José M Mato
jmmato
José M Mato
GENERAL DIRECTOR
IMI2 Programme
IMI2 Programme
General Director Office &
Precision Medicine and Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)
omillet
Óscar Millet
Principal Investigator
Precision Medicine and Metabolism Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

José M Mato is founder and General Director of the Centers bioGUNE (Bilbao) and biomaGUNE (San Sebastián), and Research Professor of the Spanish National Research Council (CSIC), Spain. A graduate in Biochemistry at the Complutense University of Madrid, Professor Mato received a PhD degree from Leiden University and was awarded the CJ Kok prize for his thesis. He was a postdoctoral fellow at the Biozentrum of the University of Basel and the National Institutes of Health, and a faculty member at the Jiménez Díaz Foundation in Madrid before been named Research Professor at the CSIC. He has been Professor of the Faculty of Medicine of the University of Navarra and Visiting Professor at the University of Pennsylvania and Thomas Jeff erson University. From 1992 to 1996 Professor Mato was President of the CSIC and in 2004 was awarded the Spanish National Research Prize in Medicine.

Latest Publications

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Latest Publications

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I

Gil-Martinez, J;Macias, I;Unione, L;Bernardo-Seisdedos, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Lain, A;Sanz-Parra, A;Mato, JM;Millet, O

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-02-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...

HEPATOLOGY

2020-11-13

S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes

Kilanczyk, E;Banales, JM;Wunsch, E;Barbier, O;Avila, MA;Mato, JM;Milkiewicz, M;Milkiewicz, P

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2020-11-01

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Bruzzone, C;Bizkarguenaga, M;Gil-Redondo, R;Diercks, T;Arana, E;de Vicuna, AG;Seco, M;Bosch, A;Palazon, A;San Juan, I;Lain, A;Gil-Martinez, J;Bernardo-Seisdedos, G;Fernandez-Ramos, D;Lopitz-Otsoa, ...

ISCIENCE

2020-10-23

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

Robinson, AE;Binek, A;Venkatraman, V;Searle, BC;Holewinski, RJ;Rosenberger, G;Parker, SJ;Basisty, N;Xie, XS;Lund, PJ;Saxena, G;Mato, JM;Garcia, BA;Schilling, B;Lu, SC;Van Eyk, JE

JOURNAL OF PROTEOME RESEARCH

2020-10-02

Reciprocal Regulation Between Forkhead Box M1/NF-kappa B and Methionine Adenosyltransferase 1A Drives Liver Cancer

Li, Y;Lu, LQ;Tu, J;Zhang, J;Xiong, T;Fan, W;Wang, JH;Li, M;Chen, YB;Steggerda, J;Peng, H;Chen, YH;Li, TWH;Zhou, ZG;Mato, JM;Seki, E;Liu, T;Yang, HP;Lu, SC

HEPATOLOGY

2020-10-01

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitisviaAMPK and mTOR regulation

Fernandez-Ramos, D;Lopitz-Otsoa, F;Delacruz-Villar, L;Bilbao, J;Pagano, M;Mosca, L;Bizkarguenaga, M;Serrano-Macia, M;Azkargorta, M;Iruarrizaga-Lejarreta, M;Sot, J;Tsvirkun, D;van Liempd, SM;Goni, ...

WORLD JOURNAL OF GASTROENTEROLOGY

2020-09-14

Abnormal concentration of porphyrins in serum from COVID-19 patients

San Juan, I;Bruzzone, C;Bizkarguenaga, M;Bernardo-Seisdedos, G;Lain, A;Gil-Redondo, R;Diercks, T;Gil-Martinez, J;Urquiza, P;Arana, E;Seco, M;de Vicuna, AG;Embade, N;Mato, JM;Millet, O

BRITISH JOURNAL OF HAEMATOLOGY

2020-08-29

PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks

Sundararaman, N;Go, J;Robinson, AE;Mato, JM;Lu, SC;Van Eyk, JE;Venkatraman, V

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

2020-07-01

Protein stability (thermodynamic and kinetic) drives the biophysical properties of the polypeptide chain (protein folding) and the protein's concentration in the cellular environment (protein homeostasis). It is the result of a delicate balance between inter- and intramolecular interactions, which can be easily altered by mutations and/or upon changes in the composition of the surrounding media. In this context, NMR spectroscopy offers a plethora of suitable experiments to investigate protein stability. In our laboratory we are currently interested in the following topics:

