated membrane remodelling and cargo selection in endosomal sorting” this Friday, October 2nd,  at 10.00 am. Supervisor:

2020/09/17

The structures of the glycan chains of the receptor binding domain (RBD) of the SARS-CoV-2...

The structures of the glycan chains of the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein expressed in human HEK293F cells have been disentangled by NMR. Moreover, the interactions of the RBD 13C-labelled glycans with different human lectin...

2020/09/08

Ezequiel Gonzalez Miranda will defend his PhD Thesis on September 11th

Ezequiel Gonzalez Miranda will defend his PhD Thesis entitled “Adaptación de un sistema de propagación de priones in in vitro para el cribado masivo de compuestos...

2020/08/13

CIC bioGUNE research reveals that a high accumulation of porphyrins is a relevant...

The article, published in the British Journal of Haematology, confirms that correcting these values may alleviate some of the symptoms of more critically ill patients. The work provides an insight into the haematological disorder asso...

2020/07/27

Immacolata Giordano will defend her PhD Thesis on July 28th

Immacolata Giordano will defend her PhD Thesis entitled “Proteostasis and Rare Diseases: Congenital Erythropoietic Porphyria and Townes-Brocks Syndrome” tomorrow, July 28th,  at 10.00 am. Supervisor:&nb...

2020/07/09

Parastoo Shahrouzi will defend her PhD Thesis on July 13th

Parastoo Shahrouzi will defend her PhD Thesis entitled “Genomic and functional regulation of TRIB1 contributes to prostate cancer pathogenesis” on July 13th at 10:00 am. Supervisor: 

2020/07/07

Research by CIC bioGUNE identifies GalNAC-MCJ as a promising therapeutic agent for...

Preclinical studies have been conducted in fatty liver toxicity models with GalNAC molecules, designed by Alnylam Pharmaceuticals, targeting the mitochondrial respiratory chain inhibitor MCJ. The work, led by Dr. Malu Martínez Chanta...

2020/07/06

Ana Loizaga Iriarte will defend her PhD Thesis on July 7th

Ana Loizaga Iriarte will defend her PhD Thesis entitled “Diseño y explotación de un circuito de investigación traslacional en cáncer de próstata” on July 7th at 10:00 am. Supervisor:

2020/07/01

On the mechanism of glycosidic bond formation

The mechanism of a key chemical reaction: the formation of the glycosidic linkage of glycans has been disentangled using a variety of chemical, NMR, kinetic and theoretical methodologies. The research has been led by Dr. Juan Luis Asensio at the

2020/06/30

CIC bioGUNE research opens up avenues for treating a highly aggressive cancer of...

The study identifies a protein (HuR/ELAVL1) as key for the growth and metastasis of malignant peripheral nerve sheath tumours. The findings indicate that inhibition of this protein represents a possible therapeutic target to attack th...

2020/06/29

...

CIC bioGUNE scientists have published an article on the response of the Chemical Biology scientific community of Spain to the COVID-19 pandemic. The letter provides an overview of different multidisciplinary and cooperative approaches that have been adopted t...

2020/06/24

Researchers from Spain and France join forces to develop new therapies against two...

PROTEOBLOOD, a French-Spanish cooperative network for the analysis of proteinopathies and the development of individualized therapies in hematological cancers, begins thanks to the cofounding of Interreg POCTEFA. Significant advances have bee...

2020/06/22

Ilaria Calloni will defend her PhD Thesis on June 29th

Ilaria Calloni will defend her PhD Thesis entitled “NMR studies of the interactions of glycan antigens with monoclonal antibodies” on June 29th at 11.00 am. Supervisors:

2020/06/22

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing...

Townes-Brocks Syndrome (TBS) is caused by dominant mutations in the gene SALL1, leading to a broad spectrum of symptoms including frequent renal and heart impairment. Recent work from Barrio’s Laboratory has shown that cells from TBS patients exhibit cilia d...

2020/06/19

Center's de-escalation plan

This image shows the processes and actions that CIC bioGUNE undertook during the past three months to keep the essential maintenance procedures and unrepeatable and unique experiments during the earliest days of the state of...

2020/06/16

Marta Palomo will defend her PhD Thesis on June 24th

Marta Palomo will defend her PhD Thesis entitled “Gene Regulatory network in Schwann cell Disorders” on June 24th at 11.00 am.  Supervisors:

2020/06/16

Blood vessels development depends on the maturation state of the pericytes that enclose...

The correct formation and architecture of vessels is essential in our organism. Alterations in vessel function are at the core of a variety of diseases.

2020/06/15

Opposing roles for the two main types of estrogen in obesity-driven mammary inflammation...

CIC bioGUNE researchers have participated in a collaborative study to explore the role of different types of the female hormone estrogen in breast cancer in obese postmenopausal women. The study shows that 17 ß-estradiol, t...

2020/06/10

CIC bioGUNE lamenta el fallecimiento del Dr. Luis Parada

El Dr. Luis Parada fue Investigador Principal del Laboratorio 3 de la Unidad de Biología Celular y Células Madre durante 5 años (2005-2010).

2020/06/02

CIC bioGUNE and Atlas Molecular Pharma discuss new therapeutic strategies against...

A CIC bioGUNE project, in which the Basque biotech company Atlas Molecular Pharma is also participating, has been selected by ...

2020/05/27

BIOLAN and CIC bioGUNE are working together to launch a new serological test for...

Science, Technology and Industry from the Basque Country to respond to the priority imposed by the pandemic: The initiative is part of a broader collaboration agreement reached between CIC bioGUNE and BIOLAN for the diagnosis of diseases and other heal...

2020/05/08

Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans...

CIC bioGUNE researchers have participated in a joint effort to synthesize and characterize the three-dimensional structure of galactosaminogalactans (GAG), a prominent cell wall component of Aspergillus fumigatus, a key fact...

2020/05/08

“Expression of Interest” For Hosting Marie Skłodowska Curie Actions Individual...

CIC bioGUNE, member of Basque Research and Technology Alliance (BRTA), is a key research center within the national a...

2020/04/23

CIC bioGUNE researchers have participated in a collective international effort to...

The existence of a new 1,2-anhydro sugar intermediate in glycoside hydrolysis has been deduced by a combination of methodologies, including organic synthesis, QM/MM calculations, KIE measurements, mass spectrometry, NMR spectroscopy and X-Ray crystallography. ...

2020/04/06

CIC bioGUNE is committing different human and material resources to the development...

The first of these aims to validate and develop fast viral diagnostic techniques for SARS-CoV-2. Diagnostic techniques would be industrially scalable and applicable to medical care, with a major focus towards the diagnosis of the different sta...

2020/03/27

A novel experimental model for the study of metastatic prostate cancer

A combination of genes alterations leads to the development of lethal metastatic prostate cancer have been identified in the study. The study provides an experimental system to understand and study the aggressiveness of prostate cance...

2020/03/25

Decoding Intercellular Communication via Hepatocyte-Secreted Extracellular Vesicles

Extracellular vesicles (EVs) play an important role in mediating cell-to-cell communication and have received significant interest from scientists studying diverse disease conditions. In this webinar, Dr. Félix Royo will walk you through his group’s work on...

2020/03/23

Dr Maria Vivanco and her team at CIC bioGUNE have participated in an international...

Dr Maria Vivanco and her team at CIC bioGUNE have participated in a...

2020/03/12

EMBO Practical Course on Techniques for mammary Gland Research

Last week (1-6 March 2020), the 3rd EMBO Practical Course on Techniques for mammary Gland Research took place at EMBL, in Heidelberg, Germany. As in previous years, the Course was organised by

2020/03/03

Research by CIC bioGUNE proposes enzyme silencing as a new therapeutic approach for...

The study, published in the journal Cell Metabolism, reveals that hepatic glutaminase (GLS1) is augmented in non-alcoholic fatty liver disease. Led by Drs. Teresa Cardoso Delgado and Malu Martínez-Chantar, the research shows that, du...

2020/02/27

Constituido el primer Grupo Español para el Estudios de las Porfirias (GEEP)

Especialistas en Medicina Interna, Hepatología, Dermatología, Bioquímica, Pediatría, Genética y Urgencias han constituido el primer Grupo Español para el Estudios de las Porfirias (GEEP), una asociación científica, multidisciplinar e i...

2020/02/25

CIC bioGUNE researchers decipher the molecular mechanism of a key enzyme in gut microbiota

The findings, published in the journal Nature Communications, will contribute to the development and design of enzymes exhibiting characteristics of biotechnological interest. The composition and physiology of human gut microbiota pla...

2020/02/25

UbiCODE Meeting SYMPOSIUM Writing and Editing the Ubiquitin Code UBIRed Meeting

From the 24th to the 27th of February, there will take place in Bilbao three scientific events related to the biomedical research on the post-translational modifications of proteins by the ubiquitin family, or...

2020/02/24

CIC bioGUNE researchers identify new molecular mechanisms involved in the regulation...

(Bilbao, 24 February 2020). Researchers at CIC bioGUNE together with other five scientific groups from Argentina, Brazil and...

2020/02/03

ARQUIMEA Group se incorpora al accionariado de ATLAS Molecular Pharma con una participación...

ATLAS Molecular Pharma, “spin-off” de CIC bioGUNE, ha identificado el ciclopirox como un fármaco contra la porfiria erit...

2020/01/28

Isaac Santos will defend his PhD thesis on February 10

Isaac Santos will defend his PhD thesis entitled “Structural determination of lipid-containing viruses by Cryo-electron microscopy” on February 10

2020/01/23

3rd edition of the Glycobasque meeting

March 12-13 CIC bioGUNE and CIC biomaGUNE are proud of announcing the 3rd edition of the Glycobasque meeting. The major aim of this workshop is to bring together t...

2020/01/17

Researchers discover the resistance mechanisms of dogs to prion diseases

This resistance could be the result of an evolutionary adaptation to carrion consumption. The research provides clues to determining new therapeutic approaches to combat prion diseases in humans.  (Bilbao, 17 J...

2020/01/07

Jorge Simón will defend his PhD thesis on January 24th

Jorge Simón will defend his PhD thesis entitled “Targeting metabolism for resolving Non-Alcoholic Steatohepatitis” on January 24th. The event will take place at UPV/EHU, SGIker  - Maria...

2019/12/12

El investigador de CIC bioGUNE Ashwin Woodhoo obtiene cerca de dos millones de euros...

Logra el único proyecto ERC Consolidator concedido a investigadores de Euskadi en la convocatoria 2019 y el primero para la temática “neurociencias y enfermedades neurológicas” otorgado en el País Vasco desde la creación de esta inici...

2019/12/11

Amaia Gonzalez Magaña will defend her PhD thesis on December 19th

Amaia Gonzalez Magaña will defend her PhD thesis entitled “Molecular recognition between PCNA and proteins involved in DNA replication and repair: p15 and p12” on December 19th. The event will take place at UPV/E...

2019/12/11

Marc Clos-Garcia will defend his PhD thesis on December 19th

Marc Clos-Garcia will defend his PhD thesis entitled “Multi-omics Integration for Biomarker Discovery” on December 19th. The event will take place at Building “Maria Goyri” (UPV / EHU, SGIker, Leioa), Sem...

2019/11/27

CIC bioGUNE organiza la Reunión anual del Grupo Español de Hipoxia y RedHYPOX (SAF2017-90794-REDT),...

Durante 2 días (Nov. 28 y 29), los participantes, pertenecientes a un amplio conjunto de instituciones (entre otras UAM,

2019/11/25

A team from CIC bioGUNE identifies an epigenetic therapy for the treatment of fatty...

CIC bioGUNE has patented the therapy and has reached an agreement with the U.S. biotech company Mitotherapeutix for clinical trials to be conducted. The findings of this re...

2019/11/19

ATLAS Molecular Pharma, galardonada con el premio “Bizkaia Sarean” a la innovación

La empresa biotecnológica ha sido premiada por la Asociación empresarial Bizkaired por su tratamiento para la porfiria eritropoyética congénita. La porfiria eritropoyética congénita es una enfermedad rara producida por un defect...

2019/11/15

9 PhD Open Positions “la Caixa” Doctoral INPhINIT Incoming Fellowship Programme 2020

The doctoral fellowship programme INPhINIT “la Caixa” 2020 is devoted to attracting talented Early-Stage Researchers—of any nationality—who wish to pursue doctoral studies in research centres accredited with the Spanish Seal o...

2019/11/11

CIC bioGUNE researchers unravel the three-dimensional structure of the African swine...

This breakthrough is the prerequisite not only for understanding the virus assembly but also for controlling and ultimately eliminating it. The African swine fever virus infects both domestic and wild pigs, with severe consequences fo...

2019/11/05

La Real Sociedad Española de Química y Elsevier premian al joven investigador Iñaki...

El objetivo de este premio es reconocer y recompensar a los jóvenes talentos de la investigación por su significativa contribución al sector, y apoyarlos en los inicios de su carrera Tres ensayos fueron...

2019/11/05

Antonio Del Sol Mesa, head of the Computational Biology group, receives the Outstanding...

Each year, the National Research Funds (FNR) presents awards in four categories highlighting both outstanding researchers and institutions, and promoting science-related activities. During the 2019 FNR Awards ceremony, one researcher from CIC

2019/10/29

Teresa Martín-Mateos will defend her PhD thesis on November 27th

Teresa Martín-Mateos will defend her PhD thesis entitled “Characterization of USP11 as a novel regulator of Hypoxia Inducible Factor α” on November 27th. Th...

2019/10/21

CIC bioGUNE, CIBERER, Plataforma Malalties Minoritàries, Institut Catalá de la...

Los medicamentos huérfanos son aquellos destinados a las enfermedades raras y que, tradicionalmente no han despertado el interés de la industria farmacéutica. Bajo el título “Designación, desarrollo y acceso de medicamento...

2019/10/17

CIC bioGUNE inaugura un nuevo sistema de espectrometría de masas que incrementa...

El nuevo sistema timsTOF Pro de la firma Bruker pone a disposición de la comunidad investigadora una capacidad de análisis proteómicos sin precedentes. Bilbao, 17 de octubre de 2019. CIC ...

2019/10/17

New study links the metabolic regulator PGC1A to the control of prostate cancer cell...

Cancer cells exploit a plethora of molecular pathways to prevail and dominate in the face of a hostile environment. Metabolism is one such process that cancer cells will tune and reprogram. In this context, the metabolic regulator PGC1α was previously reporte...

2019/10/16

The Introductory Week at CIC bioGUNE

PhD candidates familiarize with the research environment of the centre and get to know each other. From September 30th until October 4th CIC bioGUNE celebrated the 2nd edition of t...

2019/10/10

Workshop ‘Desde la formación al liderazgo’

ASEICA reúne en Bilbao a mujeres líderes en ciencia, cáncer y comunicación para visibilizar el talento femenino. Sólo dos de cada diez puestos de alta responsabilidad en la investigación oncológica están en manos de muj...

2019/10/10

Breaking the limits of the application of NMR in glycan recognition: intact glycoproteins

CIC bioGUNE scientists have developed a novel NMR-based glycoprofile analysis of an intact glycoprotein under physiological conditions that allows the semiquantitative characterization of the protein decoration by N-glycans,...

2019/10/10

CIC bioGUNE hosts the first women and leadership workshop organized by the Spanish...

Women are a majority in biomedical sciences-related careers. However, their presence in the different stages of the research path presents a pyramidal pattern. While the presence of women is the predominant among doctoral students and laboratory technicians, t...

2019/10/02

ASEICA presenta en Bilbao las claves para potenciar el liderazgo femenino en ciencia...

Workshop ‘Desde la formación al liderazgo’ Bilbao, 2 de octubre de 2019.- Sólo dos de cada diez puestos de alta responsabilidad en la investigación en cáncer están liderados por mujeres, pese a que el 60% de...

2019/09/26

JORNADA: Designación, Desarrollo y Acceso de medicamentos huérfanos

21 de Octubre de 2019 Los llamados medicamentos “huérfanos” están destinados a tratar enfermedades que, por su rareza no resultan atractivos a los patrocinadores, quienes se muestran reacios a desarrollarlo...

2019/09/25

Iratxe Macías will defend her PhD thesis on November 15th

Iratxe Macías will defend her PhD thesis entitled “Molecular basis of type I tyrosianemia. Chemical modulators of fumarylacetoacetate hydrolase as potential therapeutic agents” on November 15th. The event will take place at UPV/EHU- Sala de Conf...

2019/09/16

Network in Physical Virology

On November, the 13th, 14th and 15th  2019, the CIC bioGUNE (Bilbao; Spain) will host the meeting of the Spanish Network of Excellence in Physical Virology with the title: Brid...

2019/09/11

Paula Giménez will defend her PhD thesis on September 19th

Paula Giménez will defend her PhD thesis entitled “Bases estructurales del transporte de Mg2+ mediado por los factores homeostáticos CNNM2 y CNNM4 y de su interacción oncogénica con las fosfatasas PRL” on September 19th. The event will take p...

2019/09/10

Towards a novel synthetic Streptococcus pneumoniae vaccine

In a multidisciplinary collaborative work between the Leiden Institute of Chemistry (The Netherlands), the Amsterdam Infection and Immunity Institute (Amsterdam), the Finlay Vaccine Institute (Havana, Cuba) and CIC bioGUNE (...

2019/09/04

Researchers at CIC bioGUNE identify biomarkers useful for fibromyalgia diagnosis

The research paper, published in the journal EBioMedicine, reveals a low proportion of certain bacteria in gut microbiome in fibromyalgia patients. (Bilbao, 4 September 2019). Researchers at

2019/07/30

Avanzan en la predicción del destino celular para comprender mejor los defectos...

La investigación, publicada en la revista Nature, ha sido llevada a cabo por grupos de investigación del Luxembourg Centre for Systems Biomedicine,

2019/06/27

CIC bioGUNE se sitúa entre los 100 mejores centros de investigación en biomedicina...

El ranking se basa en la cantidad y calidad de las publicaciones de los centros así como en el prestigio de los autores (Bilbao, 27 de junio 2019). CIC bioGUNE forma parte del TOP 100 mundial de centros de investigación sin ánimo de lucro...

2019/06/19

CIC bioGUNE y la AECC de Bizkaia continúan su fructífera relación con la firma...

Mantienen desde hace ocho años una alianza estratégica con el fin de impulsar la investigación, divulgación e interacción entre los diferentes sectores relacionados con el cáncer. ...

2019/06/18

Arkaitz Carracedo obtiene el XIV Premio Fundación Banco Sabadell a la Investigación...

El jurado reconoce su innovadora contribución en el campo de la oncología y sus pioneras aportaciones para entender la progresión del cáncer de próstata. El jurado del XIV Premio Fundación Sabadell a la Investigación Biomédica ha reconocid...

2019/05/23

El ‘big data’ llevará a superar los retos de la salud personal y la financiera

El análisis de grandes volúmenes de datos, el big data , debe llevar a la sociedad a solventar problemas tanto de índole física, como es la salud personal, como económica, el bienestar

2019/05/23

El CIC bioGUNE, la colaboración como piedra angular para la medicina de precisión

La Obra Social ”la Caixa” apoya la investigación del CIC bioGUNE con ayudas que van desde los programas de doctorado INPhINIT hasta la atracción de investigadores de postdoctorado para estable...

2019/05/21

Asís Palazón, investigador de CIC bioGUNE, recibe la prestigiosa Beca FERO para...

La Fundación FERO de Investigación Oncológica entrega su beca en investigación oncológica traslacional con el objetivo de promover a jóvenes investigadores en el campo de la investigación oncológica. El equipo de Asís Palazón en CIC

2019/05/13

Bermeo Tuna World Capital impulsa una campaña solidaria para la Investigación en...

• La campaña #Bermeotunacontraelcáncer, cuyos ejes son la solidaridad y la investigación, tendrá un protagonismo especial en la Arrain Azoka de Bermeo. • #Bermeotunacontraelcáncer se llevará a cabo del 9 al 2...

