Activity Report 2021

CIC bioGUNE - Centro de Investigación Cooperativa en Biociencias


Scientific Programmes

Scientific Programmes
Research lines


Metabolic diseases

Infectious diseases

Rare diseases

The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. An integrative Bioinformatics Program extrapolates relevant conclusions from basic science.

Metabolism and Cell Signaling in Disease

  • Personalized medicine
  • Prostate Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Liver Diseases
  • Rare Diseases
  • Biomarkers for Diagnosis
  • Biomarkers for Prognosis
  • Drug Design and Discovery

Molecular Recognition and Host-Pathogen

  • Rare Diseases
  • Homeostasis
  • Viral Infections
  • Bacterial Infections
  • Prion Disease
  • Tick-Borne Disease
  • Immune Response
  • Drug Design and Discovery


  • NMR Spectroscopy
  • Macromolecular Crystallography
  • Electron Microscopy
  • Genome Analysis
  • Proteomics
  • Metabolomics
  • Animal Facility


Generation of


Commercialization of

Scientific Programmes
Metabolism & Cell Signaling in Disease






  1. Target discovery and evaluation of their therapeutic potential
  2. Cancer and more: Identification of biomarkers with potential diagnostic value
  3. Novel therapies against rare diseases
  4. The molecular basis of fibrosis
  5. Nonalcoholic steatohepatitis

The Research Programmes
Molecular Recognition & Host-Pathogen Interactions




Membrane remodelling

Animal and plant viruses

  1. Bacterial and Viral Infections: Vaccines for human and animal health
  2. Mechanisms of membrane remodelling during microbial invasion and propagation
  3. Plant vaccines and transgenics
  4. Antibiotics research and molecular characterization

The Research Programmes
Technology Platforms

Genome Analysis Platform

Proteomics Platform

Metabolomics Platform

Animal Facility

Antibodies Production

Drug Repositioning & Discovery

Nuclear Magnetic Resonance

Macromolecular Crystallography

Electron Microscopy Platform

Collaboration Models

R&D Collaborations

About Us

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Conducting research of excellence in the field of the life sciences, covering the entire value of R&D&i, including technology transfer and commercial exploitation of the generated scientific results.

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Strategic Challenges:

  • Research of excellence
  • Technology Transfer
  • Collaboration with RVCTI agents
  • International recognition
  • Training and promotion of research talent
  • Attraction and retention of talent
  • Communication and Outreach
  • Excellence in Management


Commitment to specialization and excellence

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  • Leading infrastructures
  • Human Resources
  • Technical and administrative support
  • Competitive salaries
  • Goal-Fulfillment Incentives
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Staff 2021.12.31: 0

FTE (2021): 0

Permanent Staff (FTE): 0 (43,4%)

Gender distribution

  • 0% Female
  • 0% Male
  • LISMI - Law of Social Integration of the Handicapped

212 Total CIC bioGUNE Personnel

  • 0% Research
  • 0% Administration and Services


Researchers Distribution by Professional Category

    % Woman Man
  Researchers 129 73.7 62 67
  • Principal investigators/Platform Managers 26 14.9 7 19
  • Postdoctoral Researchers/Research Assistant/Specialist 47 26.9 26 21
  • PhD Students 56 32.0 29 27
  Technicians 46 26.3 34 12

Research Distribution by Geographic Origin

Research Distribution by Geographic Origin

Austria 1
Germany 3
Greece 1
Holland 1
Italy 14
Poland 1
Portugal 1
Romania 1
Spain 176
United Kingdom 1
America 10
Asia 2
  • 0% Spain
    176 researchers
  • 0% Rest of Europe
    24 researchers
  • 0% America
    10 researchers
  • 0% Asia
    2 researchers


Total 2021 R&D Budget: 0 million €

Running R&D Projects: 0

New R&D Projects: 0


Public funding

Private funding

  • 0 % Competitive Public Funding
    14.495 K€
  • 0 % Non competitive Public Funding (Emaitek)
    6.453 K€
  • 0 % Basque Government Departments
    9.169 K€
  • 0 % R&D Contracts, Research Services & Others
    6.636 K€
  • 0 % MINECO & MEDC (Spanish Government)
    2.950 K€
  • 0 % EU & International Projects
    2.193 K€

Competitive Incomes (History)

Technology Transfer and Innovation

Economic Activity: 5.705.727

  • Basque Country: 0%
  • National: 0%
  • International: 0%

New Research Contracts 0

0 Patents Filed

0 Trade Secrets Registered

0 Licensing Agreement


Intellectual Property 2021


Social Commitment

Talent Opportunity

Fundación ONCE, CiC Biogune, Ikerbasque

CIC bioGUNE Iniciative

Fellowships programme by Fundación ONCE - CIC bioGUNE - Ikerbasque
  • Predoctoral Trainee
  • Postdoctoral Trainee
  • Postdoctoral Research Fellow


