José M Mato | CIC bioGUNE | Center for Cooperative Research in Biosciences

José M Mato

José M Mato

GENERAL DIRECTOR

General Director Office & Precision Medicine and Metabolism Lab

Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

José M Mato is founder and General Director of the Centers bioGUNE (Bilbao) and biomaGUNE (San Sebastián), and Research Professor of the Spanish National Research Council (CSIC), Spain. A graduate in Biochemistry at the Complutense University of Madrid, Professor Mato received a PhD degree from Leiden University and was awarded the CJ Kok prize for his thesis. He was a postdoctoral fellow at the Biozentrum of the University of Basel and the National Institutes of Health, and a faculty member at the Jiménez Díaz Foundation in Madrid before been named Research Professor at the CSIC. He has been Professor of the Faculty of Medicine of the University of Navarra and Visiting Professor at the University of Pennsylvania and Thomas Jeff erson University. From 1992 to 1996 Professor Mato was President of the CSIC and in 2004 was awarded the Spanish National Research Prize in Medicine.

Lastest Publications

Methionine Adenosyltransferase alpha 1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression
Murray, B;Peng, H;Barbier-Torres, L;Robinson, AE;Li, TWH;Fan, W;Tomasi, ML;Gottlieb, RA;Van Eyk, J;Lu, ZM;Mart?nez-Chantar, ML;Liangpunsakul, S;Skill, NJ;Mato, JM;Lu, SC
HEPATOLOGY
2019-12-01

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernandez-Tussy, P;Fernandez-Ramos, D;Lopitz-Otsoa, F;Simon, J;Barbier-Torres, L;Gomez-Santos, B;Nunez-Garcia, M;Azkargorta, M;Gutierrez-de Juan, V;Serrano-Macia, M;Rodriguez-Agudo, R;Iruzubieta, ...
MOLECULAR METABOLISM
2019-11-01

Methionine adenosyltransferases in liver cancer
Murray, B;Barbier-Torres, L;Fan, W;Mato, JM;Lu, SC
WORLD JOURNAL OF GASTROENTEROLOGY
2019-08-21

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease
Mato, JM;Alonso, C;Noureddin, M;Lu, SC
WORLD JOURNAL OF GASTROENTEROLOGY
2019-06-28

Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds
Panmanee, J;Bradley-Clarke, J;Mato, JM;O'Neill, PM;Antonyuk, SV;Hasnain, SS
FEBS JOURNAL
2019-06-01

Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis
Reverter, E;Lozano, JJ;Alonso, C;Berzigotti, A;Seijo, S;Turon, F;Baiges, A;Martinez-Chantar, ML;Mato, JM;Martinez-Arranz, I;La Mura, V;Hernandez-Gea, V;Bosch, J;Garcia-Pagan, JC
LIVER INTERNATIONAL
2019-04-01

NEDDylation inhibition as a new potential therapy of nonalcoholic fatty liver disease
Serrano-Macia, M;Azkargorta, M;Simon, J;Otsoa, FL;Delgado, TC;Ramos, DF;de Juan, VG;Varela-Rey, M;Goikoetxea, N;Tussy, PF;Apichueta, P;de Urturi, DS;Buque, X;Iruzubieta, P;Crespo, J;Lu, SC;Mato, ...
JOURNAL OF HEPATOLOGY
2019-04-01

Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD
Ramos, DF;Tussy, PF;Otsoa, FL;Simon, J;Torres, LB;Santos, BG;Nunez, M;Azkargorta, M;de Juan, VG;Serrano-Macia, M;Agudo, RR;Champagne, DG;Iruzubieta, P;Anguita, J;Rincon, M;Elortza, F;Anita, ...
JOURNAL OF HEPATOLOGY
2019-04-01

Aramchol, SCD1 inhibitor, improves liver glucose homeostasis in NASH
Mato, JM;delaCruz-Villar, L;Fernandez-Ramos, D;Lopitz, F;Azkargorta, M;Elortza, F;Iruarrizaga-Lejarreta, M;Alonso, C;Barbier-Torres, L;Lu, SC;Hayardeny, L;Gorfine, T;Sanyal, AJ
JOURNAL OF HEPATOLOGY
2019-04-01

The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers
Yang, JW;Murray, B;Barbier-Torres, L;Liu, T;Liu, ZQ;Yang, HP;Fan, W;Wang, JH;Li, Y;Seki, E;Mato, JM;Lu, SC
THE JOURNAL OF BIOLOGICAL CHEMISTRY
2019-02-08

Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
Blokker, BA;Maijo, M;Echeandia, M;Galduroz, M;Patterson, AM;Ten, A;Philo, M;Schungel, R;Gutierrez-de Juan, V;Halilbasic, E;Fuchs, C;Le Gall, G;Milkiewicz, M;Milkiewicz, P;Banales, JM;Rushbrook, ...
HEPATOLOGY
2019-02-01

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
Zubiete-Franco, I;Garcia-Rodriguez, JL;Lopitz-Otsoa, F;Serrano-Macia, M;Simon, J;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gutierrez-de-Juan, V;de Davalillo, SL;Carlevaris, O;Gomez, ...
EBIOMEDICINE
2019-02-01

Fine tuning of SIRT1 expression is essential to protect the liver from cholestasis
Blokker, B (Blokker, B.); Maijo, M (Maijo, M.); Philo, M (Philo, M.); Gutierrez, V (Gutierrez, V.); Halilbasic, E (Halilbasic, E.); Fuchs, C (Fuchs, C.); Legall, G (Legall, G.); Milkiewicz, ...
JOURNAL OF HEPATOLOGY
2019-04-01

2018

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice
Morrison, MC(Morrison, Martine C.);Verschuren, L(Verschuren, Lars);Salic, K(Salic, Kanita);Verheij, J(Verheij, Joanne);Menke, A(Menke, Aswin);Wielinga, PY(Wielinga, Peter Y.);Iruarrizaga-Lejarreta, ...
HEPATOLOGY COMMUNICATIONS
2018-12-01

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells
Mavila, N(Mavila, Nirmala);Tang, YY(Tang, Yuanyuan);Berlind, J(Berlind, Joshua);Ramani, K(Ramani, Komal);Wang, JH(Wang, Jiaohong);Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
HEPATOLOGY COMMUNICATIONS
2018-12-01

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Fernandez-Ramos, D(Fernandez-Ramos, David);Fernandez-Tussy, P(Fernandez-Tussy, Pablo);Lopitz-Otsoa, F(Lopitz-Otsoa, Fernando);Gutierrez-de-Juan, V(Gutierrez-de-Juan, Virginia);Navasa, N(Navasa, ...
CELL DEATH & DISEASE
2018-09-20

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
Urquiza, P(Urquiza, Pedro);Lain, A(Lain, Ana);Sanz-Parra, A(Sanz-Parra, Arantza);Moreno, J(Moreno, Jorge);Bernardo-Seisdedos, G(Bernardo-Seisdedos, Ganeko);Dubus, P(Dubus, Pierre);Gonzalez, ...
SCIENCE TRANSLATIONAL MEDICINE
2018-09-19

Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer
Liu, T(Liu, Ting);Yang, HP(Yang, Heping);Fan, W(Fan, Wei);Tu, J(Tu, Jian);Li, TWH(Li, Tony W. H.);Wang, JH(Wang, Jiaohong);Shen, H(Shen, Hong);Yang, JW(Yang, JinWon);Xiong, T(Xiong, Ting);Steggerda, ...
GASTROENTEROLOGY
2018-08-01