2019/04/29

Un trabajo colaborativo del CIBEREHD premiado por la asociación americana de pacientes...

El trabajo de investigación titulado “Role of methylation-controlled J-protein, endogenous repressor of the mitochondrial respiratory chain, in cholestatic liver disease” dirigido por

2019/04/17

“Expression of Interest” For Hosting Marie Skłodowska Curie Actions - Individual...

CIC bioGUNE is a key research center within the national and international scientific landscape and has been recognized as “

2019/04/08

CIC bioGUNE researchers decode new extremophile viruses whose assembly is related...

The researchers have studied two viruses which live in salt lakes and have an extraordinary survival capacity, and are crucial in understanding some of the viruses of today. The work, published in the journal Nature Communications, is a major step forward in ...

2019/04/02

Ana Carreras will defend her PhD thesis on April 12th

Ana Carreras will defend her PhD thesis entitled “Surface receptors that mediate the interaction of Borrelia burgdorferi with macrophages: Death and Inflammation” on April 12th. The event will take place at UPV/EHU- Sala Adela Moyua, Facultad de C...

2019/04/01

Dos proyectos de CIC bioGUNE y CIC biomaGUNE reciben Ayudas a Equipos de Investigación...

El proyecto de CIC bioGUNE seleccionado buscará un tratamiento eficaz para la enfermedad del hígado graso –un trastorno potencialmente muy grave asociado a una dieta inadecuada y al sedentarismo. La investigación de CI...

2019/03/25

CIC biomaGUNE y CIC bioGUNE certifican sus Sistemas de Gestión de la I+D+i

Ambos centros han superado los requisitos de la certificación del Sistema de I+D+i conforme la Norma UNE 166002:2014, emitido por SGS ICS Ibérica, S.A. Este logro es el resultado de la excelencia en la gestión de la Investigación, el Desarr...

2019/03/22

Glycobasque II is a joint event organized by CIC bioGUNE and CIC biomaGUNE

Glycobasque II is a joint event organized by CIC bioGUNE and CIC biomaGUNE that gathers the different research groups from Euskadi working in Glycosciences, at the border between Biology a...

2019/03/12

Jornada sobre medicina de precisión organizada por CIC bioGUNE, CIC biomaGUNE y...

Se han analizado los estudios poblacionales y el big data en medicina de precisión. Bajo el título “Medicina de precisión: medicina por tallas”, la jornada se ha celebrado en la Sociedad Bilbaína. (Bilbao, 12 de marzo...

2019/03/11

PROTEOSTASIS - European network to integrate research on intracellular proteolysis...

The COST Action PROTEOSTASIS (http://cost-proteostasis.eu/), chaired and coordinated by Dr Rosa Barrio at CIC

2019/03/08

Helena Coelho will defend her PhD thesis on March 25th

Helena Coelho will defend her PhD thesis entitled “NMR and Molecular Recognition of Compounds Related to the Immune System” on March 25th. The event will take place at UPV/EHU- Sala Adela Moyua, Facultad de Ciencia y Tecnología at 11:00H.

2019/03/07

TUBEs, SUBES and beyond: Molecular traps for the study of proteins modified by Ubiquitin...

Post-translational protein modifications by members of the Ubiquitin family has become an intense area of research as it is implicated in many biological processes and diseases, e.g. cancer and neurodegeneration. Ubiquitin-like proteins (UbL) can modify subst...

2019/03/07

CIC bioGUNE, CIC biomaGUNE y British Council organizan una jornada sobre medicina...

En el acto se analizarán los estudios poblacionales y el big data en medicina de precisión. Bajo el título “Medicina de precisión: medicina por tallas”, la jornada se celebrará el martes 12 de marzo en la Sociedad Bilbaína. ...

2019/03/04

Proyecto GLYCOVAX

GLYCOVAX es una red para la formación avanzada de científicos jóvenes en el diseño racional de vacunas innovadoras. Estas vacunas están basadas en hidratos de carbono. De hecho, h...

2019/02/27

Precision Medicine. "Sized medicine"

The workshop entitled "Precision Medicine. Sized medicine", co-organized by CiC bioGUNE and the British Council, will take place on March 12 at the Salón Francés of the Sociedad B...

2019/02/25

Mondragón and Bergara supports research in prostate cancer at CIC bioGUNE

Representatives from organized groups in Mondragón and Bergara have reached out to CIC bioGUNE research group led by Arkaitz Carracedo in the context...

2019/02/14

Extracellular Vesicles in Biomedicine

Exosomes Laboratory will participate in a new edition of the UIMP course “Extracellular Vesicles in Biomedicine” hosted in Valencia, June 26th-28th.

2019/02/11

International Day of Women and Girls in Science

The Carracedo lab in CIC bioGUNE, committed with the dissemination of science in the International day of women and girls in science. Today, February 11th, and for the coming week, members of the lab will engage in scientific and social dissemination in the f...

2019/01/28

Laura Bozal will defend her PhD thesis on February 1st

Laura Bozal will defend her PhD thesis entitled ”The role of primary cilia in Townes‐Brocks Syndrome” The event will take place at UPV/EHU- Salón de Grados, Facultad de Ciencia y Tecnología at 12:00H on February 1st.

2019/01/23

ATLAS Molecular Pharma, galardonada en los “Go Health Awards 2019” por su tratamiento...

Más de 650 proyectos nacionales e internacionales han presentado su candidatura. Las iniciativas ganadoras destacan por su carácter innovador y capacidad para mejorar la calidad de vida de los pacientes y usuarios finales. La porfiria eritropoyética cong�...

2019/01/18

A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast...

New research about the signals controlling normal and cancer stem cells in the human breast has been published in Oncogene (Nature Publishing Group), a leading cancer journal, by the group of

2019/01/17

Exosomes: toward single-particle analysis of the cellular “Deliveroo” system...

The Exosome Laboratory of CIC bioGUNE, led by Dr. Juan Manuel Falcón, has published two articles in the journal Nanoscale, a reference in nanotechnology research. In collaboration with Dr. Sergei Kruglik of...

2019/01/16

El doctor Asís Palazón se incorpora a CIC bioGUNE como investigador Ikerbasque...

Liderará el laboratorio de Inmuno-Oncología, primer grupo de investigación exclusivamente centrado en inmunología e inmunoterapia del cáncer en Euskadi. Desarrollará un proyecto financiado por la UE con 2 millones de euros para cinco años...

2019/01/15

Jornadas de Virología

Los virus dominan nuestra biosfera, siendo las entidades más abundantes. Mientras que algunos son patógenos para el ser humano, los animales y las plantas; otros son nuestros aliados en la infección y control de la proliferación de bacterias. ...

2019/01/10

12 PhD Open Positions “La Caixa” INPhINIT Incoming Fellowship Programme

The doctoral fellowship programme INPhINIT “la Caixa” is devoted to attracting talented Early-Stage Researchers—of any nationality—who wish to pursue doctoral studies in research centres accredited with the Spanish Seal of Excellence. ...

2019/01/04

Describen el comportamiento de la proteína quinasa LKB1, uno de los principales...

Los niveles de expresión de esta proteína se ven aumentados preferentemente en aquellos pacientes con una progresión rápida de la patología. La investigación, llevada a cabo en CIC CIC bioGUNE, ...

2018/12/20

CIC bioGUNE sponsors and hosts a meeting of national leaders in prostate cancer research

CIC bioGUNE sponsors and hosts a meeting of national leaders in prostate cancer research to support the development of strategic collaborations in the understanding, stratification and treatment of the disease. The meeting,...

2018/12/14

Investigadores del CIC bioGUNE proponen nuevas rutas para comprender el funcionamiento...

El hallazgo, publicado en “Proceedings of the National Academy of Sciences”, demuestra que la eficiencia de una reacción enzimática se ve afectada en gran medida por la entropía conformacional del sustrato que debe encontrarse desordenad...

2018/12/11

UBIRed: Spanish Network of Excellence with participation of CIC bioGUNE

The 1st Meeting of the Spanish Network of Excellence UBIRed took place in the Center of Molecular Biology Severa Ochoca (CSIC-UAM, Madrid) on December 5th. The objective of UBIRed is to promote networking and collaborations among Spanish research groups inte...

2018/12/03

Estíbaliz Orue-Etxebarria will defend her PhD thesis on December 20th

Estíbaliz Orue-Etxebarria will defend her PhD thesis entitled “Characterization of Wnt signaling in tamoxifen resistant breast cancer stem/progenitor cells” on December 20th. The event will take place at UPV/EHU- Salón de Grados, Facultad de Ciencia y Te...

2018/12/03

Miguel Romano will defend his PhD thesis on December 10th

Miguel Romano will defend his PhD thesis entitled ”Mecanismos de reconocimiento y control de tráfico endosomal por el complejo retrómero” on December 10th. The event will take place at UPV/EHU- Salón de Grados, Facultad de Ciencia y Tecnología at 11:00...

2018/11/30

CIC bioGUNE lidera la Red Temática de Excelencia de Investigación en Hipoxia

RedHYPOX es una iniciativa de diez grupos de investigación, especializados en los mecanismos que median las respuestas a hipoxia y su relevancia en situaciones fisiológicas y patológicas. El déficit de oxígeno o hipoxia tiene consecuencias ...

2018/11/29

El investigador de CIC bioGUNE Arkaitz Carracedo logra financiación de la Comisión...

El programa ERC Consolidator otorga 2 millones de euros para la ejecución de ideas transformadoras. El profesor de investigación Ikerbasque Arkaitz Carracedo, en el selecto grupo de científicos españoles galardonados con este proyecto en su ...

2018/11/26

CIC bioGUNE and CIC biomaGUNE facilities, recognised as Singular Scientific and Technical...

The Nuclear Magnetic Resonance (NMR) laboratory of CIC bioGUNE, in Derio, has been included in this infrastructure map which is updated every four years. The ReDIB-Molecular and Functional Imaging Facility of ...

2018/11/22

Gobierno Vasco reconoce la labor desarrollada por los investigadores Óscar Millet...

Se ha reconocido el trabajo realizado en excelencia, la especialización y la cercanía al mercado. La investigación desarrollada por el equipo del Dr. Óscar Millet en el...

2018/11/16

La Real Sociedad Española de Química concede su Medalla de Oro a Jesús Jiménez...

Alberto Fernández Tejada ha sido reconocido con el premio a Joven Investigador La Real Sociedad Española de Química (RSEQ) ha reconocido hoy a Jesús Jiménez Barbero, director científico de CIC bioGUNE, con...

2018/11/09

La empresa vasca OWL Metabolomics, spin-off de CIC bioGUNE, está especializada en...

SYNLAB y OWL Metabolomics firman un acuerdo estratégico para la comercialización en España del Test OWLiver, el único test no invasivo para el diagnóstico de hígado graso SYNLAB, líder en servicios de diagnóstico médico en el mercado...

2018/10/30

CIC bioGUNE y Deusto firman un convenio para potenciar el trabajo docente e investigador...

La Universidad se une al centro de investigación biomédica para el desarrollo de ciencia de alto nivel internacional CIC bioGUNE y la Universidad de Deusto han firmado ...

2018/10/29

Virginia Murillo will defend her PhD thesis on November 30th

Virginia Murillo will defend her PhD thesis entitled “The Role of the Wnt Receptor Frizzled-8 in Prostate Cancer Pathogenesis” on November 30th. The event will take place at UPV/EHU- Salón de Grados, Facultad de Ciencia y Tecnología at 11:00H.

2018/10/18

Más de 100 estudiantes para combatir la brecha de género en el campo de las ciencias...

El Parque Científico y Tecnológico de Bizkaia ha reunido hoy a más de 100 estudiantes de ESO para combatir la brecha de género en el campo de las ciencias...

2018/10/17

Jorge Moreno Charco will defend his PhD thesis on October 29th

Jorge Moreno Charco will defend his PhD thesis entitled “Desarrollo de un nuevo sistema de cribado masivo basado en la propagación in vitro de priones recombinantes infecciosos para la detección de compuestos con actividad anti-priónica” on October 29th...

2018/10/17

Pedro Urquiza will defend his PhD thesis on October 19th

Pedro Urquiza will defend his PhD thesis entitled “Repurposing Ciclopirox as a pharmacological chaperone active against Congenital Erythropoietic Porphyria” on October 19th. The event will take place at UPV/EHU- Salón de Grados, Facultad de Ciencia y Tecn...

2018/10/17

CIC bioGUNE and CIC biomaGUNE organise a seminar on the social value of science

The event was held today in Bilbao under the title “Social value of science: from knowledge to business”.Participants included Iosu Madariaga, Director of Technology and Strategy of the Basque Government, and Jesús Marco, Vice-President of Scient...

2018/10/16

Prof. Stephen Buchwald, from MIT, will be delivering a special lecture

Prof. Stephen Buchwald, from MIT, will be delivering a lecture at UPV/EHU (Campus Leioa) Next Monday Oct 22nd. He received the 2014 BBVA Foundation Frontiers of Knowledge. He is coming to visit us by a join CIC 

2018/10/09

Bilbao acoge el tercer congreso internacional de metabolismo y cáncer

Bilbao acoge desde hoy la tercera conferencia internacional sobre avances en la investigación del cáncer. El objetivo de estas reuniones es comunicar los avances en la comprensión del funcionamiento del cáncer para así mejorar su prevención, detección y...

2018/09/27

Richard Henderson, premio Nobel de Química 2017, participa en el análisis de la...

Richard Henderson (Edimburgo, Reino Unido, 1945), premio Nobel de Química de 2017 por su investigación sobre la microscopia crioelectrónica para la determinación de la estructura de biomoléculas con alta resolución, ha participado en el análisis de la p...

2018/09/20

Un medicamento desarrollado por CIC bioGUNE y ATLAS Molecular Pharma, en la revista...

La terapia está basada en el uso de chaperonas farmacológicas, moléculas que se unen a la proteína defectuosa corrigiendo su problema de estabilidad y permitiendo su funcionamiento correcto. La porfiria eritropoyética congénita es una enfermedad rara pr...

2018/09/19

CIC bioGUNE acoge un congreso internacional sobre el agente causal de la tuberculosis

(Bilbao, 18 de septiembre de 2018) CIC bioGUNE acoge hasta mañana 19 de septiembre el Congreso Internacional BILBO TB,  centrado en el estudio de la bacteria Mycobacterium tuberculosis, agente causal de la tuberculosis. El con...

2018/09/12

Un científico vasco, ganador en los IV Premios Jóvenes Investigadores de la Fundación...

• El Dr. Arkaitz Carracedo recibirá una beca por valor de 20.000 euros para continuar con su investigación en el tratamiento del cáncer de mama en el Centro de Investigación Cooperativa en Biociencias (CIC bioGUNE) en Viz...

2018/09/10

Miguel Zamora will defend his PhD thesis on September 14th

Miguel Zamora will defend his PhD thesis entitled “Determinación estructural del virión del Virus del mosaico de la sandía por crio-microscopía electrónica” on September 14th. The event will take place at UPV/EHU- Sala Adela Moyua, Facultad de Ciencia...

2018/07/25

La Fundación Bancaria ”la Caixa” presenta 20 proyectos clave para la investigación...

• La Fundación Bancaria ”la Caixa” ha presentado hoy los 20 proyectos seleccionados en la primera convocatoria abierta y competitiva de investigación biomédica puesta en marcha por la entidad. En el acto han intervenido Jaume Giró, director general d...

2018/06/27

Knowledge transfer from Basic Liver Research to NASH Drug Therapy Research

Galmed Pharmaceuticals recently announced that their lead NASH drug candidate, Aramchol, had achieved an FDA- regulatory-approvable endpoint demonstrating NASH resolution in the Aramchol Phase 2b, 52-week ARREST trial.  Aramchol is a conjugate of cholic a...

2018/06/20

Inauguración de los Cursos de Verano de la UPV/EHU 2018

19 Junio 2018 Palacio Miramar El pasado martes día 19 tuvo lugar la Inauguración de la XXXVII edición de los Cursos de Verano de la Universidad del País Vasco en el Palacio Miramar de San Sebastián. Al acto acudieron el Sr Lehendakari, la Sra Rec...

2018/06/09

Biophysicist and Nobel laureate Joachim Frank visited us this week

2018/06/05

Stavros Azinas will defend his PhD thesis on June 12th

Stavros Azinas will defend his PhD thesis entitled “Mechanical and structural studies of internal lipid-containing bacteriophage PRD1” on June 12th. The event will take place at UPV/EHU - Sala Adela Moyua de la Facultad de Ciencia y Tecnología at 11:00H. ...

2018/06/01

El cáncer óseo infantil podrá ser tratado evitando la quimioterapia intravenosa

•La Dra. María Blanco ha desarrollado nanosistemas terapéuticos, con diferentes fármacos antitumorales que pueden ser administrados por vía oral, para evitar la quimioterapia intravenosa en sarcomas óseos • El cáncer de hueso es uno ...

2018/05/25

TV program Lab 24 interview

2018/05/15

Researchers identify a novel link between Wnt and TGF-β signaling in cancer

A team at CIC bioGUNE, in collaboration with researchers at Turku and Åbo Akademi Universities in Finland and at Imperial College London have identified a novel link between Wnt and TGF-β signaling in prostate cancer. In their search for cell surfac...

2018/05/15

A team of researchers from the University of Brussels, the Eindhoven University of...

Since long crystals have been essential for solving the three-dimensional structures of proteins, which is crucial for understanding the molecular mechanisms of life itself. In more recent times these crystals are also used as pharmaceutical delivery ...

2018/05/08

La empresa con la ciencia española

Organizaciones y patronales vinculadas a la I+D+i manifiestan su apoyo a la investigación y se suman a la petición de la Alianza de centros Severo Ochoa y unidades María de Maeztu (SOMMa) para que la clase política aborde lo antes posible los problemas adm...

2018/05/02

Barcelona acogerá a más de un millar de investigadoras e investigadores en el congreso...

El Congreso de la “International Society for Extracellular Vesicles” ISEV 2018, que se celebra entre el 2 y el 6 de mayo, contará con la asistencia de profesionales de la química, física, biología, ingeniería y medicina interesados en los exosomas

2018/04/26

La Real Sociedad Española de Química concede su Medalla de Oro a Jesús Jiménez...

Alberto Fernández Tejada ha sido reconocido con el premio a Joven Investigador (Bilbao, 26 de abril de 2018). La junta de gobierno de la Real Sociedad Española de Química (RSEQ) ha concedido a Jesús Jiménez Barbero, director científico de CIC b...

2018/04/25

Conferencia sobre enfermedades neurodegenerativas a cargo de David Rubinsztein, investigador...

La charla se enmarca en el ciclo “Enfermedades Raras: con otra mirada” y se celebra este jueves 26 de abril, a las 19 horas, en el Salón de Actos del Archivo Foral de Bizkaia El científico hablará sobre los vínculos entre el Alzheimer ...

2018/04/23

Atlas Molecular Pharma receives approval by the US Food & Drug Administration of...

April 23, 2018 DERIO, Spain.- Atlas Molecular Pharma, a private company founded in 2015 in Derio (Spain) as a spin-off from the  Centre for Co-operative Research in Biosciences (CIC bioGUNE),   announced  today that the US ...

2018/04/20

COST Action BM1307 PROTEOSTASIS - “European network to integrate research on intracellular...

The COST Action PROTEOSTASIS BM1307, coordinated by Dr. Rosa Barrio (group leader at CIC bioGUNE) ended on the 24th of April 2018. This European network gathered 274 group members from almost all countries in Europe, and also USA and South Korea.  The Act...

2018/04/20

Final Meeting ("Proteostatic Mechanisms in Health and Disease") of the COST Action...

The COST Action BM1307 PROTEOSTASIS coordinated by Dr. Rosa Barrio (group leader at CIC bioGUNE) organized its Final Meeting- Proteostatic Mechanisms in Health and Disease- , in Athens (Greece) on the 22-24 February 2018.  The Final Meeti...