  • Pharmacological chaperones. Rare diseases (~7000 identified to date) are an area of significant medical need affecting an estimated 350 million people worldwide, with ~95% having no currently approved drug treatment. They are often produced by inherited mutations affecting the activity of a protein and It is becoming increasily clear that, most frequently, a mutation destabilizes the protein/enzyme, ultimately affecting its intracellular homeostasis. In this context, pharmacological chaperones (small molecules which bind to the protein, restoring stability and activity without affecting its function) can be applied to many diseases. In our laboratory we are investigating new methods (NMR, biophysical and biochemical) for the discovery and characterization of pharmacological chaperones against a set of diseases: congenital eryhtropoietic porphyria, tyrosianemia.
     
  • Environmental modulation of enzyme stability. The high catalytic efficiency and the exquisite enantioselectivity of an enzyme has been employed in some industrial processes to upgrade their properties in order to make them more environmentally-friendly. However, large scale industrial implementation of biotechnological reactions is often limited by the marginal stability of the enzyme in the reactor conditions. In our laboratory we employ NMR and circular dichroism to investigate the effect of external crowding agents to improve the activity and stability of several enzymes. Specifically, we are investigating the mechanism for protein haloadaptation by a combined use of site directed mutagenesis and high-resolution NMR spectroscopy.

Protocolos de Histología

Latest Publications

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I

Gil-Martinez, J;Macias, I;Unione, L;Bernardo-Seisdedos, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Lain, A;Sanz-Parra, A;Mato, JM;Millet, O

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-02-01

Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1

Bertuzzi, S;Gimeno, A;Nunez-Franco, R;Bernardo-Seisdedos, G;Delgado, S;Jimenez-Oses, G;Millet, O;Jimenez-Barbero, J;Arda, A

CHEMISTRY-A EUROPEAN JOURNAL

2020-10-29

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Bruzzone, C;Bizkarguenaga, M;Gil-Redondo, R;Diercks, T;Arana, E;de Vicuna, AG;Seco, M;Bosch, A;Palazon, A;San Juan, I;Lain, A;Gil-Martinez, J;Bernardo-Seisdedos, G;Fernandez-Ramos, D;Lopitz-Otsoa, ...

ISCIENCE

2020-10-23

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP;Oyenarte, I;Diercks, T;Quintana, JI;Gimeno, A;Coelho, H;Diniz, A;Peccati, F;Delgado, S;Bosch, A;Valle, M;Millet, O;Abrescia, NGA;Palazon, A;Marcelo, F;Jimenez-Oses, G;Jimenez-Barbero, ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Abnormal concentration of porphyrins in serum from COVID-19 patients

San Juan, I;Bruzzone, C;Bizkarguenaga, M;Bernardo-Seisdedos, G;Lain, A;Gil-Redondo, R;Diercks, T;Gil-Martinez, J;Urquiza, P;Arana, E;Seco, M;de Vicuna, AG;Embade, N;Mato, JM;Millet, O

BRITISH JOURNAL OF HAEMATOLOGY

2020-08-29

Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity

Millet, O;Cortajarena, AL;Salvatella, X;Kiessling, LL;Jimenez-Barbero, J

ACS CHEMICAL BIOLOGY

2020-07-17

H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...

JOURNAL OF PROTEOME RESEARCH

2020-06-05

An Epoxide Intermediate in Glycosidase Catalysis

Sobala, LF;Speciale, G;Zhu, S;Raich, L;Sannikova, N;Thompson, AJ;Hakki, Z;Lu, D;Abadi, SSK;Lewis, AR;Rojas-Cervellera, V;Bernardo-Seisdedos, G;Zhang, YM;Millet, O;Jimenez-Barbero, J;Bennet, ...

ACS CENTRAL SCIENCE

2020-05-27

Study of the Metabolomics of Equine Preovulatory Follicular Fluid: A Way to Improve Current In Vitro Maturation Media

Fernandez-Hernandez, P;Sanchez-Calabuig, MJ;Garcia-Marin, LJ;Bragado, MJ;Gutierrez-Adan, A;Millet, O;Bruzzone, C;Gonzalez-Fernandez, L;Macias-Garcia, B

ANIMALS

2020-05-01

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

Poveda, JA;Giudici, AM;Renart, ML;Millet, O;Morales, A;Gonzalez-Ros, JM;Oakes, V;Furini, S;Domene, C

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

2019-10-01