0000-0002-8271-612XAna M Aransay obtained her BSc in Biology from the from the University of the Basque Country (UPV/EHU) and her PhD from the Medicine of the University of Crete, Greece, under the supervision of Prof. Yannis Tselentis. During this period, she learnt all the key Molecular Biology techniques (isoenzymes, DNA cloning, DNA sequencing, PCR, PCR-RFLP, etc.) and the fundamentals of infectious disease diagnosis, species molecular typing, phylogeny and epidemiological studies.
After getting her PhD in 1999, Dr. Aransay was awarded two consecutive postdoctoral research grants from the Basque Country Government to work on a project focused on the population genetics of parasitic disease vectors. Initially, she joined the laboratory of Dr. Paul D. Ready at the Entomology Department of the Natural History Museum of London (UK) and later, she relocated to Madrid to continue her research at the National Centre of Microbiology of the Instituto de Salud Carlos III, under the supervision of Dr. Ricardo Molina.
In 2004, Dr. Aransay joined CIC bioGUNE as the Genome Analysis Platform Manager to support internal users and offer collaborative research to external researchers. The platform's main objectives include developing high-throughput technologies to enable genome characterization. This involves investigating DNA variants at the whole-genome level, analyzing the expression of coding and non-coding RNAs, and profiling DNA methylation. While the primary focus is on biomedical projects, the platform's services are also applicable to a wide range of biological research questions.
Latest Publications
2025
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Monika Gonzalez
POSTDOCTORAL RESEARCHER -
Dimitrios Kioroglou
TECHNICIANS / DOCTORAL CANDIDATES -
Laura Bárcena
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Nuria Macias
Members
SPECIALISTLatest Publications
Spatial membrane lipid remodelling encodes epithelial lineage and state in human colon cancer
Rodriguez, RM; Pérez-Romero, K; Maimó-Barceló, A; Ximelis, T; Huergo-Baños, C; Martínez, MA; Segura-Sampedro, JJ; Morales-Soriano, R; Pineño-Flores, C; García-Granero, A; Jerí, S; Aransay, AM; ...
EBIOMEDICINE
2026-09-10
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice
Cruz-Sese, J; Mirón-Alcala, M; Alfonso-Triguero, M; Olalde, J; Ruiz, L; Galbis-Gramage, N; Cortes, L; Escobar, L; Preman, P; Snellinx, A; Saito, T; Saido, TC; Saiz-Aúz, L; Rábano-Gutiérrez, ...
CELL REPORTS
2026-08-08
PVDF surface charge directs stem cell fate via mechanotransduction and calcium signaling
Martin-Iglesias, S; Varela, YR; Rodriguez-Lejarraga, P; Jiménez-Rojo, L; Eguizabal, C; Jiménez-Rojo, N; Anguita, J; Aransay, AM; Lanceros-Méndez, S; Silvan, U;
BIOMATERIALS ADVANCES
2026-08-07
Systems biology integration of miR-mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis
Ginés, I; Suau, R; Naves, JE; Bernal, C; Clua, L; Lorén, V; Pluvinet, R; Monfort-Ferré, D; Balastegui, ML; Herrero, JFS; Segú-Vergés, C; Aransay, AM; Buschbeck, M; Mañosa, M; Sumoy, L; Serena, ...
BIOCHEMISTRY AND BIOPHYSICS REPORTS
2026-08-03
Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity
de Blas, A; Andreatta, M; Antoñana-Vildosola, A; Velasco-Beltrán, P; Egia-Mendikute, L; Jiménez-Lasheras, B; Bosch, A; Barreira-Manrique, A; Oyenarte, I; Lee, SY; Heuser-Loy, C; Baldwin, JG; ...
CANCER RESEARCH
2026-06-15
Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway
Lachiondo-Ortega, S; González-Recio, I; Bravo, M; Gonzalez-Rellan, MJ; Sanz-Parra, A; Porteiro, B; Goikoetxea-Usandizaga, N; Rejano-Gordillo, CM; Zapata-Pavas, LE; Peña-Sanfélix, P; Conter, ...
MOLECULAR METABOLISM
2026-05-26
Polyamine-dependent metabolic shielding regulates alternative splicing
Zabala-Letona, A; Pujana-Vaquerizo, M; Martinez-Laosa, B; Ponce-Rodriguez, M; Garcia-Longarte, S; Mendizabal, I; Gimeno, A; Rogalska, M; Tan, J; Cabrera, D; Van Liempd, S; Ximenez-Embun, P; ...
NATURE
2026-01-14
Multi-omics biomarkers for predicting treatment response in inflammatory bowel disease
Baldan-Martin, M; Azkargorta, M; Aransay, AM; Gil-Redondo, R; Moreno-Indias, I; Iloro, I; González, PJM; Soleto,; Suarez-Trujillo, F; Ramírez, C; Lucendo, A; Gutiérrez, CR; Casbas, AG; Arranz, ...