2018/04/12

Bizi Bide, the Guipuzcoan Association on Fibromyalgia organized yesterday an informative...

2018/04/10

The ERC Advanced Grant 2017 awards puts Jesús Jiménez Barbero and Luis Liz Marzán,...

The European Research Council will provide a total of EUR 4.9 million in funding over the next 5 years for the work being done by the research groups of these two Ikerbasque research professors ERC Advanced Grants are the most prestigious in E...

2018/04/09

Conferencia sobre nuevas terapias para el tratamiento de enfermedades raras a cargo...

La charla se enmarca en el ciclo “Enfermedades Raras: con otra mirada” y se celebra este martes 10 de abril, a las 19 horas, en el Salón de Actos del Archivo Foral de Bizkaia El científico hablará sobre el uso de chaperonas farmacológi...

2018/04/09

Investigators describe the action of a protein from the bacterium that causes Lyme disease

Lyme disease, or Lyme borreliosis, is an infectious disease caused by a bacterium transmitted by ticks Understanding the factors responsible for the survival of the bacterium provides an opportunity to search for new vaccines based on this pro...

2018/03/27

Jornada sobre Hipomagnesemias hereditarias

14 de Abril de 2018 en el salón de actos del Hospital Miguel Servet de Zaragoza.

2018/03/19

José María Serratosa, médico jefe del servicio de Neurología del Hospital Universitario...

El doctor, referente en la especialidad de Neurología por su experiencia en epilepsia, figura en la lista Forbes de los 50 mejores médicos de España La conferencia, titulada “Epilespias raras: una ventana abierta al cerebro”, se celebra...

2018/03/15

CIC bioGUNE hosts The Glycovax Training Event IV (12-16, March)

GLYCOVAX is a European Training Network (ETN) funded in the framework of H2020 Marie Skłodowska- Curie ITN programme. The GLYCOVAX network aims at the education of promising young scientists who will learn how to rationally design well-defined and in...

2018/03/14

Exosomes research with the participation of the Genome Analysis Platform and The...

2018/03/13

Scientists discover a novel methodology for the detection of amyloid fibers, structures...

The research, publishedin the Proceedings of the National Academy of Sciences of the USA, opens the door toward new diagnostic methods for Alzheimer’s, Parkinson’s or prionic diseases The technique is based on the link of gold nan...

2018/03/13

Pablo Fernández Tussy will defend his PhD thesis on March 23rd

Pablo Fernández Tussy will defend his PhD thesis entitled "MicroRNAs in liver disease" on March 23rd. The event will take place at UPV/EHU- Salón de Grados de la Facultad de Medicina at 12:00H.

2018/03/05

Timothy M. Cox, director de investigación del departamento de Medicina en la Universidad...

El investigador intervendrá mañana martes en la primera jornada con la conferencia titulada “¿Qué es raro?” La conferencia, con servicio de traducción simultánea, se celebra a las 19 horas en el Salón de Actos del Archivo Foral de B...

2018/02/15

CIC bioGUNE researchers discover a relationship between Townes-Brocks Syndrome and...

The findings, published in The American Journal of Human Genetics, support the hypothesis that aberrations in primary cilia function are contributing factors to the characteristics found in people affected by TBS These findings represent a par...

2018/02/15

Reconocimiento a la labor docente de CIC bioGUNE por la Facultad de Ciencia y Tecnología...

El viernes, 22 de diciembre a las 12.00, en el Paraninfo de la Facultad de Ciencia y Tecnología de la UPV/EHU (barrio Sarriena s/n, Leioa), tuvo lugar el acto de Navidad de la Facultad de Ciencia y Tecnología. El acto fue organizado por Esther Domínguez, de...

2018/02/06

La aecc financia con 300.000€ un proyecto inter-ciberehd para combatir el cáncer biliar

• Está dirigido a investigar de manera multidisciplinar el colangiocarcinoma (CCA), un tipo de cáncer hepático con muy mal pronóstico. • El proyecto persigue esclarecer los procesos que originan su desarrollo, así como identificar nuevos biomarcadore...

2018/02/06

Vanesa Venegas will defend her PhD thesis on February 22nd

Vanesa Venegas will defend her PhD thesis entitled "Influencia de la región N-terminal de la proteína del prion en la susceptibilidad al mal plegamiento, mantenimiento de las características de cepa y neurotoxicidad" on February 22nd. The event w...

2018/02/06

Montse Tersa will defend her PhD thesis on February 22nd

Montse Tersa will defend her PhD thesis entitled "Structural Basis for Substrate Recognition and Catalysis of the Mycobacterial Acyltransferase PatA" on February 22nd. The event will take place at UPV/EHU- Sala de Juntas de la Bilblioteca Central at...

2018/01/24

European Research Training Network to decipher the ubiquitin code

As of 1st of January, the ITN project UbiCODE has started ! The network is coordinated by Dr Manuel S. Rodríguez (ITAV-CNRS) and co-coordinated by Dr Rosa Barrio at CIC bioGUNE. The UPV/EHU (Leioa) collaborates as Associated Partner in the project. ...

2018/01/22

Arkaitz Carracedo, galardonado con el VII Premio Nacional de Investigación en Cáncer...

(Bilbao, 22 de enero de 2018). El jurado del VII Premio Nacional de Investigación en Cáncer “Doctores Diz Pintado”, convocado por la Fundación de Investigación del Cáncer de la Universidad de Salamanca (FICUS)-Centro de Investigación del Cá...

2017/12/18

A new therapy for paracetamol-induced fulminant liver damage

A team of researchers from CIC bioGUNE, CIBEREHD and the University of Vermont College of Medicine has identified the MCJ protein as a potential therapeutic target in patients with fulminant liver failure caused by the overuse of paracetamol T...

2017/12/14

The European Medicines Agency (EMA) favorably comments on the orphan drug designation...

• Congenital erythropoietic porphyria is a rare, very serious and incurable disease. • It is a repositioned drug, which has already been tested in humans for other specifications. • Repositioning is obtained after years ...

2017/11/30

Lorea Valcárcel will defend her PhD thesis on December 18th

Lorea Valcárcel will defend her PhD thesis entitled 'Transcriptional control of prostate cancer metabolism' on December 18th. The event will take place at UPV/EHU- Salón de grados de la Facultad de Ciencia y Tecnología at 3.30pm.

2017/11/29

CIC bioGUNE y OWL Metabolomics participan en un innovador proyecto de investigación...

El objetivo del proyecto LITMUS es optimizar y validar las pruebas de diagnóstico para la evaluación temprana de los pacientes con hígado graso no alcohólico e identificar a los que tienen mayor riesgo de desarrollar inflamación severa y cirrosis ...

2017/11/23

PRACTICAL WORKSHOP: Bioinformatics Tools to study exosomes ´ effects

CIC bioGUNE hosted a Practical Workshop entitled “Bioinformatics Tools to study exosomes effects” organized by the Metabolomics, Proteomics and Genome Analysis Platforms, along with the Exosomes Laboratory of the center. The workshop was funded by GEIVEX (...

2017/11/16

Research reveals the importance of various cofactors in determining the biological...

The work advances understanding of the pathogenesis of prion strains and their ability to propagate in different tissues and hosts Furthermore, the research proposes a mechanism potentially explaining the different locations of prion strains i...

2017/11/02

Without transfer there is no innovation and without innovation there is no future

  • This morning Alicante has started the 100xCiencia.2 meeting, which today and tomorrow brings together the vanguard of Spanish research: the Severo Ochoa and María de Maeztu centers of excellence. • The meeting was opened by Carmen Vela...

2017/10/27

Arkaitz Carracedo, galardonado con el Premio “Constantes y Vitales” en la categoría...

La entrega de premios de esta campaña de responsabilidad corporativa de laSexta y Fundación AXA se ha celebrado hoy en Madrid El jurado ha valorado que Arkaitz Carracedo haya desarrollado una línea de investigación original a través de pl...

2017/10/24

Unraveling the mechanism of glycosyl transfer reactions

Glycosyltransferases (GTs) play essential roles in nature. GTs catalyze the transfer of a sugar moiety to a broad range of acceptor molecules, including mono-, oligo- and polysaccharides, proteins, lipids, and small organic molecules. As a consequence, GTs gen...

2017/10/24

Julen Tomás Cortazar will defend his PhD thesis on October 27th

Julen Tomás Cortazar will defend his PhD thesis, entitled "Identification of tick saliva antigens as vaccine candidates and immunotherapeutics", on October 27th at 11.00H. The event will take place at the Salón de grados de la Facultad de Ciencia ...

2017/10/20

CIC bioGUNE awarded by the FUNDACIÓN INOCENTE INOCENTE for the research work of...

The work of Dr. Rosa Barrio, Chair of PROTEOSTASIS, in the field of rare diseases was recognized by the Spanish foundation "FUNDACIÓN INOCENTE INOCENTE". This foundation aims to support activities that promote the quality of life of children facing different ...

2017/10/18

Nace la Alianza de centros y unidades de excelencia Severo Ochoa y María de Maeztu

• La Secretaria de Estado de I+D+i, Carmen Vela, ha presidido la primera reunión de la nueva Alianza de Excelencia Severo Ochoa y María de Maeztu.   • El principal objetivo de la alianza es promover y fortalecer internacionalmente ...

2017/10/10

Breaking the limits in analyzing carbohydrate recognition by NMR: Resolving Branch-Selective...

The biological recognition of complex-type N-glycans is part of many key physiological and pathological events. In fact, protein glycosylation is required for proper biological and biophysical function and often, alterations in glycosylation are related to dis...

2017/10/09

Más de 10.000 personas apoyan la investigación sobre cáncer de mama

Más de 10.000 personas se dieron cita el domingo 8 de octubre en la IV Carrera Solidaria contra el cáncer de mama, organizada en Bilbao por la Asociación de Cáncer de Mama de Bizkaia (Acambi). Los 50.000 euros recaudados en la prueba se de...

2017/10/09

Centros de investigación europeos con experiencia en enfermedades transmitidas por...

CIC bioGUNE organiza la cuarta reunión del consorcio ANTIDotE Tratan de identificar y probar proteínas de la saliva de la garrapata que pudieran usarse como vacunas   (Bilbao, 9 de octubre de 2017). El investigador del CIC bioGUNE Jua...

2017/10/09

Daniele Parisi will defend his PhD thesis on January 5th

Daniele Parisi will defend his PhD thesis entitled 'Analysis of mRNA 3' tagging pathway components' on January 5th. The event will take place at University of Liverpool at 9.00am.

2017/10/04

Un miembro del Comité Científico de CIC bioGUNE, premio Nobel de Química 2017

Richard Henderson participa en el diseño de las líneas estratégicas del centro Joachim Frank ha sido maestro del doctor en Biología Molecular, Mikel Valle, investigador en CIC bioGUNE La Real Academia Sueca de Ciencias ha ...

2017/09/28

A CIC bioGUNE research team has identified a potential target for the design of antiviral...

The study has discovered a mechanism which controls the assembly of potyviruses Potyviruses constitute one of the largest groups of plant pathogens and cause diseases affecting crops The research study, led by Dr. Mikel Valle�...

2017/09/26

Meeting COST Action Proteostatic Mechanisms in Health and Disease

Proteostatic Mechanisms in Health and Disease, The Final COST Action BM1307 Meeting 22-24 February 2018,  Athens,  Greece   The COST Action BM1307 PROTEOSTASIS coordinated by Dr. Rosa Barrio (group leader at CIC bioGUNE) organizes the 4th PROT...

2017/09/25

Alicante acoge el encuentro internacional sobre transferencia y co-creación en...

• “100xCiencia.2” tendrá lugar del 2 al 3 de noviembre de 2017 en Alicante. • Acudirán destacados científicos de 40 centros y unidades de investigación “Severo Ochoa” y “María de Maeztu”, respectivamente. ...

2017/09/22

CIC bioGUNE celebra su acreditación como "Centro de Excelencia Severo Ochoa"

Félix Goñi, catedrático de la UPV/EHU, ha ofrecido una conferencia El acto ha sido clausurado por Estíbaliz Hernáez, viceconsejera de Tecnología, Innovación y Competitividad del Gobierno Vasco   (Bilbao, 22 de septiembre de 2017)...

2017/09/19

CIC bioGUNE recoge su acreditación como "Centro de Excelencia Severo Ochoa"

El acto de entrega del distintivo ha tenido lugar hoy en el Ministerio de Economía, Industria y Competitividad La acreditación tiene una duración de cuatro años y se obtiene a través de un proceso de evaluación y selección basado en cri...

2017/09/19

Justyna Mleczko will defend her PhD thesis on October 19th

Justyna Mleczko will defend her PhD thesis entitled ' Study of extracellular vesicles secreted by experimental models of metabolic syndrome, and their effects on adipocytes' on October 19th. The event will take place at University of Liverpool at 13...

2017/09/19

Mirian Sánchez Morán will defend her PhD thesis on October 3rd

Mirian Sánchez Morán will defend her PhD thesis entitled 'Identificación de variantes genéticas implicadas en el desarrollo de dislexia y falta de atención: Estrategias de caso-control y loci de rasgos cuantitativos' on october 3rd. The event w...

2017/08/30

Natalia Comino will defend her PhD thesis on September 26th

Natalia Comino will defend her PhD thesis entitled 'Structural Basis of Glycogen Biosynthesis Regulation in Bacteria' on September 26th. The event will take place at UPV/EHU- Sala de Juntas de la Biblioteca Central at 11.00am.

2017/08/04

Giacomo Domenici will defend his PhD thesis on September 21st

Giacomo Domenici will defend his PhD thesis, entitled "Role of Sox9 transcription factor in human breast epithelial cells, breast cancer stem cells and tamoxifen resistance", on September 21st . The event will take place at UPV/EHU-Salón de Grados ...

2017/08/02

Inspiring stories from PROTEOSTASIS COST Action or how to boost your research career...

The COST Action PROTEOSTASIS led by Dr. Rosa Barrio (CIC bioGUNE), has elaborated a video summarizing the experience of the members of the network. PROTEOSTASIS main objective is to facilitate research and collaborations in the fields of Ubiqu...

2017/07/27

Summary of activities of the COST European Network of Extracellular Vesicles in Health...

The COST European Network of Extracellular Vesicles in Health and Disease in which CIC bioGUNE has actively participated by hosting in the Exosomes laboratory several short-term scientific missions (STSM) has recently finalized, and the consortium has created ...

2017/06/29

A research team from CIC bioGUNE identifies a metabolic pathway which contributes...

Prostate cancer often exhibits molecular changes which support its growth The research unravels a mechanism through which prostate cancer produces metabolites essential for tumour biology The study, led by Dr. Arkaitz Carraced...

2017/06/27

Georgina Ormaza will defend her PhD thesis on July 4th

Georgina Ormaza will defend her PhD thesis, entitled "Structure-function relationships of tumor suppressor", on July 4th at 11.00H. The event will take place at the Salón de Grados- Facultad de Ciencia y Tecnología de la UPV/EHU

2017/06/26

CIC bioGUNE EM community awarded with long-term programme access to Titan microscopes...

CIC bioGUNE scientists have been awarded by eBIC (Diamond Light Source, UK) with a BLOCK-ALLOCATION-GROUP (BAG) for performing high-resolution cryo-electron microscopy (cryo-EM) studies on the topic: High-resolution cryo-electron microscopy of molecular recogn...

2017/06/14

CIC bioGUNE acoge una jornada para estudiantes sobre perspectivas de futuro tras...

Los ponentes han ofrecido su visión sobre el futuro de las carreras profesionales en la industria, la universidad y los centros de investigación Alumnos de 4º de grado y de máster han participado en esta iniciativa organizada por CIC bioGU...

2017/06/13

Jesús Jiménez Barbero, nuevo miembro de la European Academy of Sciences (EURASC)

La Academia reconoce y elige a los mejores científicos europeos con el objeto de impulsar la ciencia en Europa   (Bilbao, 13 de junio de 2017). Jesús Jiménez Barbero, director científico de CIC bioGUNE e investigador del programa Ikerbasque, ...

2017/06/01

Jesús Jiménez Barbero has been elected as Fellow of the European Academy of Sciences

Jesús Jiménez Barbero has been elected as Fellow of the European Academy of Sciences. The European Academy of Sciences (EURASC) is a non-profit non-governmental, independent organization of the most distinguished scholars and engineers performing forefront r...

2017/05/25

Investigadores de CIC bioGUNE revelan la complejidad estructural de la maquinaria...

Ambos trabajos, co-liderados por el investigador Ikerbasque Nicola GA Abrescia, han sido publicados en la revista Nature Communications El estudio sobre la interacción del virus de la fiebre aftosa con su receptor celular, la integrina alfaVb...

2017/05/22

Molecular mechanism of G protein activation by GIV, a protein that promotes metástasis

(Bilbao, 22 May 2017). The insufficient mechanistic information on metastasis has precluded the development of efficient therapeutics for fighting this process. However, the Gα-Interacting,  Vesicle-associtated  (GIV) protein has emerged as a very p...

2017/05/16

La Sociedad Química de Hungría premia a Jesús Jiménez Barbero, director científico...

Reconoce la trayectoria del científico con el premio HSC Gamboa Winkler (Bilbao, 16 de mayo de 2017). La Sociedad Química de Hungría ha galardonado a Jesús Jiménez Barbero, director científico de CIC bioGUNE, con el premio Gamboa Winkler. ...

2017/05/15

1st meeting of the research groups in Euskadi working in glycosciences

  The first workshop of different research groups from Euskadi working in Glycosciences, at the border between Biology and Chemistry, has taken place at CIC bioGUNE on May 15th.   A number of researchers with complementary perspectives presented t...

2017/05/08

Identifican que la inhibición del factor de transcripción p63 en el hígado mejora...

Investigadores de CIC bioGUNE, de la Universidad de Santiago de Compostela.  del CIBEREHD, CIBEROBN y del CIBERONC constatan que los factores de transcripción p53 y p63 regulan la cantidad de grasa que almacena el hígado El trabajo ha s...

2017/04/06

CIC bioGUNE, acreditado como “Centro de Excelencia Severo Ochoa”

La acreditación es el mayor reconocimiento de centro de excelencia de España El proceso de evaluación se ha llevado a cabo por un comité científico internacional integrado por personal investigador de reconocido prestigio e impacto ...

2017/04/04

NEIKER y CIC bioGUNE firman un acuerdo de colaboración para realizar actividades...

Han firmado un acuerdo de colaboración para favorecer los contactos y la colaboración entre el personal investigador de ambos centros. Comparten algunas líneas de investigación como son las relacionadas con las enfermedades transmitidas po...

2017/03/29

Lucía Barbier will defend her PhD thesis on April 24th

Lucía Barbier will defend her PhD thesis, entitled " Targeting mitochondria and post-translation modifications: new promising approaches for the treatment of liver disease”, on April 24th at 11.00H. The event will take place at the Salón de Grad...

2017/03/29

Imanol Zubiete will defend his PhD thesis on April 7th

Imanol Zubiete will defend his PhD thesis, entitled "Post-translational modifications in liver disease”, on April 7th at 11.00H. The event will take place at the Sala de juntas- Facultad de Medicina de la UPV/EHU.

2017/03/28

Atlas Molecular Pharma recibe una ayuda del programa NEOTEC para el desarrollo empresarial

La empresa, creada por CIC bioGUNE, se encargará de desarrollar una tecnología que permita detectar moléculas que aporten estabilidad a las proteínas implicadas en el desarrollo de ciertas enfermedades raras Las ayudas del Programa NEOTEC ...

2017/03/23

Los grupos de investigación sobre exosomas en Euskadi se reúnen en CIC bioGUNE...

Estas vesículas secretadas al exterior celular son consideradas como importantes mediadores de procesos fisiológicos y biomarcadores de enfermedades El taller, organizado por el investigador Juan Manuel Falcón, reúne a los grupos de trabaj...

