Juan Manuel Falcón | CIC bioGUNE | Center for Cooperative Research in Biosciences

Juan Manuel Falcón

PRINCIPAL INVESTIGATOR

Ikerbasque Research Professor

Exosomes Lab & Metabolomics Platform

Orcid:

0000-0003-3133-0670

Email: jfalcon@cicbiogune.es

Phone: 4219 / 944 061 319

Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

Biochemist and cellular biologist with wide experience in performing high-content omics-based analyses. During his Ph.D at the Biomedical Research Institute "Alberto Sols" in Madrid, Dr. Falcon carried out an extensive biochemical analysis of the Ycf1 carrier of S. cerevisiae, as model for the study of CFTR protein that is responsible of Cystic Fibrosis (CF) human disease. As postdoctoral fellow in the Universidad Autonoma de Madrid participated in the generation of the knockout mouse for the POMT1 gene codifying the O-mannosyltransferase protein 1, an essential enzyme in development, and with implications in muscular dystrophies. As postdoctoral researcher in the Human Genetics Department of University of California, Los Angeles (USA) he focused on the biochemical and functional characterization of proteins associated with the Hermansky-Pudlak syndrome (HPS) which is caused by defects in the formation of specialized organelles named lysosome-related organelles (e.g. melanosomes, platelet dense granules) using mouse and flies as model organisms. In 2006, he moved to CIC bioGUNE and started his research in the study on EXOSOMES –extracellular vesicles of endocytic origin- as a source for biomarker discovery and a tool for therapeutic applications, and METABOLOMICS as a platform for unraveling markers and metabolic pathways altered in diseases. Thanks to a number of national and international collaborations Dr. Falcon´s group has characterized exosomes secreted by many in vivo and in vitro experimental models of several diseases, as well as from different body fluids. In addition, identification of MOLECULAR CHAPERONES that increase in vivo stability of proteins implicated in METABOLIC RARE DISEASES-caused by protein miss-folding (e.g. Cystic fibrosis, Porphyries) is a collaborative project in which Dr. Falcon´s group is actively achieving. Currently, his main research line is focused on identification of minimally invasive markers for hepatic, infectious and neurological disorders by applying high-content technologies (e.g. metabolomics) on different biological sources including body fluids and exosomes.

Latest Publications

Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma
Rackles, E;Lopez, PH;Falcon-Perez, JM
SEMINARS IN CANCER BIOLOGY
2022-12-01

ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection
Albert, M;Vazquez, J;Falcon-Perez, JM;Balboa, MA;Liesa, M;Balsinde, J;Guerra, S
MICROBIOLOGY SPECTRUM
2022-12-01

Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH)
Gallego-Duran, R;Albillos, A;Ampuero, J;Arechederra, M;Banares, R;Blas-Garcia, A;Berna, G;Caparros, E;Delgado, TC;Falcon-Perez, JM;Frances, R;Fernandez-Barrena, MG;Graupera, I;Iruzubieta, P;Nevzorova, ...
GASTROENTEROLOGIA Y HEPATOLOGIA
2022-11-01

miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma
de la Cruz-Ojeda, P;Schmid, T;Boix, L;Moreno, M;Sapena, V;Praena-Fernandez, JM;Castell, FJ;Falcon-Perez, JM;Reig, M;Brune, B;Gomez-Bravo, MA;Giraldez, A;Bruix, J;Ferrer, MT;Muntane, J
CELLS
2022-09-01

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV-Cell Interaction and Functional Activation of Endothelial Cells
Clos-Sansalvador, M;Garcia, SG;Moron-Font, M;Williams, C;Reichardt, NC;Falcon-Perez, JM;Bayes-Genis, A;Roura, S;Franquesa, M;Monguio-Tortajada, M;Borras, FE
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022-09-01

microRNA-based signatures obtained from endometrial fluid identify implantative endometrium
Ibanez-Perez, J;Diaz-Nunez, M;Clos-Garcia, M;Lainz, L;Iglesias, M;Diez-Zapirain, M;Rabanal, A;Barcena, L;Gonzalez, M;Lozano, JJ;Marigorta, UM;Gonzalez, E;Royo, F;Aransay, AM;Subiran, N;Matorras, ...
HUMAN REPRODUCTION
2022-08-27

Oral Progenitor Cell Line-Derived Small Extracellular Vesicles as a Treatment for Preferential Wound Healing Outcome
Knight, R;Board-Davies, E;Brown, H;Clayton, A;Davis, T;Karatas, B;Burston, J;Tabi, Z;Falcon-Perez, JM;Paisey, S;Stephens, P
STEM CELLS TRANSLATIONAL MEDICINE
2022-08-23

Reproducibility of extracellular vesicle research
Nieuwland, R;Siljander, PRM;Falcon-Perez, JM;Witwer, KW
EUROPEAN JOURNAL OF CELL BIOLOGY
2022-08-01

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples
Bordanaba-Florit, G;van Liempd, S;Cabrera, D;Royo, F;Falcon-Perez, JM
METABOLITES
2022-08-01

Extracellular vesicles from thyroid cancer harbor a functional machinery involved in extracellular matrix remodeling
Bravo-Miana, RD;Soler, MF;Ceschin, DG;Royo, F;Negretti-Borga, DM;Azkargorta, M;Elortza, F;Montesinos, MD;Pellizas, CG;Falcon-Perez, JM;Donadio, AC
EUROPEAN JOURNAL OF CELL BIOLOGY
2022-08-01

A Comprehensive Metabolomics Analysis of Fecal Samples from Advanced Adenoma and Colorectal Cancer Patients
Telleria, O;Alboniga, OE;Clos-Garcia, M;Nafria-Jimenez, B;Cubiella, J;Bujanda, L;Falcon-Perez, JM
METABOLITES
2022-06-01

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming
Colyn, L;Alvarez-Sola, G;Latasa, MU;Uriarte, I;Herranz, JM;Arechederra, M;Vlachogiannis, G;Rae, C;Pineda-Lucena, A;Casadei-Gardini, A;Pedica, F;Aldrighetti, L;Lopez-Lopez, A;Lopez-Gonzalvez, ...
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2022-05-26

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodriguez-Agudo, R;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Fernandez-Tussy, P;Fernandez-Ramos, D;Lachiondo-Ortega, S;Gonzalez-Recio, I;Gil-Pitarch, C;Mercado-Gomez, M;Moran, L;Bizkarguenaga, ...
ANTIOXIDANTS
2022-05-01

Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing
Heras, KL;Royo, F;Garcia-Vallicrosa, C;Igartua, M;Santos-Vizcaino, E;Falcon-Perez, JM;Hernandez, RM
STEM CELL RESEARCH & THERAPY
2022-04-08

Hypoxia-induced HIF1 alpha activation regulates small extracellular vesicle release in human embryonic kidney cells
Muniz-Garcia, A;Romero, M;Falcon-Perez, JM;Murray, P;Zorzano, A;Mora, S
SCIENTIFIC REPORTS
2022-01-27

