Mikel Valle
mvalle
Mikel Valle
GROUP LEADER
CryoEM of Biological Macromolecules Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

His research interest is focused on the structural characterization of macromolecular machines by cryo-electron microscopy (cryoEM). After his PhD in Madrid, he joined Prof. Joachim Frank in the USA, where Dr. Valle tasted the latest developments in cryoEM applied to the study of the ribosome. This period was really fruitful, and several classic articles revealed fundamental aspects of the ribosomal functioning during translation. After a short period as civil servant in the Spanish Research Council (CSIC), Mikel Valle joined CIC bioGUNE in 2006. Since then, Dr. Valle leads a team focused on several projects, from ribosomal structure to large metabolic enzymes, always by means of cryoEM, a powerful structural biology technique. His research has recently delivered the highest  resolution structure for a plant flexible filamentous virus.

Latest Publications

2022

2021

2020

2019

2018

2017

2016

The structural study of biological macromolecules is key to understand their functioning. By means of cryo-electron microscopy we can obtain 3D maps biological complexes under nearly physiological conditions, and the latest developments in the field allow for near-atomic resolution, providing detailed observation of molecules. The aim of the team is to describe the structure and the conformational changes associated with the biological function. We focus on motors involved in universal biological functions where interactions between protein and nucleic acids are essential. Structural studies of ribosomes during translation allow the understanding of the mechanisms which govern protein synthesis. In this process, interactions with translation factors and interference by several antibiotics are especially important. We also analyze the structure of flexible filamentous viruses, a group of plant pathogens, and large oligomeric enzymes such as pyruvate carboxylase.

Latest Publications

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation

Eraña, H; Díaz-Domínguez, CM; Charco, JM; Vidal, E; González-Miranda, E; Pérez-Castro, MA; Piñeiro, P; López-Moreno, R; Sampedro-Torres-Quevedo, C; Fernández-Veiga, L; Tasis-Galarza, J; Lorenzo, ...

ACTA NEUROPATHOLOGICA COMMUNICATIONS

2023-09-07

Genomic insights into metabolic flux in hummingbirds

Gershman, A; Hauck, Q; Dick, M; Jamison, JM; Tassia, M; Agirrezabala, X; Muhammad, S; Ali, R; Workman, RE; Valle, M; Wong, GW; Welch, KC; Timp, W;

GENOME RESEARCH

2023-05-01

Effect of ATG12-ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion

Iriondo, MN; Etxaniz, A; Varela, YR; Ballesteros, U; Lázaro, M; Valle, M; Fracchiolla, D; Martens, S; Montes, LR; Goñi, FM; Alonso, A;

CELLULAR AND MOLECULAR LIFE SCIENCES

2023-02-01

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase

López-Alonso, JP; Lázaro, M; Gil-Cartón, D; Choi, PH; Tong, L; Valle, M;

NATURE COMMUNICATIONS

2022-10-19

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes

Ballesteros, U; Etxaniz, A; Iriondo, MN; Varela, YR; Lazaro, M; Viguera, AR; Montes, LR; Valle, M; Goni, FM; Alonso, A;

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

2022-05-26

A switch from α-helical to β-strand conformation during co-translational protein folding

Agirrezabala, X; Samatova, E; Macher, M; Liutkute, M; Maiti, M; Gil-Carton, D; Novacek, J; Valle, M; Rodnina, MV;

EMBO JOURNAL

2022-01-07

3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme

Lázaro, M; Melero, R; Huet, C; López-Alonso, JP; Delgado, S; Dodu, A; Bruch, EM; Abriata, LA; Alzari, PM; Valle, M; Lisa, MN;

COMMUNICATIONS BIOLOGY

2021-06-03

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazón, A; Marcelo, F; Jiménez-Osés, ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis

Galisteo-González, F; Monasterio, BG; Gil, D; Valle, M; Goñi, FM;

SCIENTIFIC REPORTS

2020-01-15

Structure of Turnip mosaic virus and its viral-like particles

Cuesta, R; Yuste-Calvo, C; Gil-Cartón, D; Sánchez, F; Ponz, F; Valle, M;

SCIENTIFIC REPORTS

2019-10-28

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Canal-Martín, A; Sastre, J; Sánchez-Barrena, MJ; Canales, A; Baldominos, S; Pascual, N; Martínez-González, L; Molero, D; Fernández-Valle, ME; Sáez, E; Blanco-Gabella, P; Gómez-Rubio, E; Martín-Santamaría, ...

NATURE COMMUNICATIONS

2019-06-26

Structural Homology Between Nucleoproteins of ssRNA Viruses

Valle, M; Harris Jr; Bhella, D;

VIRUS PROTEIN AND NUCLEOPROTEIN COMPLEXES

2018-01-01

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses

Zamora, M; Méndez-López, E; Agirrezabala, X; Cuesta, R; Lavín, JL; Sánchez-Pina, MA; Aranda, MA; Valle, M;

SCIENCE ADVANCES

2017-09-01

Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism

Artetxe, I; Ugarte-Uribe, B; Gil, D; Valle, M; Alonso, A; García-Sáez, AJ; Goñi, FM;

BIOPHYSICAL JOURNAL

2017-08-22

Coating Graphene Oxide with Lipid Bilayers Greatly Decreases Its Hemolytic Properties

Monasterio, BG; Alonso, B; Sot, J; García-Arribas, AB; Gil-Cartón, D; Valle, M; Zurutuza, A; Goñi, FM;

LANGMUIR

2017-08-22

Ribosome rearrangements at the onset of translational bypassing

Agirrezabala, X; Samatova, E; Klimova, M; Zamora, M; Gil-Carton, D; Rodnina, MV; Valle, M;

SCIENCE ADVANCES

2017-06-01

"Pyruvate Carboxylase, Structure and Function"

Valle, M; Harris Jr; MarlesWright, J;

MACROMOLECULAR PROTEIN COMPLEXES: STRUCTURE AND FUNCTION

2017-01-01

Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins

Morante, K; Bellomio, A; Gil-Cartón, D; Redondo-Morata, L; Sot, J; Scheuring, S; Valle, M; González-Mañas, JM; Tsumoto, K; Caaveiro, JMM;

JOURNAL OF BIOLOGICAL CHEMISTRY

2016-09-09

Lipid Modulation of LC3/GABARAP-Mediated Autophagosomal Elongation

Alonso, A; Landajuela, A; Hervas, JH; Anton, Z; Montes, LR; Gil, D; Valle, M; Rodriguez, JF; Goni, FM;

BIOPHYSICAL JOURNAL

2016-02-16

Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation

Landajuela, A; Hervás, JH; Antón, Z; Montes, LR; Gil, D; Valle, M; Rodriguez, JF; Goñi, FM; Alonso, A;

BIOPHYSICAL JOURNAL

2016-01-19