2017/03/16

CIC bioGUNE, British Council y AECC continúan con el ciclo de conferencias divulgativas...

El investigador Johan Hyllner, responsable científico de la Cell and Gene Therapy Catapult de Londres, intervendrá el próximo martes en la segunda jornada Hablará sobre las terapias génicas y celulares que permiten el tratamiento y preven...

2017/03/08

El consejero de Salud del Gobierno Vasco, Jon Darpón, visita las instalaciones de...

José María Mato, director general, y Jesús Jiménez, director científico, han presentado las aplicaciones de las investigaciones que lleva a cabo el centro en el ámbito de las biociencias   (Bilbao, 8 de marzo de 2017). CIC bioGUNE ha recibido este...

2017/02/23

Arkaitz Carracedo, galardonado con el premio Radio Bilbao a la Excelencia 2017 en...

El trabajo del investigador Ikerbasque en CIC bioGUNE ha sido reconocido por “seguir desentrañando los mecanismos del cáncer” (Bilbao, 23 de febrero de 2017). Arkaitz Carracedo, investigador Ikerbasque en CIC bioGUNE, ha sido galardonado en los premios ...

2017/02/22

La metabolómica puede mejorar el diagnóstico y el tratamiento de la enfermedad...

CIC bioGUNE y OWLMetabolomics identifican dos subtipos de NAFLD El estudio, realizado en 535 pacientes con diagnóstico de NAFLD a los que se les ha determinado más de 400 lípidos distintos, ha sido publicado en la revista Gastroenterology ...

2017/02/15

CIC bioGUNE, British Council y AECC organizan el ciclo de conferencias divulgativas...

El investigador Bart Vanhaesebroeck, profesor del UCL Cancer Institute de Londres, intervendrá este jueves en la primera jornada Ha dedicado su carrera a descubrir el funcionamiento de las proteínas de nuestras células y al diseño de fárm...

2017/02/10

Amelie Schober will defend her PhD thesis on February 13th

Amelie Schober will defend her PhD thesis, entitled "Establishment and characterisation of USP29 as a novel regulator of Hypoxia Inducible Factor α", on February 13th . The event will take place at University of Liverpool.

2017/02/07

CIC bioGUNE research on nerve regeneration after injury, selected as one of the most...

The work of the Ikerbasque researcher Ashwin Woodhoo will be published in a collection of selected articles on autophagy in the Keystone Symposium 2017 Dr. Woodhoo’s study has also been selected as one of the most relevant articles of the la...

2017/02/02

Un proyecto de CIC bioGUNE sobre biomarcadores de detección del cáncer de próstata...

El Consejo Europeo de Investigación apoya con 150.000 euros la investigación para acelerar la transición entre el laboratorio y la comercialización El proyecto de CIC bioGUNE ha sido seleccionado junto a otros 43 trabajos ...

2017/01/25

CIC bioGUNE- CIBEREHD researchers describe for the first time the involvement of...

Liver fibrosis is an integral part in the progression of chronic liver disease, a health problem related to type 2 diabetes and obesity, the twin epidemics of the 21st century. In spite of the high economic and health burden associated with chronic liver disea...

2017/01/20

A comprehensive biotin-based toolbox to study protein homeostasis: A community resource...

Protein homeostasis is at the heart of human wellbeing. Numerous diseases such as cancer and neurodegeneration are caused by imbalances in protein synthesis, degradation, and recycling.  The family of ubiquitin-like proteins (UbLs) is responsible for the ...

2017/01/19

La potente mirada de una Euskadi del futuro

El pasado Julio investigadores de la Universidad de Oxford (UK), del Instituto Nacional del Cáncer - NIH (US) y CIC bioGUNE (Spain) publicaron en la revista científica Nature Methods (Stuart, Subramanian, Abrescia,  ‘The democratization of cryo-EM’,...

2017/01/17

Discovery of a new mechanism to understand certain interspecies prion transmission...

The article describes an alternative replicative process in which certain prion strains fail to adapt to the host The work uncovers the reasons behind the extremely low susceptibility of horses to prion infection Joaquín Cast...

2017/01/10

CIC bioGUNE researchers uncover the molecular mechanism of PCNA protein sliding on DNA

The work, published in the journal Nature Communications, suggests modulator molecules of sliding as possible functional inhibitors In the long term, the research may help to uncover PCNA inhibitors potentially useful for cancer treatment

2016/12/05

CIC bioGUNE researchers discover a molecular recognition mechanism which enables...

  The work, coordinated by the Ikerbasque researcher Aitor Hierro, has been published in Cell, the journal with the highest impact factor in the field of biomedicine and molecular biology The research describes the recognition mechanism ...

2016/11/29

Multidisciplinary Research Training Program To Uncover Cellular Control Of Immuno-Metabolism...

The EU Marie Sklodowska-Curie Innovative Training Network (ITN) “TRAIN” (“Tribbles Research and Innovation Network”) was officially launched on 12th September 2016 at the kick-off meeting that took place at the facilities of Intelligent Pharma, Barcelo...

2016/11/22

Deporte e investigación unidos para luchar a favor de la salud masculina

  El Getxo Errugbia, en colaboración con el grupo CAYSO (Cáncer Y Sociedad), organizará el próximo sábado 26 la Movember Fest, destinada a recaudar fondos para Movember Foundation España. Pero antes de todo, ¿qué es Movember? Movember, comúnmen...

2016/10/27

CIC bioGUNE statement on the use of research animals

CIC bioGUNE has joined the Agreement on Openness on Animal Research, promoted by the Federation of Scientific Societies in Spain (COSCE), with the collabora...

2016/10/17

La marea rosa vuelve a Bilbao

Este domingo 16 de octubre se ha celebrado la 3ª Carrera solidaria contra el cáncer de mama en Bilbao organizada por la Asociación Acambi. Más de 10,000 personas se reunieron en la explanada del Guggenheim para apoyar, con sus pasos, la investigación cont...

2016/10/13

Juan Manuel Ramírez will defend his PhD thesis on October 17th

Juan Manuel Ramírez will defend his PhD thesis, entitled "In vivo strategies for the study of ubiquitination and ubiquitin-related diseases: application to Angelman syndrome”, on October 17th at 12.00H. The event will take place at the Salón de ...

2016/10/06

Luca Unione will defend his PhD thesis on October 18th

Luca Unione will defend his PhD thesis, entitled "Sugars and Proteins: The Role of Dynamics in Molecular Interactions", on October 18th at 11.30H. The event will take place at the salón de actos "Colegio Oficial de Farmacéuticos", aulario de la Fa...

2016/10/05

Expertos internacionales se reúnen en Bilbao para discutir sobre cáncer

CIC bioGUNE organiza “Translational research in cancer cell metabolism”, un congreso sobre metabolismo y cáncer La conferencia que se celebra hasta el jueves en el Palacio Euskalduna de Bilbao reúne a 200 investigadores de 25 países ...

2016/09/26

The University of the Basque Country has awarded Juan Luis García Rodríguez the...

The University of the Basque Country has awarded Juan Luis García Rodríguez the Extraordinary Doctoral Prize 2015-2016 for the thesis entitled “LKB1 in Liver Physiology”. His work, directed by Dr. Maria Luz Martinez Chantar at the Metabolomics Unit of CI...

2016/09/22

Assembly of large, salty and fat viruses: when a bit of grease helps

  The Structural Virology group led by Nicola Abrescia attended and contributed to the 10th user’s conference of the Spanish Supercomputing Network (Red Española de Supercomputacion-RES) which was held in Leon (Spain) on the 20th...

2016/09/12

New drug discovery company in the area of rare diseases

The new company, Atlas Molecular Pharma, aims to develop a technology capable of detecting molecules which stabilize proteins involved in the development of certain rare diseases The venture capital firm CRB Inverbío, Kereon Partners and other private invest...

2016/09/06

Amaia Arruabarrena will defend her PhD thesis on September 16th

Amaia Arruabarrena will defend her PhD thesis, entitled "Metabolic Alterations in Prostate Cancer Pathogenesis”, on September 16th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencias y Tecnología de la UPV/ EHU...

2016/08/24

A new study sheds further light on vulnerabilities in aggressive breast cancer

Triple negative breast cancer is characterised by a lack of markers indicating the most effective treatment strategies A study led by the group of Dr. Arkaitz Carracedo in CIC bioGUNE identifies a protein which could be the subject of new trea...

2016/07/19

Translational research in cancer cell metabolism conference

Cancer metabolism is a rapidly evolving research area. The main aim of this conference is to bring together cancer researchers to present their work in the context of its monitoring or manipulatin...

2016/07/05

Jesús Jiménez-Barbero has been appointed member of the Editorial Advisory Board...

Jesús Jiménez-Barbero has been appointed member of the Editorial Advisory Board of ACS Omega, a new multidisciplinary, open access and online journal that represents a new approach from American Chemical Society Publications for chemists, materials scientist...

2016/06/30

Announcement of the 3rd PROTEOSTASIS Action Meeting: “Proteostasis and its Biological...

About the meeting The COST Action BM1307 PROTEOSTASIS coordinated by Dr. Rosa Barrio (group leader at CIC bioGUNE) organizes the 3rd PROTEOSTASIS Action Meeting: “Proteostasis and its Biological Implications” on 2nd-5...

2016/06/29

CIC bioGUNE inaugurates a Nuclear Magnetic Resonance spectrometer for the study of...

The innovative equipment has been acquired with financial support from the Department of Territorial and Economic Development of the Bizkaia Provincial Government Amongst other things, the equipment will be used to determ...

2016/06/24

Lucia Mayela Gayosso will defend her PhD thesis on July 5th

Lucia Mayela Gayosso will defend her PhD thesis, entitled " Desarrollo de líneas celulares competentes para la replicación de priones humanos mediante la reprogramación de fibroblastos de pacientes genéticamente susceptibles”, on July 5th at 1...

2016/06/21

Almudena Gerpe will defend her PhD thesis on July 6th

Almudena Gerpe will defend her PhD thesis, entitled "Estudio de la regulación de PHD1 y PHD3 por SUMO”, on July 6th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/06/21

La Academia de Ciencias Médicas de Bilbao nombra a Óscar Millet presidente de su...

La centenaria institución interrelaciona la sanidad con la sociedad   (Bilbao, 21 de junio de 2016). La Academia de Ciencias Médicas de Bilbao ha nombrado a Óscar Millet presidente de ...

2016/06/17

Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing

  About this book: High throughput sequencing (HTS) technologies have conquered the genomics and epigenomics worlds. The applications of HTS methods are wide, and can be used to sequence everyt...

2016/06/15

MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization...

  Aortic stenosis (AS) is the most common form of human heart valve diseases.  Once symptoms develop, there is an inexorable deterioration with a poor prognosis. When the aortic valve is obstructed, the he...

2016/06/10

CIC bioGUNE acoge una conferencia de Andrew Hessel, referente mundial en biología...

Es investigador de Autodesk Research San Francisco y co-fundador de Pink Army Cooperative, la primera cooperativa biotecnológica del mundo   (Bilbao, 10 de junio de 2016). CIC bioGUNE, centro ...

2016/05/25

CIC bioGUNE researchers identify immune cell checkpoints that regulate cell responsiveness...

The research describes the role of the mitochondrial MCJ protein in the metabolism of immune cells The work, conducted in collaboration with the University of Vermont, has recently been published in the journal Immunity, ...

2016/05/23

The metabolism of prostate cancer cells is a determining factor for the development...

The expression of a central regulator of cell metabolism, PGC1A is associated with prostate cancer aggressiveness The research paves the way for the identification of patients at risk of developing metastatic disease

2016/05/18

Estudio molecular de exosomas, sangre y microbioma en Fibromialgia

La Fibromialgia es una enfermedad crónica que cursa con dolor intenso en numerosos puntos del cuerpo, que se estima la padece un 3% de la población y para la cual no existe un diagnóstico eficaz. El gobierno Vasco ha concedido al Dr. Juan M Falcon-Perez un ...

2016/05/16

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan...

Allergy may be combated by using Allergen immunotherapy (AIT). However, AIT displays a variety of shortcomings, related to security, efficacy, duration, and patient compliance. In this context, using a multidisciplinary approach combining synthetic che...

2016/05/16

The mechanism of sulfur transfer across protein-protein interfaces: the CSD model system

Cellular mobilization of elemental sulfur (S) is a crucial step for the biosynthesis of several entities essential for life, including amino acids, vitamins, and modified RNA nucleosides. However, the exact mechanism behind some of the related transpersulfurat...

2016/05/16

Our scientists develop a novel fragment-based combinatorial Nuclear Magnetic Resonance...

One of the most expensive and time-consuming tasks in the drug discovery process aims at developing selective binders from promiscuous lead compounds. A team of scientists from CSIC (IQOG, IQFR, and CIB), the Universities of La Rioja and Zaragoza and CIC bioGU...

2016/05/16

Immunological adjuvants may help to stimulate the immune response to the co-administered...

Immunological adjuvants may help to stimulate the immune response to the co-administered antigens. Therefore, they have become increasingly important for developing prophylactic and therapeutic vaccines. In this context, using a multidisciplinary approach comb...

2016/04/12

CIC bioGUNE, only Spanish research centre selected in the latest call for applications...

The centre will research into the metabolism of hummingbirds, capable of storing and burning fat very rapidly The HFSPO will provide over one million euros in funds for the project   (Bilbao, 12 April 2016). CIC bioGUNE, the Centre for Coopera...

2016/03/17

Patricia Zuñiga will defend her PhD thesis on April 8th

Patricia Zuñiga will defend her PhD thesis, entitled "Implicación de LKB1 en la patogénesis y progresión del cáncer de próstata”, on April 8th at 12.30H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnolog�...

2016/02/15

Investigadores de CIC bioGUNE participan en el 2º Encuentro Industrias Bio-Salud...

En el encuentro organizado por Basque Biocluster han intervenido la Dra. María Vivanco y el Dr. Joaquín Castilla(Bilbao, 12 de febrero de 2016). Los investigadores de CIC bioGUNE María Vivanco y Joaquín Castilla han part...

2016/02/09

Observation at atomic resolution of an enzyme opens a pathway for inhibition of colon...

A team of scientists from CIC bioGUNE, University of Liverpool and Cedars-Sinai hospital in California, using high-resolution structures, have determined the catalytic steps of the enzyme MATα2. This study opens up a new pathway in the development o...

2016/02/08

CIC bioGUNE y la AECC celebran el 5º aniversario de su colaboración con un...

El presente y el futuro en la investigación de cáncer de hígado y la transferencia desde el laboratorio al paciente han centrado las intervenciones de los investigadores del centro (Bilbao, 9 de febrero de 2016). CIC bioGUNE, ce...

2016/02/04

La creación de REDiEX potenciará la medicina personalizada en España

 CIC bioGUNE participa en esta red que nace con la voluntad de potenciar las interacciones científicas La Red de Excelencia e Innovación en Exosomas aportará nuevas estrategias terapéuticas en enfermedades parasitarias y ...

2016/02/01

CIC bioGUNE celebra su undécimo aniversario con una conferencia científica...

El premio Príncipe de Asturias de Investigación Científica y Técnica (2014) ha disertado sobre la transferencia de la investigación a la empresa (Bilbao, 29 de enero de 2016). CIC bioGUNE, centro vasco de investigaci&oac...

2016/01/13

Lucia Pirone will defend her PhD thesis on February 18^th

Lucia Pirone will defend her PhD thesis, entitled "Post-translational modifications by SUMO and ubiquitin-like proteins; role of sumoylation on SALL proteins", on February 18th at 12.00H. The event will take place at the Salón de Grados de la ...

2016/01/13

The ubiquitin ligase TRAIP binds PCNA and protects the genome in response to replication...

The replication of the genetic material can be blocked or slowed down by different causes creating replication stress in the cell. This is the primary source of genome instability, and the cell triggers a replication stress response to prevent it. Researchers ...

2016/01/12

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

While current therapies have achieved modest successes in some cancers, significant problems remain with most of our approaches to treatment. In particular, many newer targeted therapies are extremely expensive, highly toxic and not effective for rare types o...

2016/01/11

Paulina Pluta will defend her PhD thesis on February 2^nd

Paulina Pluta will defend her PhD thesis, entitled "Computational and biophysical methods for the characterization of protein-protein and protein-ligand interactions", on February 2nd at 11.00H. The event will take place at the Salón de Grados...

2016/01/11

David Gil will defend his PhD thesis on January 11^th

David Gil will defend his PhD thesis, entitled "Automatización de la adquisición y procesamiento de datos en microscopía electrónica tridimensional", on January 11th at 12.00. The event will take place at the aula (Planta...

2015/12/22

Beca de investigación AECC Bizkaia

La mañana del 22 de diciembre tuvo lugar la firma de la última beca de investigación del año, concedida en esta ocasión a Mª Luz Martínez Chantar, una de las investigadoras jefe del CIC bioGUNE (Centro de Inves...

2015/12/21

1st meeting of the Spanish Hypoxia Network (HypoxiaNet.es)

 HypoxiaNET.es is an open initiative to all researchers (basic, clinical and industrial) with a common interest in the study of cellular and molecular mechanisms that mediate the responses to changes in oxygen availability. Hypoxia occurs in a wide range ...

2015/12/18

Highest resolution structure of a flexuous filamentous plant virus

 Flexible filamentous viruses are eukaryotic RNA viruses and economically important plant pathogens. Their viral particles contain several hundred copies of a helically arrayed coat protein (CP) protecting a (+)ssRNA. A research team from CICbioGUNE has d...

2015/12/09

Hasier Eraña will defend his PhD thesis on December 21^st

Hasier Eraña will defend his PhD thesis, entitled "Estudio de los determinantes moleculares que modulan la resistencia del conejo a la infección por priones utilizando un modelo de propagación in vitro", on December 21st at 12.00...

2015/12/09

Understanding proteins that only work with a pinch of salt

 Life on earth exhibits an enormous adaptive capacity and living organisms can be found even in extreme environments. For instance, halophilic archaea thrieve in highly saline lakes with KCl concentrations between 2M and 6M. To avoid the osmotic shock, ha...

2015/12/01

Ganeko Bernardo will defend his PhD thesis on December 15^th

Ganeko Bernardo will defend his PhD thesis, entitled "Structural characterization of helices A and B of Kv7.2 channel bound to Calmodulin. The calcium effect.", on December 15th at 11.00H. The event will take place at the Salón de Grados de la...

2015/11/23

A key moment for science

- The Center for Cooperative Research in Biosciences CIC bioGUNE has managed to observe empirically for the first time a chemical species with a short lifetime that is generated during the formation and cleavage of sugars - The experimental demonst...

2015/11/17

Evolution of SUMO function and chain formation in insects.

To understand the function and mechanisms of postranslational modification is crucial to understand protein function. Modifications by the Small Ubiquitin-like Modifier (SUMO) to target proteins are proven to be important in critical developmental proc...

2015/10/30

Carrera contra el Cáncer de Mama - Bilbao 2015

El pasado domingo 25, 10.000 camisetas rosas llenaron Bilbao de color y esperanza. Acambi (Asociación de Cáncer de Mama de Bizkaia) y el Gimnasio Urtzi organizaron por segundo año consecutivo la Carrera Solidaria contra el Cáncer de...

2015/10/19

The CIC bioGUNE's International Scientific Board will meet to design the strategies...

- The International Scientific Advisory Board, made up of leading international researchers, will hold its tri-annual meeting in order to analyse the research centre's scientific output in recent years and its projects for the future.- The sessions w...

2015/10/08

The article "Insight into the Assembly of Viruses with Vertical Single β-barrel...

by Gil-CartonGil-Carton D, Jaakkola ST, Charro D, Peralta B, Castaño-Díez D, Oksanen HM, Bamford DH, Abrescia NG. Structure. 2015, 23:1866-1877. doi: 10.1016/j.str.2015.07.015. Epub 2015 Aug 27. Within an activity of 2 months the artic...