Ammonium nutrition interacts with iron homeostasis in Brachypodium distachyon
De la Pena, M;Marin-Pena, AJ;Urmeneta, L;Coleto, I;Castillo-Gonzalez, J;van Liempd, SM;Falcon-Perez, JM;Alvarez-Fernandez, A;Gonzalez-Moro, MB;Marino, D
JOURNAL OF EXPERIMENTAL BOTANY
2022-01-01

2021

Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
de Paredes, AGG;Villanueva, C;Blanco, C;Genesca, J;Manicardi, N;Garcia-Pagan, JC;Calleja, JL;Aracil, C;Morillas, RM;Poca, M;Penas, B;Augustin, S;Abraldes, JG;Alvarado, E;Royo, F;Garcia-Bermejo, ...
JHEP REPORTS
2021-12-01

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
Witwer, KW;Goberdhan, DCI;O'Driscoll, L;Thery, C;Welsh, JA;Blenkiron, C;Buzas, EI;Di Vizio, D;Erdbrugger, U;Falcon-Perez, JM;Fu, QL;Hill, AF;Lenassi, M;Lotvall, J;Nieuwland, R;Ochiya, T;Rome, ...
JOURNAL OF EXTRACELLULAR VESICLES
2021-12-01

Interplay between Genome, Metabolome and Microbiome in Colorectal Cancer
Garcia-Etxebarria, K;Clos-Garcia, M;Telleria, O;Nafria, B;Alonso, C;Iruarrizaga-Lejarreta, M;Franke, A;Crespo, A;Iglesias, A;Cubiella, J;Bujanda, L;Falcon-Perez, JM
CANCERS
2021-12-01

Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
Sousa, D;Lima, RT;Lopes-Rodrigues, V;Gonzalez, E;Royo, F;Xavier, CPR;Falcon-Perez, JM;Vasconcelos, MH
CELLS
2021-11-01

Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer
Shephard, AP;Giles, P;Mbengue, M;Alraies, A;Spary, LK;Kynaston, H;Gurney, MJ;Falcon-Perez, JM;Royo, F;Tabi, Z;Parthimos, D;Errington, RJ;Clayton, A;Webber, JP
JOURNAL OF EXTRACELLULAR VESICLES
2021-10-01

Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
Fernandez-Checa, JC;Bagnaninchi, P;Ye, H;Sancho-Bru, P;Falcon-Perez, JM;Royo, F;Garcia-Ruiz, C;Konu, O;Miranda, J;Lunov, O;Dejneka, A;Elfick, A;McDonald, A;Sullivan, GJ;Aithal, GP;Lucena, MI;Andrade, ...
JOURNAL OF HEPATOLOGY
2021-10-01

Human Serum Extracellular Vesicle Proteomic Profile Depends on the Enrichment Method Employed
Azkargorta, M;Iloro, I;Escobes, I;Cabrera, D;Falcon-Perez, JM;Elortza, F;Royo, F
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021-10-01

Extracellular Vesicles in the Fungi Kingdom
Liebana-Jordan, M;Brotons, B;Falcon-Perez, JM;Gonzalez, E
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021-07-01

Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles
Guillermo, BF;Royo, F;Kruglik, SG;Falcon-Perez, JM
NATURE PROTOCOLS
2021-06-16

Transcriptomic Profiling of the Liver Sinusoidal Endothelium during Cirrhosis Reveals Stage-Specific Secretory Signature
Manicardi, N;Fernandez-Iglesias, A;Abad-Jorda, L;Royo, F;Azkargorta, M;Ortega-Ribera, M;Sanfeliu-Redondo, D;Martinez-Alcocer, A;Elortza, F;Hessheimer, AJ;Fondevila, C;Lozano, JJ;Garcia-Pagan, ...
CANCERS
2021-06-01

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Erdbrugger, U;Blijdorp, CJ;Bijnsdorp, IV;Borras, FE;Burger, D;Bussolati, B;Byrd, JB;Clayton, A;Dear, JW;Falcon-Perez, JM;Grange, C;Hill, AF;Holthofer, H;Hoorn, EJ;Jenster, G;Jimenez, CR;Junker, ...
JOURNAL OF EXTRACELLULAR VESICLES
2021-05-01

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic beta cells
Gesmundo, I;Pardini, B;Gargantini, E;Gamba, G;Birolo, G;Fanciulli, A;Banfi, D;Congiusta, N;Favaro, E;Deregibus, MC;Togliatto, G;Zocaro, G;Brizzi, MF;Luque, RM;Castano, JP;Bocchiotti, MA;Arolfo, ...
JCI INSIGHT
2021-03-08

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia
Nguyen, TL;Nokin, MJ;Teres, S;Tome, M;Bodineau, C;Galmar, O;Pasquet, JM;Rousseau, B;van Liempd, S;Falcon-Perez, JM;Richard, E;Muzotte, E;Rezvani, HR;Priault, M;Bouchecareilh, M;Redonnet-Vernhet, ...
MOLECULAR ONCOLOGY
2021-02-13

Extracellular vesicles in hepatology: Physiological role,involvement in pathogenesis, and therapeutic opportunities
Azparren-Angulo, M;Royo, F;Gonzalez, E;Liebana, M;Brotons, B;Berganza, J;Goni-de-Cerio, F;Manicardi, N;Abad-Jorda, L;Gracia-Sancho, J;Falcon-Perez, JM
PHARMACOLOGY & THERAPEUTICS
2021-02-01

Identification of Isomeric N-Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry
Torano, JS;Aizpurua-Olaizola, O;Wei, N;Li, TH;Unione, L;Jimenez-Oses, G;Corzana, F;Somovilla, VJ;Falcon-Perez, JM;Boons, GJ
CHEMISTRY-A EUROPEAN JOURNAL
2021-01-14

Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules
Royo, F;Azkargorta, M;Lavin, JL;Clos-Garcia, M;Cortazar, AR;Gonzalez-Lopez, M;Barcena, L;del Portillo, HA;Yanez-Mo, M;Marcilla, A;Borras, FE;Peinado, H;Guerrero, I;Vales-Gomez, M;Cereijo, U;Sardon, ...
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2021-01-12

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01

3D Cell Cultures as Prospective Models to Study Extracellular Vesicles in Cancer
Bordanaba-Florit, G;Madarieta, I;Olalde, B;Falcon-Perez, JM;Royo, F
CANCERS
2021-01-01

Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease?
Gonzalez, E;Azkargorta, M;Garcia-Vallicrosa, C;Prieto-Elordui, J;Elortza, F;Blanco-Sampascual, S;Falcon-Perez, JM
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2021-01-01

2020

Rigor and standardization of extracellular vesicle research: Paving the road towards robustness
Nieuwland, R;Falcon-Perez, JM;Thery, C;Witwer, KW
JOURNAL OF EXTRACELLULAR VESICLES
2020-12-01

Thermophoresis as a technique for separation of nanoparticle species in microfluidic devices
Errarte, A;Martin-Mayor, A;Aginagalde, M;Iloro, I;Gonzalez, E;Falcon-Perez, JM;Elortza, F;Bou-Ali, MM
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
2020-10-01