Use of a metabolomic approach to non-invasively diagnose non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Bril, F(Bril, Fernando);Millan, L(Millan, Laura);Kalavalapalli, S(Kalavalapalli, Srilaxmi);McPhaul, MJ(McPhaul, Michael J.);Caulfield, MP(Caulfield, Michael P.);Martinez-Arranz, I(Martinez-Arranz, ...
DIABETES, OBESITY & METABOLISM
2018-07-01

Metabolomic-Based Noninvasive Serum Test to Diagnose Nonalcoholic Steatohepatitis: Results From Discovery and Validation Cohorts
Mayo, R(Mayo, Rebeca);Crespo, J(Crespo, Javier);Martinez-Arranz, I(Martinez-Arranz, Ibon);Banales, JM(Banales, Jesus M.);Arias, M(Arias, Mayte);Minchole, I(Minchole, Itziar);de la Fuente, RA(Aller ...
HEPATOLOGY COMMUNICATIONS
2018-07-01

The liver-specific deletion of the respiratory chain inhibitor MCJ attenuates NAFLD progression by enhancing hepatic beta-oxidation
Barbier-Torres, L (Barbier-Torres, L.); Delgado, TC (Delgado, T. C.); Iruzubieta, P (Iruzubieta, P.); Ramos, DF (Ramos, D. F.); de Juan, VG (de Juan, V. G.); Varela-Rey, M (Varela-Rey, M.); ...
JOURNAL OF HEPATOLOGY
2018-04-01

Targeting the NAFLD metabolome and the shaping of precision medicine for patients with NASH
Iruarrizaga-Lejarreta, M (Iruarrizaga-Lejarreta, M.); Martinez-Arranz, I (Martinez-Arranz, I.); Morrison, MC (Morrison, M. C.); Varela-Rey, M (Varela-Rey, M.); Ramos, DF (Ramos, D. F.); Delacruz-Villar, ...
JOURNAL OF HEPATOLOGY
2018-04-01

Glutaminase 1 targeting in non-alcoholic steatohepatitis
Simon, J (Simon, J.); Nunez, M (Nunez, M.); Tussy, PF (Tussy, P. F.); Barbier-Torres, L (Barbier-Torres, L.); Ramos, DF (Ramos, D. F.); Santos, BG (Santos, B. G.); Otsoa, FL (Otsoa, F. L.); ...
JOURNAL OF HEPATOLOGY
2018-04-01

Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy
Maldonado, LY(Maldonado, Lauren Y.);Arsene, D(Arsene, Diana);Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
EXPERIMENTAL BIOLOGY AND MEDICINE
2018-01-01

Liver cancer-associated changes to the proteome: what deserves clinical focus?
Mato, JM(Mato, Jose M.);Elortza, F(Elortza, Felix);Lu, SC(Lu, Shelly C.);Brun, V(Brun, Virginie);Paradela, A(Paradela, Alberto);Corrales, FJ(Corrales, Fernando J.)
EXPERT REVIEW OF PROTEOMICS
2018-01-01

2017

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Barbier-Torres, L(Barbier-Torres, Lucia);Iruzubieta, P(Iruzubieta, Paula);Fernandez-Ramos, D(Fernandez-Ramos, David);Delgado, TC(Delgado, Teresa C.);Taibo, D(Taibo, Daniel);Guitierrez-de-Juan, ...
NATURE COMMUNICATIONS
2017-12-12

Role of Aramchol in Steatohepatitis and Fibrosis in Mice
Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, Marta);Varela-Rey, M(Varela-Rey, Marta);Fernandez-Ramos, D(Fernandez-Ramos, David);Martinez-Arranz, I(Martinez-Arranz, Ibon);Delgado, TC(Delgado, ...
HEPATOLOGY COMMUNICATIONS
2017-11-01

A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients
Cano, A(Cano, Ainara);Marino, Z(Marino, Zoe);Millet, O(Millet, Oscar);Martinez-Arranz, I(Martinez-Arranz, Ibon);Navasa, M(Navasa, Miquel);Falcon-Perez, JM(Manuel Falcon-Perez, Juan);Perez-Cormenzana, ...
SCIENTIFIC REPORTS
2017-09-05

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso, C(Alonso, Cristina);Fernandez-Ramos, D(Fernandez-Ramos, David);Varela-Rey, M(Varela-Rey, Marta);Martinez-Arranz, I(Martinez-Arranz, Ibon);Navasa, N(Navasa, Nicolas);Van Liempd, SM(Van ...
GASTROENTEROLOGY
2017-05-01

Prohibitin 1 Suppresses Liver Cancer Tumorigenesis in Mice and Human Hepatocellular and Cholangiocarcinoma Cells
Fan, W(Fan, Wei);Yang, HP(Yang, Heping);Liu, T(Liu, Ting);Wang, JH(Wang, Jiaohong);Li, TWH(Li, Tony W. H.);Mavila, N(Mavila, Nirmala);Tang, YY(Tang, Yuanyuan);Yang, JW(Yang, JinWon);Peng, H(Peng, ...
HEPATOLOGY
2017-04-01

A morphological method for ammonia detection in liver
Gutierrez-de-Juan, V(Gutierrez-de-Juan, Virginia);de Davalillo, SL(Lopez de Davalillo, Sergio);Fernandez-Ramos, D(Fernandez-Ramos, David);Barbier-Torres, L(Barbier-Torres, Lucia);Zubiete-Franco, ...
PLOS ONE
2017-03-20

Deregulated Neddylation in Liver Fibrosis
Zubiete-Franco, I(Zubiete-Franco, Imanol);Fernadez-Tussy, P(Fernandez-Tussy, Pablo);Barbier-Torres, L(Barbier-Torres, Lucia);Simon, J(Simon, Jorge);Fernadez-Ramos, D(Fernandez-Ramos, David);Lopitz-Otsoa, ...
HEPATOLOGY
2017-02-01

Aramchol reduces established fibrosis in MCD diet animal model
Varela-Rey, M(Varela-Rey, M.);Fernandez-Ramos, D(Fernandez-Ramos, D.);Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, M.);Van Liempd, SM(Van Liempd, S. M.);DelaCruz-Villar, L(delaCruz-Villar, ...
JOURNAL OF HEPATOLOGY
2017-01-01

2016

Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes
Ramani, K(Ramani, Komal);Mavila, N(Mavila, Nirmala);Ko, KS(Ko, Kwang Suk);Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
JOURNAL OF BIOLOGICAL CHEMISTRY
2016-11-11

MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease
Lu, SC(Lu, Shelly C.);Mato, JM(Mato, Jose M.);Espinosa-Diez, C(Espinosa-Diez, Cristina);Lamas, S(Lamas, Santiago)
FREE RADICAL BIOLOGY & MEDICINE
2016-11-01

Deregulated Methionine Adenosyltransferase alpha 1, c-Myc, and Maf Proteins Together Promote Cholangiocarcinoma Growth in Mice and Humans
Yang, HP(Yang, Heping);Liu, T(Liu, Ting);Wang, JH(Wang, Jiaohong);Li, TW(Li, Tony W. H.);Fan, W(Fan, Wei);Peng, H(Peng, Hui);Krishnan, A(Krishnan, Anuradha);Gores, GJ(Gores, Gregory J.);Mato, ...
HEPATOLOGY
2016-08-01

Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension
Seijo, S(Seijo, Susana);Lozano, JJ(Jose Lozano, Juan);Alonso, C(Alonso, Cristina);Miquel, R(Miquel, Rosa);Berzigotti, A(Berzigotti, Annalisa);Reverter, E(Reverter, Enric);Turon, F(Turon, Fanny);Martinez-Chantar, ...
LIVER INTERNATIONAL : OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF THE LIVER
2016-07-01

Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum H-1-NMR Spectroscopy
Embade, N(Embade, Nieves);Marino, Z(Marino, Zoe);Diercks, T(Diercks, Tammo);Cano, A(Cano, Ainara);Lens, S(Lens, Sabela);Cabrera, D(Cabrera, Diana);Navasa, M(Navasa, Miquel);Falcon-Perez, JM(Falcon-Perez, ...
PLOS ONE
2016-05-09

Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes
...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2016-02-23

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Zubiete-Franco, I(Zubiete-Franco, Imanol);Garcia-Rodriguez, JL(Garcia-Rodriguez, Juan Luis);Martinez-Una, M(Martinez-Una, Maite);Martinez-Lopez, N(Martinez-Lopez, Nuria);Woodhoo, A(Woodhoo, ...
JOURNAL OF HEPATOLOGY
2016-02-01

Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis
Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
HEPATOLOGY
2016-01-01

2015

Methionine adenosyltransferase alpha 2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells
Tomasi, ML(Tomasi, Maria Lauda);Ryoo, M(Ryoo, Minjung);Ramani, K(Ramani, Komal);Tomasi, I(Tomasi, Ivan);Giordano, P(Giordano, Pasquale);Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
ONCOTARGET
2015-11-10

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Tomasi, ML (Tomasi, Maria Lauda );Ryoo, M (Ryoo, Minjung );Ramani, K (Ramani, Komal );Tomasi, I (Tomasi, Ivan );Giordano, P (Giordano, Pasquale );Mato, JM (Mato, José M );Lu, SC (Lu, ...
ONCOTARGET
2015-11-10

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1
Barbier-Torres, L(Barbier-Torres, Lucia);Beraza, N(Beraza, Naiara);Fernandez-Tussy, P(Fernandez-Tussy, Pablo);Lopitz-Otsoa, F(Lopitz-Otsoa, Fernando);Fernandez-Ramos, D(Fernandez-Ramos, David);Zubiete-Franco, ...
HEPATOLOGY
2015-10-01

Enhancing metabolomics research through data mining
Martinez-Arranz, I(Martinez-Arranz, Ibon);Mayo, R(Mayo, Rebeca);Perez-Cormenzana, M(Perez-Cormenzana, Miriam);Minchole, I(Minchole, Itziar);Salazar, L(Salazar, Lorena);Alonso, C(Alonso, Cristina);Mato, ...
JOURNAL OF PROTEOMICS
2015-09-08

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Gomez-Sanchez, JA(Gomez-Sanchez, Jose A.);Carty, L(Carty, Lucy);Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, Marta);Palomo-Irigoyen, M(Palomo-Irigoyen, Marta);Varela-Rey, M(Varela-Rey, Marta);Griffith, ...
THE JOURNAL OF CELL BIOLOGY
2015-07-06

Data in support of enhancing metabolomics research through data mining
Martinez-Arranz, I(Martinez-Arranz, Ibon);Mayo, R(Mayo, Rebeca);Perez-Cormenzana, M(Perez-Cormenzana, Miriam);Minchole, I(Minchole, Itziar);Salazar, L(Salazar, Lorena);Alonso, C(Alonso, Cristina);Mato, ...
DATA IN BRIEF
2015-06-01

Integrative Genomic Signatures Of Hepatocellular Carcinoma Derived from Nonalcoholic Fatty Liver Disease
Frades, I(Frades, Itziar);Andreasson, E(Andreasson, Erik);Mato, JM(Maria Mato, Jose);Alexandersson, E(Alexandersson, Erik);Matthiesen, R(Matthiesen, Rune);Martinez-Chantar, ML(Martinez-Chantar, ...
PLOS ONE
2015-05-20

A METABOLIC DEFINITION OF NASH AND ITS RESOLUTION BY S-ADENOSYLMETHIONINE IN Mat1a KO MICE
Mato, JM(Mato, J. M.);Fernandez-Ramos, D(Fernandez-Ramos, D.);Martinez-Arranz, I(Martinez-Arranz, I.);Mayo, R(Mayo, R.);van Liempd, SC(van Liempd, S. C.);Sann, H(Sann, H.);Platon, J(Platon, ...
JOURNAL OF HEPATOLOGY
2015-04-01

Methionine Adenosyltransferase 2B-GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells
Peng, H(Peng, Hui);Li, TWH(Li, Tony W. H.);Yang, HP(Yang, Heping);Moyer, MP(Moyer, Mary P.);Mato, JM(Mato, Jose M.);Lu, SC(Lu, Shelly C.)
THE AMERICAN JOURNAL OF PATHOLOGY
2015-04-01

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease
Martinez-Una, M(Martinez-Una, Maite);Varela-Rey, M(Varela-Rey, Marta);Mestre, D(Mestre, Daniela);Fernandez-Ares, L(Fernandez-Ares, Larraitz);Fresnedo, O(Fresnedo, Olatz);Fernandez-Ramos, D(Fernandez-Ramos, ...
JOURNAL OF HEPATOLOGY
2015-03-01

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
Barbier-Torres, L(Barbier-Torres, Lucia);Delgado, TC(Delgado, Teresa C.);Garcia-Rodriguez, JL(Garcia-Rodriguez, Juan L.);Zubiete-Franco, I(Zubiete-Franco, Imanol);Fernandez-Ramos, D(Fernandez-Ramos, ...
ONCOTARGET
2015-02-10

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernandez-Alyarezl, S(Fernandez-Alyarezl, Sara);Gutierrez-de Juan, V(Gutierrez-de Juan, Virginia);Zubiete-Franco, L(Zubiete-Franco, Lmanol);Barbier-Torres, L(Barbier-Torres, Lucia);Lahoz, A(Lahoz, ...
LABORATORY INVESTIGATION; A JOURNAL OF TECHNICAL METHODS AND PATHOLOGY
2015-02-01

Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways
Garcia-Ruiz, C(Garcia-Ruiz, Carmen);Mato, JM(Mato, Jose M.);Vance, D(Vance, Dennis);Kaplowitz, N(Kaplowitz, Neil);Fernandez-Checa, JC(Fernandez-Checa, Jose C.)
JOURNAL OF HEPATOLOGY
2015-01-01

S-Adenosylmethionine and Methylthioadenosine Inhibit beta-Catenin Signaling by Multiple Mechanisms in Liver and Colon Cancer
Li, TWH(Li, Tony W. H.);Peng, H(Peng, Hui);Yang, HP(Yang, Heping);Kurniawidjaja, S(Kurniawidjaja, Steven);Panthaki, P(Panthaki, Parizad);Zheng, YH(Zheng, Yuhua);Mato, JM(Mato, Jose M.);Lu, SC(Lu, ...
MOLECULAR PHARMACOLOGY
2015-01-01