2015/09/30

Gabriel Ortega will defend his PhD thesis on October 5^th

Gabriel Ortega will defend his PhD thesis, entitled "Structural Studies of the Hypersaline Adaptation of Proteins belonging to Halophilic Archaea", on October 5th at 11.00H. The event will take place at the Salón de Grados of the Facultad de C...

2015/09/29

BM1307 PROTEOSTASIS Meeting in collaboration with EMBO (18th to 22nd September 2015)....

 About the meeting The COST Action BM1307 PROTEOSTASIS coordinated by Dr. Rosa Barrio (leader researcher at CIC bioGUNE) organized its third meeting in parallel with the EMBO Conference on "Ubiquitin and ubiquitin-like modifiers: from molecular...

2015/09/16

Cellular and molecular heterogeneity in breast cancer

 Breast cancer is a very heterogeneous disease. We now know that breast tumors contain cells with properties of stem cells (cancer stem cells, CSCs) that support tumor initiation and resistance to current therapies. Furthermore, the heterogeneous nature o...

2015/09/15

The quest of anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related...

The expression of MUC1, a glycoprotein displaying complex oligosaccharides, is usually increased with aberrant glycosylation in tumour cells. In fact, the carbohydrate side chains are now incomplete and different epitopes, including the Tn antigen (α-GalN...

2015/09/03

A study shows the peripheral nervous system regeneration capacity after a lesion

- The project, led by CIC bioGUNE and University College London, has discovered a new mechanism that facilitates the regeneration of the layer that surrounds the neurons in the peripheral nervous system after suffering a lesion. - The loss of this i...

2015/08/31

The unexplored archaeal domain and its viruses

Archaeal viruses represents one of the most challenging and yet unknown area of investigation. Archaeal viruses live in extreme environments (alkaline, acidic conditions, hyper-salinity and elevated temperature), conditions reminiscent of what Earth woul...

2015/08/07

A new study shows that rabbits are not resistant to infection by prions

 - A project led by CIC bioGUNE shows that rabbits are susceptible to spongiform encephalopathies, neurodegenerative diseases caused by prions.- The research, published in the journal PLOS Pathogens, used real prions regularly found in livestock spe...

2015/08/05

BRCA1, a breast cancer predisposition gene, a potential contributor in a human and...

 Amyotrophic lateral sclerosis (ALS) is characterised by selective motoneuron degeneration in the spinal cord, brainstem and motor cortex leading to progressive muscle weakness, atrophy and paralysis. Growing evidence suggest that microglia are implicated...

2015/07/24

Steroids and Insulin pathways collaborate to promote tissue growth

How organisms reach their final size is a crucial question in Biology that is deeply related with the mechanisms involved in cell growth control and the pathologies associated to the misregulation of this process, such are cancer and developmental diseas...

2015/07/20

Discovered the potential of a DNA regulator in the treatment of liver diseases

 - Research led by CIC-BioGUNE has achieved the remission of the biliary cirrhosis phenotype by controlling the activity of an epigenetic regulator. - The research, in which the University of California (UCLA) took part, was carried out using genetic...

2015/07/20

Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted...

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa, Blanca Suárez-Merino, Sébastien Lecommandoux, and Pedro Heredia. J. Biomed. Nanotechnol. 11, 2034-2049 (2015...

2015/07/15

Mammary Stem Cells

A book has recently been published on "Mammary Stem Cells", as part of the prestigious series on Methods in Molecular Biology from Springer. The book has been edited by Maria dM Vivanco, Group Leader at CIC bioGUNE, and includes cutting-edge methods ...

2015/07/15

Chafik Harrathi will defend his PhD thesis on July 28^th

Chafik Harrathi will defend his PhD thesis, entitled "Estudio de la susceptibilidad/resistencia del ganado ovino a la infección por priones utilizando modelos de propagación in vitro", on July 28th at 12.00H. The event will take place i...

2015/07/15

Molecular processes affecting mammary luminal progenitor fate

 In contrast to most mammalian organs, the mammary gland develops mostly after birth. Mammary epithelium is a bilayered structure formed by luminal and myoepithelial cells. Luminal cells are responsible for producing milk. When the mammary gland grows, ne...

2015/07/15

Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical...

 Detection of molecular recognition processes requires robust, specific and easily implementable sensing methods, especially for screening applications related to the drug discovery process. Within a collaborative project between the research groups of Ni...

2015/07/14

Laura Palomo Díaz will defend her PhD thesis on July 28th

Laura Palomo Díaz will defend her PhD thesis, entitled "Metabolic implications and characterization of hepatic extracellular vesicles in drug-induced liver injury", on July 28th at 11.00H. The event will take place in Sala Anexa, Departamento ...

2015/07/06

New pharmacological therapies for treating the most aggressive form of porphyria

- Research led by the Center for Cooperative Research in Biosciences seeks to obtain effective methods for changing the stability of the enzyme that causes development of congenital erythropoietic porphyria.- The research, which has received financ...

2015/07/01

Prohibitins (PHBs) comprise an evolutionary conserved and ubiquitously expressed...

Prohibitins (PHBs) comprise an evolutionary conserved and ubiquitously expressed family of proteins with a variety of suggested activities in different cellular compartments. Given the implication of PHB1 in many vital functions, we generated a liver-specific ...

2015/06/29

The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures

 The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures. This molecule is expressed in ca. 90 % of carcinomas, and there is a direct correlation between the aggressiveness of the carcinoma and the occurrence of th...

2015/06/22

Marie Skłodowska-Curie action awarded to carry out structure-function studies...

 Bilbao, June 15th, 2015: Virologist Dr. Hani Boshra has been awarded with an Individual Fellowship Marie Skłodowska-Curie action (MSCA) to study Schmallenberg virus (SV) in the group of Dr. Nicola GA Abrescia at the Structural Biology Unit at the CI...

2015/06/16

Healing tears

 - CIC bioGUNE and the company Bioftalmik have been working on a project that has identified a broad catalogue of endogenous peptides in human tears, and some of them have antimicrobial properties.  - This research, published in the Journal of P...

2015/06/09

The barrier preventing fatal disease transmission from deer to humans is identified

- Research by the University of California in co-operation with the Ikerbasque researcher Joaquin Castilla's team at CIC bioGUNE, gains deeper knowledge in resistance and propagation mechanisms of certain prions. - The research, published by t...

2015/05/21

Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico...

Endogenous peptides are valuable targets in the analysis of biological processes. The tear film contains proteins and peptides released by the tear duct mucosal cells, including antimicrobial peptides involved in the protection against exogenous pathogen...

2015/05/13

A new book on the role of carbohydrates in nature, with special emphasis on their...

A new book on the role of carbohydrates in nature, with special emphasis on their roles in disease, is available. The book has been edited by J. Jiménez-Barbero, Scientific Director of CIC bioGUNE, together with two other scientific colleagues from CSIC...

2015/05/08

Defense of the PhD Thesis of Leire Herboso

Leire Herboso will defend her PhD thesis, entitled "El papel de los receptores SR-BI en la esteroidogénesis y de la Hormona Ecdisona en el crecimiento ", on May 12th at 12.00H. The event will take place in Salón de grados at the Univers...

2015/05/08

The scientific director of CIC biomaGUNE, Luis Liz-Marzán, elected member...

 - Along with José María Mato and Soledad Penadés, three scientists from CIC bioGUNE and CIC biomaGUNE are now part of the scientific institution. - The researcher, doctor in chemistry from the University of Santiago de Com...

2015/04/21

Centros de investigación y empresas ‘bio' de Euskadi buscan estrechar...

- Los centros de investigación CIC biomaGUNE y CIC bioGUNE y el cluster de empresas ‘bio', Basque Biocluster, organizan una jornada para impulsar ámbitos de oportunidad y de cooperación.- El acto tendrá lugar en la sede ...

2015/03/30

Protein homeostasis project brings researchers together

Intracellular proteolysis is critical to maintaining cellular homeostasis, and aberrations in this process play a central role in pathologies such as cancers, immune diseases and neurodegenerative conditions. The PROTEOSTASIS project aims to coordinate and int...

2015/03/17

The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism...

 PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is overexpressed in cancer, direct...

2015/03/16

Revealing the mode of binding between the DNA repair machinery and a carcinogenic protein

 - A team from CIC bioGUNE led by Francisco J. Blanco has determined the structure of the complex formed by the p15 protein, present in several kinds of cancer and part of the cellular DNA repair machinery. - The structure reveals "a novel and ...

2015/03/04

Ramón Areces Foundation funds research on therapeutic application of exosomes

 - The study is coordinated by CIC bioGUNE researcher Juan Manuel Falcón-Pérez, an expert in exosome studies  - The Ramón Areces Foundation has granted 122,000 euros for this 3-year project. (Bilbao, March 2015).- The ...

2015/02/17

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

 Liver Cancer, the fifth most common cancer worldwide and the third leading cause of death, is a very complex and heterogeneous pathology with multiple and distinct signaling pathways that converge in the same malignant transformation. The laboratory of M...

2015/02/16

Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis...

 The interactions between aromatic moieties and aliphatic entities are of paramount importance for essential molecular recognition events. In particular, CH-pi contacts are present in a variety of biomolecular complexes, and provide the impetus for differ...

2015/02/12

TV3 telethon funds Alzheimer's disease study by CIC bioGUNE and CIC biomaGUNE

- The project has secured 400,000 euros in funding from the telethon that the Catalan public TV channel organises every year, and which in 2013 raised money for neurodegenerative diseases.- The project focuses on the interaction of two proteins lin...

2015/01/26

Ikerbasque researcher Jesús Jiménez Barbero is appointed new scientific...

- A CSIC Research Professor and current president of the Spanish Royal Society of Chemistry (RSEQ), he joins the centre as an Ikerbasque researcher. - Between 2009 and 2014 he was the director of the Department of Chemical and Physical Biology at t...

2015/01/26

Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase fromMycobacterium...

 Mycobacterium tuberculosis is a human pathogen that causes tuberculosis, a disease that kills ca. 2 million people worldwide every year. The occurrence of multidrug and extensively drug-resistant strains of M. tuberculosis have emerged in a way that they...

2015/01/22

Structure and interactions of a multifunctional domain of HuR protein

The human antigen R (HuR) is a powerful regulator of cancer. By binding and stabilizing certain messenger RNA molecules, it promotes the production of other proteins related to cell proliferation, survival, angiogenesis and metastasis, and therefore is a...

2015/01/14

10º aniversario del Centro de Investigación Cooperativa en Biociencias

 Una década de biociencias en Euskadi- El centro vasco es hoy una realidad dentro del panorama científico nacional e internacional como agente generador de conocimiento en el área de las biociencias- Ha percibido 90 M€ de f...

2014/12/23

Exosomes involved in tissue and organ formation

 - A study conducted by CIC bioGUNE, in collaboration with Severo Ochoa Molecular Biology Centre, shows that a Hedgehog protein travels through exosomes, which are small vesicles that are released towards the outside of the cell. - Considered for man...

2014/12/16

Nora Bengoa will defend her PhD thesis on December 18th

Nora Bengoa will defend her PhD thesis, entitled "Noncanonical Wnts and their Receptors in Neural Differentiation", on December 18th at 4 pm. The event will take place in Salón de grados of the Faculty of Medicine at the University of Basque ...

2014/12/12

Elisa Aida da Silva Ferrada will defend her PhD thesis on December 22^nd

Elisa Aida da Silva Ferrada will defend her PhD thesis, entitled " Role of ubiquitin and SUMO molecules in the regulation of cellular factors", on December 22nd at 11.00H. The event will take place in Salón de grados at the Universi...

2014/12/10

One of our latest publications about Legionella appears as Scientific Highlight in...

A long-standing question in the field of microbial pathogenesis is how virulence factors are regulated within host cells and how their activity is specifically directed toward a particular host cell compartment. Now, Legionella pneumophila resolves this dilemm...

2014/12/09

Exosomes participate in the Hedgehog gradient formation required in development

 Tissue and organ formation require a tight concerted coordination of many different cell types that have to proliferate and differentiate in the right place and moment. For proper development, the organism establishes a spatio-temporal expression of spec...

2014/12/02

Marta Iruarrizaga will defend her PhD thesis on December 11th

Marta Iruarrizaga will defend her PhD thesis, entitled "Control of gene expression during schwann cell myelination and in pathological conditions", on December 11th ...

2014/11/19

Study discovers how rare disease causing cardiovascular and cognitive disorders is...

- This rare disease is homocystinuria, which affects 1 in every 250,000 children born in Spain and has recently been included in neonatal screening - A study conducted by CIC bioGUNE and the University of Colorado (US) has discovered the three-dimen...

2014/11/18

Structure of a protein interaction key for microtubule elongation

Cell division involves the segregation of the genetic material into the daughter cells that, when not properly controlled, may produce aberrant chromosomes and lead to cancer. Microtubule elongation plays a key role in the machine that regulates the dist...

2014/10/28

The 7th Fero Grant is awarded to a study by Arkaitz Carracedo concerning new targets...

- The CIC bioGUNE received the award from the cancer research foundation yesterday. - His project concerns a protein present in almost all the most aggressive breast cancers.- The jury stressed that "the project is multidisciplinary, hig...

2014/10/06

International experts in cell signalling and cancer metabolism gather at CIC bioGUNE

- From tomorrow until Thursday a congress will gather 120 scientists. - It is one of the most important European events in this field.- Its goal is to bring together the knowledge of basic science and clinical researchers  (Bilbao, Octob...

2014/10/03

Resistir el déficit de oxígeno

 Ya lo dijo Darwin "no son las especies más fuertes las que sobreviven, ni las más inteligentes, sino aquellas que se adaptan mejor al cambio". El oxígeno es vital y su déficit puede resultar dramático. Los org...

2014/10/01

The first non-invasive test to diagnose fatty liver disease is awarded two patents...

- The diagnostic test, which correctly categorises the disease in 94% of patients, is already being marketed as Owl Liver by the Basque company Owl. - The company will start to market the test in Brazil and Mexico in the autumn, and has signed an ag...

2014/09/22

Discovery of a new therapeutic target to fight against Legionella

- The bacteria releases a protein in human cells, called VipD, that facilitates its intracellular survival.- This discovery may open the door to design new methods to fight legionellosis.- This breakthrough is the result ...

2014/09/17

El Diputado de Promoción Económica visita bioGUNE para conocer su nuevo...

- Imanol Pradales ha acudido hoy a conocer este nuevo equipamiento- Se ha adquirido con el apoyo de la Diputac...

2014/09/16

Scottish Ubiquigent will sell a product developed by CIC bioGUNE and Histocell to...

 - The project is born from research projects undertaken in the CIC bioGUNE research centre on genetically modified mouse cells.  - Basque company Histocell will be responsible for the product manufacturing process, which will be marketed by the Scot...

2014/08/12

A switch in Wnt signaling mediates early differentiation of human neural stem cells.

 A new study from the Cell Biology and Stem Cells Unit focuses on secreted proteins called Wnts, which are particularly important for tissue development and morphogenesis. Purified proteins and small molecules that regulate Wnt signaling are increasingly ...

2014/07/30

US patent issued for a new CIC bioGUNE product to develop new cancer treatments

 - Tandem-repeated Ubiquitin Binding Entities (TUBEs) enable the identification of biomarkers, new therapeutic targets and drugs against different pathologies including oncology and neurodegenerative diseases.- The American company LifeSensors has c...

2014/07/18

Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human...

 During mitotic cell division chromosomes need to be repackaged into daughter cells, a complicated process guided by several protein regulators, which are themselves tightly regulated. Targeted destruction of those proteins by cellular machinery is achiev...

2014/07/08

Discovery of a protein that allows brain stem cells to generate new neurons

 - A study conducted on mice, in which CIC bioGUNE is involved, has revealed that the MTP-MMP protein 'unblocks' this type of cell- Understanding this process may help to find new approaches to combat neurodegenerative diseases.- The r...

2014/06/26

CIC bioGUNE's Animal Unit renews the accreditation that certifies the use of...

 The Animal Unit of the CIC bioGUNE has renewed its "Full Accreditation" by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). 
AAALAC International is a private, non-profit organization that promotes the ...

2014/06/20

A possible pathway for inhibiting liver and colon cancer growth is found

 - A study by CIC bioGUNE, the University of Liverpool and the US research centre USC-UCLA has revealed the structure of a protein complex involved in these diseases- This discovery will help to determine which part of the protein will need to be bl...

2014/06/16

Tuning intracellular homeostasis of human uroporphyrinogen III synthase by engineering...

 Congenital erythropoietic porphyria (CEP) results from a deficiency in uroporphyrinogen III synthase enzyme (UROIIIS) activity that ultimately stems from deleterious mutations in the uroS gene. CEP presents with a plethora of different symptoms, with pat...

2014/05/30

La química de carbohidratos rinde homenaje a la trayectoria científica...

- El fundador y ex-director científico de CIC biomaGUNE es una de las grandes referencias internacionales en la investigación en la química de los carbohidratos.- Opinan sobre Manuel Martín-Lomas: - José M Mato: ...

2014/05/20

Medalla de la Real Sociedad Española de Química a la trayectoria científica...

 - Se trata del mayor reconocimiento que concede anualmente la RSEQ a la carrera científica de un investigador - "Me siento muy orgulloso de ver mi nombre en una lista tan destacada de químicos", afirma(San Sebasti...

2014/05/07

Cultivar para recoger, la inversión en investigación para el futuro...

 La innovación es el futuro, y debe desempeñar una función cardinal en el cambio de modelo económico que nuestra sociedad necesita. Una de las preguntas fundamentales en este aspecto es: ¿Cómo se llega a conseguir u...

2014/04/30

Ubiquitin profiling in liver using a transgenic mouse with biotinylated ubiquitin

 Ubiquitination is behind most cellular processes, with ubiquitin substrates being regulated variously according to the number of covalently conjugated ubiquitin molecules and type of chain formed. Researchers from CIC bioGUNE, led by the group of Ikerbas...

2014/03/31

Lysine Methylation Mapping of Crenarchaeal DNA-Directed RNA Polymerases by Collision-Induced...

 Enzymatic machineries fundamental for information processing (e.g. transcription, replication, translation) in Archaea are simplified versions of their eukaryotic counterparts. This is clearly noticeable in the conservation of sequence and structure of c...

2014/03/26

Abnormal levels of a molecule are associated with diabetic neuropathy

 - Researchers from CIC bioGUNE have revealed that the molecule SAMe causes changes in the genome that affect the peripheral nervous system - Diabetic neuropathy affects between 60% and 70% of diabetes sufferers - The study led by Dr. Ashw...

2014/03/13

S-adenosylmethionine levels regulate the Schwann cell DNA methylome

 Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. Schwann cell myelination is a highly orchestrated and complex develop...

2014/02/06

El investigador británico Mark Kearney
explica en Bilbao la relación...

 - El científico británico abrirá el jueves 6 de febrero (19.30 horas) la IX edición del ciclo de conferencias organizado por la Fundación BBVA y CIC bioGUNE - Ofrecerá una conferencia titulada 'Cómo promov...

2014/01/31

CIC bioGUNE celebra su noveno aniversario

- El centro vasco de investigación en biociencias ha celebrado su noveno aniversario con una conferencia a cargo del investigador Óscar Marín CIC bioGUNE ha celebrado hoy su noveno aniversario con una conferencia a cargo del cie...

2014/01/14

Sox2 promotes tamoxifen resistance in breast cancer cells

 A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr Zabalza (Hospital of Galdakao) and Dr López-Ruiz (PreteImagen) has been published this week in the prestigious journal EMBO Molecular ...

2014/01/10

European network to carry out research on protein life cycle

 - CIC bioGUNE leads the Proteostasis initiative, with more than 100 participant European laboratories.- Companies, universities and research centres from 20 countries, specialising in the degradation and modification of cell proteins, are involved.- Imba...