Año 1

Año 2 Año 3 Año 4 Año 5 Año 6

Triennial endowment: 34.000€




Triennial endowment: 63.600€




Five-year endowment: 76.400€




Predoctoral 1

Triennial call

Predoctoral 2

Postdoctoral Trainee 1

Triennial call

Postdoctoral Trainee 2

Postdoctoral Researcher 1

Five-year call

Postdoctoral Researcher 2

General indicators: Equality Plan

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Equality Plan



Equality commission:
25N Challenge
  • Micromachismos: ¿Te atreves a saber si estás libre de ellos?
  • A mí me violenta: Testimonios


New partner: in process

Due Diligence

CLINIC PHASE 2 (2022-2023)
Treatment of Congenital Erythropoietic Porphyria (PEC)

Starting date: 18 september 2020

Focus: Ownership, research, design, consulting, innovation and development, exploitation of technologies applied to the processing and analysis of biological, biochemical, biotechnological and medical data

  • (DFB): 22 June 2021
  • Activity: 1 October 2021
  • Incomes 2021: 95000 €
  • Job creation: 1 position (2021) + 1 position (2022)

Control COVID-19


To prevent

  • Mask
  • Limited people
  • Cleaning
  • Lunch: 1 - 2 people
  • Interpersonal distance
  • Tests



> 90%


Human Resources Funding


Investigator: Leire Moreno
Mentor: Asís Palazón
Investigator: Antonio Franconetti
Mentor: Jesús Jiménez-Barbero
Investigator: Amaia Ercilla
Mentor: Arkaitz Carracedo
Investigator: Francesca Pecatti
Mentor: Gonzalo Jiménez Osés

Marco Piva

Cancer Cell Signaling & Metabolism Lab

Teresa Cardoso

Liver Disease Lab

Urko M. Marigorta

Integrative Genomics Lab (Group Leader)


Pablo Valverde
PI: Jesús Jiménez Barbero

MSCA Global Fellowship

Doctoral candidate:
Klaudia Sobczak
PI: June Ereño Orbea



Doctoral candidate:
Ander de Blas
PI: Asís Palazón

Investigador Predoctoral AECC

Ikerbasque Research Fellows

Amaia Arruabarrena

Marco Piva

Competitive Funding Projects



June Ereño
Arkaitz Carracedo


Università degli studio di Napoli
Federico II

Instituto de Investigación Biomédica
de Bellvitge (IDIBELL)

EU Joint Programmes
Joaquín Castilla
Mauro D'Amato


Istituto di Ricerche Farmacologiche
Mario Negri

University of


Funded projects: 0 projects
Total Grant Amount (3 years): 0 M€
Doctoral Candidates: 0 FPI

Mauro D'Amato, Rosa Barrio, José María Mato, Malu Martínez Chantar, Robert Kypta, Alberto Fernández Tejada, María dM Vivanco, Antonio del Sol, Aitor Hierro

Public Funding - Euskadi

COVID-19 - Fundación BIOEF – EITB Maratoia

Óscar Millet (CIC bioGUNE)

Urko M. Marigorta (CIC bioGUNE)

David Otaegui (Biodonostia)

Grants for research and development projects in Health
Department of Health Basque Government


Óscar Millet (CIC bioGUNE)

Public Funding - State

Incorporación al Consorcio CIBER Enfermedades Infecciosas

Joaquín Castilla

Ayudas para las Infraestructuras Científicas y Técnicas Singulares (ICTS)

Óscar Millet

Pruebas de Concepto, Proyectos de I+D+i

José M. Mato

Alberto Fernández Tejada

Robert Kypta

Pruebas de Investigación de Medicina Personalizada de Precisión

Urko M. Marigorta
Coordination: Jorge Ferrer

Private Funding


Health Research 2021

Asís Palazón
Coordination: Sonia Guedan (IDIBAPS)

Von Hippel-Lindau Disease

Edurne Berra

Postdoctoral Talent Programme

Isabel Mendizabal

R&D Pilot Project Awards

Coordination: Nicola GA Abrescia

Research Grants

Coordination: Urko M. Marigorta


Héctor Rodríguez

Edurne Berra

Arkaitz Carracedo

Ayudas a la Investigación 2021 Biomedicina y Salud

Competitive Funding Tech Transfer Projects

Malu Martínez Chantar


Desarrollo Tecnológico en Salud 2020

Mch20: Detecting liver damage through urine



INNOVATION with Technological Centers Hospitals

Asís Palazón


Desarrollo Tecnológico en Salud 2021

Development of precision serology assays for the post-pandemic era.