2014

Systems biology for hepatologists.
Mato, Jose M.; Luz Martinez-Chantar, M.; Lu, Shelly C.
HEPATOLOGY
2014-08-01

Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance
Carrasco, Manuel; Rabaneda, Luis G.; Murillo-Carretero, Maribel; Ortega-Martinez, Sylvia; Martinez-Chantar, Maria L.; Woodhoo, Ashwin; Luka, Zigmund; Wagner, Conrad; Lu, Shelly C.; Mato, Jose ...
HIPPOCAMPUS
2014-07-01

Structure and function study of the complex that synthesizes S-adenosylmethionine.
Murray, Ben; Antonyuk, Svetlana V.; Marina, Alberto; Van Liempd, Sebastiaan M.; Lu, Shelly C.; Mato, Jose M.; Hasnain, S. Samar; Rojas, Adriana L.
IUCRJ
2014-07-01

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity.
Rodriguez-Suarez, Eva; Gonzalez, Esperanza; Hughes, Chris; Conde-Vancells, Javier; Rudella, Andrea; Royo, Felix; Palomo, Laura; Elortza, Felix; Lu, Shelly C.; Mato, Jose M.; Vissers, Johannes ...
JOURNAL OF PROTEOMICS
2014-05-30

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Garcia-Rodriguez, Juan L.; Barbier-Torres, Lucia; Fernandez-Alvarez, Sara; Gutierrez-de Juan, Virginia; Monte, Maria J.; Halilbasic, Emina; Herranz, Daniel; Alvarez, Luis; Aspichueta, Patricia; ...
HEPATOLOGY
2014-05-01

S-adenosylmethionine levels regulate the schwann cell DNA methylome.
Varela-Rey, Marta; Iruarrizaga-Lejarreta, Marta; Jose Lozano, Juan; Maria Aransay, Ana; Fernandez, Agustin F.; Luis Lavin, Jose; Mosen-Ansorena, David; Berdasco, Maria; Turmaine, Marc; Luka, ...
NEURON
2014-03-05

Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells (vol 288, pg 23161, 2013)
Yang, Heping; Zheng, Yuhua; Li, Tony W. H.; Peng, Hui; Fernandez-Ramos, David; Martinez-Chantar, Maria L.; Rojas, Adriana L.; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF BIOLOGICAL CHEMISTRY
2014-01-10

Surfing Transcriptomic Landscapes. A Step beyond the Annotation of Chromosome 16 Proteome
Segura, Victor; Alberto Medina-Aunon, Juan; Mora, Maria I.; Martinez-Bartolome, Salvador; Abian, Joaquin; Aloria, Kerman; Antunez, Oreto; Arizmendi, Jesus M.; Azkargorta, Mikel; Barcelo-Batllori, ...
JOURNAL OF PROTEOME RESEARCH
2014-01-01

2013

Excess S-adenosylmethionine Reroutes Phosphatidylethanolamine Towards Phosphatidylcholine and Triglyceride Synthesis
Martinez-Una, Maite; Varela-Rey, Marta; Cano, Ainara; Fernandez-Ares, Larraitz; Beraza, Naiara; Aurrekoetxea, Igor; Martinez-Arranz, Ibon; Garcia-Rodriguez, Juan L.; Buque, Xabier; Mestre, Daniela; ...
HEPATOLOGY
2013-10-01

Methionine Adenosyltransferase 2B, HuR, and Sirtuin 1 Protein Cross-talk Impacts on the Effect of Resveratrol on Apoptosis and Growth in Liver Cancer Cells
Yang, Heping; Zheng, Yuhua; Li, Tony W. H.; Peng, Hui; Fernandez-Ramos, David; Martinez-Chantar, Maria L.; Rojas, Adriana L.; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF BIOLOGICAL CHEMISTRY
2013-08-09

A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma
Huidobro, Covadonga; Torano, Estela G.; Fernandez, Agustin F.; Urdinguio, Rocio G.; Rodriguez, Ramon M.; Ferrero, Cecilia; Martinez-Camblor, Pablo; Boix, Loreto; Bruix, Jordi; Luis Garcia-Rodriguez, ...
JOURNAL OF MOLECULAR MEDICINE-JMM
2013-08-01

Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer
Tomasi, Maria Lauda; Ryoo, Minjung; Skay, Anna; Tomasi, Ivan; Giordano, Pasquale; Mato, Jose M.; Lu, Shelly C.
EXPERIMENTAL CELL RESEARCH
2013-07-15

A fast method for the quantitation of key metabolites of the methionine pathway in liver tissue by high-resolution mass spectrometry and hydrophilic interaction ultra-performance liquid chromatography
van Liempd, S.; Cabrera, D.; Mato, J. M.; Falcon-Perez, J. M.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2013-06-01

Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension
Seijo, Susana; Jose Lozano, Juan; Alonso, Cristina; Reverter, Enric; Miquel, Rosa; Abraldes, Juan G.; Luz Martinez-Chantar, Maria; Garcia-Criado, Angeles; Berzigotti, Annalisa; Castro, Azucena; ...
AMERICAN JOURNAL OF GASTROENTEROLOGY
2013-06-01

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer
Peng, Hui; Dara, Lily; Li, Tony W. H.; Zheng, Yuhua; Yang, Heping; Tomasi, Maria Lauda; Tomasi, Ivan; Giordano, Pasquale; Mato, Jose M.; Lu, Shelly C.
HEPATOLOGY
2013-06-01

Non-invasive detection of drug toxicity in rats by solid-phase extraction and MALDI-TOF analysis of urine samples
Iloro, Ibon; Gonzalez, Esperanza; Gutierrez-de Juan, Virginia; Mato, Jose M.; Falcon-Perez, Juan M.; Elortza, Felix
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2013-03-01

Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease
Vazquez-Chantada, Mercedes; Gonzalez-Lahera, Aintzane; Martinez-Arranz, Ibon; Garcia-Monzon, Carmelo; Regueiro, Manuela M.; Garcia-Rodriguez, Juan L.; Schlangen, Karin A.; Mendibil, Inaki; Rodriguez-Ezpeleta, ...
HEPATOLOGY
2013-02-01

A metabolic signature predicts biological age in mice
Tomas-Loba, Antonia; Bernardes de Jesus, Bruno; Mato, Jose M.; Blasco, Maria A.
AGING CELL
2013-02-01

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma
Yang, Heping; Cho, Michele E.; Li, Tony W. H.; Peng, Hui; Ko, Kwang Suk; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF CLINICAL INVESTIGATION
2013-01-01

Spanish Human Proteome Project: Dissection of Chromosome 16
Segura, V.; Medina-Aunon, J. A.; Guruceaga, E.; Gharbi, S. I.; Gonzalez-Tejedo, C.; Sanchez del Pino, M. M.; Canals, F.; Fuentes, M.; Ignacio Casal, J.; Martinez-Bartolome, S.; Elortza, F.; ...
JOURNAL OF PROTEOME RESEARCH
2013-01-01

2012

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity
Gonzalez, Esperanza; van Liempd, Sebastiaan; Conde-Vancells, Javier; Gutierrez-de Juan, Virginia; Perez-Cormenzana, Miriam; Mayo, Rebeca; Berisa, Agustin; Alonso, Cristina; Marquez, Cesar A.; ...
METABOLOMICS
2012-12-01