International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19
Borger, V;Weiss, DJ;Anderson, JD;Borras, FE;Bussolati, B;Carter, DRF;Dominici, M;Falcon-Perez, JM;Gimona, M;Hill, AF;Hoffman, AM;de Kleijn, D;Levine, BL;Lim, R;Lotvall, J;Mitsialis, SA;Monguio-Tortajada, ...
CYTOTHERAPY
2020-09-01

Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee
Royo, F;Thery, C;Falcon-Perez, JM;Nieuwland, R;Witwer, KW
CELLS
2020-09-01

Variability in Cerebrospinal Fluid MicroRNAs Through Life
Prieto-Fernandez, E;Lopez-Lopez, E;Martin-Guerrero, I;Barcena, L;Gonzalez-Lopez, M;Aransay, AM;Lozano, JJ;Benito, J;Falcon-Perez, JM;Garcia-Orad, A
MOLECULAR NEUROBIOLOGY
2020-07-16

Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer
Clos-Garcia, M;Garcia, K;Alonso, C;Iruarrizaga-Lejarreta, M;D'Amato, M;Crespo, A;Iglesias, A;Cubiella, J;Bujanda, L;Falcon-Perez, JM
CANCERS
2020-05-01

Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc
Gonzalez-Mendez, L;Gradilla, AC;Sanchez-Hernandez, D;Gonzalez, E;Aguirre-Tamaral, A;Jimenez-Jimenez, C;Guerra, M;Aguilar, G;Andres, G;Falcon-Perez, JM;Guerrero, I
EMBO JOURNAL
2020-04-20

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
Lapitz, A;Arbelaiz, A;O'Rourke, CJ;Lavin, JL;La Casta, A;Ibarra, C;Jimeno, JP;Santos-Laso, A;Izquierdo-Sanchez, L;Krawczyk, M;Perugorria, MJ;Jimenez-Aguero, R;Sanchez-Campos, A;Riano, I;Gonzalez, ...
CELLS
2020-03-14

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Simon, J;Nunez-Garcia, M;Fernandez-Tussy, P;Barbier-Torres, L;Fernandez-Ramos, D;Gomez-Santos, B;Buque, X;Lopitz-Otsoa, F;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Rodriguez-Agudo, R;Bizkarguenaga, ...
CELL METABOLISM
2020-03-03

The future of Extracellular Vesicles as Theranostics - an ISEV meeting report
Soekmadji, C;Li, B;Huang, YY;Wang, HF;An, TX;Liu, CC;Pan, WL;Chen, J;Cheung, L;Falcon-Perez, JM;Gho, YS;Holthofer, HB;Le, MTN;Marcilla, A;O'Driscoll, L;Shekari, F;Shen, TL;Torrecilhas, ...
JOURNAL OF EXTRACELLULAR VESICLES
2020-01-01

2019

Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
Clayton, A;Boilard, E;Buzas, EI;Cheng, L;Falcon-Perez, JM;Gardiner, C;Gustafson, D;Gualerzi, A;Hendrix, A;Hoffmann, A;Jones, J;Lasser, C;Lawson, C;Lenassi, M;Nazarenko, I;O'Driscoll, L;Pink, ...
JOURNAL OF EXTRACELLULAR VESICLES
2019-12-01

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
Russell, AE;Sneider, A;Witwer, KW;Bergese, P;Bhattacharyya, SN;Cocks, A;Cocucci, E;Erdbrugger, U;Falcon-Perez, JM;Freeman, DW;Gallagher, TM;Hu, SS;Huang, YY;Jay, SM;Kano, S;Lavieu, G;Leszczynska, ...
JOURNAL OF EXTRACELLULAR VESICLES
2019-12-01

Metabolic Nano-Machines: Extracellular Vesicles Containing Active Enzymes and Their Contribution to Liver Diseases
Angulo, MA;Royo, F;Falcon-Perez, JM
CURRENT PATHOBIOLOGY REPORTS
2019-12-01

Metabolomics Applied to the Study of Extracellular Vesicles
Williams, C;Palviainen, M;Reichardt, NC;Siljander, PRM;Falcon-Perez, JM
METABOLITES
2019-11-12

EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer
Roman-Canal, B;Moiola, CP;Gatius, S;Bonnin, S;Ruiz-Miro, M;Gonzalez, E;Ojanguren, A;Recuero, JL;Gil-Moreno, A;Falcon-Perez, JM;Ponomarenko, J;Porcel, JM;Matias-Guiu, X;Colas, E
SCIENTIFIC REPORTS
2019-10-21

Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy
Unione, L;Lenza, MP;Arda, A;Urquiza, P;Lain, A;Falcon-Perez, JM;Jimenez-Barbero, J;Millet, O
ACS CENTRAL SCIENCE
2019-09-25

Hereditary tyrosinemia type I-associated mutations in fumarylacetoacetate hydrolase reduce the enzyme stability and increase its aggregation rate
Macias, I;Lain, A;Bernardo-Seisdedos, G;Gil, D;Gonzalez, E;Falcon-Perez, JM;Millet, O
JOURNAL OF BIOLOGICAL CHEMISTRY
2019-08-30

Assessing the role of surface glycans of extracellular vesicles on cellular uptake
Williams, C;Pazos, R;Royo, F;Gonzalez, E;Roura-Ferrer, M;Martinez, A;Gamiz, J;Reichardt, NC;Falcon-Perez, JM
SCIENTIFIC REPORTS
2019-08-15

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
Clos-Garcia, M;Andres-Marin, N;Fernandez-Eulate, G;Abecia, L;Lavin, JL;van Liempd, S;Cabrera, D;Royo, F;Valero, A;Errazquin, N;Vega, MCG;Govillard, L;Tackett, MR;Tejada, G;Gonzalez, E;Anguita, ...
EBIOMEDICINE
2019-08-01

EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer
Roman-Canal, B;Tarragona, J;Moiola, CP;Gatius, S;Bonnin, S;Ruiz-Miro, M;Sierra, JE;Rufas, M;Gonzalez, E;Porcel, JM;Gil-Moreno, A;Falcon-Perez, JM;Ponomarenko, J;Matias-Guiu, X;Colas, E
JOURNAL OF TRANSLATIONAL MEDICINE
2019-06-20

EV-Associated miRNAs from Peritoneal Lavage are a Source of Biomarkers in Endometrial Cancer
Roman-Canal, B;Moiola, CP;Gatius, S;Bonnin, S;Ruiz-Miro, M;Gonzalez, E;Gonzalez-Tallada, X;Llordella, I;Hernandez, I;Porcel, JM;Gil-Moreno, A;Falcon-Perez, JM;Ponomarenko, J;Matias-Guiu, X;Colas, ...
CANCERS
2019-06-18

Tetraspanin-decorated extracellular vesicle-mimetics as a novel adaptable reference material
Lozano-Andres, E;Libregts, SF;Toribio, V;Royo, F;Morales, S;Lopez-Martin, S;Vales-Gomez, M;Reyburn, HT;Falcon-Perez, JM;Wauben, MH;Soto, M;Yanez-Mo, M
JOURNAL OF EXTRACELLULAR VESICLES
2019-06-01