Technology Transfer Projects
Basque Funding

Asís Palazón

Cancer Cell Therapy (CAR-T)


Óscar Millet

José M. Mato

Newborn Diagnosis for Congenital Diseases

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Beta tester


Funding Entity













Grand Total

Public National











Private National













Public Euskadi







Public Europe









Private International











Private Euskadi



Private Europe



















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Programa Centros Fundación Científica AECC

First Follow-up
December 10, 2021

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Accreditation Fundación AECC

UNE166002 R&D Management

December 9 & 10, 2021

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Certificado SGS ENAC

AENOR 166002

Basque Funding

Coordinator: CIC bioGUNE

Coordinator: Óscar Millet

Institutional Clinical Collaboration

Mix Laboratory for Translational Research in Prostate

Promoted by Arkaitz Carracedo

5-year Impact Factor*: 7.915

PI3K-regulated Glycine N-methyltransferase is  required for the development of prostate cancer

Amaia Zabala-Letona 1,2 Amaia Arruabarrena-Aristorena 1,3,4 Sonia Fernandez-Ruiz 1,2 Cristina Viera 1,3 Onintza Carlevaris 1, Amaia Ercilla 1,2 Isabel Mendizabal 1,3,4 Teresa Martin 1 Alice Macchia 1,5,4 Laura Camacho 1,5 Mikel Pujana-Vaquerizo 1, Pilar Sanchez-Mosquera 1 Verónica Torrano 1,2,5 Natalia Martin-Martin 1,2,4 Patricia Zuniga-Garcia 1 Mireia Castillo-Martin 6, Aitziber Ugalde-Olano 2,7,6 Ana Loizaga-Iriarte 2,4,8 Miguel Unda 2,4,8 Jose M. Mato 1,9 Edurne Berra 1,2 María L. Martinez-Chantar 1,9,7 Arkaitz Carracedo 1,2,3,4,5,10 

4Traslational prostate cancer Research lab, CIC bioGUNE-Basurto, Biocruces Bizkaia Health Research Institute

  • Foster corporate collaboration with Hospitals
  • Foster translational R&D to Hospitals (preclinical and clinical)
  • Provide Offers for Joint services
  • Armonize bi-directional flow of ideas from bench to bedside

Technology Transfer and Innovation

8 Invention Disclosures (IDF) filed by CIC bioGUNE investigators

Intellectual Property
Patent List (5 European priority filing)
  • Methods for the generation of stem cell memory T cells for adoptive T cell therapy
  • miRNA signature for identification of the receptive endometrium
  • Saponin-based adjuvants and vaccines
  • new formulation for ciclopirox
  • Self/adjuvanting saponins
Industrial secrets (4 registered)

Business Leads generation

  • 0 New business leads
  • 0 New MTA
  • 0 New CDA signed with companies
  • 0 Sponsorship Agreements
  • 0 Licensing Options
  • 0 Licensing Agreement
  • 0 Ongoing Industrial Doctorates




Average Impact Factor

40% Collaboration RVCTI


Scientific Highlights

Microscopic colitis

Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H

. Nat Rev Dis Primers. 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2

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Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Eijsbouts C, Zheng T, Kennedy NA, Bonfiglio F, Anderson CA, Moutsianas L, Holliday J, Shi J, Shringarpure S; 23andMe Research Team, Voda AI; Bellygenes Initiative, Farrugia G, Franke A, Hübenthal M, Abecasis G, Zawistowski M, Skogholt AH, Ness-Jensen E, Hveem K, Esko T, Teder-Laving M, Zhernakova A, Camilleri M, Boeckxstaens G, Whorwell PJ, Spiller R, McVean G, D'Amato M, Jostins L, Parkes M

Nat Genet. 2021 Nov;53(11):1543-1552. doi: 10.1038/s41588-021-00950-8

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, Brugge H, Oelen R, de Vries DH, van der Wijst MGP, Kasela S, Pervjakova N, Alves I, Favé MJ, Agbessi M, Christiansen MW, Jansen R, Seppälä I, Tong L, Teumer A, Schramm K, Hemani G, Verlouw J, Yaghootkar H, Sönmez Flitman R, Brown A, Kukushkina V, Kalnapenkis A, Rüeger S, Porcu E, Kronberg J, Kettunen J, Lee B, Zhang F, Qi T, Hernandez JA, Arindrarto W, Beutner F; BIOS Consortium; i2QTL Consortium, Dmitrieva J, Elansary M, Fairfax BP, Georges M, Heijmans BT, Hewitt AW, Kähönen M, Kim Y, Knight JC, Kovacs P, Krohn K, Li S, Loeffler M, Marigorta UM, Mei H, Momozawa Y, Müller- Nurasyid M, Nauck M, Nivard MG, Penninx BWJH, Pritchard JK, Raitakari OT, Rotzschke O, Slagboom EP, Stehouwer CDA, Stumvoll M, Sullivan P, 't Hoen PAC, Thiery J, Tönjes A, van Dongen J, van Iterson M, Veldink JH, Völker U, Warmerdam R, Wijmenga C, Swertz M, Andiappan A, Montgomery GW, Ripatti S, Perola M, Kutalik Z, Dermitzakis E, Bergmann S, Frayling T, van Meurs J, Prokisch H, Ahsan H, Pierce BL, Lehtimäki T, Boomsma DI, Psaty BM, Gharib SA, Awadalla P, Milani L, Ouwehand WH, Downes K, Stegle O, Battle A, Visscher PM, Yang J, Scholz M, Powell J, Gibson G, Esko T, Franke L