JOURNAL OF CROHNS & COLITIS
2026-01-01
Systems biology-driven miR-mRNA integration identifies potential steroid-refractoriness biomarkers in ulcerative colitis and reveals a conserved mechanism across species
Mir, IG; Suau, R; Naves, JE; Bernal, C; Clua, L; Monfort-Ferré, D; Pluvinet, R; Herrero, JFS; Segú, C; Aransay, AM; Ciria, MM; Sumoy, L; Serena, C; Moral, ED; Almero, JM;
JOURNAL OF CROHNS & COLITIS
2026-01-01
Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory
Pasco, ST; Martin-Ruiz, I; Araujo-Aris, S; Barriales, D; Castelo, J; Egia-Mendikute, L; Gonzalez, M; Martin, JE; Molina, E; Mugica, M; Palacios, A; Seoane, I; Gutiez, N; Atondo, E; Fernández, ...
IMMUNOLOGY
2025-10-01
E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p
Apodaka-Biguri, M; Simao, AL; González-Romero, F; Mestre, D; Rodrigues, PM; Aurrekoetxea, I; Gómez-Santos, B; Buqué, X; Nieva-Zuluaga, A; de Gauna, MR; Fernandez-Puertas, I; Gomez-Jauregui, ...
HEPATOLOGY
2025-07-28
Identification of Potential Biomarkers for Langerhans Cell Histiocytosis Diagnosis Through Proteomics and Small RNA Analysis
Garcia-Barcena, C; Azkargorta, M; Bilbao-Aldaiturriaga, N; Gutiérrez-Camino, A; Aransay, AM; Elortza, F; Astigarraga, I; Garcia-Obregon, S;
PEDIATRIC BLOOD & CANCER
2025-12-01
Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans
Aparicio-Fernandez, L; Cazalis-Bereicua, N; Areitio, M; Rodriguez-Erenaga, O; Abio-Dorronsoro, L; Martin-Souto, L; Buldain, I; Márquez, J; Benedicto, A; Arteta, B; Macias-Cámara, N; Gonzalez, ...
SCIENTIFIC REPORTS
2025-11-17
A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer
Ercilla, A; Crespo, JR; Garcia-Longarte, S; Fidalgo, M; del Palacio, S; Martin-Martin, N; Carlevaris, O; Astobiza, I; Fernández-Ruiz, S; Guiu, M; Bárcena, L; Mendizabal, I; Aransay, AM; Graupera, ...
MOLECULAR ONCOLOGY
2025-09-15
Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination
Martin-Martin, N; Garcia-Longarte, S; Corres-Mendizabal, J; Lazcano, U; Astobiza, I; Bozal-Basterra, L; Herranz, N; van Splunder, H; Carlevaris, O; Pujana-Vaquerizo, M; Blasco, MT; Aransay, ...
GENOME BIOLOGY
2025-06-03
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene
Sampedro-Torres-Quevedo, C; Eraña, H; Charco, JM; Díaz-Domínguez, CM; San-Juan-Ansoleaga, M; Fernández-Muñoz, E; Gonçalves-Anjo, N; Galarza-Ahumada, J; Cortazar, AR; Nespolo, RF; Quintero-Galvis, ...
PLOS PATHOGENS
2025-06-01
Structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator
Martinez-Castillo, A; Barriales, D; Azkargorta, M; Zalamea, JD; Ardá, A; Jimenez-Barbero, J; Gonzalez-Lopez, M; Aransay, AM; Marín-López, A; Fikrig, E; Elortza, F; Anguita, J; Abrescia, NGA; ...
JOURNAL OF VIROLOGY
2025-04-24
Syndecan-3 positively regulates the pro-inflammatory function of macrophages
Lee, SY; Prieto-Fernández, E; Egia-Mendikute, L; Antonaña-Vildosola, A; Velasco-Beltrán, P; Bosch, A; Jimenez-Lasheras, B; de Blas, A; de Durana, JED; Valdaliso-Díez, E; Bozal-Basterra, L; Ercilla, ...
CELLULAR AND MOLECULAR LIFE SCIENCES
2025-04-07
Harnessing Plasma Biomarkers to Predict Immunotherapy Outcomes in Hepatocellular Carcinoma: The Role of cfDNA, ctDNA, and Cytokines
Vargas-Accarino, E; Higuera, M; Bermúdez-Ramos, M; Soriano-Varela, A; Torrens, M; Pons, M; Aransay, AM; Martín, JE; Rodríguez-Frías, F; Merino, X; Mínguez, B;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025-03-20
Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics
Hernandez-Unzueta, I; Telleria-Gonzalez, U; Aransay, AM; Rodriguez, JEM; Sanz, E; Márquez, J;
FRONTIERS IN PHARMACOLOGY
2025-03-19