Modification of the glycosylation of extracellular vesicles alters their biodistribution in mice
Royo, F;Cossio, U;de Angulo, AR;Llop, J;Falcon-Perez, JM
NANOSCALE
2019-01-28

Raman tweezers microspectroscopy of circa 100 nm extracellular vesicles
Kruglik, SG;Royo, F;Guigner, JM;Palomo, L;Seksek, O;Turpin, PY;Tatischeff, I;Falcon-Perez, JM
NANOSCALE
2019-01-28

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress
Pascua-Maestro, R;Gonzalez, E;Lillo, C;Ganfornina, MD;Falcon-Perez, JM;Sanchez, D
FRONTIERS IN CELLULAR NEUROSCIENCE
2019-01-10

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models
Royo, F;Gil-Carton, D;Gonzalez, E;Mleczko, J;Palomo, L;Perez-Cormenzana, M;Mayo, R;Alonso, C;Falcon-Perez, JM
JOURNAL OF EXTRACELLULAR VESICLES
2019-01-01

A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
Prieto-Fernandez, E;Aransay, AM;Royo, F;Gonzalez, E;Lozano, JJ;Santos-Zorrozua, B;Macias-Camara, N;Gonzalez, M;Garay, RP;Benito, J;Garcia-Orad, A;Falcon-Perez, JM
THERANOSTICS
2019-01-01

2018

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
Urquiza, P;Lain, A;Sanz-Parra, A;Moreno, J;Bernardo-Seisdedos, G;Dubus, P;Gonzalez, E;Gutierrez-de-Juan, V;Garcia, S;Erana, H;Juan, IS;Macias, I;Ben Bdira, F;Pluta, P;Ortega, G;Oyarzabal, J;Gonzalez-Muniz, ...
SCIENCE TRANSLATIONAL MEDICINE
2018-09-19

Abundance of Cytochromes in Hepatic Extracellular Vesicles Is Altered by Drugs Related With Drug-Induced Liver Injury
Palomo, L;Mleczko, JE;Azkargorta, M;Conde-Vancells, J;Gonzalez, E;Elortza, F;Royo, F;Falcon-Perez, JM
HEPATOLOGY COMMUNICATIONS
2018-09-01

Targeted UPLC-MS Metabolic Analysis of Human Faeces Reveals Novel Low-Invasive Candidate Markers for Colorectal Cancer
Cubiella, J;Clos-Garcia, M;Alonso, C;Martinez-Arranz, I;Perez-Cormenzana, M;Barrenetxea, Z;Berganza, J;Rodriguez-Llopis, I;D'Amato, M;Bujanda, L;Diaz-Ondina, M;Falcon-Perez, JM
CANCERS
2018-09-01

The First Dose of Fingolimod Affects Circulating Extracellular Vesicles in Multiple Sclerosis Patients
Saenz-Cuesta, M;Alberro, A;Munoz-Culla, M;Osorio-Querejeta, I;Fernandez-Mercado, M;Lopetegui, I;Tainta, M;Prada, A;Castillo-Trivino, T;Falcon-Perez, JM;Olascoaga, J;Otaegui, D
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2018-08-01

Characterization of Plasmodium vivax Proteins in Plasma-Derived Exosomes From Malaria-Infected Liver-Chimeric Humanized Mice
Gualdron-Lopez, M;Flannery, EL;Kangwanrangsan, N;Chuenchob, V;Fernandez-Orth, D;Segui-Barber, J;Royo, F;Falcon-Perez, JM;Fernandez-Becerra, C;Lacerda, MVG;Kappe, SHI;Sattabongkot, J;Gonzalez, ...
FRONTIERS IN MICROBIOLOGY
2018-06-25

Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma
Yeung, V;Webber, JP;Dunlop, EA;Morgan, H;Hutton, J;Gurney, M;Jones, E;Falcon-Perez, J;Tabi, Z;Errington, R;Clayton, A
NANOSCALE
2018-05-14

Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
Clos-Garcia, M;Loizaga-Iriarte, A;Zuniga-Garcia, P;Sanchez-Mosquera, P;Cortazar, AR;Gonzalez, E;Torrano, V;Alonso, C;Perez-Cormenzana, M;Ugalde-Olano, A;Lacasa-Viscasillas, I;Castro, A;Royo, ...
JOURNAL OF EXTRACELLULAR VESICLES
2018-05-07

Serum and urine extracellular vesicles contain mRNA biomarkers for primary sclerosing cholangitis (PSC) and cholangiocarcinoma (CCA)
Arbelaiz, A;Lapitz, A;Krawczyk, M;Santos-Laso, A;Lavin, JL;Perugorria, MJ;Jimenez-Aguero, R;Lacasta, A;Ibarra, C;Sanchez-Campos, A;Jimeno, JP;Gonzalez, E;Lammert, F;Marzioni, M;Macias, R;Marin, ...
JOURNAL OF HEPATOLOGY
2018-04-01

Novel protein biomarkers in serum extracellular vesicles for the diagnosis of primary sclerosing cholangitis (PSC) in patients with ulcerative colitis (UC)
Lapitz, A;Arbelaiz, A;Azkargorta, M;Krawczyk, M;Santos-Laso, A;Perugorria, MJ;Jimenez-Aguero, R;Lacasta, A;Ibarra, C;Sanchez-Campos, A;Gonzalez, E;Lammert, F;Milkiewicz, P;Marzioni, M;Marin, ...
JOURNAL OF HEPATOLOGY
2018-04-01

Glutaminase 1 targeting in non-alcoholic steatohepatitis
Simon, J;Nunez, M;Tussy, PF;Barbier-Torres, L;Ramos, DF;Santos, BG;Otsoa, FL;de Juan, VG;Alonso, C;Iruzubieta, P;Liempd, SMV;Castro, A;Varela-Rey, M;Falcon-Perez, J;Villa, E;Crespo, J;Lu, SC;Matos, ...
JOURNAL OF HEPATOLOGY
2018-04-01

Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives
Williams, C;Royo, F;Aizpurua-Olaizola, O;Pazos, R;Boons, GJ;Reichardt, NC;Falcon-Perez, JM
JOURNAL OF EXTRACELLULAR VESICLES
2018-03-04

Extracellular Vesicles from Hypoxic Adipocytes and Obese Subjects Reduce Insulin-Stimulated Glucose Uptake
Mleczko, J;Ortega, FJ;Falcon-Perez, JM;Wabitsch, M;Fernandez-Real, JM;Mora, S
MOLECULAR NUTRITION & FOOD RESEARCH
2018-03-01

Mass spectrometry for glycan biomarker discovery
Aizpurua-Olaizola, O;Torano, JS;Falcon-Perez, JM;Williams, C;Reichardt, N;Boons, GJ
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
2018-03-01