Nat Genet. 2021 Sep;53(9):1300-1310. doi: 10.1038/s41588-021-00913-z

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Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy

Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS

Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023

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Systemic Inflammation in Preclinical Ulcerative Colitis

Bergemalm D, Andersson E, Hultdin J, Eriksson C, Rush ST, Kalla R, Adams AT, Keita Ã…V, D'Amato M, Gomollon F, Jahnsen J; IBD Character Consortium, Ricanek P, Satsangi J, Repsilber D, Karling P, Halfvarson J

Gastroenterology. 2021 Nov;161(5):1526-1539.e9. doi: 10.1053/j.gastro.2021.07.026

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Multi-Omics Analyses Show Disease, Diet, and Transcriptome Interactions With the Virome

Mihindukulasuriya KA, Mars RAT, Johnson AJ, Ward T, Priya S, Lekatz HR, Kalari KR, Droit L, Zheng T, Blekhman R, D'Amato M, Farrugia G, Knights D, Handley SA, Kashyap PC

Gastroenterology. 2021 Oct;161(4):1194-1207.e8. doi: 10.1053/j.gastro.2021.06.077

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Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

Zheng T, Ellinghaus D, Juzenas S, Cossais F, Burmeister G, Mayr G, Jørgensen IF, Teder-Laving M, Skogholt AH, Chen S, Strege PR, Ito G, Banasik K, Becker T, Bokelmann F, Brunak S, Buch S, Clausnitzer H, Datz C; DBDS Consortium, Degenhardt F, Doniec M, Erikstrup C, Esko T, Forster M, Frey N, Fritsche LG, Gabrielsen ME, Gräßle T, Gsur A, Gross J, Hampe J, Hendricks A, Hinz S, Hveem K, Jongen J, Junker R, Karlsen TH, Hemmrich-Stanisak G, Kruis W, Kupcinskas J, Laubert T, Rosenstiel PC, Röcken C, Laudes M, Leendertz FH, Lieb W, Limperger V, Margetis N, Mätz-Rensing K, Németh CG, Ness-Jensen E, Nowak-Göttl U, Pandit A, Pedersen OB, Peleikis HG, Peuker K, Rodriguez CL, Rühlemann MC, Schniewind B, Schulzky M, Skieceviciene J, Tepel J, Thomas L, Uellendahl-Werth F, Ullum H, Vogel I, Volzke H, von Fersen L, von Schönfels W, Vanderwerff B, Wilking J, Wittig M, Zeissig S, Zobel M, Zawistowski M, Vacic V, Sazonova O, Noblin ES; 23andMe Research Team, Farrugia G, Beyder A, Wedel T, Kahlke V, Schafmayer C, D'Amato M, Franke A

Gut. 2021 Apr 22;70(8):1538–49. doi: 10.1136/gutjnl-2020-323868

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TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Esparza-Baquer A, Labiano I, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Jimenez-Agüero R, Riaño I, Landa A, La Casta A, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ

Gut. 2021 Jul;70(7):1345-1361. doi: 10.1136/gutjnl-2019-319227

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Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells

Nolan LM, Cain AK, Clamens T, Furniss RCD, Manoli E, Sainz-Polo MA, Dougan G, Albesa-Jové D, Parkhill J, Mavridou DAI, Filloux A

Nat Microbiol. 2021 Sep;6(9):1199-1210. doi: 10.1038/s41564-021-00950-8

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Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH

Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML

J Hepatol. 2021 Jul;75(1):34-45. doi: 10.1016/j.jhep.2021.01.043

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Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ

J Hepatol. 2021 Oct;75(4):935-959. doi: 10.1016/j.jhep.2021.06.021

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Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models

Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Santos-Laso A, Azkargorta M, Elortza F, Martinez-Chantar ML, Perugorria MJ, Aspichueta P, Marzioni M, LaRusso NF, Bujanda L, Drenth JPH, Banales JM

J Hepatol. 2021 Feb;74(2):394-406. doi: 10.1016/j.jhep.2020.09.010

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Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold

Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, Bunzel HA, Helgeson RC, Houk KN, Jiménez-Osés G, Hilvert D

Nat Chem. 2021 Mar;13(3):231-235. doi: 10.1038/s41557-020-00628-4  

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The Importance of Computational Modeling in Stem Cell Research

Del Sol A, Jung S

Trends Biotechnol. 2021 Feb;39(2):126-136. doi: 10.1016/j.tibtech.2020.07.006

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Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Prieto-Fernández E, Egia-Mendikute L, Vila-Vecilla L, Bosch A, Barreira- Manrique A, Lee SY, García-Del Río A, Antoñana-Vildosola A, Jiménez-Lasheras B, Moreno-Cugnon L, Jiménez-Barbero J, Berra E, Ereño-Orbea J, Palazon A

