Pablo Salvador Valera Sapena
Pablo Salvador Valera Sapena
DOCTORAL CANDIDATE
Cancer Cell Signaling And Metabolism Lab
Email: pvalera.cicbiomagune@cicbiogune.es
Phone: 4234 / 944 061 323
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

Germline gain-of-function MMP11 variant results in an aggressive form of colorectal cancer

Martin-Morales, L;Manzano, S;Rodrigo-Faus, M;Vicente-Barrueco, A;Lorca, V;Nunez-Moreno, G;Bragado, P;Porras, A;Caldes, T;Garre, P;Gutierrez-Uzquiza, A

INTERNATIONAL JOURNAL OF CANCER

2022-10-03

CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets

Caloto, R;Lorenzo-Martin, LF;Quesada, V;Carracedo, A;Bustelo, XR

BIOLOGY-BASEL

2022-10-01

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

Feu, S;Unzueta, F;Ercilla, A;Perez-Venteo, A;Jaumot, M;Agell, N

PLOS ONE

2022-08-15

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson, SM;Schmidt, DR;Heyman, JE;'Brien, JPO;Liu, AC;Israelsen, WJ;Dayton, TL;Sehgal, R;Bronson, RT;Freinkman, E;Mak, HH;Fanelli, GN;Malstrom, S;Bellinger, G;Carracedo, A;Pandolfi, PP;Courtney, ...

CANCER RESEARCH

2022-07-01

Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer

Arruabarrena-Aristorena, A;Toska, E

FRONTIERS IN ONCOLOGY

2022-06-14

High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML

Aldaz, P;Martin-Martin, N;Saenz-Antonanzas, A;Carrasco-Garcia, E;Alvarez-Satta, M;Elua-Pinin, A;Pollard, SM;Lawrie, CH;Moreno-Valladares, M;Sampron, N;Hench, J;Lovell-Badge, R;Carracedo, A;Matheu, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-05-01

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Rodriguez-Agudo, R;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Fernandez-Tussy, P;Fernandez-Ramos, D;Lachiondo-Ortega, S;Gonzalez-Recio, I;Gil-Pitarch, C;Mercado-Gomez, M;Moran, L;Bizkarguenaga, ...

ANTIOXIDANTS

2022-05-01

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, AM;Abaurrea, A;Azcoaga, P;Lopez-Velazco, JI;Manzano, S;Rodriguez, J;Rezola, R;Egia-Mendikute, L;Valdes-Mora, F;Flores, JM;Jenkins, L;Pulido, L;Osorio-Querejeta, I;Fernandez-Nogueira, ...

JOURNAL OF CLINICAL INVESTIGATION

2022-04-01

Angiocrine polyamine production regulates adiposity

Monelli, E;Villacampa, P;Zabala-Letona, A;Martinez-Romero, A;Llena, J;Beiroa, D;Gouveia, L;Chivite, I;Zagmutt, S;Gama-Perez, P;Osorio-Conles, O;Muixi, L;Martinez-Gonzalez, A;Castillo, SD;Martin-Martin, ...

NATURE METABOLISM

2022-03-14

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Zabala-Letona, A;Arruabarrena-Aristorena, A;Fernandez-Ruiz, S;Viera, C;Carlevaris, O;Ercilla, A;Mendizabal, I;Martin, T;Macchia, A;Camacho, L;Pujana-Vaquerizo, M;Sanchez-Mosquera, P;Torrano, ...

ONCOGENESIS

2022-02-23