Low-dose statin treatment increases prostate cancer aggressiveness
Caro-Maldonado, A;Camacho, L;Zabala-Letona, A;Torrano, V;Fernandez-Ruiz, S;Zamacola-Bascaran, K;Arreal, L;Valcarcel-Jimenez, L;Martin-Martin, N;Flores, JM;Cortazar, AR;Zuniga-Garcia, P;Arruabarrena-Aristorena, ...
ONCOTARGET
2018-01-05

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017
Clayton, A;Buschmann, D;Byrd, JB;Carter, DRF;Cheng, L;Compton, C;Daaboul, G;Devitt, A;Falcon-Perez, JM;Gardiner, C;Gustafson, D;Harrison, P;Helmbrecht, C;Hendrix, A;Hill, A;Hoffman, A;Jones, ...
JOURNAL OF EXTRACELLULAR VESICLES
2018-01-01

The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: Biophysical and physiological implications
Manni, MM;Sot, J;Arretxe, E;Gil-Redondo, R;Falcon-Perez, JM;Balgoma, D;Alonso, C;Goni, FM;Alonso, A
CHEMISTRY AND PHYSICS OF LIPIDS
2018-01-01

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Thery, C(Thery, Clotilde);Witwer, KW(Witwer, Kenneth W.);Aikawa, E(Aikawa, Elena);Alcaraz, MJ(Jose Alcaraz, Maria);Anderson, JD(Anderson, Johnathon D.);Andriantsitohaina, R(Andriantsitohaina, ...
JOURNAL OF EXTRACELLULAR VESICLES
2018-01-01

Essentials of extracellular vesicles: posters on basic and clinical aspects of extracellular vesicles
Nieuwland, R;Falcon-Perez, JM;Soekmadji, C;Boilard, E;Carter, D;Buzas, EI
JOURNAL OF EXTRACELLULAR VESICLES
2018-01-01

2017

Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility
Witwer, KW;Soekmadji, C;Hill, AF;Wauben, MH;Buzas, EI;Di Vizio, D;Falcon-Perez, JM;Gardiner, C;Hochberg, F;Kurochkin, IV;Lotvall, J;Mathivanan, S;Nieuwland, R;Sahoo, S;Tahara, H;Torrecilhas, ...
JOURNAL OF EXTRACELLULAR VESICLES
2017-11-15

Role of Aramchol in Steatohepatitis and Fibrosis in Mice
Iruarrizaga-Lejarreta, M;Varela-Rey, M;Fernandez-Ramos, D;Martinez-Arranz, I;Delgado, TC;Simon, J;Gutierrez-de Juan, V;delaCruz-Villar, L;Azkargorta, M;Lavin, JL;Mayo, R;van Liempd, SM;Aurrekoetxea, ...
HEPATOLOGY COMMUNICATIONS
2017-11-01

Serum Extracellular Vesicles Contain Protein Biomarkers for Primary Sclerosing Cholangitis and Cholangiocarcinoma
Arbelaiz, A;Azkargorta, M;Krawczyk, M;Santos-Laso, A;Lapitz, A;Perugorria, MJ;Erice, O;Gonzalez, E;Jimenez-Aguero, R;Lacasta, A;Ibarra, C;Sanchez-Campos, A;Jimeno, JP;Lammert, F;Milkiewicz, ...
HEPATOLOGY
2017-10-01

A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients
Cano, A;Marino, Z;Millet, O;Martinez-Arranz, I;Navasa, M;Falcon-Perez, JM;Perez-Cormenzana, M;Caballeria, J;Embade, N;Forns, X;Bosch, J;Castro, A;Mato, JM
SCIENTIFIC REPORTS
2017-09-05

BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus
van Liempd, SM;Cabrera, D;Lee, FY;Gonzalez, E;Dell'Angelica, EC;Ghiani, CA;Falcon-Perez, JM
SCIENTIFIC REPORTS
2017-07-12

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06

A novel community driven software for functional enrichment analysis of extracellular vesicles data
Pathan, M(Pathan, Mohashin);Keerthikumar, S(Keerthikumar, Shivakumar);Chisanga, D(Chisanga, David);Alessandro, R(Alessandro, Riccardo);Ang, CS(Ang, Ching-Seng);Askenase, P(Askenase, Philip);Batagov, ...
JOURNAL OF EXTRACELLULAR VESICLES
2017-05-26

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso, C;Fernandez-Ramos, D;Varela-Rey, M;Martinez-Arranz, I;Navasa, N;Van Liempd, SM;Trueba, JLL;Mayo, R;Ilisso, CP;de Juan, VG;Iruarrizaga-Lejarreta, M;delaCruz-Villar, L;Minchole, I;Robinson, ...
GASTROENTEROLOGY
2017-05-01

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles
Lopes-Rodrigues, V;Di Luca, A;Mleczko, J;Meleady, P;Henry, M;Pesic, M;Cabrera, D;van Liempd, S;Lima, RT;O'Connor, R;Falcon-Perez, JM;Vasconcelos, MH
SCIENTIFIC REPORTS
2017-03-17

Isolation and characterization of exosomes derived from fertile sheep hydatid cysts
Siles-Lucas, M;Sanchez-Ovejero, C;Gonzalez-Sanchez, M;Gonzalez, E;Falcon-Perez, JM;Boufana, B;Fratini, F;Casulli, A;Manzano-Romana, R
VETERINARY PARASITOLOGY
2017-03-15

Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanism
Royo, F;Moreno, L;Mleczko, J;Palomo, L;Gonzalez, E;Cabrera, D;Cogolludo, A;Vizcaino, FP;van-Liempd, S;Falcon-Perez, JM
SCIENTIFIC REPORTS
2017-02-17

Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes
Royo, F;Palomo, L;Mleczko, J;Gonzalez, E;Alonso, C;Martinez, I;Perez-Cormenzana, M;Castro, A;Falcon-Perez, JM
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES : OFFICIAL JOURNAL OF THE EUROPEAN FEDERATION FOR PHARMACEUTICAL SCIENCES
2017-02-15

Aramchol reduces established fibrosis in MCD diet animal model
Varela-Rey, M;Fernandez-Ramos, D;Iruarrizaga-Lejarreta, M;Van Liempd, SM;DelaCruz-Villar, L;de Davalillo, SL;Martin-Ruiz, I;Aurrekoetxea, I;Buque, X;Lavin, JL;Aransay, AM;Hayardeny, L;Alonso, ...
JOURNAL OF HEPATOLOGY
2017-01-01

Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma.
Arbelaiz A; Azkargorta M; Krawczyk M; Santos-Laso A; Lapitz A; Perugorria MJ; Erice O; Gonzalez E; Jimenez-Agüero R; Lacasta A; Ibarra C; Sanchez-Campos A; Jimeno JP; Lammert ...
HEPATOLOGY
2017-01-01

2016

A Novel Sensitive Method to Measure Catechol-O-Methyltransferase Activity Unravels the Presence of This Activity in Extracellular Vesicles Released by Rat Hepatocytes
Casal, E;Palomo, L;Cabrera, D;Falcon-Perez, JM
FRONTIERS IN PHARMACOLOGY
2016-12-23

