Jesús Jiménez-Barbero
jjbarbero
Jesús Jiménez-Barbero
SCIENTIFIC DIRECTOR
ERC Advanced Grant Ikerbasque Research Professor
ERC Advanced Grant Ikerbasque Research Professor
Scientific Director Office & Chemical Glycobiology Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Earlier in his career, JJB worked at CERMAV-CNRS, Grenoble, 1986 (Predoc); Univ. Zurich (Switzerland), 1987 (Postdoc); National Institute for Medical Research (UK) 1988 (Postdoc; and Carnegie Mellon Univ., USA; 1990-92 (Postdoc and visiting). After working at IQOG-CSIC (1992-2002) as tenured and senior research scientist (1996), he held a CSIC Research Professor position at CIB-CSIC since 2002. He has also held Visiting Professorships at École Normale Supérieure, Paris (2004), Univ. Pierre et Marie Curie, Paris VI, (2009), and Univ. Milano-Bicocca (2010-12). From the management perspective, he was the President of the Royal Society of Chemistry of Spain (Jan 2012-Jan 2018), and was Secretary General of the same Institution (2004-11). He has been the Head of the Chemistry Panel of the National Plan for Research of the Ministry of Economy and Competitiveness between 2009 and 2018, and the representative of Spain in the CMST committee of EU-COST (2012-14). He is ChemPubSoc FEllow (2015) and Member of the European Academy of Sciences (2017). Besides managing his research group, with already 25 PhD students supervised as well as more than 30 postdocs, he was serving as Head of Department of Chem & Phys Biol Dept. at CIB-CSIC from 2009-2014. He was appointed Ikerbasque Research Professor in 2013 and therefore, he moved to the Basque Country to become Scientific Director of CIC bioGUNE (Nov 2014).

Latest Publications

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2009

From the scientific perspective, the research group is focused in exploring molecular recognition events from the chemical perspective, mostly in unravelling the molecular basis of the recognition of glycans by receptors in solution.

The group employs a multidisciplinary approach, using the synergic combination of organic synthesis, protein biochemistry and molecular biology, biophysics, molecular modeling, and NMR, using a wide network of collaborations with specialists worldwide.

Major contributions in the field include our systematic studies on the interactions of glycans with specific lectins (the 1st reported NMR structure of a glycan/lectin complex was achieved in his lab in 1995). Such detailed investigations have contributed significantly to our global understanding of glycan-mediated interactions in health and disease, including infectious and inflammatory processes. These studies conducted to the 2010 International Whistler Award in Carbohydrate Chemistry, following the Bruker award of the NMR division of RSEQ (2008) and the Janssen-Cilag award of RSEQ (2003).

The group does not only apply, but also develop, NMR methods for studying the structural and dynamic properties of ligands and their interaction with relevant proteins. Particularly, the fine chemical details of the interactions between sugars and proteins have been explored, with special emphasis on the relative role of sugar-aromatic stacking forces in the recognition process. The origin and relative importance of the forces that mediate these interactions are still under study and are a key part of the research in the group. Recent advances in our research are focused on disentangling how receptors recognise a given epitope in complex N-glycans, which present multiple epitopes. This has lead to the use of a precise NMR methodology, even using living cells, assisted by molecular dynamics and biophysical and structural biology methods, including X-ray crystallography. Recent methodology developments have permitted to use paramagnetic metals (lanthanides) to unravel hidden conformational features of N-glycans and to detect their molecular recognition events. The use of lanthanides is complementary to the employment and generation of other chemical novel NMR-sensitive tags, especially those based on 19F nuclei. The expansion, exploitation, and generalization of these novel concepts is generating a breakthrough in the field, with huge possibilities in the molecular recognition arena, permitting the access to the detailed study of the interactions of large and complex glycans, which were previously inaccessible to the study by NMR or other means, due to their intrinsic flexibility.