Assays for Methionine gamma-Lyase and S-Adenosyl-L-homocysteine Hydrolase Based on Enzymatic Formation of CdS Quantum Dots in Situ
Saa, Laura; Mato, Jose M.; Pavlov, Valeri
ANALYTICAL CHEMISTRY
2012-11-06

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
Woodhoo, Ashwin; Iruarrizaga-Lejarreta, Marta; Beraza, Naiara; Garcia-Rodriguez, Juan L.; Embade, Nieves; Fernandez-Ramos, David; Martinez-Lopez, Nuria; Gutierrez-De Juan, Virginia; Arteta, ...
HEPATOLOGY
2012-11-01

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
von Montfort, Claudia; Matias, Nuria; Fernandez, Anna; Fucho, Raquel; Conde de la Rosa, Laura; Luz Martinez-Chantar, Maria; Mato, Jose M.; Machida, Keigo; Tsukamoto, Hidekazu; Murphy, Michael ...
JOURNAL OF HEPATOLOGY
2012-10-01

S-ADENOSYLMETHIONINE IN LIVER HEALTH, INJURY, AND CANCER
Lu, Shelly C.; Mato, Jose M.
PHYSIOLOGICAL REVIEWS
2012-10-01

Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1
Martinez-Lopez, Nuria; Garcia-Rodriguez, Juan L.; Varela-Rey, Marta; Gutierrez, Virginia; Fernandez-Ramos, David; Beraza, Naiara; Aransay, Ana M.; Schlangen, Karin; Jose Lozano, Juan; Aspichueta, ...
GASTROENTEROLOGY
2012-09-01

S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers
Tomasi, Maria Lauda; Tomasi, Ivan; Ramani, Komal; Pascale, Rosa Maria; Xu, Jun; Giordano, Pasquale; Mato, Jose M.; Lu, Shelly C.
HEPATOLOGY
2012-09-01

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase
Gomez-Santos, Laura; Luka, Zigmund; Wagner, Conrad; Fernandez-Alvarez, Sara; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.; Beraza, Naiara
HEPATOLOGY
2012-08-01

Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine
Schroeder, Paul C.; Fernandez-Irigoyen, Joaquin; Bigaud, Emilie; Serna, Antonio; Renandez-Alcoceba, Ruben; Lu, Shelly C.; Mato, Jose M.; Prieto, Jesus; Corrales, Fernando J.
JOURNAL OF PROTEOMICS
2012-06-06

Magnetic superspace groups and symmetry constraints in incommensurate magnetic phases
Perez-Mato, J. M.; Ribeiro, J. L.; Petricek, V.; Aroyo, M. I.
JOURNAL OF PHYSICS-CONDENSED MATTER
2012-04-25

The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development
Iruarrizaga-Lejarreta, Marta; Varela-Rey, Marta; Jose Lozano, Juan; Fernandez-Ramos, David; Rodriguez-Ezpeleta, Naiara; Embade, Nieves; Lu, Shelly C.; van der Kraan, Peter M.; Davidson, Esmeralda ...
JOURNAL OF NEUROSCIENCE
2012-04-04

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Embade, Nieves; Fernandez-Ramos, David; Varela-Rey, Marta; Beraza, Naiara; Sini, Marcella; Gutierrez de Juan, Virginia; Woodhoo, Ashwin; Martinez-Lopez, Nuria; Rodriguez-Iruretagoyena, Begona; ...
HEPATOLOGY
2012-04-01

Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression
Barr, J.; Caballeria, J.; Martinez-Arranz, I.; Dominguez-Diez, A.; Alonso, C.; Muntane, J.; Perez-Cormenzana, M.; Garcia-Monzon, C.; Mayo, R.; Martin-Duce, A.; Romero-Gomez, M.; Lo Iacono, O.; ...
JOURNAL OF PROTEOME RESEARCH
2012-04-01

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation
Tomasi, Maria Lauda; Li, Tony W. H.; Li, Mei; Mato, Jose M.; Lu, Shelly C.
JOURNAL OF CELLULAR PHYSIOLOGY
2012-04-01

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice
Li, Tony W. H.; Yang, Heping; Peng, Hui; Xia, Meng; Mato, Jose M.; Lu, Shelly C.
CARCINOGENESIS
2012-02-01

2011

Methionine Adenosyltransferase 1A Gene Deletion Disrupts Hepatic Very Low-Density Lipoprotein Assembly in Mice
Cano, Ainara; Buque, Xabier; Martinez-Una, Maite; Aurrekoetxea, Igor; Menor, Ariane; Garcia-Rodriguez, Juan L.; Lu, Shelly C.; Luz Martinez-Chantar, M.; Mato, Jose M.; Ochoa, Begona; Aspichueta, ...
HEPATOLOGY
2011-12-01

Where Are We in the Search for Noninvasive Nonalcoholic Steatohepatitis Biomarkers?
Mato, Jose M.; Lu, Shelly C.
HEPATOLOGY
2011-10-01

A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma
Schroeder, Paul C.; Segura, Victor; Ignacio Riezu, Jose; Sangro, Bruno; Mato, Jose M.; Prieto, Jesus; Santamaria, Enrique; Corrales, Fernando J.
FUNCTIONAL & INTEGRATIVE GENOMICS
2011-09-01

HIGH-FREQUENCY ULTRASOUND IMAGING FOR LONGITUDINAL EVALUATION OF NON-ALCOHOLIC FATTY LIVER DISEASE PROGRESSION IN MICE
Fernandez-Dominguez, Itziar; Javier Echevarria-Uraga, J.; Gomez, Nieves; Luka, Zigmund; Wagner, Conrad; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.; Rodriguez-Cuesta, Juan
ULTRASOUND IN MEDICINE AND BIOLOGY
2011-07-01

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells
Yang, Heping; Li, Tony W. H.; Peng, Jian; Mato, Jose M.; Lu, Shelly C.
BIOCHEMICAL JOURNAL
2011-06-01

The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: An Adaptation to the Warburg Effect?
Mato, Jose M.; Lu, Shelly C.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
2011-05-01

Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration
Varela-Rey, Marta; Beraza, Naiara; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, Maria L.
EXPERIMENTAL BIOLOGY AND MEDICINE
2011-04-01

A HUNDRED YEARS OF VITAMINS
Ma Mato, Jose
ARBOR-CIENCIA PENSAMIENTO Y CULTURA
2011-01-01

Tribute Letters to Salvador de Aza Salvador de Aza, Vicepresident of the CSIC
Maria Mato, Jose; Martin-Lomas, Manuel
BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO
2011-01-01

2010

Liver-Specific Deletion of Prohibitin 1 Results in Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice
Ko, Kwang Suk; Tomasi, Maria Lauda; Iglesias-Ara, Ainhoa; French, Barbara A.; French, Samuel W.; Romani, Komal; Jose Lozano, Juan; Oh, Pilsoo; He, Lina; Stiles, Bangyan L.; Li, Tony W. H.; Yang, ...
HEPATOLOGY
2010-12-01

Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma from Nonalcoholic Steatohepatitis
Martinez-Lopez, Nuria; Varela-Rey, Marta; Fernandez-Ramos, David; Woodhoo, Ashwin; Vazquez-Chantada, Mercedes; Embade, Nieves; Espinosa-Hevia, Luis; Javier Bustamante, Francisco; Parada, Luis ...
HEPATOLOGY
2010-11-01