Comparative miRNA Analysis of Urine Extracellular Vesicles Isolated through Five Different Methods
Royo, F;Diwan, I;Tackett, MR;Zuniga, P;Sanchez-Mosquera, P;Loizaga-Iriarte, A;Ugalde-Olano, A;Lacasa, I;Perez, A;Unda, M;Carracedo, A;Falcon-Perez, JM
CANCERS
2016-12-01

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer
Torrano, V;Royo, F;Peinado, H;Loizaga-Iriarte, A;Unda, M;Falcon-Perez, JM;Carracedo, A
CURRENT OPINION IN PHARMACOLOGY
2016-08-01

Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum H-1-NMR Spectroscopy
Embade, N;Marino, Z;Diercks, T;Cano, A;Lens, S;Cabrera, D;Navasa, M;Falcon-Perez, JM;Caballeria, J;Castro, A;Bosch, J;Mato, JM;Millet, O
PLOS ONE
2016-05-09

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity
Zhao, YT;Feresin, RG;Falcon-Perez, JM;Salazar, G
TRAFFIC
2016-03-01

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Royo, F;Zuniga-Garcia, P;Torrano, V;Loizaga, A;Sanchez-Mosquera, P;Ugalde-Olano, A;Gonzalez, E;Cortazar, AR;Palomo, L;Fernandez-Ruiz, S;Lacasa-Viscasillas, I;Berdasco, M;Sutherland, JD;Barrio, ...
ONCOTARGET
2016-02-09

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Zubiete-Franco, I;Garcia-Rodriguez, JL;Martinez-Una, M;Martinez-Lopez, N;Woodhoo, A;Gutierrez-De Juan, V;Beraza, N;Lage-Medina, S;Andrade, F;Fernandez, ML;Aldamiz-Echevarria, L;Fernandez-Ramos, ...
JOURNAL OF HEPATOLOGY
2016-02-01

Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array
Welton, JL;Brennan, P;Gurney, M;Webber, JP;Spary, LK;Carton, DG;Falcon-Perez, JM;Walton, SP;Mason, MD;Tabi, Z;Clayton, A
JOURNAL OF EXTRACELLULAR VESICLES
2016-01-01

Different EV enrichment methods suitable for clinical settings yield different subpopulations of urinary extracellular vesicles from human samples
Royo, F;Zuniga-Garcia, P;Sanchez-Mosquera, P;Egia, A;Perez, A;Loizaga, A;Arceo, R;Lacasa, I;Rabade, A;Arrieta, E;Bilbao, R;Unda, M;Carracedo, A;Falcon-Perez, JM
JOURNAL OF EXTRACELLULAR VESICLES
2016-01-01

2015

Circulating RNA: looking at the liver through a frosted glass
Falcon-Perez, JM;Royo, F
BIOMARKERS : BIOCHEMICAL INDICATORS OF EXPOSURE, RESPONSE, AND SUSCEPTIBILITY TO CHEMICALS
2015-10-03

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses
Baixauli, F;Acin-Perez, R;Villarroya-Beltri, C;Mazzeo, C;Nunez-Andrade, N;Gabande-Rodriguez, E;Ledesma, MD;Blazquez, A;Martin, MA;Falcon-Perez, JM;Redondo, JM;Enriquez, JA;Mittelbrunn, M
CELL METABOLISM
2015-09-01

Cell-derived extracellular vesicles as a platform to identify low-invasive disease biomarkers
Gonzalez, E;Falcon-Perez, JM
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
2015-07-01

Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN
Ugalde-Olano, A;Egia, A;Fernandez-Ruiz, S;Loizaga-Iriarte, A;Zuniga-Garcia, P;Garcia, S;Royo, F;Lacasa-Viscasillas, I;Castro, E;Cortazar, AR;Zabala-Letona, A;Martin-Martin, N;Arruabarrena-Aristorena, ...
METHODS
2015-05-01

Methods for extracellular vesicles isolation in a hospital setting
Saenz-Cuesta, M;Arbelaiz, A;Oregi, A;Irizar, H;Osorio-Querejeta, I;Munoz-Culla, M;Banales, JM;Falcon-Perez, JM;Olascoaga, J;Otaegui, D
FRONTIERS IN IMMUNOLOGY
2015-02-13

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
Lener, T(Lener, Thomas);Gimona, M(Gimona, Mario);Aigner, L(Aigner, Ludwig);Borger, V(Boerger, Verena);Buzas, E(Buzas, Edit);Camussi, G(Camussi, Giovanni);Chaput, N(Chaput, Nathalie);Chatterjee, ...
JOURNAL OF EXTRACELLULAR VESICLES
2015-01-01

Biological properties of extracellular vesicles and their physiological functions
Yanez-Mo, M(Yanez-Mo, Maria);Siljander, PRM(Siljander, Pia R. -M.);Andreu, Z(Andreu, Zoraida);Zavec, AB(Zavec, Apolonija Bedina);Borras, FE(Borras, Francesc E.);Buzas, EI(Buzas, Edit I.);Buzas, ...
JOURNAL OF EXTRACELLULAR VESICLES
2015-01-01

2014

Considerations for applying metabolomics to the analysis of extracellular vesicles
Palomo, L;Casal, E;Royo, F;Cabrera, D;van-Liempd, S;Falcon-Perez, JM
FRONTIERS IN IMMUNOLOGY
2014-12-23

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion
Gradilla, AC;Gonzalez, E;Seijo, I;Andres, G;Bischoff, M;Gonzalez-Mendez, L;Sanchez, V;Callejo, A;Ibanez, C;Guerra, M;Ortigao-Farias, JR;Sutherland, JD;Gonzalez, M;Barrio, R;Falcon-Perez, JM;Guerrero, ...
NATURE COMMUNICATIONS
2014-12-01

Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria
ben Bdira, F;Gonzalez, E;Pluta, P;Lain, A;Sanz-Parra, A;Falcon-Perez, JM;Millet, O
HUMAN MOLECULAR GENETICS
2014-11-01

Microarray-Based Identification of Lectins for the Purification of Human Urinary Extracellular Vesicles Directly from Urine Samples
Echevarria, J;Royo, F;Pazos, R;Salazar, L;Falcon-Perez, JM;Reichardt, NC
CHEMBIOCHEM
2014-07-21

Sorting signal targeting mRNA into hepatic extracellular vesicles
Szostak, N;Royo, F;Rybarczyk, A;Szachniuk, M;Blazewicz, J;del Sol, A;Falcon-Perez, JM
RNA BIOLOGY
2014-07-01

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity
Rodriguez-Suarez, E;Gonzalez, E;Hughes, C;Conde-Vancells, J;Rudella, A;Royo, F;Palomo, L;Elortza, F;Lu, SC;Mato, JM;Vissers, JPC;Falcon-Perez, JM
JOURNAL OF PROTEOMICS
2014-05-30

