Mikel Valle
mvalle
Mikel Valle
PRINCIPAL INVESTIGATOR
CryoEM of Biological Macromolecules Lab
Orcid: 0000-0001-8268-6912
Email: mvalle@cicbiogune.es
Phone: 4309 / 946 572 503
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

His research interest is focused on the structural characterization of macromolecular machines by cryo-electron microscopy (cryoEM). After his PhD in Madrid, he joined Prof. Joachim Frank in the USA, where Dr. Valle tasted the latest developments in cryoEM applied to the study of the ribosome. This period was really fruitful, and several classic articles revealed fundamental aspects of the ribosomal functioning during translation. After a short period as civil servant in the Spanish Research Council (CSIC), Mikel Valle joined CIC bioGUNE in 2006. Since then, Dr. Valle leads a team focused on several projects, from ribosomal structure to large metabolic enzymes, always by means of cryoEM, a powerful structural biology technique. His research has recently delivered the highest  resolution structure for a plant flexible filamentous virus.

Latest Publications
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
Lopez-Alonso, JP;Lazaro, M;Gil-Carton, D;Choi, PH;Tong, L;Valle, M
NATURE COMMUNICATIONS
2022-10-19
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
Ballesteros, U;Etxaniz, A;Iriondo, MN;Varela, YR;Lazaro, M;Viguera, AR;Montes, LR;Valle, M;Goni, FM;Alonso, A
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2022-07-01
A switch from alpha-helical to beta-strand conformation during co-translational protein folding
Agirrezabala, X;Samatova, E;Macher, M;Liutkute, M;Maiti, M;Gil-Carton, D;Novacek, J;Valle, M;Rodnina, MV
EMBO JOURNAL
2022-01-07

2021

3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme
Lazaro, M;Melero, R;Huet, C;Lopez-Alonso, JP;Delgado, S;Dodu, A;Bruch, EM;Abriata, LA;Alzari, PM;Valle, M;Lisa, MN
COMMUNICATIONS BIOLOGY
2021-06-03

2020

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, MP;Oyenarte, I;Diercks, T;Quintana, JI;Gimeno, A;Coelho, H;Diniz, A;Peccati, F;Delgado, S;Bosch, A;Valle, M;Millet, O;Abrescia, NGA;Palazn, A;Marcelo, F;Jimnez-Oss, G;Jimnez-Barbero, ...
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-10-22
Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis
Galisteo-Gonzalez, F;Monasterio, BG;Gil, D;Valle, M;Goni, FM
SCIENTIFIC REPORTS
2020-01-15

2019

Structure of Turnip mosaic virus and its viral-like particles
Cuesta, R;Yuste-Calvo, C;Gil-Carton, D;Sanchez, F;Ponz, F;Valle, M
SCIENTIFIC REPORTS
2019-10-28
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Canal-Martin, A;Sastre, J;Sanchez-Barrena, MJ;Canales, A;Baldominos, S;Pascual, N;Martinez-Gonzalez, L;Molero, D;Fernandez-Valle, ME;Saez, E;Blanco-Gabella, P;Gomez-Rubio, E;Martin-Santamaria, ...
NATURE COMMUNICATIONS
2019-06-26

2018

Structural Homology Between Nucleoproteins of ssRNA Viruses
Valle, M
SUB-CELLULAR BIOCHEMISTRY
2018-01-01

2017

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses
Zamora, M;Mendez-Lopez, E;Agirrezabala, X;Cuesta, R;Lavin, JL;Sanchez-Pina, MA;Aranda, MA;Valle, M
SCIENCE ADVANCES
2017-09-01
Coating Graphene Oxide with Lipid Bilayers Greatly Decreases Its Hemolytic Properties
Monasterio, BG;Alonso, B;Sot, J;Garcia-Arribas, AB;Gil-Carton, D;Valle, M;Zurutuza, A;Goni, FM
LANGMUIR : THE ACS JOURNAL OF SURFACES AND COLLOIDS
2017-08-22
Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism
Artetxe, I;Ugarte-Uribe, B;Gil, D;Valle, M;Alonso, A;Garcia-Saez, AJ;Goni, FM
BIOPHYSICAL JOURNAL
2017-08-22
Ribosome rearrangements at the onset of translational bypassing
Agirrezabala, X;Samatova, E;Klimova, M;Zamora, M;Gil-Carton, D;Rodnina, MV;Valle, M
SCIENCE ADVANCES
2017-06-01
"Pyruvate Carboxylase, Structure and Function"
Valle, M
SUB-CELLULAR BIOCHEMISTRY
2017-01-01