2014/01/07

SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR...

 Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous work highlighted the re...

2013/12/23

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine...

 Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic syndrome. Although these con...

2013/12/18

The Movember Foundation has renewed by second year the EXOSOMES GAP1 project

Thanks to this award CIC bioGUNE researchers in close collaboration with the Basurto Hospital and the BIOEF Foundation are studying a special type of small vesicles called exosomes aiming to reveal novel low invasive markers for prostate cancer. During the fir...

2013/12/12

Rare disease that causes cardiovascular and mental disorders

3D structure of key...

 - CIC bioGUNE researchers have discovered the 3D structure of a protein (CBS), whose dysfunction causes the disease known as homocystinuria, with an international incidence that varies between 1 in 50,000 and 1 in 200,000 individuals and a mortality rate...

2013/12/09

What goes wrong in Angelman Syndrome? Fruit flies give us the insight

 Angelman syndrome (AS) is a severe neurodevelopmental disorder related to autism, which presents also with intellectual disability. The cause of AS is the loss of function in the brain of the ubiquitin E3 ligase coded by the UBE3A gene, which is located ...

2013/11/29

Structural basis for the allosteric regulation of human cystathionine beta synthase,...

 Cystathionine β-synthase (CBS) is the key enzyme in the transsulfuration pathway controlling the flux of sulfur from methionine to cysteine, which is a precursor of glutathione (the main cellular antioxidant), taurine (the major constituent of bile ...

2013/11/11

A protein that 'rebels' against breast cancer treatment

- A study headed by the researcher María Vivanco, at CIC bioGUNE, has shown that the protein SOX2 makes tumour cells insensitive to hormone therapy.- This study helps us to understand how some tumours return, despite having been treated, and can e...

2013/10/30

Structural virology: making an impact in biology through hybrid methods

 The study of virus structures has contributed to structure biology methodological advances that go beyond virus-specific methods and are generally applicable (molecular replacement and non-crystallographic symmetry are only two of the best known examples...

2013/10/29

One of our groups opens the way to combatting dermatological disorders associated...

- The prestigious scientific journal PNAS has published a study from Dr. Oscar Millet's group, in collaboration with the University of Bordeaux, which shows that drugs can be used to fight this extremely rare disease.- Gunther's disease is ...

2013/10/17

Mechanism of Membranous Tunnelling Nanotube Formation in Viral Genome Delivery

- The laboratory of Dr. Abrescia has described for the first time how the virus PRD1 uses lipids and proteins that are part of its structure to generate a nanotube used to translocate its genome and to penetrate and infect cells.  - The finding coul...

2013/10/16

CIC bioGUNE discovers a new form of virus reproduction

- The laboratory of Dr. Abrescia has described for the first time how the virus PRD1 uses lipids and proteins that are part of its structure to generate a nanotube used to translocate its genome and to penetrate and infect cells.  - The finding coul...

2013/10/04

UPV/EHU awards one of our groups with the Special Doctoral Dissertation Award in...

 The Postgraduate Committee of the UPV/EHU awarded Dr. Nuria Martinez-Lopez with the Special Doctoral Dissertation Award in Health Sciences in the year 2010/2011 for her doctoral thesis entitled, "THE ROLE OF THE SERINE/THREONINE KINASE LKB1 IN THE P...

2013/10/01

"Ayuda a investigación Oncológica 2013" grant awarded to...

 After studying the evaluation report by the A.N.E.P. (Agencia Nacional de Evaluación y Prospectiva), the Scientific Foundation Board of the "Asociación Española contra el Cáncer - AECC" at its 19th June 2013 meeting,...

2013/09/19

The Spanish Association Against Cancer (AECC) awards one of our groups with a three...

Pablo Fernadez Tussy, from Mª Luz Martinez Chantar's Laboratory in the Metabolomics Unit, has been awarded with a three years PhD ...

2013/09/18

Best poster presentation award in The Metabolic Regulation section of the XXXVI Congreso...

 Lucia Barbier, PhD student at the Metabolomics Unit, received...

2013/09/11

EU allocates €1.5m funding to Arkaitz Carracedo's prostate cancer research...

- The European Research Council has given the CIC bioGUNE researcher an ERC Starting Grant, aimed at young researchers, to study the diagnosis and treatment of the most common cancer...

2013/09/09

Ceramide-1-phosphate trafficking regulates intracellular eicosanoic lipid levels...

 In the presence of harmful stimuli, intracellular production of eicosanoids triggers the pro-inflammatory response. However, chronic inflammation has obvious deleterious effects and it has been associated with different pathologies including ...

2013/09/03

European project searches for tick-borne disease antidote

- CIC bioGUNE is taking part in the European project ANTIDotE, which aims to find components in the arthropod's saliva that would help to prevent diseases caused by its bite. - Ticks transmit various kinds of bacteria, viruses and parasites, cau...

2013/09/03

Structural Basis for the Interaction of the Golgi-Associated Retrograde Protein Complex...

Fusion of transport vesicles with the appropriate target compartment is a tightly regulated process for cargo delivery in the endomembrane system of all eukaryotic cells. This process depends on tethering factors that capture transport vesicles and SNARE prote...

2013/07/29

Sensing low amino acids levels on the ribosome explored by cryoEM

In some bacteria the scarcity of amino acids is sensed on the ribosome, where RelA, the stringent factor, is activated by the presence of cognate and deacylated tRNA. Amino acid starvation and low levels of charged tRNAs stall translation, and this is th...

2013/07/22

Abren un nuevo frente en la lucha contra
el cáncer de hígado

 - Una investigación del director de CIC bioGUNE, José María Mato, pone las bases para una nueva aproximación al tratamiento del cáncer de hígado más común, el Carcinoma Hepatocelular (HCC, en sus si...

2013/07/08

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular...

 MAT1A is the main gene involved in the hepatic synthesis of S-adenosylmethionine (SAMe), the principal biological methyl donor and a precursor of polyamines and glutathione synthesis. We have previously shown that the disruption of MAT1A in mice induces ...

2013/06/20

Abrescia's group has recently published its new book-chapter: Combined Approaches...

Nicola Abrescia, Ikerbasque Research Professor and PI at the Structural Biology Unit at CIC bioGUNE has led the accomplishment of an exhaustive book-chapter on the hybridization of methods to determine the three-dimensional structure of viruses. This boo...

2013/06/14

The eBook "Bioinformatics for High Throughput Sequencing" is one of the...

 Since its online publication on Oct 25, 2011, there has been a total of 10268 chapter downloads for the book "Bioinformatics for High Throughput Sequencing" (edited by Naiara Rodriguez-Ezpeleta, Michael Hackenberg and Ana M. Aransay) on Springe...

2013/06/12

Nanoparticles for controlled drug release

 - Researchers from CIC bioGUNE are participating in the study of a novel technique that allows medicines to be transported inside nanoparticles.  - Once these nanoparticles reach their target, drug release is controlled by applying a magnetic ...

2013/05/16

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

The covalent attachment of adenosine monophosphate (AMP) to proteins, a process called AMPylation (adenylylation), has recently emerged as a novel theme in microbial pathogenesis. While AMPylases from various pathogenic microorganisms have recently been ...

2013/04/29

Ikerbasque y CIC bioGUNE convierten euskadi en un referente internacional en biociencias

 o Los 12 investigadores Ikerbasque en CIC bioGUNE han captado más de 3 millones de euros y han publicado más de 50 estudios. o 5 de los 12 investigadores son de origen vasco. Se trata de investigadores que han desarrollado su carrera f...

2013/04/24

Discovery of a gene involved in fatty liver disease

  - An international research consortium led by CIC bioGUNE has found that the gene SLC2A1 is associated with non-alcoholic fatty liver disorders, whose complete genetic basis is still unclear. - Non-alcoholic fatty liver disease is one of the leadin...

2013/04/22

Regulating the regulators: Steroid hormone synthesis is controlled by SUMO, Ftz-f1...

Steroid hormones are cholesterol derivates that control many aspects of animal physiology, including development, growth, energy storage and reproduction. In insects, the main steroid hormone is ecdysone, which gets activated in pulses that precede molting and...

2013/04/19

New insight into the regulation of prostate gland morphogenesis

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE, Imperial College London and DKFZ Heidelberg have uncovered a novel link between the tumor suppressor Dkk-3 and TGF-β signaling. The study, by Romero, Kawano et al., is published in the...

2013/04/08

Shedding light on new metabolic pathways implicated in cancer

The group of Arkaitz Carracedo at CIC bioGUNE has corresponded a review article in the prestigious journal Nature Reviews Cancer where he revisits the metabolic pathways required to sustain cancer cell survival and growth. In this Progress article, Dr. Carrace...

2013/02/25

The great human protein 'encyclopaedia'

 - The Basque research centre CIC bioGUNE is participating in one of the largest international science projects after the Human Genome Project. - Bodies from all over the world who have joined together to form the Human Proteome Organisation (HUPO) a...

2013/02/21

CIC bioGUNE researchers to take part in the Basque Network of Food Safety Experts

 - This network will support the Food Safety Scientific Committee who advise the Basque Government(Bilbao, 21 february 2013).- CIC bioGUNE researchers -Mikel Valle, Nicola Abrescia, Juan Anguita and Jokin Castilla- will join an expert network providing ad...

2013/02/14

Novel designed molecules could stop colon cancer metastasis

 - A Basque research consortium has carried out a study in mice showing that novel synthetic molecules stop the growth of colon cancer and its propagation to the liver.- This work opens the possibility for the future development of modified molecules with...

2013/02/13

Novel antagonists in early and late stages of cancer development.

 A multidisciplinary research team led by groups from CIC bioGUNE and the University of the Basque Country has developed a novel family of synthetic compounds with strong antiproliferative and antimetastatic activity in a murine model of colon carcinoma. ...

2013/02/12

Proteomics Platform at CIC bioGUNE participates in the Chromosome Centric Project...

 With the generation of a well characterized human genome map together with the availability of in depth transcriptomics, the genesis of C-HPP came from the realization that the proteomic community was well placed to study the full complexity of human pro...

2013/02/06

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty...

 Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathologies including steatosis and non-alcoholic steatohepatitis (NASH), and may progress to cirrhosis and its complications such as hepatocarcinoma. NAFLD is the most common caus...

2013/01/17

Eight years of biosciences

 - Research centre CIC bioGUNE is celebrating its eighth anniversary with a conference by Catalan researcher Modesto OrozcoThe Basque Center for Cooperative Research in Biosciences, CIC bioGUNE, is eight years old, and to celebrate it has organised ...

2013/01/09

Analía Núñez-O'Mara defends her PhD thesis on January 16th, 2013

 Analía Núñez-O'Mara will defend her PhD thesis, entitled " HIF Prolil Hidroxilasa 3 (PHD3), un doble centinela en la regulación de HIF: Implicación de la modificación por SUMO ", on January 16th, at...

2013/01/03

A new path for the future generation of glucose-measuring biosensors

- CIC bioGUNE researchers have proven the close connection between proteins that were thought to be completely independent and isolated- This discovery could lead to new glucose measurement methods in blood, which i...

2012/12/11

Famelab, el certamen internacional de monólogos científicos, llega...

FameLab nació en 2005 gracias a una idea original del Festival de Cheltenham, cuyo principal objetivo era fomentar la divulgación de la ciencia identificando, formando y dando a...

2012/12/11

S-adenosylmethionine in Liver Health, Injury, and Cancer

 In this article, published in Physiological Reviews, Shelly Lu, from the Keck School of Medicine at the USC in Los Angeles and José Mato, from bioGUNE, review the work they have carried out in collaboration during the last 15 years on S-adenosylme...

2012/12/10

LKB1: Friend or foe?

- Researchers from CIC bioGUNE have found that LKB1 protein, which is commonly used to inhibit the proliferation of breast, lung and cervical cancers, stimulates the growth of liver cancers in mice.

2012/12/05

A joint study between the CNIO and CIC bioGUNE identifies metabolomic biomarkers...

 - These findings were obtained in a study of 1500 metabolites in blood, thus making it the most in-depth analysis to date in this research field.- The work, which is published today in the on-line version of the journal Agi...

2012/12/05

A metabolic signature predicts the biological age in mice

It is the metabolism, not the genes or the proteins, what defines better the phenotype of an organism. Consequently, the study of the unique metabolic signature that specific cellular processes leave behind is the most promising approach to determine phenotypi...

2012/11/30

Jevgenia Tamjar defends his PhD thesis on December 3th, 2012

Jevgenia Tamjar will defend his PhD thesis, on December 3th, at 11:30 o'clock. The event will take place in "Sala anexa al Paraninfo", at the University of Basque Country (Leioa).

2012/11/29

David Fernández Ramos defends his PhD thesis on December 5th, 2012

 David Fernández Ramos will defend his PhD thesis, entitled "New Oncogenic Drivers in Hepatocellular Carcinoma: Role of the RNA Binding Protein Hu Antigen R", on December 5th, at 12 o'clock. The event will take place in "Sal&oacu...

2012/11/21

Algunos de los retos pasados y futuros de la Virología Estructural

Los virus se extienden por toda la biosfera. Algunos de ellos son patógenos para los seres humanos y los animales; otros son nuestros aliados al infectar y controlar la proliferación de bacterias indeseadas. Indudablemente estas maquinarias minia...

2012/11/20

¿Podemos poner a dieta el cáncer?

Arkaitz Carracedo de la Unidad de Proteómica nos explica en una entrevista en Radio Euskadi, cómo se produce y desarrolla el cáncer, y cómo las investigaciones sobre el metabolismo de las células tumorales lo señala co...

2012/11/16

Glucose-galactose binding protein: e pur si muove.

 Protein function is often coupled to internal dynamics. Periplasmic binding proteins are bi-domain bacterial proteins that can recognize many different nutrients and oligoelements, required for the survival of the organism. They constitute a beautiful ex...

2012/11/15

Jornada de divulgación: Alimenta tus emociones.

 En la jornada se abordará la relación existente entre la alimentación y la felicidad, así como la influencia en nuestro estado emocional y en el estilo de vida que desarrollemos.Toda la información relativa al evento,

2012/10/11

CIC NETWORK reúne a representantes políticos para debatir sobre política...

Racionalizar el sistema vasco de ciencia, tecnología e innovación y alcanzar la media europea en inversión en I+D+i para el año 2015 fueron los dos objetivos compartidos por los representantes de EAJ-PNV, PSE-EE, PP y EH Bildu en el...

2012/10/05

Forum on Scientific Policy this October 11th at 11:00am

Con motivo de la próxima convocatoria de elecciones al Parlamento Vasco, el próximo día 21 de octubre, la revista CIC Network -impulsada por la red de Centros de Investigación Cooperativa (CIC) de Euskadi- ha convocado un F&oac...

2012/10/01

First symposium of leading Spanish scientists who use Drosophila in their biomedical...

 More than 40 scientists from 11 centres, including CIC bioGUNE, bear out the strength of the science performed with the fruit fly in Spain.CIC bioGUNE scientists

2012/10/01

First 1st Board Meeting of the UPStream Consortium organized by CIC bioGUNE in Bilbao

 CIC bioGUNE leads the UPStream project, an excellence training program for young scientists investigating the biochemical process of ubiquitylation and other related modifications. The

2012/10/01

Metabolomics and proteomics, two key technologies in modern biology

 - International experts will discuss recent technological advances and the applications of these techniques in a conference entitled "Metabolomics & Proteomics. Technology and Applications" to be held in Derio (1-3 October).

2012/09/19

LKB1 drives Ras activation in bad prognosis hepatocellular carcinoma: A new axis...

 Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers and it is becoming a major health problem. HCC incidence is growing with more than 750.000 annual cases worldwide. Liver cirrhosis at a high risk of HCC development has abnormal S...

2012/09/18

CIC bioGUNE y CIC biomaGUNE, dos centros, un objetivo

- Ambos centros de investigación en biociencias y biomateriales cuentan con más de 200 investigadores y han acometido inversiones por valor de 75 M€ desde 2005.- Han obtenido 158 M€ proce...

2012/09/13

Iñigo Urkullu visita las instalaciones de CIC bioGUNE

 El Presidente del Partido Nacionalista Vasco (EAJ-PNV) y candidato a Lehendakari en las próximas elecciones autonómicas del 21 de octubre, Iñigo Urkullu, visitó las instalaciones de CIC bioGUNE el pasado día 11 de septi...

2012/09/12

Pubmed ratings place the CIC bioGUNE Animal Unit's work in the top 10

 The publication "Clinical biochemistry parameters in C57BL/6J mice after blood collection from the submandibular vein and retroorbital plexus" (Fernandez et al., 2010), was the third most downloaded article (1903 hits) of the Journal of the Ame...

2012/09/04

The therapeutic potential of cellular fat oxidation in bone-marrow transplants and...

 - Dr. Arkaitz Carracedo of Biogune takes part in two studies which provide evidence for a crucial role of the PML protein in the regulation of cellular fat oxidation, with important implications in physio-pathological processes

2012/08/20

Burning fat for cellular fitness: friend or foe?

 Fat accumulation and elimination in developed societies is an increasing health and aesthetic concern. But there is more to this process than just the impact of lipid accumulation on the organism. Lipids are one of the most concentrated sources of energy...

2012/08/02

Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA

 Multi-subunit RNA polymerases (RNAPs) in all three domains of life share a common ancestry. The composition of the archaeal RNAP (aRNAP) is not identical between phyla and species, with subunits Rpo8 and Rpo13 found in restricted subsets of archaea. Whil...

2012/07/13

HuR plays a critical role in liver fibrosis development

 Hepatic fibrosis is the common consequence of chronic liver diseases such as viral and autoimmune hepatitis, alcohol consumption, biliary obstruction, and non-alcoholic fatty liver disease. Activation of hepatic stellate cells (HSC) is the key pathogenic...

2012/07/10

Synthetic solutions to combat infections

Biogune researcher, Juan Anguita, in collaboration with scientists of the University of Massachusetts, has proven the efficiency of synthetic antimicrobials. These synthetic compounds have a double effect, on the one hand, they comba...

2012/06/27

Viruses find new ancestors

 - Biogune researchers and scientists from the Universities of Oxford and Helsinki propose a radically different structure-based classification of viruses. - Virus classification has been traditionally based on th...

2012/06/26

CIC bioGUNE to hold exosome expert meeting

 - The meeting will gather the Spanish work group that studies exosomes, formed after the last conference in Gothenburg organised by the International Society for Extracellular Vesicles. The group aims to promote the study of exosomes in the field...

2012/06/04

When fat meets inflammation: NK cells are to blame

 - Researchers from the Center for Cooperative Research in Biosciences, CIC bioGUNE (Bizkaia), led by Dr. Naiara Beraza, have found that NK cells play a key role in promoting liver inflammation at early stages of non-alcoholic steatohepatitis (NAS...

2012/06/04

NK cells are the main contributors to the chronification of liver inflammation in...

 Glycine N-methyltransferase (GNMT) is the key enzyme that catabolizes S-adenosylmethionine (SAMe), the main methyl donor of the body that tightly controls cell growth, apoptosis and proliferation. GNMT is regulated during chronic liver disease. We previo...

2012/05/24

Ugo Mayor, from Funcional Genomic Unit, have collaborated in the book "Ubiquitin...

 Ugo Mayor, from Laboratory 4 at Functional Genomics Unit, have collaborated in the book "Ubiquitin Family Modifiers and the Proteasome" with the chapter titled "Deciphering tissue-specific ubiquitylation by mass spectrometry". 

2012/05/22

New non-invasive test for fatty liver disease diagnosis developed

 - Researchers at Biogune, in collaboration with OWL Genomics, CIBERehd and eleven hospitals and research centres from Spain, France and United States, have developed the first metabolome-based serum test for the non-invasive diagnostic of non-alc...

2012/05/07

Post-transcriptional regulation of Schwann cell development

 Schwann cells are the dominant glia cells in the peripheral nervous system (PNS) and associate with axons in peripheral nerve trunks. These cells control neuronal survival in the embryo, provide myelin that is essential for normal movement and sensation ...