A Pilot Study on the Potential of RNA-Associated to Urinary Vesicles as a Suitable Non-Invasive Source for Diagnostic Purposes in Bladder Cancer
Perez, A;Loizaga, A;Arceo, R;Lacasa, I;Rabade, A;Zorroza, K;Mosen-Ansorena, D;Gonzalez, E;Aransay, AM;Falcon-Perez, JM;Unda-Urzaiz, M;Royo, F
CANCERS
2014-03-01

Human Mammospheres Secrete Hormone-Regulated Active Extracellular Vesicles
Gonzalez, E;Piva, M;Rodriguez-Suarez, E;Gil, D;Royo, F;Elortza, F;Falcon-Perez, JM;Vivanco, MD
PLOS ONE
2014-01-03

2013

Transcriptome of Extracellular Vesicles Released by Hepatocytes
Royo, F;Schlangen, K;Palomo, L;Gonzalez, E;Conde-Vancells, J;Berisa, A;Aransay, AM;Falcon-Perez, JM
PLOS ONE
2013-07-11

A fast method for the quantitation of key metabolites of the methionine pathway in liver tissue by high-resolution mass spectrometry and hydrophilic interaction ultra-performance liquid chromatography
van Liempd, S;Cabrera, D;Mato, JM;Falcon-Perez, JM
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2013-06-01

Meeting report of the European mouse complex genetics network SYSGENET
Delprato, A;Aransay, AM;Kollmus, H;Schughart, K;Falcon-Perez, JM
MAMMALIAN GENOME
2013-06-01

Non-invasive detection of drug toxicity in rats by solid-phase extraction and MALDI-TOF analysis of urine samples
Iloro, I;Gonzalez, E;Gutierrez-de Juan, V;Mato, JM;Falcon-Perez, JM;Elortza, F
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2013-03-01

2012

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity
Gonzalez, E;van Liempd, S;Conde-Vancells, J;Gutierrez-de Juan, V;Perez-Cormenzana, M;Mayo, R;Berisa, A;Alonso, C;Marquez, CA;Barr, J;Lu, SC;Mato, JM;Falcon-Perez, JM
METABOLOMICS
2012-12-01

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
Kalra, Hina; Simpson, Richard J.; Ji, Hong; Aikawa, Elena; Altevogt, Peter; Askenase, Philip; Bond, Vincent C.; Borras, Francesc E.; Breakefield, Xandra; Budnik, Vivian; Buzas, Edit; Camussi, ...
PLOS BIOLOGY
2012-12-01

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability
Bastos-Amador, P;Royo, F;Gonzalez, E;Conde-Vancells, J;Palomo-Diez, L;Borras, FE;Falcon-Perez, JM
JOURNAL OF PROTEOMICS
2012-06-27

Cellular Uptake of Gold Nanoparticles Bearing HIV gp120 Oligomannosides
Arnaiz, B;Martinez-Avila, O;Falcon-Perez, JM;Penades, S
BIOCONJUGATE CHEMISTRY
2012-04-01

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
Simon, D;Garcia-Garcia, E;Royo, F;Falcon-Perez, JM;Avila, J
FEBS LETTERS
2012-01-02

Tau Overexpression Results in Its Secretion via Membrane Vesicles
Simon, D;Garcia-Garcia, E;Gomez-Ramos, A;Falcon-Perez, JM;Diaz-Hernandez, M;Hernandez, F;Avila, J
NEURODEGENERATIVE DISEASES
2012-01-01

2011

Intracellular Rescue of the Uroporphyrinogen III Synthase Activity in Enzymes Carrying the Hotspot Mutation C73R
Fortian, A;Gonzalez, E;Castano, D;Falcon-Perez, JM;Millet, O
JOURNAL OF BIOLOGICAL CHEMISTRY
2011-04-15

STRUCTURAL, THERMODYNAMIC, AND MECHANISTICAL STUDIES IN UROPORPHYRINOGEN III SYNTHASE: MOLECULAR BASIS OF CONGENITAL ERYTHROPOIETIC PORPHYRIA
Fortian, A;Castano, D;Gonzalez, E;Lain, A;Falcon-Perez, JM;Millet, O
ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY: PROTEIN STRUCTURE AND DISEASES, VOL 83
2011-01-01

2010

Overview of extracellular microvesicles in drug metabolism
Conde-Vancells, J;Gonzalez, E;Lu, SC;Mato, JM;Falcon-Perez, JM
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
2010-05-01

Sub-proteome approach to the knowledge of liver
Falcon-Perez, JM;Lu, SC;Mato, JM
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

Virtual Expert Mass Spectrometrist: iTRAQ tool for database-dependent search, quantitation and result storage
Rodriguez-Suarez, E;Gubb, E;Alzueta, IF;Falcon-Perez, JM;Amorim, A;Elortza, F;Matthiesen, R
PROTEOMICS
2010-04-01

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples
Conde-Vancells, J;Rodriguez-Suarez, E;Gonzalez, E;Berisa, A;Gil, D;Embade, N;Valle, M;Luka, Z;Elortza, F;Wagner, C;Lu, SC;Mato, JM;Falcon-Perez, JM
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

2009

miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments
Hackenberg, M;Sturm, M;Langenberger, D;Falcon-Perez, JM;Aransay, AM
NUCLEIC ACIDS RESEARCH
2009-07-01

2008

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
Conde-Vancells, J;Rodriguez-Suarez, E;Embade, N;Gil, D;Matthiesen, R;Valle, M;Elortza, F;Lu, SC;Mato, JM;Falcon-Perez, JM
JOURNAL OF PROTEOME RESEARCH
2008-12-01

2007

Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes
Falcon-Perez, JM;Dell'Angelica, EC
EXPERIMENTAL CELL RESEARCH
2007-04-15

The discovery of cell-secreted extracellular vesicles (EVs) including EXOSOMES has provided a new cellular component with the ability to influence different biological and pathological processes. In the last years these vesicles has attracted the interest in clinical, pharmaceutical and manufacturing areas. All cellular systems in culture or forming part of a tissue in the body secrete EVs containing proteins, nucleic acids, lipids and metabolites into the environment. They have been shown to act as important mediators of intercellular communication and regulators of cellular niches, and their altered characteristics in many diseases suggest them to be helpful for the diagnostic purposes. Our group has been working in exosomes since 2006 and acquired wide experience in isolate and characterize these vesicles from different biofluids and cell lines, in normal and pathological conditions. Our current scientific interests are:

1) To elucidate the functional role of exosomes in metabolism.

The goal is to identify genes, proteins and metabolites that form part of the exosomes in normal and pathological conditions. The improvement in the knowledge of the cargo of these vesicles will provide also clues about the functional role and implications of them in biology. Technological advances in the past 20 years have permitted large-scale measurements of biochemical and cellular constituents for study as a unified whole, creating all the ‘-omics’ technologies including proteomics, genomics and more recently metabolomics. The group has already showed the presence in hepatic exosomes of an elevated number of metabolic enzymes involved in endogenous and xenobiotics compounds, and we are currently studying the implications of these vesicles in the metabolism of those compounds.

2) To develop diagnosis and therapeutics tools based on exosomes.