2016

Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins
Morante, K;Bellomio, A;Gil-Carton, D;Redondo-Morata, L;Sot, J;Scheuring, S;Valle, M;Gonzalez-Manas, JM;Tsumoto, K;Caaveiro, JMM
THE JOURNAL OF BIOLOGICAL CHEMISTRY
2016-09-09
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation
Landajuela, A;Hervas, JH;Anton, Z;Montes, LR;Gil, D;Valle, M;Rodriguez, JF;Goni, FM;Alonso, A
BIOPHYSICAL JOURNAL
2016-01-19

2015

Lipidic nanovesicles stabilize suspensions of metal oxide nanoparticles
Jimenez-Rojo, N;Lete, MG;Rojas, E;Gil, D;Valle, M;Alonso, A;Moya, SE;Goni, FM
CHEMISTRY AND PHYSICS OF LIPIDS
2015-10-01
Structural Insights into tRNA Dynamics on the Ribosome
Agirrezabala, X;Valle, M
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2015-05-01
The hexameric structure of the human mitochondrial replicative helicase Twinkle
Fernandez-Millan, P;Lazaro, M;Cansiz-Arda, S;Gerhold, JM;Rajala, N;Schmitz, CA;Silva-Espina, C;Gil, D;Bernado, P;Valle, M;Spelbrink, JN;Sola, M
NUCLEIC ACIDS RESEARCH
2015-04-30
Histones Cause Aggregation and Fusion of Lipid Vesicles Containing Phosphatidylinositol-4-Phosphate
Lete, MG;Sot, J;Gil, D;Valle, M;Medina, M;Goni, FM;Alonso, A
BIOPHYSICAL JOURNAL
2015-02-17

2014

High-Melting Lipid Mixtures and the Origin of Detergent-Resistant Membranes Studied with Temperature-Solubilization Diagrams
Sot, J;Manni, MM;Viguera, AR;Castaneda, V;Cano, A;Alonso, C;Gil, D;Valle, M;Alonso, A;Goni, FM
BIOPHYSICAL JOURNAL
2014-12-16
Functional Conformations for Pyruvate Carboxylase during Catalysis Explored by Cryoelectron Microscopy
Lasso, G;Yu, LPC;Gil, D;Lazaro, M;Tong, L;Valle, M
STRUCTURE
2014-06-10

2013

The ribosome triggers the stringent response by RelA via a highly distorted tRNA
Agirrezabala, X;Fernandez, IS;Kelley, AC;Carton, DG;Ramakrishnan, V;Valle, M
EMBO REPORTS
2013-09-01

2012

Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes
Mechaly, AE;Bellomio, A;Morante, K;Agirre, J;Gil-Carton, D;Valle, M;Gonzalez-Manas, JM;Guerin, DMA
JOURNAL OF STRUCTURAL BIOLOGY
2012-11-01
Model systems of precursor cellular membranes: long-chain alcohols stabilize spontaneously formed oleic acid vesicles (vol 102, pg 278, 2012)
Rendon, Adela; Carton, David Gil; Sot, Jesus; Garcia-Pacios, Marcos; Montes, L-Ruth; Valle, Mikel; Arrondo, Jose-Luis R.; Goni, Felix M.; Ruiz-Mirazo, Kepa
BIOPHYSICAL JOURNAL
2012-04-04
Model Systems of Precursor Cellular Membranes: Long-Chain Alcohols Stabilize Spontaneously Formed Oleic Acid Vesicles
Rendon, A;Carton, DG;Sot, J;Garcia-Pacios, M;Montes, R;Valle, M;Arrondo, JLR;Goni, FM;Ruiz-Mirazo, K
BIOPHYSICAL JOURNAL
2012-01-18

2011

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli
Julian, P;Milon, P;Agirrezabala, X;Lasso, G;Gil, D;Rodnina, MV;Valle, M
PLOS BIOLOGY
2011-07-01
Almost lost in translation. Cryo-EM of a dynamic macromolecular complex: the ribosome
Valle, M
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
2011-05-01
Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process
Landeta, O;Landajuela, A;Gil, D;Taneva, S;Di Primo, C;Sot, B;Valle, M;Frolov, VA;Basanez, G
JOURNAL OF BIOLOGICAL CHEMISTRY
2011-03-11
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA
Melero, R;Rajagopalan, S;Lazaro, M;Joerger, AC;Brandt, T;Veprintsev, DB;Lasso, G;Gil, D;Scheres, SHW;Carazo, JM;Fersht, AR;Valle, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2011-01-11

2010

Cryo-EM Analysis Reveals New Insights into the Mechanism of Action of Pyruvate Carboxylase
Lasso, G;Yu, LPC;Gil, D;Xiang, S;Tong, LA;Valle, M
STRUCTURE
2010-10-13
Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples
Conde-Vancells, J;Rodriguez-Suarez, E;Gonzalez, E;Berisa, A;Gil, D;Embade, N;Valle, M;Luka, Z;Elortza, F;Wagner, C;Lu, SC;Mato, JM;Falcon-Perez, JM
PROTEOMICS CLINICAL APPLICATIONS
2010-04-01