Emerg Microbes Infect. 2021 Dec;10(1):1065-1076. doi: 10.1080/22221751.2021.1932607

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Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM, Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W, Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A, Castro DS, Biernaskie J, Del Sol A, Schuurmans C

Neuron. 2021 Sep 15;109(18):2847-2863.e11. doi: 10.1016/j.neuron.2021.07.007

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Preventing Memory Effects in Surface-Enhanced Raman Scattering Substrates by Polymer Coating and Laser-Activated Deprotection

Plou J, Charconnet M, García I, Calvo J, Liz-Marzán LM

ACS Nano. 2021 May 25;15(5):8984-8995. doi: 10.1021/acsnano.1c01878

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Identification of proximal SUMO- dependent interactors using SUMO-ID

Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD

Nat Commun. 2021 Nov 18;12(1):6671. doi: 10.1038/s41467-021-26807-6

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O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan MJ, Fondevila MF, Fernandez U, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Dp Chantada-Vazquez M, Garcia-Vence M, Bravo SB, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R

Nat Commun. 2021 Aug 20;12(1):5068. doi: 10.1038/s41467-021-25390-0

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A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

Gonçalves CA, Larsen M, Jung S, Stratmann J, Nakamura A, Leuschner M, Hersemann L, Keshara R, Perlman S, Lundvall L, Thuesen LL, Hare KJ, Amit I, Jørgensen A, Kim YH, Del Sol A, Grapin-Botton A

. Nat Commun. 2021 May 25;12(1):3144. doi: 10.1038/s41467-021-23295-6

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Evolution of DNA methylation in the human brain

Jeong H, Mendizabal I, Berto S, Chatterjee P, Layman T, Usui N, Toriumi K, Douglas C, Singh D, Huh I, Preuss TM, Konopka G, Yi SV

Nat Commun. 2021 Apr 1;12(1):2021. doi: 10.1038/s41467-021-21917-7

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A computer-guided design tool to increase the efficiency of cellular conversions

Jung S, Appleton E, Ali M, Church GM, Del Sol A

Nat Commun. 2021 Mar 12;12(1):1659. doi: 10.1038/s41467-021-21801-4

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Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer

Shephard AP, Giles P, Mbengue M, Alraies A, Spary LK, Kynaston H, Gurney MJ, Falcón-Pérez JM, Royo F, Tabi Z, Parthimos D, Errington RJ, Clayton A, Webber JP

J Extracell Vesicles. 2021 Oct;10(12):e12150. doi: 10.1002/jev2.12150

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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borràs FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Falcón-Pérez JM, Grange C, Hill AF, Holthöfer H, Hoorn EJ, Jenster G, Jimenez CR, Junker K, Klein J, Knepper MA, Koritzinsky EH, Luther JM, Lenassi M, Leivo J, Mertens I, Musante L, Oeyen E, Puhka M, van Royen ME, Sánchez C, Soekmadji C, Thongboonkerd V, van Steijn V, Verhaegh G, Webber JP, Witwer K, Yuen PST, Zheng L, Llorente A, Martens-Uzunova ES

J Extracell Vesicles. 2021 May;10(7):e12093. doi: 10.1002/jev2.12093

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S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

Ramani K, Robinson AE, Berlind J, Fan W, Abeynayake A, Binek A, Barbier- Torres L, Noureddin M, Nissen NN, Yildirim Z, Erbay E, Mato JM, Van Eyk JE, Lu SC

Hepatology. 2022 Feb;75(2):280-296. doi: 10.1002/hep.32130

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Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Goikoetxea-Usandizaga N, Serrano-Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez-Redondo M, Lachiondo-Ortega S, Rodríguez-Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero-Díaz D, Alfano B, Bravo M, González-Recio I, Mercado-Gómez M, Gil-Pitarch C, Mabe J, Gracia-Sancho J, Abecia L, Lorenzo Ó, Martín-Sanz P, Abrescia NGA, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela-Rey M, Martínez-Chantar ML

Hepatology. 2022 Mar;75(3):550-566. doi: 10.1002/hep.32149

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Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma

Colyn L, Bárcena-Varela M, Ã�lvarez-Sola G, Latasa MU, Uriarte I, Santamaría E, Herranz JM, Santos-Laso A, Arechederra M, Ruiz de Gauna M, Aspichueta P, Canale M, Casadei-Gardini A, Francesconi M, Carotti S, Morini S, Nelson LJ, Iraburu MJ, Chen C, Sangro B, Marin JJG, Martinez-Chantar ML, Banales JM, Arnes- Benito R, Huch M, Patino JM, Dar AA, Nosrati M, Oyarzábal J, Prósper F, Urman J, Cubero FJ, Trautwein C, Berasain C, Fernandez-Barrena MG, Avila MA