2012/04/16

NASH predictive test

 In collaboration with OWL Genomics, CIBERehd, eleven hospitals and other Research Centers from Spain, France and the United States, our re...

2012/03/20

CIC bioGUNE leads European researcher training project

 - The Basque research Centre is coordinating UPStream, an excellence training programme for young scientists investigating the biochemical process of ubiquitylation and other related modifications - The project, ...

2012/03/19

Our researchers from Laboratory 3 at Proteomics Research Unit, have collaborated...

 Researchers from Laboratory 3 at Proteomics Research Unit, have collaborated in the book "Ubiquitin Family Modifiers and the Proteasome" with the chapter titled "Isolation of Ubiquitylated Proteins Using Tandem Ubiquitin-Binding Entities&...

2012/03/13

Mad rabbit disease

 - Our scientists have shown that rabbits, which were previously thought to be resistant to prion diseases, can also develop such infections. - This research, led by Dr. Joaquín Castilla, has been publishe...

2012/03/13

Mad rabbit disease

 The ability of prions to infect some species and not others is determined by the transmission barrier. This unexplained phenomenon led to the belief that certain species were not susceptible to transmissible spongiform encephalopathies (TSEs) and therefo...

2012/03/07

Metabolomics as a Tool for Preclinical Studies.

 Juan Manuel Falcón will participate in the MS Technology Days organized by Waters Corporation between the days 20th and 21st of March that will take place in Madrid and Barcelona with the speach "Metabolomics as a Tool for Preclinical Studies...

2012/03/01

Extracellular Microvesicles as Biological Source for Biomarker Discovery

Juan Manuel Falcón has participated in the conference "Extracellular Microvesicles as Biological Source for Biomarker Discovery", organized by the Luxembourg Center for System Biology, University of Luxembourg the 29th of February and hosted ...

2012/02/27

Valentine Comaills will defend her PhD thesis on March 2nd

 Valentine Comaills will defend her PhD thesis, entitled "Retinoic acid and estrogen signalling pathways in tamoxifen resistant breast cancer cells", on March 2nd, at 13.00H. The event will take place in 'Salón de grados de la Faculta...

2012/02/27

Women and science

Our research, Edurne Berra, will participate in the fisrt edition of the conference "Women and science".

2012/02/27

The structure of the dimerization domain of the tumor suppressor ING4 reveals the...

 A collaborative work between the groups of Ignacio Palmero (CSIC), Guillermo Montoya (CNIO) and Francisco J Blanco (CIC bioGUNE) shows that the dimerization domain of ING4 forms an antiparallel coiled-coil structure with important implications for chrom...

2012/02/13

A prestigious American foundation will fund research at Biogune into Angelman Syndrome

 The group led by Dr. Ugo Mayor aims to identify the protein substrates responsible for this genetic disorder by using a new strategy for capturing neuronal ubiquitin conjugates in the fruit fly.The March of Dimes Fo...

2012/01/31

Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding...

 According to a study carried out by researchers at CIC bioGUNE (Proteomics Unit and Proteomics Platform), the use of Tandem repeated Ubiquitin Binding Entities (TUBEs) under non-denaturing conditions followed by mass spectrometry analysis to study global...

2012/01/31

New mechanism involved in the development of hepatocellular carcinoma and colon cancer.

 Hepatocellular carcinoma (HCC) is a neoplasm with poor prognosis and represents the fifth most common cancer worldwide. The research team leaded by Dr. M. Luz Martínez-Chantar at the Metabolomics Unit of CICbioGUNE had previously reported that the...

2012/01/13

New therapeutic target to fight liver cancer discovered

 Researchers from the Center for Cooperative Research in Biosciences, CIC bioGUNE (Bizkaia), led by Dr. Maria Luz Martínez Chantar, have found a close relationship between high levels of HuR protein and the malignancy of hepatocellular carc...

2012/01/11

Recently, researchers from the Metabolomics Unit have collaborated in the new book...

 Hepatic differentiation is a complex process that requires the balanced regulation of multiple pathways. Significant advances have been made in understanding the molecular mechanisms that modulate the onset of hepatogenesis, including the regulatory effe...

2012/01/11

Arkaitz Carracedo: searching the keys of cancer

Small interview to one of our researchers in Teknopolis TV show

2011/12/21

CIC bioGUNE researchers, Mikel Valle and Xabier Agirrezabala, have collaborated in...

 Mikel Valle and Xabier Agirrezabala have collaborated in the new book edited by Joachim Frank with the chapter entitled "Structure and dynamics of the ribosome as revealed by cryo-electron microscopy".  About the book: &n...

2011/12/19

First Engineered Human GLTP

 The rational engineering of proteins with desirable properties is an emerging field that relies on structural studies. A research team of CICbioGUNE leaded by Lucy Malinina reported first structure-guided engineering of the lipid binding features of huma...

2011/12/12

Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in...

 Very-low-density lipoprotein (VLDL) secretion provides a mechanism to export triglycerides (TG) from the liver to peripheral tissues, maintaining lipid homeostasis. In non-alcoholic fatty-liver disease (NAFLD) VLDL secretion disturbances are unclear. Res...

2011/11/04

CIC bioGUNE researchers, Ana María Aransay and Naiara Rodríguez-Ezpeleta,...

 Ana María Aransay and Naiara Rodríguez-Ezpeleta, with the collaboration of Michael Hackenberg, have published their...

2011/10/27

Researchers, doctors and health managers analyse prevention challenges in Bilbao

 The conference took place on Thursday 27 October, at the Basque Government's Health Office in Bilbao, and involved two debates - one on "Biomarkers for early diagnosis" and another on "Prevention: evidence and perspectives"...

2011/10/18

The second health innovation cycle will take place on the 27th of october, 2011

The second health innovation cycle, conducted by Fundación Ciencias de la Salud, will take place on the 27th of october, 2011.

2011/10/10

Discovery of a cell mechanism that reduces effectiveness of breast cancer treatment

 - Researchers from Massachusetts General Hospital, Harvard Medical School and CIC bioGUNE discover a complex cell mechanism activated by a protein - HOXB9 - that becomes an obstacle for radiation effectiveness.- The study was rec...

2011/10/10

De novo induction of amyloid-β deposition in vivo

 Alzheimer's disease (AD), the most common type of senile dementia, is associated to the buildup of misfolded amyloid-β (Aβ) in the brain. Although compelling evidences indicate that the misfolding and oligomerization of Aβ is the trigg...

2011/10/05

A new study attributes infectivity to Alzheimer's disease

 - It is still premature to conclude that this type of senile dementia is infectious as, for example, HIV or prion diseases, but indications of its possibl...

2011/09/30

CIC bioGUNE welcomes the presentation of the new season of Teknopolis television show

 This Sunday, October 2, starts the fourteenth season of the science and technology show 'Teknopolis', produced by Elhuyar for Euskal Telebista. The presentation of the new season took place Thurs...

2011/09/26

A consortium of Basque institutions patents a product to foretell drug-related hepatic...

- The project, named LIVERTOX, involves the research centre CIC bioGUNE and the companies Owl Genomics, MD Renal and Faes Farma. It has been funded by the Bizkaia Provincial Council. - In addition to its clinical relevance, hepatotoxi...

2011/09/14

The Center for Cooperative Research in Biosciences, CIC bioGUNE, hosts from 12 to...

  - Leading researchers, including President of the Metabolomics Society, Dr. Robert Hall, will be present at the meeting. - Metabolomics is the latest addition to the "-omics" sciences, which include genomics ...

2011/08/16

Alternate Models of RNA Looping on Nova-1 Protein in Splicing

 Nova proteins are implicated in alternate splicing regulation of specific neuronal genes and expressed exclusively in neurons. Recent issue of journal STRUCTURE (1) reported the results of structural study of Nova-1 that summarized the efforts of eleven ...

2011/07/29

José M Mato appointed as a member of the new Society of CSIC Presidents

 Prof. José M Mato, General Director of CIC bioGUNE and CIC biomaGUNE, has become part of the new Society of CSIC Presidents, an advisory body consisting of all former CSIC Presidents, which was established on 19 July with the aim of improving the ...

2011/07/18

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia...

 Researchers from CICbioGUNE in collaboration with the Max Planck Institute for Biophysical Chemistry have described the first initiation complex for E. coli ribosomes during translation.  The selection of mRNA, of the correct start codon, and of the...

2011/07/14

Prof. Neil Kaplowitz's special lecture available in our Video section

 Interplay of Stress Signaling and Mitochondria in Hepatotoxicity: watch it!

2011/07/07

The activity of SALL transcriptional repressors depends on their HDAC and their SUMOylation...

 The SALL (Spalt-like) family of zinc finger transcription factors is conserved throughout evolution and is involved in fundamental biological processes, including stem cell maintenance and carcinogenesis. In humans, mutations in SALL genes are associated...

2011/07/01

Rapid identification of fluorochrome modification sites in proteins

 Conjugation of a fluorescent dye to the ε-amino groups of protein lysine residues maximizes the detection sensitivity in binding assays or cell imaging. However the evaluation of the homogeneity of the population of the modified molecules and the i...

2011/06/15

Marco Piva will defend his PhD thesis on June 16, 2011 at 11:00, in Salón...

The thesis is entitled: "Implication of breast cancer stem cells in tamoxifen resistance"

2011/06/13

La aecc concede 300.000€ a CIC bioGUNE para impulsar la investigación...

  - La Asociación Española Contra el Cáncer (aecc) y su Junta Provincial de Bizkaia conceden dos becas al centro de investigación vasco, con una dotación de 300.000 euros, en forma de dos convenios de colaboraci&...

2011/05/19

José M Mato receives the prestigious "XLIII Jímenez Díaz...

 -> The award was granted by the Conchita Rábado de Jiménez Díaz Foundation, an institution in which Professor Mato began his scientific activity 40 years ago.-> Nobel Prizes such as Hans A. Krebs, Arthu...

2011/05/19

Macromolecular crowding fails to fold a globular halophilic protein in cells

 Scientists from the Structural Biology Unit in collaboration with researchers of the University of North Carolina at Chapel Hill have investigated the folding of a halophilic globular protein inside the cells by heteronuclear NMR spectroscopy. In vitro, ...

2011/05/02

The metabolism of cancer: Warburg effect mediated by ROS and HIF

 In Cancer cells, the reprogramming of cellular metabolism requires a glycolitic shift that provides the source of lipids, amino acids and nucleic acids needed for tumor progression and proliferation. Critical roles for posttranslational modifications of ...

2011/04/29

miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput...

 We present a new version of miRanalyzer, a web server and stand-alone tool for the detection of known and prediction of new microRNAs in highthroughput sequencing experiments. The new version has been notably improved regarding speed, scope and available...

2011/04/13

Intracellular Rescue of the Uroporphyrinogen III Synthase Activity in Enzymes Carrying...

 In a collaborative effort between the Metabolomics Unit and the Structural Biology Unit, CICbioGUNE researchers have unravelled the mechanism by which the most aggressive mutation found in uroporphyrinogen III synthase enzyme gene produces congenital ery...

2011/04/01

Discovery of a protein that alters the nutrition of breast cancer cells

A study published in the prestigious journal Cancer Cell in March gives us a better understanding of the causes underlying the development of cancer, especially breast cancer, by revealing that the lack or loss of a cell protein known as SIRT3 is involved in t...

2011/03/31

Series of Lectures 2011: Prof. Sir Tom Blundell

Sir Tom Blundell, Professor and Director of Investigation in the Department of Biochemistry of the University of Cambridge (United Kingdom), have explained in a conference organized by CIC bioGUNE and FBBVA in Bilbao, how the knowledge that is being generated ...

2011/03/18

Series of Lectures 2011: Peter H. Seeberger

A bottle of refreshment, a remote control and four dolls are the means that Swiss chemistry Peter Seeberger uses to explain the importance of sugars for the health. Seeberger, university professor of Chemistry Organic in Free University of Berlin, has explaine...

2011/03/17

Nuria Martínez defends her PhD thesis on March 22, 2011

Nuria Martínez will defend her PhD thesis on March 22, 2011, in Salón de Grados de la Facultad de Medicina at University of Basque Country. The thesis is entitled: The Role of Serine/Threonine Kinase Lkb1 In The Proliferation Of Hepatocellular Ca...

2011/03/17

The sirtuin SIRT3 counteracts HIF1A-mediated metabolic reprogramming in cancer

 Researchers at Harvard Medical School in collaboration with a group from CIC bioGUNE reveal a tumor suppressive activity for the deacetylase SIRT3 in the regulation of cancer cell metabolism. SIRT3 is a NAD-dependent sirtuin that modulates the acti...

2011/03/11

Jose Luis Bilbao receives in Leasehold Palace 71 people and 40 companies that participated...

The General Deputy of Bizkaia, Jose Luis Bilbao, has received in the Leasehold Palace 71 people and 40 companies that have participated in the last years in the Aid Program of Bizkaia:xede for the hiring, education, and retaining highly qualified scientists.

2011/03/03

Series of Lectures 2011: José Elguero

First day of Center's Series of Lectures 2011: Química y Salud

2011/02/11

Structural studies of a eukaryotic pore-forming toxin.

 Collaboration between the University of the Basque Country and the Structural Biology Unit in CIC bioGUNE brought some new insights into functioning of a membrane protein. The joint teams report the crystallographic and the membrane-inserted structures o...

2011/02/10

Designed endonucleases in gene therapy for the Bubble Boy syndrome

 A collaborative work from research groups at CIC bioGUNE, CNIO, CRG and Cellectis shows how meganucleases can be tailored to induce homologous recombination in human cells and repair the defective gene causing severe combined immunodeficiency (SCID).

2011/02/08

Oestrogen reduces the aggressiveness of breast cancer

According to a study carried out by researchers at CIC bioGUNE, led by Dr. María Vivanco, oestrogen reduces the proportion of stem cells in breast cancer, and this may correlate with a less aggressive prognosis.

2011/02/03

CIC bioGUNE celebrates its sixth anniversary with a special lecture by Professor...

(Bilbao, 29 January 2011).- On 28th of January, the Centre for Cooperative Research in Biosciences, CIC bioGUNE, commemorated its sixth anniversary with a star guest, Professor Jesús Ávila, a renowned scientist who has accumulated many awards thr...

2011/01/26

Javier Conde Vancells defends his PhD thesis on February 2nd, 2011

Javier Conde Vancells will defend his PhD thesis, entitled "Molecular and Functional Study of Exosome-like Vesicles as a New Source of Non-invasive Biomarkers for Liver Disease", on February 2nd, at 12 o'clock. The event will take place in 'S...

2011/01/20

Prohibiting hepatocytes to lose control

  Hepatocellular carcinoma (HCC) is the most frequent primary malignant tumor type in the liver. Whereas the etiology frequently involves viral infection or alcoholic cirrhosis, it can often be preceded by non-alcoholic steatohepatitis (NASH). Critically...

2011/01/20

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis,...

 Prohibitin 1 is a highly conserved, ubiquitously expressed protein that participates in diverse processes including mitochondrial chaperone interactions, growth and apoptosis. Researchers from the Division of Gastroenterology and Liver Diseases, USC Rese...

2011/01/19

Different DNA binding modes for p53 tumor suppressor

 Tumor suppressor p53 is a transcription factor that plays a central role in cell cycle control, and mutations in the protein are related to nearly 50 % of human tumours. Collaboration between groups of Alan Fersht (MRC) and Mikel Valle (CICbioGUNE) has p...

2011/01/11

New insight into the regulation of neuronal differentiation by Wnt proteins

Researchers from the Cell Biology and Stem Cells Unit and the Genome Analysis Group at CIC bioGUNE have discovered novel functions for two members of the Wnt protein family during neural differentiation of stem cells.

2011/01/11

Two recent publications reveal how cancer-associated mutations in ING1 and ING4 genes...

 Collaborative work between the groups of Ignacio Palmero (Instituto de Investigaciones Biomédicas-CSIC) and Francisco J Blanco (CIC bioGUNE) has unveiled the molecular implications of mutations in two of the tumor suppressors detected in cancers.

2011/01/04

'Teknopolis': De cerca: Ugo Mayor

Aparición en Teknopolis de Ugo Mayor. Teknopolis, programa de divulgación científica emitido en ETB. Teknopolis pretende difundir contenidos científicos de carácter general y realizaciones científico-tecnológica...

2010/12/21

The workshop on patents and their role in knowledge and technology transfer.

The workshop on patents and their role in knowledge and technology transfer took place in CIC bioGUNE on the 17th of December. The meeting was opened by the director of CIC bioGUNE, Jose M. Mato, followed by talks given by Manuel Martín Lomas, director ...

2010/11/29

The First National Conference on Prion Diseases takes place in CIC bioGUNE

Over a hundred experts attended the First National Conference on Prion Diseases which took place in CIC bioGUNE on 25th and 26th of November. The object of the conference was to bring together the professionals involved in the prion reseach on different levels...

2010/11/16

From the lab to the market: patents as vehicles of knowledge's transfer

On the 17th of December, 2010, CIC bioGUNE will host a half day seminar on patents as vehicles of knowledge's transfer. The seminar opens at 9:30 in Atrio of the building 800. Available downloads:

2010/11/16

CIC bioGUNE patents a new system to treat Günter's disease

CIC bioGUNE has patented a new system that can help alleviate the symptoms of a rare, aggressive disease, congenital erythropoietic porphyria, more commonly known as Gunther's disease. The Centre is examining the possibility of developing a new drug that impro...

2010/10/29

Ubiquitination during neural development

Ubiquitination of neuronal proteins is an essential regulatory mechanism of brain function. The failure of this process has been associated with Parkinson's and Alzheimer's diseases. Ubiquitin proteomic studies performed on neuronal cell lines provided interes...

2010/10/18

A novel strategy to isolate ubiquitin conjugates reveals a role of ubiquitination...

Ubiquitination of neuronal proteins is an essential regulatory mechanism of brain function. Its failure is associated with a number of neurodegenerative conditions, including Parkinson's and Alzheimer's diseases. However, isolation of neuronal ubiquitin conjug...

2010/10/06

Joint Workshop UPV/EHU - CIC bioGUNE: Introduction to Tomography Techniques in TEM

UPV/EHU - CIC bioGUNE Joint Workshop on tomography techniques in TEM will take place on 6th of October, at Joxe Mari Korta building, Donostia, and on 7th of October, in building 801's atrium, CIC bioGUNE, Derio. Please see attached files for more informati...

2010/10/05

Estrogen affects the proportion of stem cells in the breast

Researchers from Maria Vivanco's laboratory at Cell Biology and Stem Cells Unit of CIC bioGUNE, in collaboration with clinicians from several hospitals in the Basque country and Cantabria, have recently reported that estrogen reduces the size of the human brea...

2010/10/01

Blood test developed for non-alcoholic fatty liver disease diagnosis

Researchers from the Metabolomics unit at CICbioGUNE-CIBERehd and OWL Genomics Ltd. (Bilbao, Spain) have used metabolomics technology to develop a blood test for non-alcoholic fatty liver disease (NAFLD) diagnosis. This research has been recently published in ...

2010/09/29

Expertos internacionales en Resonancia Magnética Nuclear se dan cita en CIC bioGUNE

Centro de Investigación Cooperativa en Biociencias, CIC bioGUNE, acoge estos días la V Reunión Bienal de Resonancia Magnética (RMN) que organiza la Real Sociedad Española de Química (RSEQ), en la que se darán ci...

2010/09/27

A consortium of Biscayan entities will develop an innovative computer tool to predict...

Participating in the project, called LIVERTOX, are the research centreCIC bioGUNE, the companies Owl Genomics, MD Renal and FaesFarma, which is financed by the Provincial Council of Biscay.Apart from the clinical importance of the project, he...