2009

Averaging of Electron Subtomograms and Random Conical Tilt Reconstructions through Likelihood Optimization
Scheres, SHW;Melero, R;Valle, M;Carazo, JM
STRUCTURE
2009-12-09
A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A
Yu, LPC;Xiang, S;Lasso, G;Gil, D;Valle, M;Tong, L
STRUCTURE
2009-06-10
Maximum likelihood refinement of electron microscopy data with normalization errors
Scheres, SHW;Valle, M;Grob, P;Nogales, E;Carazo, JM
JOURNAL OF STRUCTURAL BIOLOGY
2009-05-01

2008

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
Conde-Vancells, J;Rodriguez-Suarez, E;Embade, N;Gil, D;Matthiesen, R;Valle, M;Elortza, F;Lu, SC;Mato, JM;Falcon-Perez, JM
JOURNAL OF PROTEOME RESEARCH
2008-12-01
Structure of ratcheted ribosomes with tRNAs in hybrid states
Julian, P;Konevega, AL;Scheres, SHW;Lazaro, M;Gil, D;Wintermeyer, W;Rodnina, MV;Valle, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2008-11-04

2007

Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex
Tidow, H;Melero, R;Mylonas, E;Freund, SMV;Grossmann, JG;Carazo, JM;Svergun, DI;Valle, M;Fersht, AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2007-07-24

The structural study of biological macromolecules is key to understand their functioning. By means of cryo-electron microscopy we can obtain 3D maps biological complexes under nearly physiological conditions, and the latest developments in the field allow for near-atomic resolution, providing detailed observation of molecules. The aim of the team is to describe the structure and the conformational changes associated with the biological function. We focus on motors involved in universal biological functions where interactions between protein and nucleic acids are essential. Structural studies of ribosomes during translation allow the understanding of the mechanisms which govern protein synthesis. In this process, interactions with translation factors and interference by several antibiotics are especially important. We also analyze the structure of flexible filamentous viruses, a group of plant pathogens, and large oligomeric enzymes such as pyruvate carboxylase.

Latest Publications

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase

Lopez-Alonso, JP;Lazaro, M;Gil-Carton, D;Choi, PH;Tong, L;Valle, M

NATURE COMMUNICATIONS

2022-10-19

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes

Ballesteros, U;Etxaniz, A;Iriondo, MN;Varela, YR;Lazaro, M;Viguera, AR;Montes, LR;Valle, M;Goni, FM;Alonso, A

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

2022-07-01

A switch from alpha-helical to beta-strand conformation during co-translational protein folding

Agirrezabala, X;Samatova, E;Macher, M;Liutkute, M;Maiti, M;Gil-Carton, D;Novacek, J;Valle, M;Rodnina, MV

EMBO JOURNAL

2022-01-07

3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme

Lazaro, M;Melero, R;Huet, C;Lopez-Alonso, JP;Delgado, S;Dodu, A;Bruch, EM;Abriata, LA;Alzari, PM;Valle, M;Lisa, MN

COMMUNICATIONS BIOLOGY

2021-06-03

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP;Oyenarte, I;Diercks, T;Quintana, JI;Gimeno, A;Coelho, H;Diniz, A;Peccati, F;Delgado, S;Bosch, A;Valle, M;Millet, O;Abrescia, NGA;Palazn, A;Marcelo, F;Jimnez-Oss, G;Jimnez-Barbero, ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis

Galisteo-Gonzalez, F;Monasterio, BG;Gil, D;Valle, M;Goni, FM

SCIENTIFIC REPORTS

2020-01-15

Structure of Turnip mosaic virus and its viral-like particles

Cuesta, R;Yuste-Calvo, C;Gil-Carton, D;Sanchez, F;Ponz, F;Valle, M

SCIENTIFIC REPORTS

2019-10-28

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Canal-Martin, A;Sastre, J;Sanchez-Barrena, MJ;Canales, A;Baldominos, S;Pascual, N;Martinez-Gonzalez, L;Molero, D;Fernandez-Valle, ME;Saez, E;Blanco-Gabella, P;Gomez-Rubio, E;Martin-Santamaria, ...

NATURE COMMUNICATIONS

2019-06-26

Structural Homology Between Nucleoproteins of ssRNA Viruses

Valle, M

Sub-cellular biochemistry

2018-01-01

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses

Zamora, M;Mendez-Lopez, E;Agirrezabala, X;Cuesta, R;Lavin, JL;Sanchez-Pina, MA;Aranda, MA;Valle, M

Science advances

2017-09-01