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients
Bertola, Adeline; Bonnafous, Stephanie; Anty, Rodolphe; Patouraux, Stephanie; Saint-Paul, Marie-Christine; Iannelli, Antonio; Gugenheim, Jean; Barr, Jonathan; Mato, Jose M.; Le Marchand-Brustel, ...
PLOS ONE
2010-10-22

Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease
Barr, Jonathan; Vazquez-Chantada, Mercedes; Alonso, Cristina; Perez-Cormenzana, Miriam; Mayo, Rebeca; Galan, Asier; Caballeria, Juan; Martin-Duce, Antonio; Tran, Albert; Wagner, Conrad; Luka, ...
JOURNAL OF PROTEOME RESEARCH
2010-09-01

Fatty Liver and Fibrosis in Glycine N-Methyltransferase Knockout Mice Is Prevented by Nicotinamide
Varela-Rey, Marta; Martinez-Lopez, Nuria; Fernandez-Ramos, David; Embade, Nieves; Calvisi, Diego F.; Woodhoo, Aswhin; Rodriguez, Juan; Fraga, Mario F.; Julve, Josep; Rodriguez-Millan, Elisabeth; ...
HEPATOLOGY
2010-07-01

HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis
Vazquez-Chantada, Mercedes; Fernandez-Ramos, David; Embade, Nieves; Martinez-Lopez, Nuria; Varela-Rey, Marta; Woodhoo, Ashwin; Luka, Zigmund; Wagner, Conrad; Anglim, Paul P.; Finnell, Richard ...
GASTROENTEROLOGY
2010-05-01

Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice
Li, Jiaping; Ramani, Komal; Sun, Zhanfeng; Zee, Chishing; Grant, Edward G.; Yang, Heping; Xia, Meng; Oh, Pilsoo; Ko, Kwangsuk; Mato, Jose M.; Lu, Shelly C.
AMERICAN JOURNAL OF PATHOLOGY
2010-05-01

Overview of extracellular microvesicles in drug metabolism
Conde-Vancells, Javier; Gonzalez, Esperanza; Lu, Shelly C.; Mato, Jose M.; Falcon-Perez, Juan M.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
2010-05-01

Sub-proteome approach to the knowledge of liver
Falcon-Perez, Juan M.; Lu, Shelly C.; Mato, Jose M.
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples
Conde-Vancells, Javier; Rodriguez-Suarez, Eva; Gonzalez, Esperanza; Berisa, Agustin; Gil, David; Embade, Nieves; Valle, Mikel; Luka, Zigmund; Elortza, Felix; Wagner, Conrad; Lu, Shelly C.; Mato, ...
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

Non-alcoholic fatty liver disease proteomics
Rodriguez-Suarez, Eva; Duce, Antonio M.; Caballeria, Juan; Martinez Arrieta, Felix; Fernandez, Estefania; Gomara, Carolina; Alkorta, Nere; Ariz, Usue; Luz Martinez-Chantar, M.; Lu, Shelly C.; ...
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice
Martinez-Chantar, M. L.; Lu, S. C.; Mato, J. M.; Luka, Z.; Wagner, C.; French, B. A.; French, S. W.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
2010-04-01

Changes in the Expression of Methionine Adenosyltransferase Genes and S-Adenosylmethionine Homeostasis During Hepatic Stellate Cell Activation
Ramani, Komal; Yang, Heping; Kuhlenkamp, John; Tomasi, Lauda; Tsukamoto, Hidekazu; Mato, Jose M.; Lu, Shelly C.
HEPATOLOGY
2010-03-01

Binding of S-Methyl-5 '-Thioadenosine and S-Adenosyl-L-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair
Lucas, Maria; Antonio Encinar, Jose; Astigarraga Arribas, Egoitz; Oyenarte, Iker; Gomez Garcia, Inmaculada; Kortazar, Danel; Fernandez, Jose A.; Mato, Jose M.; Luz Martinez-Chantar, Maria; Alfonso ...
JOURNAL OF MOLECULAR BIOLOGY
2010-02-26

2009

Purification, crystallization and preliminary crystallographic analysis of protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homologue of gamma-AMPK
Gomez Garcia, Inmaculada; Kortazar, Danel; Oyenarte, Iker; Maria Mato, Jose; Luz Martinez-Chantar, Maria; Alfonso Martinez-Cruz, Luis
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2009-08-01

Impaired Liver Regeneration in Mice Lacking Glycine N-Methyltransferase
Varela-Rey, Marta; Fernandez-Ramos, David; Martinez-Lopez, Nuria; Embade, Nieves; Gomez-Santos, Laura; Beraza, Naiara; Vazquez-Chantada, Mercedes; Rodriguez, Juan; Luka, Zigmund; Wagner, Conrad; ...
HEPATOLOGY
2009-08-01

S-Adenosylmethionine in the Chemoprevention and Treatment of Hepatocellular Carcinoma in a Rat Model
Lu, Shelly C.; Ramani, Komal; Ou, Xiaopeng; Lin, Mark; Yu, Victor; Ko, Kwangsuk; Park, Ryan; Bottiglieri, Teodoro; Tsukamoto, Hidekazu; Kanel, Gary; French, Samuel W.; Mato, Jose M.; Moats, ...
HEPATOLOGY
2009-08-01

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells
Li, Tony W. H.; Zhang, Qingsong; Oh, Pilsoo; Xia, Meng; Chen, Hui; Bemanian, Sean; Lastra, Natalie; Circ, Magda; Moyer, Mary Pat; Mato, Jose M.; Aw, Tak Yee; Lu, Shelly C.
MOLECULAR PHARMACOLOGY
2009-07-01

Hepatocellular carcinoma in GNMT-/- mice
Wagner, Conrad; Luka, Zigmund; Mato, Jose M.
TOXICOLOGY AND APPLIED PHARMACOLOGY
2009-06-01

Phenotypic Differences Between Two Gnmt-/- Mouse Models for Hepatocellular Carcinoma Reply
Luka, Zigmund; Luz Martinez-Chantar, M.; Lu, Shelly C.; Wager, Conrad; Mato, Jose M.
HEPATOLOGY
2009-06-01

Non-alcoholic steatohepatitis and animal models: Understanding the human disease
Varela-Rey, Marta; Embade, Nieves; Ariz, Usue; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, M. Luz
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2009-05-01

CD133(+) Liver Cancer Stem Cells from Methionine Adenosyl Transferase 1A-Deficient Mice Demonstrate Resistance to Transforming Growth Factor (TGF)-beta-Induced Apoptosis
Ding, Wei; Mouzaki, Marialena; You, Hanning; Laird, Joshua C.; Mato, Jose; Lu, Shelly C.; Rountree, C. Bart
HEPATOLOGY
2009-04-01

The CBS Domain Protein MJ0729 of Methanocaldococcus jannaschii Is a Thermostable Protein with a pH-Dependent Self-Oligomerization
Alfonso Martinez-Cruz, Luis; Encinar, Jose A.; Kortazar, Danel; Prieto, Jesus; Gomez, Javier; Fernandez-Millan, Pablo; Lucas, Maria; Astigarraga Arribas, Egoitz; Andres Fernandez, Jose; Luz ...
BIOCHEMISTRY
2009-03-31