2010/09/27

Blood test developed for non-alcoholic fatty liver disease diagnosis

The metabolomics-based blood test developed by OWL Genomics andCIC bioGUNE will contribute to the early diagnosis of NASH, whichaffects up to 24% of the US and European population. "This is the first application of a novel experimental approach for...

2010/09/23

Open Day Presentation for MSc students

On Thursday, 23rd of September, CIC bioGUNE will be hosting a group of Master's students from the UPV and University of Cantabria Molecular Biology and Biomedicine course. The students will attend a short talk and will be given a guided tour of CIC bioGUNE lab...

2010/09/22

Critical role of LKB1-Akt pathway activation in the proliferation of hepatocellular...

Researchers from the Metabolomics unit at CICbioGUNE-CIBERehd have recently observed that the enzyme LKB1, which had been initially considered a tumor suppressor, performs the opposite function in hepatocarcinoma cells derived from liver tumors of non-alcoholi...

2010/09/10

Mutations That Cause Neurodegenerative Disorders

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a progressive neuromuscular disease that weakens and eventually destroys motor neurons (components of the nervous system that connect the brain with the skeletal muscles). 4-8 per 10...

2010/09/01

Structural Basis for the Wobbler Mouse Neurodegenerative Disorder

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex: the GARP complex is involved in tethering endosome-derived vesicles to the trans-Golgi network. This study sheds light on two importa...

2010/07/28

Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Fibroblast growth factor 21 (FGF21) is a hepatic protein that plays a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat. Its systemic administration to obese rodents and diabetic monkeys leads to improved glucose ...

2010/07/12

Work-shop Consorcio SICI-Consolider (Spanish Initiative on Ion Channels)

Expertos internacionales debaten en Bilbao sobre los avancesen la investigación en canales iónicos, proteínas que tienen unpapel clave en enfermedades como epilepsia, arritmia,trastornos mentales o cáncer

2010/07/01

Xavier Tadeo Campillo defends his PhD thesis

On 01/07/2010, Xavier Tadeo Campillo from Oscar Millet's lab defended his PhD thesis: CStructural basis for the aminoacids composition of halophilic proteins and its relationship with enzimatic activity and stability. The event took place in Aula Magna Enr...

2010/06/24

Advisory Board visits CIC bioGUNE

The Scientific Advisory Board visited the centre between June 16th and 18th, marking the 5th anniversary of the CIC bioGUNE Research Centre's launch. Professors Richard H. Finnell, Angela Gronenborn, Juan Rodés, Roma Rozen, and Roger M. Burnett took...

2010/06/24

Novel Function and Intracellular Localization of Methionine Adenosyltransferase 2β...

Human methionine adenosyltransferase 2B (MAT2B) gene encodes two major splicing variants, V1 and V2, which are differentially expressed in normal tissues. Both variants are induced in human liver cancer and regulate growth. Researchers from the Division of Gas...

2010/06/23

Liher Imaz presented his Ph.D. thesis on Wednesday, 23rd of June.

Liher Imaz successfully defended his Ph.D. thesis on Wednesday, 23rd of June, at 12 o'clock, in the "Sala Anexa al Paraninfo" at the School of Science and Technology at the Basque Country University (Leioa). The thesis title: Estudio de asociaci&...

2010/06/23

Post-translational modification by sumoylation is crucial to the activity of the...

The Spalt-like (Sall) family of zinc finger transcription factors is conserved throughout evolution and is involved in fundamental biological processes, as well as in embryonic stem cell maintenance. Little is known about the post-translational modifications t...

2010/06/22

The Long History of the European People

    A large proportion of diseases that affect the welfare of human populations have a genetic component. Researchers have put in a vast effort in order to correlate the incidence of a particular disease with a particular gene. Those efforts have been...

2010/06/01

The structure of the cellular stress sensor Gadd45α has been determined by NMR

The Gadd45 nuclear proteins modulate the response of mammalian cells to genetoxic and physiological stress. Gadd45 regulate DNA repair, cell cycle, apoptosis, and modulate tumor formation by interacting with other proteins. Human Gadd45α is predominantly ...

2010/05/25

Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and...

The mechanism underlying prion strain mutation in the absence of nucleic acids remains unresolved. Using susceptible transgenic mice, two prevalent chronic wasting disease (CWD) prion strains were identified - with divergent biological properties but composed ...

2010/05/19

Harvard University and the Pasteur Institute will use CIC bioGUNE technology for...

Several international scientific institutions of wide renown, such as Harvard University and Pasteur Institute have signed collaboration agreements with the Centre for Co-operative Research in Biosciences, CIC bioGUNE. Thanks to this agreement, they will be ab...

2010/05/18

CIC bioGUNE researchers take part in a project to control the prion epidemic affecting...

(Bilbao, 13 May 2010).- Researchers at the Centre for Cooperative Research in Bioscience, CIC bioGUNE, in collaboration with the University of Kentucky (USA), have discovered a new way to control the stability of certain types of prions (the pathogen agents re...

2010/05/11

A large-scale genetic study confirms that Basque people are a homogeneous group distinguishable...

(Bilbao, May 10, 2010).- A new population genetics study coordinated by the Centre for Cooperative Research in Biosciences (CIC bioGUNE) confirms that native Basque population, both in Spanish regions and the French Basque Country, is a genetically homogeneous...

2010/05/07

High-density SNP genotyping detects homogeneity of Spanish and French Basques, and...

Researchers from the Co-operative Research Center, CIC bioGUNE, from the Basque Foundation for Health Innovation and Research and from the Department of Genetics, Physical Anthropology and Animal Physiology of the University of the Basque Country, have present...

2010/05/06

The Crystal Structure of Protein MJ1225 from Methanocaldococcus jannaschii Shows...

In mammals, 5′-AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic serine/threonine kinase subunit (alpha) and two regulatory subunits (beta and gamma). The gamma-subunit senses the intracellular energy status by compe...

2010/04/28

Interacting Pathologies

Workers in Texas and Chile, including Joachin Castilla (who is now at the CIC bioGUNE Institute), have shown a link between the pathological mechanisms of Alzheimer's disease and Prion disease in a mouse model system. A group of human diseases is associated wi...

2010/04/23

CIC bioGUNE y el Instituto Tomás Pascual firman un convenio de colaboración...

(Bilbao, 22 de abril de 2010).- El Centro de Investigación Cooperativa en Biociencias, CIC bioGUNE, y el Instituto Tomás Pascual han firmado un convenio de colaboración con el objetivo de fomentar la formación y difusión del ...

2010/04/22

Researchers from CIC bioGUNE take part in SYSGENET European Network

(Bilbao, 23rd April 2010) - The European Science Foundation (ESF), which belongs to the European Union, with its COST programme (European Co-operation in Science and Technology), approved the creation of the network called SYSGENET (BM0901: European system for...

2010/04/21

Sorting of the Alzhermer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex.

A new Signal-Adaptor Interaction between Alzheimer's Disease Amyloid Precursor Protein and the AP-4 Complex has been published in the March edition of Developmental Cell, with Adriana L Rojas, manager of the macromolecular crystallography platform of CIC b...

2010/04/20

A new link between Alzheimer's and prion diseases.

(Bilbao, March 2010). Researchers from the Co-operative Research Center, CIC bioGUNE, and from the University of Texas Medical School, Houston (USA), discovered a new link between Alzheimer's and prion pathologies, which is based on the misfolding of a pro...

2010/04/16

Molecular cross talk between misfolded proteins in animal models of Alzheimer's...

The work whose results suggest an interaction between Alzheimer's and prion pathologies has been published in the March edition of The Journal of Neuroscience, with Joaquín Castilla, the head of CIC bioGUNE's Prion Lab, as one of the authors. ...

2010/04/01

Bruno Sergio Mafra Simoes defends his PhD thesis.

On 01/04/2010, Bruno Sergio Mafra Simoes from María dM Vivanco's lab defended his PhD thesis: Characterisation of human breast stem/progenitor cells. The event took place in Sala Anexa al Paraninfo, Facultad de Ciencias y Tecnología, UPV/EHU.

2010/03/30

Ciclo en Tierra de Nadie: Conversaciones sobre Ciencias y Letras

El discurso científico se rige, esencialmente por la razón; el humanístico, por el sentimiento. Pero ambos, científicos y humanistas, tienen por objeto común la atención a la Naturaleza y al Hombre. Desde esta postura,...

2010/03/26

New insight into the role of Wnt-11 in prostate cancer

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE and Imperial College London have studied the function of Wnt-11 in prostate cancer. They report that Wnt-11 promotes prostate tumour cell survival, migration and differentiation into neuroend...

2010/03/24

Encuentros científicos Eureka Café - Alimentos transgénicos:...

(Bilbao, 22 de marzo de 2010).- La catedrática de Bioquímica y Biología Molecular de la Universidad del País Vasco (UPV/EHU), Mertxe de Renobales y el presidente de la Asociación por el Derecho a la Salud -Osalde-, Mario Fern...

2010/03/24

Advances in protein quantitation using iTRAQ labeling

Proteomics Platform group at CIC bioGUNE has recently published two papers focused on the methodological aspects of protein quantitation by liquid chromatography coupled to tandem mass spectrometry, using iTRAQ labeling. The work by Casado-Vela et al., (Proteo...

2010/03/22

Basque Business Association's President visits CIC bioGUNE

Mr. Miguel Lazpiur, President of the Basque Business Confederation (Confebask), visited today, 22nd of March, CIC bioGUNE's facilities at the Technological Park of Bizkaia. The Basque businessmen representative has been received in the center by its general di...

2010/03/18

Timing is everything

Current estimates by the World Health Organization indicate that, worldwide, about 1.6 billion (BMI >25 kg/m2) adults are overweight and 400 million are obese (BMI >30 kg/m2), and in developed countries with a westernized style of life about two-thirds o...

2010/03/17

Diagonal-free signals

Members of the NMR Platform and the Structural Biology Unit lead by Tammo Diercks have developed a new pulse sequence that improves the acquisition of spatial restrains (NOEs), a required step during the protein structure determination by NMR spectroscopy. Thi...

2010/03/15

To mutate or not to mutate: that's the question

Palms, fingers and thumbs are not just parts of the human body. They are also terms used to describe the structural elements that make up the catalytic core of fundamental enzymes such as DNA polymerases. These enzymes are present across the three kingdoms of ...

2010/03/05

Bypass of an aromatic amine lesion by Y-family polymerase Dpo4.

An international team of researchers from MSKCC (USA), NYU (USA) and CICbioGUNE reported a detailed insight into the mechanisms by which Dpo4, a member of the Y-family DNA polymerases, bypasses an aromatic amine lesion. To do this, researchers solved crystal s...

2010/03/03

Novel properties of LDL atherogenic particles uncovered by NMR

A team of researchers from CIC bioGUNE and the Hospital de la Santa Creu i Sant Pau, in Barcelona, have measured 2D-NMR spectra of the surface-exposed lysine residues of the apoB-100 protein in both LDL(-) and LDL(+) subfractions. The differences found between...

2010/02/24

A new laboratory at CIC bioGUNE will research the mad cow disease

The Prion Laboratory of the Proteomics Unit of CIC bioGUNE has started its work in the Building 502 in the Bizkaia Technology Park. The main objective of this Laboratory is "to study in depth the transmissible spongiform diseases (TSEs)", explained J...

2010/02/23

DNA replication with a polymerase of Y-family can cause new mutations.

Researchers from CIC bioGUNE, the Spanish Center for Co-operative Research in Biosciences(laboratory of Lucy Malinina), and their colleagues from the Memorial Sloan-Kettering Cancer Center from New York and the University of New York (USA), have found that DNA...

2010/02/16

CIC bioGUNE's 5th Anniversary Presentation file now available

CIC bioGUNE's 5th Anniversary Presentation file is now available for your perusal or download.

2010/02/11

Diagonal-Free 3D/4D HN,HN-TROSY-NOESY-TROSY.

Researchers at the CIC bioGUNE NMR facility have developed a novel NMR method for measuring crucial atomic distances for protein structure determination with unprecedented resolution, coverage and purity. The new diagonal-free 3D/4D HN,HN-TROSY-NOESY-TROSY com...

2010/02/05

Nota de Prensa: CIC bioGUNE, 'buque insignia' de la apuesta vasca por las biociencias

(Derio, 29 de enero de 2010).- El centro de Investigación Cooperativa en Biociencias, CIC bioGUNE, celebra hoy viernes, día 29 de enero, su quinto aniversario desde que fuera inaugurado oficialmente, con una 'carta de presentación' que con...

2010/02/05

Structure of the Tumor Suppressor ING4

The tumor suppressor ING4 regulates gene transcription by recruiting chromatin remodeling complexes to active promoters. A team of CIC bioGUNE researchers has investigated the structure of ING4 and found that it forms dimers in vitro and in vivo. The analysis ...

2010/02/02

5th Anniversary videos

Compilation of short videos from different televisions about our 5th anniversary special conference and also about what's being done in our scientific groups.January 28thOn TVE (TeleNorte)

2010/01/27

Minister of Industry and Minister of Health visit CIC bioGUNE

Basque Minister of Industry (Bernabé Unda), Vice-minister of Industry (Juan Goicolea), Minister of Health (Rafael Bengoa) and Vice-minister of Health (Olga Rivera) visited CIC bioGUNE on Jan 27th, 2010.

2010/01/27

HOXB9 promotes breast cancer progression

Aberrant expression of transcription factors has been implicated in tumorigenesis. Investigators from the Cell Biology and Stem Cells Unit at CIC bioGUNE and groups at Massachusetts General Hospital and Harvard Medical School have shown that HOXB9 is ...

2010/01/22

CIC bioGUNE Platforms Brochure 2009

CIC bioGUNE Platforms Brochure 2009 is now vailable for your perusal. Please see the Press Area or the pdf file below.

2010/01/20

New insight into the regulation of axon growth by GSK-3, a protein kinase implicated...

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE have uncovered a function for the neuron-specific variant of the protein kinase GSK-3. The study is the outcome of a project initially funded by the British Council Researcher Exchange Progra...

2010/01/19

New insights into the regulation of liver de-differentiation, development and human...

HuR/Methyl-HuR and AUF1 provide a post-transcriptional regulatory mechanism of MAT1A and MAT2A, the two isoforms of the MAT enzyme, responsible for the levels of hepatic S-adenosylmethionine.Researchers from the Metabolomics Unit at CICbioGUNE-CIBERehd led by ...

2010/01/04

CIC bioGUNE Annual Report 2009

CIC bioGUNE Annual Report 2009 is now available for download: please see Press Area menu entry or click here to see the pdf file.

2009/12/16

Proteins that 'resist' salt.

Structural Basis for the Aminoacid Composition of Proteins from Halophilic Archea.A group of researchers from CIC bioGUNE, led by Dr. Oscar Millet, has found the answer to one of the mysteries that has been rife in the scientific communi...

2009/12/11

Protein MJ0100: an open-to-closed conformational change in its CBS motif pair.

Binding of 5'-methylthioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair.The group of Alfonso Martínez from the Structural Biology Unit of CIC bioGUNE has recently publi...

2009/12/04

BCAM - CIC bioGUNE Workshop on Cell Population Dynamics takes place on the 4th of...

Cell Population Dynamics - laboratory analysis and mathematical modelling.The workshop, to take place on the 4th of December in BCAM (Basque Center For Applied Mathematics, Bizkaia Technology Park, Building 500) is to bring together some experimental and mathe...

2009/12/03

The Minister of Health visits CIC bioGUNE's Technological Platforms.

Yesterday, December the 2nd, the Minister of Health in the Basque Government, Rafael Bengoa, visited CIC bioGUNE's facilities in the Technological Park of Bizkaia, for the first time since assuming his new role in the Basque Government.

2009/11/18

Illumina workshop at CIC bioGUNE on November 25th.

Illumina workshop will take place in CIC bioGUNE on November 25th ( Atrio 800, 10.30- 13.30 ). Please see the pdf file for the progamme and further information.

2009/11/10

Symantec workshop takes place in CIC bioGUNE on the 10th of November

2009/11/09

Basque Government's Minister of Industry and Innovation Visits CIC bioGUNE

The Minister of Industry and Innovation of the Basque Government, Bernabé Unda, visited today the CIC bioGUNE facilities in the Technological Park of Bizkaia; it was his first official visit to the center since assuming his new position in the Basque Go...

2009/11/03

The role of surface tension in protein stability

The group of Oscar Millet from the Structural Biology Unit of CIC bioGUNE has recently published a study on the influence of the surface tension on protein stability. Specifically, the effect of certain cosolutes (inorganic salts) on protein stability has been...

2009/10/28

CIC bioGUNE and Proteomika create the largest catalogue of proteins from endometrial...

Researchers from the Cooperative Research Centre in Biosciences CIC bioGUNE and from a Basque company Proteomika have published the most comprehensive proteomic characterisation of aspirated endometrial fluid that has been managed so far. This will allow scien...

2009/10/27

Researchers from CIC bioGUNE identify a risk gene that affects regeneration of the liver

Researchers from the Biosciences Co-operative Research Centre, CIC bioGUNE, and the Centre for Networked Biomedical Research into Hepatic and Digestive Diseases (CIBERehd) have discovered that the deficiency of the GNMT gene affects regeneration of the liver a...

2009/10/21

The Deputy Minister of Industry and Innovation Visits CIC bioGUNE

The Deputy Minister for Industry and Innovation in the Basque Government, Pedro Hernandez, visited today the facilities of the Structural Biology Unit, CIC bioGUNE, in Bizkaia Technology Park. He was shown the different technological platforms housed in the bu...

2009/10/07

SGI Roadshow 2009 seminar took place in CIC bioGUNE on the 7th October, 2009

SGI Roadshow 2009 seminar took place in CIC bioGUNE on the 7th October, 2009 between 9:30 and 13:00. Please see the programme for more information. See SGI web site here

2009/10/02

EMBO Reports describes the new tool for capturing ubiquitylated proteins (TUBEs),...

On October the 2nd EMBO Reports published a paper describing new tools to capture ubiquitylated proteins, called TUBEs (Tandem-repeated Ubiquitin Binding E...

2009/09/30

CIC bioGUNE- VICOMTECH joint workshop took place on the 2nd of October, 2009

CIC bioGUNE- VICOMTECH joint workshop held at CIC bioGUNE, on the 2nd of October, 2009.

2009/09/25

Ane Fullaondo defended her doctoral thesis on September 29th, 2009.

Ane Fullaondo from D. Gubb's lab presented her doctoral thesis entitled "The role of Spn42Dd serpin in the innate immune response" on September 29th, 2009. The event took place at UPV/ EHU, Campus Leioa, in the room adjoining 'Paraninfo'.

2009/09/21

Comprehensive proteomic analysis of human endometrial fluid aspirate published by...

The group of Felix Elortza at the Proteomics Platform of CIC bioGUNE has recently published a comprehensive proteomic characterization of the human endometrial fluid from healthy women. The work was carried out in collaboration with Proteomika S.L, with the sa...

2009/09/15

CIC bioGUNE Laboratories are offering the opportunity to undertake Master/PhD studies...

2009/09/15

CIC bioGUNE open day for PhD students took place on September 21st.

Open day for potential PhD students took place in CIC bioGUNE on the 21st of September. After a series of talks delivered by the heads of several of the CIC bioGUNE's laboratories the students took part in a tour of the center's facilities.

2009/09/14

Alzheimer Research Project: sample collection notes

Alzheimer Disease Research Project Sample Collection.We thank all the people who have shown interest in the research project related to Alzheimer Disease carried out by several medical groups (coordinated by the BIOEFFoundation) and CIC bioGUNE. Please note th...

2009/09/10

CIC bioGUNE - FAES FARMA Joint Workshop took place in CIC bioGUNE on September 8th.

FAES FARMA presentations and and CIC bioGUNE presentations were given by the scientists from both centers, following the general introduction talks by José M Mato and María Luisa Lucero. The talks, on variety of topics, were followed by disscusio...