Hepatology. 2021 Jun;73(6):2380-2396. doi: 10.1002/hep.31642

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Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome

Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O

Hepatology. 2021 Jul;74(1):148-163. doi: 10.1002/hep.31676

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Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development

Font-Díaz J, Jiménez-Panizo A, Caelles C, Vivanco MD, Pérez P, Aranda A, Estébanez-Perpiñá E, Castrillo A, Ricote M, Valledor AF

Semin Cancer Biol. 2021 Aug;73:58-75. doi: 10.1016/j.semcancer.2020.12.007

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Chemoenzymatic Synthesis of Complex N-Glycans of the Parasite S. mansoni to Examine the Importance of Epitope Presentation on DC-SIGN recognition

Srivastava AD, Unione L, Bunyatov M, Gagarinov IA, Delgado S, Abrescia NGA, Ardá A, Boons GJ

Angew Chem Int Ed Engl. 2021 Aug 23;60(35):19287-19296. doi: 10.1002/anie.202105647

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Unambiguous Tracking of Protein Phosphorylation by Fast High-Resolution FOSY NMR*

Lesovoy DM, Georgoulia PS, Diercks T, Mate�ko-Burmann I, Burmann BM, Bocharov EV, Bermel W, Orekhov VY

Angew Chem Int Ed Engl. 2021 Oct 25;60(44):23540-23544. doi: 10.1002/anie.202102758

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Selective 13 C-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

Moure MJ, Gimeno A, Delgado S, Diercks T, Boons GJ, Jiménez-Barbero J, Ardá A

Angew Chem Int Ed Engl. 2021 Aug 16;60(34):18777-18782. doi: 10.1002/anie.202106056

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Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM

Le T, Jeanne Dit Fouque K, Santos-Fernandez M, Navo CD, Jiménez-Osés G, Sarksian R, Fernandez-Lima FA, van der Donk WA

J Am Chem Soc. 2021 Nov 10;143(44):18733-18743. doi: 10.1021/jacs.1c09370

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Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds

Garcia-Borràs M, Kan SBJ, Lewis RD, Tang A, Jimenez-Osés G, Arnold FH, Houk KN

J Am Chem Soc. 2021 May 12;143(18):7114-7123. doi: 10.1021/jacs.1c02146

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A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit

Schedlbauer A, Iturrioz I, Ochoa-Lizarralde B, Diercks T, López-Alonso JP, Lavin JL, Kaminishi T, Çapuni R, Dhimole N, de Astigarraga E, Gil-Carton D, Fucini P, Connell SR

Sci Adv. 2021 Jun 4;7(23):eabf7547. doi: 10.1126/sciadv.abf7547

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Trimethylamine N-oxide is a new plant molecule that promotes abiotic stress tolerance

Catalá R, López-Cobollo R, Berbís MÃ�, Jiménez-Barbero J, Salinas J.

Sci Adv. 2021 May 19;7(21):eabd9296. doi: 10.1126/sciadv.abd9296

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Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19

Jung S, Potapov I, Chillara S, Del Sol A

Sci Adv. 2021 Feb 3;7(6):eabe5735. doi: 10.1126/sciadv.abe5735

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FunRes: resolving tissue-specific functional cell states based on a cell-cell communication network model

Jung S, Singh K, Del Sol A

Brief Bioinform. 2021 Jul 20;22(4):bbaa283. doi: 10.1093/bib/bbaa283

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An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity

Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme- Ã�lvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L

Clin Cancer Res. 2021 Jun 1;27(11):3167-3177. doi: 10.1158/1078-0432.CCR-20-4625

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pH-Responsive Self-Assembly of Amyloid Fibrils for Dual Hydrolase-Oxidase Reactions

Diaz-Caballero M, Navarro S, Nuez-Martinez M, Peccati F, Rodriguez-Santiago L, Sodupe M, Teixidor F, Ventura S

ACS Catalysis. 2021 Jan 15; 11(2): 595-607. doi: 10.1021/acscatal.0c03093

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E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

González-Romero F, Mestre D, Aurrekoetxea I, O'Rourke CJ, Andersen JB, Woodhoo A, Tamayo-Caro M, Varela-Rey M, Palomo-Irigoyen M, Gómez-Santos B, de Urturi DS, Núñez-García M, García-Rodríguez JL, Fernández-Ares L, Buqué X, Iglesias-Ara A, Bernales I, De Juan VG, Delgado TC, Goikoetxea-Usandizaga N, Lee R, Bhanot S, Delgado I, Perugorria MJ, Errazti G, Mosteiro L, Gaztambide S, Martinez de la Piscina I, Iruzubieta P, Crespo J, Banales JM, Martínez-Chantar ML, Castaño L, Zubiaga AM, Aspichueta P

Cancer Res. 2021 Jun 1;81(11):2874-2887. doi: 10.1158/0008-5472.CAN-20-2052

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Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating

Harley CA, Bernardo-Seisdedos G, Stevens-Sostre WA, Jones DK, Azevedo MM, Sampaio P, Lorga-Gomes M, Trudeau MC, Millet O, Robertson GA, Morais-Cabral JH

Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2108796118. doi: 10.1073/pnas.2108796118

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Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy

Plou J, Molina-Martínez B, García-Astrain C, Langer J, García I, Ercilla A, Perumal G, Carracedo A, Liz-Marzán LM

Nano Lett. 2021 Oct 27;21(20):8785-8793. doi: 10.1021/acs.nanolett.1c03070

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Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Masoodi M, Gastaldelli A, Hyötyläinen T, Arretxe E, Alonso C, Gaggini M, Brosnan J, Anstee QM, Millet O, Ortiz P, Mato JM, Dufour JF, Oreši� M

Nat Rev Gastroenterol Hepatol. 2021 Dec;18(12):835-856. doi: 10.1038/s41575-021-00502-9

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Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms

Saha A, Bello D, Fernández-Tejada A

Chem Soc Rev. 2021 Sep 20;50(18):10451-10485. doi: 10.1039/d0cs01275k

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Natural and synthetic carbohydrate- based vaccine adjuvants and their mechanisms of action

Pifferi C, Fuentes R, Fernández-Tejada A

Nat Rev Chem. 2021;5(3):197-216. doi: 10.1038/s41570-020-00244-3

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Computational Stem Cell Biology: Open Questions and Guiding Principles

Cahan P, Cacchiarelli D, Dunn SJ, Hemberg M, de Sousa Lopes SMC, Morris SA, Rackham OJL, Del Sol A, Wells CA

Cell Stem Cell. 2021 Jan 7;28(1):20-32. doi: 10.1016/j.stem.2020.12.012

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Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions

Franconetti A, Ardá A, Asensio JL, Blériot Y, Thibaudeau S, Jiménez-Barbero J

Acc Chem Res. 2021 Jun 1;54(11):2552-2564. doi: 10.1021/acs.accounts.1c00021

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Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

Bordanaba-Florit G, Royo F, Kruglik SG, Falcón-Pérez JM

Nat Protoc. 2021 Jul;16(7):3163-3185. doi: 10.1038/s41596-021-00551-z

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Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities

Azparren-Angulo M, Royo F, Gonzalez E, Liebana M, Brotons B, Berganza J, Goñi-de-Cerio F, Manicardi N, Abad-Jordà L, Gracia-Sancho J, Falcon-Perez JM

Pharmacol Ther. 2021 Feb;218:107683. doi: 10.1016/j.pharmthera.2020.107683

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Editorial Activity

  • Joaquín Castilla
    Advisory Board

    Juan Anguita
    Editor Board

  • Óscar Millet
    Associate Editor

  • Óscar Millet
    Editor Board

  • Juan Anguita
    Editor Board

  • Malu Martínez Chantar
    Editor Board

  • Óscar Millet
    Editor Board

  • Rosa Barrio
    Editor Board

    Juan Anguita
    Senior Editor

    Óscar Millet
    Editor Board

  • Félix Elortza
    Editor Board

  • Malu Martínez Chantar
    Associate Editor

  • Asís Palazón
    Associate Editor

    Juan Anguita
    Guest Associate Editor

  • Joaquín Castilla
    Associate Editor

  • Rosa Barrio
    Associate Editor

  • Rosa Barrio

  • María Vivanco
    Editor Board

  • Arkaitz Carracedo
    Consultant Editor

  • Jesús Jiménez-Barbero
    Associate Editor

  • Jesús Jiménez-Barbero
    Advisory Board

  • Malu Martínez Chantar
    Editor Board

  • Antonio Del Sol
    Editor Board

    Óscar Millet
    Editor Board

  • Félix Elortza
    Editor Board

  • Edurne Berra
    Associate Editor

  • Juan Manuel Falcón
    Deputy Editor

  • Jesús Jiménez-Barbero
    Advisory Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Robert Kypta
    Editor Board

  • Jesús Jiménez-Barbero
    Editor Board

  • Óscar Millet
    Editor Board

  • Joaquín Castilla
    Editor Board

  • Joaquín Castilla
    Editor Board

  • Juan Anguita
    Editor Board

Training – Doctoral Candidates

The CIC bioGUNE Advanced Training Program

Introductory week: September 27th to October 1st


0 in progress

Collaboration RVCTI



Thesis Rafael López Moreno

May 28
Rafael López Moreno

Estudio de la diversidad y estabilidad de diferentes priones recombinantes infecciosos para dilucidar los mecanismos moleculares que rigen el fenómeno de cepa

Thesis José Daniel Martínez Ordóñez

June 8
José Daniel Martínez Ordóñez

Novel ligand-based 19F-NMR and computational approaches for studying sugar-lectin molecular recognition events

Thesis Maria Pia Lenza

June 18
Maria Pia Lenza

Deciphering the recognition features of glycans by human lectins at the molecular level