S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis
Tomasi, Maria Lauda; Iglesias-Ara, Ainhoa; Yang, Heping; Ramani, Komal; Feo, Francesco; Pascale, Maria Rosa; Luz Martinez-Chantar, M.; Mato, Jose M.; Lu, Shelly C.
GASTROENTEROLOGY
2009-03-01

Evidence for LKB1/AMP-Activated Protein Kinase/Endothelial Nitric Oxide Synthase Cascade Regulated by Hepatocyte Growth Factor, S-Adenosylmethionine, and Nitric Oxide in Hepatocyte Proliferation
Vazquez-Chantada, Mercedes; Ariz, Usue; Varela-Rey, Marta; Embade, Nieves; Martinez-Lopez, Nuria; Fernandez-Ramos, David; Gomez-Santos, Laura; Lamas, Santiago; Lu, Shelly C.; Luz Martinez-Chantar, ...
HEPATOLOGY
2009-02-01

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
Lara, E.; Mai, A.; Calvanese, V.; Altucci, L.; Lopez-Nieva, P.; Martinez-Chantar, M. L.; Varela-Rey, M.; Rotili, D.; Nebbioso, A.; Ropero, S.; Montoya, G.; Oyarzabal, J.; Velasco, S.; Serrano, ...
ONCOGENE
2009-02-01

2008

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
Conde-Vancells, Javier; Rodriguez-Suarez, Eva; Embade, Nieves; Gil, David; Matthiesen, Rune; Valle, Mikel; Elortza, Felix; Lu, Shelly C.; Mato, Jose M.; Falcon-Perez, Juan M.
JOURNAL OF PROTEOME RESEARCH
2008-12-01

Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100
Lucas, Maria; Kortazar, Danel; Astigarraga, Egoitz; Fernandez, Jose A.; Mato, Jose M.; Martinez-Chantar, Maria Luz; Martinez-Cruz, Luis Alfonso
ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
2008-10-01

S-adenosylmethionine and proliferation: new pathways, new targets
Martinez-Lopez, Nuria; Varela-Rey, Marta; Ariz, Usue; Embade, Nieves; Vazquez-Chantada, Mercedes; Fernandez-Ramos, David; Gomez-Santos, Laura; Lu, Shelly C.; Mato, Jose M.; Martinez-Chantar, ...
BIOCHEMICAL SOCIETY TRANSACTIONS
2008-10-01

Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice
Ko, Kwangsuk; Yang, Heping; Noureddin, Mazen; Iglesia-Ara, Ainhoa; Xia, Meng; Wagner, Conrad; Luka, Zigmund; Mato, Jose M.; Lu, Shelly C.
LABORATORY INVESTIGATION
2008-10-01

Report of the 9th HLPP Workshop - October 2007, Seoul, Korea
Zheng, Junjie; Gaol, Xue; Mato, Jose; Beretta, Laura; He, Fuchu
PROTEOMICS
2008-09-01

Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii
Fernandez-Millan, Pablo; Kortazar, Danel; Lucas, Maria; Martinez-Chantar, Maria Luz; Astigarraga, Egoitz; Fernandez, Jose Andres; Sabas, Olatz; Albert, Armando; Mato, Jose M.; Martinez-Cruz, ...
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
2008-07-01

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Martinez-Chantar, M. Luz; Vazquez-Chantada, Mercedes; Ariz, Usue; Martinez, Nuria; Varela, Marta; Luka, Zigmund; Capdevila, Antonieta; Rodriguez, Juan; Aransay, Ana M.; Matthiesen, Rune; Yang, ...
HEPATOLOGY
2008-04-01

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
Rountree, C. Bart; Senadheera, Shantha; Mato, Jose M.; Crooks, Gay M.; Lu, Shelly C.
HEPATOLOGY
2008-04-01

S-Adenosylmethionine in cell growth, apoptosis and liver cancer
Lu, Shelly C.; Mato, Jose M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2008-03-01

Methionine metabolism and liver disease
Mato, Jose M.; Martinez-Chantar, M. Luz; Lu, Shelly C.
ANNUAL REVIEW OF NUTRITION
2008-01-01

2007

Genetic Polymorphisms in the Methylenetetrahydrofolate reductase and Thymidylate synthase genes and risk of hepatocellular carcinoma
Yuan, Jian-Min; Lu, Shelly C.; Van den Berg, David; Govindarajan, Sugantha; Zhang, Zhen-Quan; Mato, Jose M.; Yu, Mimi C.
HEPATOLOGY
2007-09-01

Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells
Chen, Hui; Xia, Meng; Lin, Mark; Yang, Heping; Kuhlenkamp, John; Li, Tony; Sodir, Nicole M.; Chen, Yong-Heng; Josef-Lenz, Heinz; Laird, Peter W.; Clarke, Steven; Mato, Jose M.; Lu, Shelly C.
GASTROENTEROLOGY
2007-07-01

Role of S-adenosyl-L-methionine in liver health and injury
Mato, Jose M.; Lu, Shelly C.
HEPATOLOGY
2007-05-01

The 2006 Human Liver Proteome Project (HLPP) Workshops
Mato, Jose M.; He, Fuchu; Beretta, Laura
PROTEOMICS CLINICAL APPLICATIONS
2007-05-01

Identification of a gene-pathway associated with non-alcoholic steatohepatitis
Rubio, Angel; Guruceaga, Elizabeth; Vazquez-Chantada, Mercedes; Sandoval, Juan; Martinez-Cruz, L. Alfonso; Segura, Victor; Sevilla, Jose L.; Podhorski, Adam; Corrales, Fernando J.; Torres, Luis; ...
JOURNAL OF HEPATOLOGY
2007-04-01

Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionline and methylthioadenosine
Ou, Xiaopeng; Yang, Heping; Ramani, Komal; Ara, Ainhoa Iglesias; Chen, Hui; Mato, Jose M.; Lu, Shelly C.
BIOCHEMICAL JOURNAL
2007-01-01

Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells
Rodriguez, Jose L.; Boukaba, Abdelhalim; Sandoval, Juan; Georgieva, Elena I.; Latasa, M. Ujue; Garcia-Trevijano, Elena R.; Serviddio, Gaetano; Nakamura, Toshikazu; Avila, Matias A.; Sastre, ...
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2007-01-01

2006

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
Lu, Shelly C.; Martinez-Chantar, M. Luz; Mato, Jose M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2006-10-01

Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
Rodriguez, Jose L.; Sandoval, Juan; Serviddio, Gaetano; Sastre, Juan; Morante, Maria; Perrell, Maria-Giulia; Martinez-Chantar, Maria L.; Vina, Jose; Vina, Juan R.; Mato, Jose M.; Avila, Matias ...
BIOCHEMICAL JOURNAL
2006-09-15

S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase
Martinez-Chantar, Maria L.; Vazquez-Chantada, Mercedes; Garnacho, Marta; Latasa, M. Ujue; Varela-Rey, Marta; Dotor, Javier; Santamaria, Monica; Martinez-Cruz, Luis A.; Parada, Luis A.; Lu, Shelly ...
GASTROENTEROLOGY
2006-07-01

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic S-adenosylmethionine: Relevance in human liver diseases
Santamaria, E; Munoz, J; Fernandez-Irigoyen, J; Sesma, L; Mora, MI; Berasain, C; Lu, SC; Mato, JM; Prieto, J; Avila, MA; Corrales, FJ
JOURNAL OF PROTEOME RESEARCH
2006-04-01