Exosomes constitutes a platform to identify low-invasive disease biomarkers. The group is currently comparing the composition of exosomes in different scenarios in order to generate a repertoire of differentially expressed molecules that could be candidate biomarker of disease. In addition, behind the idea to obtain a "magic bullet" – a desired activity encapsulated in a vehicle with a known specific target- the group is trying to define the cellular preferences displayed by exosomes. In this aspect the group is focused in identifying the molecular determinants that define the cellular specificity, and also the molecular machinery involved in the biogenesis of exosomes. A better knowledge of the biology and the mechanisms of action of exosomes will help to manipulate these vesicles with therapeutics purposes.

Members

POST DOCTORAL RESEARCHER

Elisabeth Rackles
Félix Royo

TECHNICIANS / DOCTORAL CANDIDATES

Clara Garcia Vallicrosa
Patricia Hernández Lopez
Esperanza González Jiménez
María Azparren Angulo
Marc Liébana Jordán
Guillermo Bordanaba Florit

MSCA-ITN Fellow

Latest Publications

Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma

Rackles, E;Lopez, PH;Falcon-Perez, JM

SEMINARS IN CANCER BIOLOGY

2022-12-01

ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection

Albert, M;Vazquez, J;Falcon-Perez, JM;Balboa, MA;Liesa, M;Balsinde, J;Guerra, S

MICROBIOLOGY SPECTRUM

2022-12-01

Gallego-Duran, R;Albillos, A;Ampuero, J;Arechederra, M;Banares, R;Blas-Garcia, A;Berna, G;Caparros, E;Delgado, TC;Falcon-Perez, JM;Frances, R;Fernandez-Barrena, MG;Graupera, I;Iruzubieta, P;Nevzorova, ...

GASTROENTEROLOGIA Y HEPATOLOGIA

2022-11-01

miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma

de la Cruz-Ojeda, P;Schmid, T;Boix, L;Moreno, M;Sapena, V;Praena-Fernandez, JM;Castell, FJ;Falcon-Perez, JM;Reig, M;Brune, B;Gomez-Bravo, MA;Giraldez, A;Bruix, J;Ferrer, MT;Muntane, J

CELLS

2022-09-01

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV-Cell Interaction and Functional Activation of Endothelial Cells

Clos-Sansalvador, M;Garcia, SG;Moron-Font, M;Williams, C;Reichardt, NC;Falcon-Perez, JM;Bayes-Genis, A;Roura, S;Franquesa, M;Monguio-Tortajada, M;Borras, FE

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-09-01

microRNA-based signatures obtained from endometrial fluid identify implantative endometrium

Ibanez-Perez, J;Diaz-Nunez, M;Clos-Garcia, M;Lainz, L;Iglesias, M;Diez-Zapirain, M;Rabanal, A;Barcena, L;Gonzalez, M;Lozano, JJ;Marigorta, UM;Gonzalez, E;Royo, F;Aransay, AM;Subiran, N;Matorras, ...

HUMAN REPRODUCTION

2022-08-27

Oral Progenitor Cell Line-Derived Small Extracellular Vesicles as a Treatment for Preferential Wound Healing Outcome

Knight, R;Board-Davies, E;Brown, H;Clayton, A;Davis, T;Karatas, B;Burston, J;Tabi, Z;Falcon-Perez, JM;Paisey, S;Stephens, P

STEM CELLS TRANSLATIONAL MEDICINE

2022-08-23

Reproducibility of extracellular vesicle research

Nieuwland, R;Siljander, PRM;Falcon-Perez, JM;Witwer, KW

EUROPEAN JOURNAL OF CELL BIOLOGY

2022-08-01

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples

Bordanaba-Florit, G;van Liempd, S;Cabrera, D;Royo, F;Falcon-Perez, JM

METABOLITES

2022-08-01

HPLC-(Q)-TOF-MS-Based Study of Plasma Metabolic Profile Differences Associated with Age in Pediatric Population Using an Animal Model

Alboniga, OE;Gonzalez-Mendia, O;Blanco, ME;Alonso, RM

METABOLITES

2022-08-01

Members

SPECIALIST

Sebastiaan Martijn Van Liempd
Oihane Elena Albóniga Díez

TECHNICIANS / DOCTORAL CANDIDATES

Diana Cabrera

Latest Publications

Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma

Rackles, E;Lopez, PH;Falcon-Perez, JM

SEMINARS IN CANCER BIOLOGY

2022-12-01

ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection

Albert, M;Vazquez, J;Falcon-Perez, JM;Balboa, MA;Liesa, M;Balsinde, J;Guerra, S

MICROBIOLOGY SPECTRUM

2022-12-01

GASTROENTEROLOGIA Y HEPATOLOGIA

2022-11-01

miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma

de la Cruz-Ojeda, P;Schmid, T;Boix, L;Moreno, M;Sapena, V;Praena-Fernandez, JM;Castell, FJ;Falcon-Perez, JM;Reig, M;Brune, B;Gomez-Bravo, MA;Giraldez, A;Bruix, J;Ferrer, MT;Muntane, J

CELLS

2022-09-01

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV-Cell Interaction and Functional Activation of Endothelial Cells

Clos-Sansalvador, M;Garcia, SG;Moron-Font, M;Williams, C;Reichardt, NC;Falcon-Perez, JM;Bayes-Genis, A;Roura, S;Franquesa, M;Monguio-Tortajada, M;Borras, FE

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-09-01

microRNA-based signatures obtained from endometrial fluid identify implantative endometrium

Ibanez-Perez, J;Diaz-Nunez, M;Clos-Garcia, M;Lainz, L;Iglesias, M;Diez-Zapirain, M;Rabanal, A;Barcena, L;Gonzalez, M;Lozano, JJ;Marigorta, UM;Gonzalez, E;Royo, F;Aransay, AM;Subiran, N;Matorras, ...

HUMAN REPRODUCTION

2022-08-27

Oral Progenitor Cell Line-Derived Small Extracellular Vesicles as a Treatment for Preferential Wound Healing Outcome

Knight, R;Board-Davies, E;Brown, H;Clayton, A;Davis, T;Karatas, B;Burston, J;Tabi, Z;Falcon-Perez, JM;Paisey, S;Stephens, P

STEM CELLS TRANSLATIONAL MEDICINE

2022-08-23

Reproducibility of extracellular vesicle research

Nieuwland, R;Siljander, PRM;Falcon-Perez, JM;Witwer, KW

EUROPEAN JOURNAL OF CELL BIOLOGY

2022-08-01

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples

Bordanaba-Florit, G;van Liempd, S;Cabrera, D;Royo, F;Falcon-Perez, JM

METABOLITES

2022-08-01

Extracellular vesicles from thyroid cancer harbor a functional machinery involved in extracellular matrix remodeling

Bravo-Miana, RD;Soler, MF;Ceschin, DG;Royo, F;Negretti-Borga, DM;Azkargorta, M;Elortza, F;Montesinos, MD;Pellizas, CG;Falcon-Perez, JM;Donadio, AC

EUROPEAN JOURNAL OF CELL BIOLOGY

2022-08-01