Thesis Miguel Ángel Pérez Castro

Sept 17
Miguel Ángel Pérez Castro

Generación de distintas cepas de priones recombinantes como herramienta para el estudio del malplegamiento espontáneo en las enfermedades priónicas

Thesis Iraia Laredo Auñón

Sept 22
Iraia Laredo Auñón

Vaccine immunomodulation and protection mechanisms against

Thesis Lucia Maio

Nov 26
Lucia Maio

Designed Metallo-Tags for Probing Natural Systems

Thesis Cristina Risueño

Dic 1
Cristina Risueño

Modulating the Conformational Plasticity of Tetraspanin CD81 by Ligand Binders and its Implication in Cellular and Viral Processes

Thesis Saray Sánchez Yagüe

Dic 13
Saray Sánchez Yagüe

Antibody-mediated inhibition of Wnt-11 in prostate cancer

Thesis Diego Barriales

Dic 20
Diego Barriales

Plasticity of macrophage responses to activating factors

Degree in Medicine.
University of Deusto

2020-2021 & 2021-2022


Chemistry Applied to Life Sciences
Coordinated by Joaquín Castilla


Homeostasis and regulation
Coordinated by Edurne Berra







Clinical/medical genetics
Coordinated by Ana M Aransay and Urko M Marigorta

New Scientific Advisory Board (SAB)


Ikerbasque y el Departamento de Educación reconocen y visibilizan la labor de las mujeres investigadoras

Dra. Malu Martínez Chantar

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Best PhD Thesis in NMR

Pablo Valverde

Borja Mateos


16th Anniversary Lecture

Christmas Lecture

Joint Meeting
Nov 19th

Faes Farma
CIC Biogune

Joint Meeting CIC Biogune-Faes Farma

AECC patients
Nov 22th

Asociación contra el cáncer Bizkaia

AECC patients

BactiVax Meeting
Nov 22-25th


BactiVax Meeting

Scientific Outreach


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Scientific Annual Review

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Scientific Annual Review


A new Strategic Plan (2022-2025) has been presented to the general Board of CIC bioGUNE in November 2021.

CIC bioGUNE investigators publish more than 200 publications in 2021. More than 30% have been presented in D1 Journals. CIC publications are cited more than 9000 times in 2021.

CIC bioGUNE investigators file 5 EPO and 1 PCT applications.

CIC bioGUNE researchers are awarded with 58 new competitive R+D projects, funded by public and private institutions. 171 R+D projects are running along 2021.

Mauro D'Amato joins CIC bioGUNE as Group Leader of the Gastrointestinal Genetics Lab.

CIC bioGUNE renews the certification as "Agente Científico Tecnológico" of the Basque Network of Science, Technology and Innovation as well as its AAALAC seal for the animal facility.

CIC bioGUNE approves its new Equality Plan.

The Mixed Laboratory for Translational Research in Prostate Cancer is created through the alliance os CIC bioGUNE with OSI Basurto Hospital and Biocruces Bizkaia Health Institute.  

ATLAS MOLECULAR PHARMA. S.L., spin-off company of CIC bioGUNE, finishes a round of share capital increase above 3 M€, to enter into the Clinical Phases I & II of its drug to treat Congenital Erythropoietic Porphyria.

CIC bioGUNE researchers participate in teaching tasks in the Medicine Degree at the University of Deusto, coordinating subjects in the first and second year.

Our Prion Diseases lab has been incorporated to the Infectious Diseases CIBER of Carlos III Health Institute.

CIC bioGUNE has kept its working capacity during the second year of the pandemic, establishing a specific plan that combines responsibility, safety, and focused research. Massive PCR and antibody analysis for all the members have been periodically carried out. Several collaborative projects on COVID-19, integrating 12 CIC bioGUNE research groups and different institutions and agents have continued to be developed during 2021. Seven publications on COVID-19-related topics have been presented along the year.

CIC bioGUNE keeps its position within the top 100 NPO/NGO Institutions worldwide (position 48th) in Life Sciences, according to Nature Index 2021.

CIC bioGUNE continues with its strategic plan to keep and reinforce the key infrastructures: new actions for acquisition of diverse equipment have been carried out, including the purchase of equipment for Biolayer Interferometry, Mosquito for X-Ray diffraction, fluorescence cytometer, MALDI TOF/TOF, HPLC-MS, together with the update of the animal facility. Moreover, CIC bioGUNE has purchased new spaces (980 m2) at Building 800 of the Bizkaia Technology Park. A proposal to renew one of the NMR consoles at the NMR platform (Singular Infrastructure of the State) has been granted.

Despite the pandemic, the introductory week (October 4-8) for the new Doctoral Candidates at CIC bioGUNE has been delivered in person with great success.

Competitive funding at CIC bioGUNE surpasses 14 M€, more than 2/3 of total funding. Private funding goes beyond 30% of total funding.


Jeremy K. Nicholson (ANPC)


Óscar Millet




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