2005

Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis
Fernandez-Irigoyen, J; Santamaria, E; Sesma, L; Munoz, J; Riezu, JI; Caballeria, J; Lu, SC; Prieto, J; Mato, JM; Avila, MA; Corrales, FJ
PROTEOMICS
2005-12-01

Homocysteine, the bad thiol
Mato, JM; Lu, SC
HEPATOLOGY
2005-05-01

Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
Lu, SC; Mato, JM
ALCOHOL
2005-04-01

Correlation between gene expression and GO semantic similarity
Sevilla, JL; Segura, V; Podhorski, A; Guruceaga, E; Mato, JM; Martinez-Cruz, LA; Corrales, FJ; Rubio, A
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
2005-01-01

2004

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
Berasain, C; Hevia, H; Fernandez-Irigoyen, J; Larrea, E; Caballeria, J; Mato, JM; Prieto, J; Corrales, FJ; Garcia-Trevijanoa, ER; Avila, MA
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
2004-11-05

Methylthioadenosine
Avila, MA; Garcia-Trevijano, ER; Lu, SC; Corrales, FJ; Mato, JM
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2004-11-01

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5 '-methylthioadenosine
Veal, N; Hsieh, CL; Xiong, SG; Mato, JM; Lu, S; Tsukamoto, H
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
2004-08-01

S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S)
Yang, HP; Sadda, MR; Li, M; Zeng, Y; Chen, LX; Bae, WJ; On, XP; Runnegar, MT; Mato, JM; Lu, SC
HEPATOLOGY
2004-07-01

Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A
Chen, LX; Zeng, Y; Yang, HP; Lee, TD; French, SW; Corrales, FJ; Garcia-Trevijano, ER; Avila, MA; Mato, JM; Lu, SC
FASEB JOURNAL
2004-03-01

Members

María Lauzirica González
Begoña Bareño

Protein stability (thermodynamic and kinetic) drives the biophysical properties of the polypeptide chain (protein folding) and the protein's concentration in the cellular environment (protein homeostasis). It is the result of a delicate balance between inter- and intramolecular interactions, which can be easily altered by mutations and/or upon changes in the composition of the surrounding media. In this context, NMR spectroscopy offers a plethora of suitable experiments to investigate protein stability. In our laboratory we are currently interested in the following topics:

Pharmacological chaperones. Rare diseases (~7000 identified to date) are an area of significant medical need affecting an estimated 350 million people worldwide, with ~95% having no currently approved drug treatment. They are often produced by inherited mutations affecting the activity of a protein and It is becoming increasily clear that, most frequently, a mutation destabilizes the protein/enzyme, ultimately affecting its intracellular homeostasis. In this context, pharmacological chaperones (small molecules which bind to the protein, restoring stability and activity without affecting its function) can be applied to many diseases. In our laboratory we are investigating new methods (NMR, biophysical and biochemical) for the discovery and characterization of pharmacological chaperones against a set of diseases: congenital eryhtropoietic porphyria, tyrosianemia.
Environmental modulation of enzyme stability. The high catalytic efficiency and the exquisite enantioselectivity of an enzyme has been employed in some industrial processes to upgrade their properties in order to make them more environmentally-friendly. However, large scale industrial implementation of biotechnological reactions is often limited by the marginal stability of the enzyme in the reactor conditions. In our laboratory we employ NMR and circular dichroism to investigate the effect of external crowding agents to improve the activity and stability of several enzymes. Specifically, we are investigating the mechanism for protein haloadaptation by a combined use of site directed mutagenesis and high-resolution NMR spectroscopy.

Members

Lastest Publications

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

Poveda, JA;Giudici, AM;Renart, ML;Millet, O;Morales, A;Gonzalez-Ros, JM;Oakes, V;Furini, S;Domene, C

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

2019-10-01

Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy

Unione, L;Lenza, MP;Arda, A;Urquiza, P;Lain, A;Falcon-Perez, JM;Jimenez-Barbero, J;Millet, O

ACS CENTRAL SCIENCE

2019-09-25

NMR-based newborn urine screening for optimized detection of inherited errors of metabolism

Embade, N;Cannet, C;Diercks, T;Gil-Redondo, R;Bruzzone, C;Anso, S;Echevarria, LR;Ayucar, MMM;Collazos, L;Lodoso, B;Guerra, E;Elorriaga, IA;Kortajarena, MA;Legorburu, AP;Fang, F;Astigarraga, ...

SCIENTIFIC REPORTS

2019-09-10

Hereditary tyrosinemia type I-associated mutations in fumarylacetoacetate hydrolase reduce the enzyme stability and increase its aggregation rate

Macias, I;Lain, A;Bernardo-Seisdedos, G;Gil, D;Gonzalez, E;Falcon-Perez, JM;Millet, O

JOURNAL OF BIOLOGICAL CHEMISTRY

2019-08-30

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Escobedo, A;Topal, B;Kunze, MBA;Aranda, J;Chiesa, G;Mungianu, D;Bernardo-Seisdedos, G;Eftekharzadeh, B;Gairi, M;Pierattelli, R;Felli, IC;Diercks, T;Millet, O;Garcia, J;Orozco, M;Crehuet, R;Lindorff-Larsen, ...

NATURE COMMUNICATIONS

2019-05-02

From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-alpha-mannosidase

Lu, D(Lu, Dan);Zhu, S(Zhu, Sha);Sobala, LF(Sobala, Lukasz F.);Bernardo-Seisdedos, G(Bernardo-Seisdedos, Ganeko);Milet, O(Milet, Oscar);Zhang, YM(Zhang, Yongmin);Jimenez-Barbero, J(Jimenez-Barbero, ...

ORGANIC LETTERS

2018-12-07

Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria

Serrano-Mendioroz, I(Serrano-Mendioroz, Irantzu);Sampedro, A(Sampedro, Ana);Serna, N(Serna, Naroa);de Salamanca, RE(Enriquez de Salamanca, Rafael);Sanz-Parra, A(Sanz-Parra, Arantza);Corrales, ...

Human molecular genetics

2018-11-01

Directional coupling of oligodendrocyte connexin-47 and astrocyte connexin-43 gap junctions

Fasciani, I(Fasciani, Ilaria);Pluta, P(Pluta, Paula);Gonzalez-Nieto, D(Gonzalez-Nieto, Daniel);Martinez-Montero, P(Martinez-Montero, Paloma);Molano, J(Molano, Jesus);Paino, CL(Paino, Carlos ...

Glia

2018-11-01

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

Urquiza, P(Urquiza, Pedro);Lain, A(Lain, Ana);Sanz-Parra, A(Sanz-Parra, Arantza);Moreno, J(Moreno, Jorge);Bernardo-Seisdedos, G(Bernardo-Seisdedos, Ganeko);Dubus, P(Dubus, Pierre);Gonzalez, ...

Science translational medicine

2018-09-19

Structural basis of pyrrole polymerization in human porphobilinogen deaminase

Pluta, P(Pluta, Paula);Roversi, P(Roversi, Pietro);Bernardo-Seisdedos, G(Bernardo-Seisdedos, Ganeko);Rojas, AL(Rojas, Adriana L.);Cooper, JB(Cooper, Jonathan B.);Gu, S(Gu, Shuang);Pickersgill, ...

Biochimica et biophysica acta

2018-09-01