Key projects of the group involve detailed multidisciplinary investigations on galectins and C-type lectins, under the guidance of Dr. Ana Ardá (Ramón y Cajal fellow), as well as on siglecs, a novel research topic for the group, under the supervision of Dr. June Ereño-Orbea (Ikerbasque Research Fellow). The different members of the group enjoy from different collaborations throughout the world, including Europe, North America, South America, Australia, and Asia. Besides the funding from AEI, the group is currently funded by the EC (ERC AdG 2018 RECGLYCANMR to J. Jimenez-Barbero, ITN 2019 BactiVAX to J Jimenez-Barbero, and ITN 2020 Glytunes to J. Ereño-Orbea). Research collaborations and contracts with different companies within the Basque Country, Spain, and other countries in Europe also provide added value to our investigations.

Latest Publications

Introducing the Catalytic Amination of Silanes via Nitrene Insertion

Rodriguez, AM;Perez-Ruiz, J;Molina, F;Poveda, A;Perez-Soto, R;Maseras, F;Diaz-Requejo, MM;Perez, PJ

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2022-06-15

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Stagnoli, S;Peccati, F;Connell, SR;Martinez-Castillo, A;Charro, D;Millet, O;Bruzzone, C;Palazon, A;Arda, A;Jimenez-Barbero, J;Ereno-Orbea, J;Abrescia, NGA;Jimenez-Oses, G

FRONTIERS IN MICROBIOLOGY

2022-04-15

Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling

Coelho, H;de las Rivas, M;Grosso, AS;Diniz, A;Soares, CO;Francisco, RA;Dias, JS;Companon, I;Sun, LB;Narimatsu, Y;Vakhrushev, SY;Clausen, H;Cabrita, EJ;Jimenez-Barbero, J;Corzana, F;Hurtado-Guerrero, ...

JACS AU

2022-03-28

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Unione, L;Moure, MJ;Lenza, MP;Oyenarte, I;Ereno-Orbea, J;Arda, A;Jimenez-Barbero, J

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2022-03-07

Prof. Jesus Jimenez-Barbero: Disentangling Molecular Recognition of Carbohydrates

Franconetti, A;Angulo, J

CURRENT MEDICINAL CHEMISTRY

2022-01-01

Polyglucosylation of Rutin Catalyzed by Cyclodextrin Glucanotransferase from Geobacillus sp.: Optimization and Chemical Characterization of Products

Gonzalez-Alfonso, JL;Poveda, A;Arribas, M;Hirose, Y;Fernandez-Lobato, M;Ballesteros, AO;Jimenez-Barbero, J;Plou, FJ

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

2021-12-29

Targeting transthyretin in Alzheimers disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimers disease

Cotrina, EY (Cotrina, Ellen Y.); Santos, LM (Santos, Luis Miguel); Rivas, J (Rivas, Josep); Blasi, D (Blasi, Daniel); Leite, JP (Leite, Jose Pedro); Liz, MA (Liz, Marcia A.); Busquets, MA (Antonia ...

European journal of medicinal chemistry

2021-12-15

Sulfation Code and Conformational Plasticity of L-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate

Shanthamurthy, CD;Gimeno, A;Ben-Arye, SL;Kumar, NV;Jain, P;Padler-Karavani, V;Jimenez-Barbero, J;Kikkeri, R

ACS CHEMICAL BIOLOGY

2021-11-19

The Flexibility of Oligosaccharides Unveiled Through Residual Dipolar Coupling Analysis

Poveda, A;Fittolani, G;Seeberger, PH;Delbianco, M;Jimenez-Barbero, J

FRONTIERS IN MOLECULAR BIOSCIENCES

2021-11-10

Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide

Pietri, GP;Tontini, M;Brogioni, B;Oldrini, D;Robakiewicz, S;Henriques, P;Calloni, I;Abramova, V;Santini, L;Malic, S;Miklic, K;Lisnic, B;Bertuzzi, S;Unione, L;Balducci, E;de Ruyck, J;Romano, ...

FRONTIERS IN MOLECULAR BIOSCIENCES

2021-10-14