José M Mato
jmmato
José M Mato
GENERAL DIRECTOR
IMI2 Programme
IMI2 Programme
General Director Office &
Precision Medicine and Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)
omillet
Óscar Millet
Principal Investigator
Precision Medicine and Metabolism Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

José M Mato is founder and General Director of the Centers bioGUNE (Bilbao) and biomaGUNE (San Sebastián), and Research Professor of the Spanish National Research Council (CSIC), Spain. A graduate in Biochemistry at the Complutense University of Madrid, Professor Mato received a PhD degree from Leiden University and was awarded the CJ Kok prize for his thesis. He was a postdoctoral fellow at the Biozentrum of the University of Basel and the National Institutes of Health, and a faculty member at the Jiménez Díaz Foundation in Madrid before been named Research Professor at the CSIC. He has been Professor of the Faculty of Medicine of the University of Navarra and Visiting Professor at the University of Pennsylvania and Thomas Jeff erson University. From 1992 to 1996 Professor Mato was President of the CSIC and in 2004 was awarded the Spanish National Research Prize in Medicine.

Latest Publications

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

Latest Publications

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan, MJ;Fondevila, MF;Fernandez, U;Rodriguez, A;Varela-Rey, M;Veyrat-Durebex, C;Seoane, S;Bernardo, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bilbao, J;Iglesias, C;Novoa, E;Ameneiro, ...

NATURE COMMUNICATIONS

2021-08-20

Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts

Masuda, R;Lodge, S;Nitschke, P;Spraul, M;Schaefer, H;Bong, SH;Kimhofer, T;Hall, D;Loo, RL;Bizkarguenaga, M;Bruzzone, C;Gil-Redondo, R;Embade, N;Mato, JM;Holmes, E;Wist, J;Millet, O;Nicholson, ...

JOURNAL OF PROTEOME RESEARCH

2021-08-06

Deregulated 14-3-3 zeta and methionine adenosyltransferase alpha 1 interplay promotes liver cancer tumorigenesis in mice and humans

Lu, LQ;Zhang, J;Fan, W;Li, Y;Wang, JH;Li, TWH;Torres, LB;Mato, JM;Liu, T;Seki, E;Matsuda, M;Tomasi, ML;Bhowmick, NA;Yang, HP;Lu, SC

ONCOGENE

2021-08-04

A molecular signature for the metabolic syndrome by urine metabolomics

Bruzzone, C;Gil-Redondo, R;Seco, M;Barragan, R;de la Cruz, L;Cannet, C;Schafer, H;Fang, F;Diercks, T;Bizkarguenaga, M;Gonzalez-Valle, B;Lain, A;Sanz-Parra, A;Coltell, O;de Letona, AL;Spraul, ...

CARDIOVASCULAR DIABETOLOGY

2021-07-28

Metabolic Landscape of the Mouse Liver by Quantitative P-31 Nuclear Magnetic Resonance Analysis of the Phosphorome

Bernardo-Seisdedos, G;Bilbao, J;Fernandez-Ramos, D;Lopitz-Otsoa, F;de Juan, VG;Bizkarguenaga, M;Mateos, B;Fondevila, MF;Abril-Fornaguera, J;Diercks, T;Lu, SC;Nogueiras, R;Mato, JM;Millet, O

HEPATOLOGY

2021-06-15

Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

Bhattacharya, D;Basta, B;Mato, JM;Craig, A;Fernandez-Ramos, D;Lopitz-Otsoa, F;Tsvirkun, D;Hayardeny, L;Chandar, V;Schwartz, RE;Villanueva, A;Friedman, SL

JHEP REPORTS

2021-06-01

Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...

CELL DEATH & DISEASE

2021-05-28

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;Bruzzone, C;Bizkarguenaga, M;Embade, N;Gil-Redondo, R;Martinez-Chantar, ML;Lopez-Hoyos, ...

COMMUNICATIONS BIOLOGY

2021-04-20

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I

Gil-Martinez, J;Macias, I;Unione, L;Bernardo-Seisdedos, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Lain, A;Sanz-Parra, A;Mato, JM;Millet, O

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-02-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

Protein stability (thermodynamic and kinetic) drives the biophysical properties of the polypeptide chain (protein folding) and the protein's concentration in the cellular environment (protein homeostasis). It is the result of a delicate balance between inter- and intramolecular interactions, which can be easily altered by mutations and/or upon changes in the composition of the surrounding media. In this context, NMR spectroscopy offers a plethora of suitable experiments to investigate protein stability. In our laboratory we are currently interested in the following topics:

  • Pharmacological chaperones. Rare diseases (~7000 identified to date) are an area of significant medical need affecting an estimated 350 million people worldwide, with ~95% having no currently approved drug treatment. They are often produced by inherited mutations affecting the activity of a protein and It is becoming increasily clear that, most frequently, a mutation destabilizes the protein/enzyme, ultimately affecting its intracellular homeostasis. In this context, pharmacological chaperones (small molecules which bind to the protein, restoring stability and activity without affecting its function) can be applied to many diseases. In our laboratory we are investigating new methods (NMR, biophysical and biochemical) for the discovery and characterization of pharmacological chaperones against a set of diseases: congenital eryhtropoietic porphyria, tyrosianemia.
     
  • Environmental modulation of enzyme stability. The high catalytic efficiency and the exquisite enantioselectivity of an enzyme has been employed in some industrial processes to upgrade their properties in order to make them more environmentally-friendly. However, large scale industrial implementation of biotechnological reactions is often limited by the marginal stability of the enzyme in the reactor conditions. In our laboratory we employ NMR and circular dichroism to investigate the effect of external crowding agents to improve the activity and stability of several enzymes. Specifically, we are investigating the mechanism for protein haloadaptation by a combined use of site directed mutagenesis and high-resolution NMR spectroscopy.

Protocolos de Histología

Latest Publications

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan, MJ;Fondevila, MF;Fernandez, U;Rodriguez, A;Varela-Rey, M;Veyrat-Durebex, C;Seoane, S;Bernardo, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bilbao, J;Iglesias, C;Novoa, E;Ameneiro, ...

NATURE COMMUNICATIONS

2021-08-20

Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts

Masuda, R;Lodge, S;Nitschke, P;Spraul, M;Schaefer, H;Bong, SH;Kimhofer, T;Hall, D;Loo, RL;Bizkarguenaga, M;Bruzzone, C;Gil-Redondo, R;Embade, N;Mato, JM;Holmes, E;Wist, J;Millet, O;Nicholson, ...

JOURNAL OF PROTEOME RESEARCH

2021-08-06

A molecular signature for the metabolic syndrome by urine metabolomics

Bruzzone, C;Gil-Redondo, R;Seco, M;Barragan, R;de la Cruz, L;Cannet, C;Schafer, H;Fang, F;Diercks, T;Bizkarguenaga, M;Gonzalez-Valle, B;Lain, A;Sanz-Parra, A;Coltell, O;de Letona, AL;Spraul, ...

CARDIOVASCULAR DIABETOLOGY

2021-07-28

Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection

Gray, N;Lawler, NG;Zeng, ANX;Ryan, M;Bong, SH;Boughton, BA;Bizkarguenaga, M;Bruzzone, C;Embade, N;Wist, J;Holmes, E;Millet, O;Nicholson, JK;Whiley, L

METABOLITES

2021-07-01

Metabolic Landscape of the Mouse Liver by Quantitative P-31 Nuclear Magnetic Resonance Analysis of the Phosphorome

Bernardo-Seisdedos, G;Bilbao, J;Fernandez-Ramos, D;Lopitz-Otsoa, F;de Juan, VG;Bizkarguenaga, M;Mateos, B;Fondevila, MF;Abril-Fornaguera, J;Diercks, T;Lu, SC;Nogueiras, R;Mato, JM;Millet, O

HEPATOLOGY

2021-06-15

Identification of novel UROS mutations in a patient with congenital erythropoietic porphyria and efficient treatment by phlebotomy

Blouin, JM;Ged, C;Bernardo-Seisdedos, G;Cabantous, T;Pinson, B;Poli, A;Puy, H;Millet, O;Gouya, L;Morice-Picard, F;Richard, E

MOLECULAR GENETICS AND METABOLISM REPORTS

2021-06-01

NMR of glycoproteins: profiling, structure, conformation and interactions

Unione, L;Arda, A;Jimenez-Barbero, J;Millet, O

CURRENT OPINION IN STRUCTURAL BIOLOGY

2021-06-01

Improving the Pharmacological Properties of Ciclopirox for Its Use in Congenital Erythropoietic Porphyria

Bernardo-Seisdedos, G;Charco, JM;SanJuan, I;Garcia-Martinez, S;Urquiza, P;Erana, H;Castilla, J;Millet, O

JOURNAL OF PERSONALIZED MEDICINE

2021-06-01

Cosolute modulation of protein oligomerization reactions in the homeostatic timescale

Mateos, B;Bernardo-Seisdedos, G;Dietrich, V;Zalba, N;Ortega, G;Peccati, F;Jimenez-Oses, G;Konrat, R;Tollinger, M;Millet, O

BIOPHYSICAL JOURNAL

2021-05-18

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;Bruzzone, C;Bizkarguenaga, M;Embade, N;Gil-Redondo, R;Martinez-Chantar, ML;Lopez-Hoyos, ...

COMMUNICATIONS BIOLOGY

2021-04-20