Activity Report 2020

CIC bioGUNE - Centro de Investigación Cooperativa en Biociencias

 

Scientific Programmes

Scientific Programmes
Research lines

Cancer

Metabolic diseases

Infectious diseases

Rare diseases

The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. An integrative Bioinformatics Program extrapolates relevant conclusions from basic science.

Metabolism and Cell Signaling in Disease

  • Personalized medicine
  • Prostate Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Liver Diseases
  • Rare Diseases
  • Biomarkers for Diagnosis
  • Biomarkers for Prognosis
  • Drug Design and Discovery

Molecular Recognition and Host-Pathogen

  • Rare Diseases
  • Homeostasis
  • Viral Infections
  • Bacterial Infections
  • Prion Disease
  • Tick-Borne Disease
  • Immune Response
  • Drug Design and Discovery

Platforms

  • NMR Spectroscopy
  • Macromolecular Crystallography
  • Electron Microscopy
  • Genome Analysis
  • Proteomics
  • Metabolomics
  • Animal Facility

 

Generation of
knowledge

Technology
transfer

Commercialization of
results

Scientific Programmes
Metabolism & Cell Signaling in Disease

Brain

Breast

Colon

Liver

Prostate

  1. Target discovery and evaluation of their therapeutic potential
  2. Cancer and more: Identification of biomarkers with potential diagnostic value
  3. Novel therapies against rare diseases
  4. The molecular basis of fibrosis
  5. Nonalcoholic steatohepatitis

The Research Programmes
Molecular Recognition & Host-Pathogen Interactions

Parasites

Vaccines

Antibiotics

Membrane remodelling

Animal and plant viruses

  1. Bacterial and Viral Infections: Vaccines for human and animal health
  2. Mechanisms of membrane remodelling during microbial invasion and propagation
  3. Plant vaccines and transgenics
  4. Antibiotics research and molecular characterization

The Research Programmes
Technology Platforms

Genome Analysis Platform

Proteomics Platform

Metabolomics Platform

Animal Facility

Antibodies Production

Drug Repositioning & Discovery

Nuclear Magnetic Resonance

Macromolecular Crystallography

Electron Microscopy Platform

Collaboration Models

Services
R&D Collaborations
Consulting

About Us

flecha abajo-derecha

Mission:

Conducting research of excellence in the field of the life sciences, covering the entire value of R&D&i, including technology transfer and commercial exploitation of the generated scientific results.

flecha derecha-abajo

Strategic Challenges:

  • Research of excellence
  • Technology Transfer
  • Collaboration with RVCTI agents
  • International recognition
  • Training and promotion of research talent
  • Attraction and retention of talent
  • Communication and Outreach
  • Excellence in Management

Strategy:

Commitment to specialization and excellence

flecha derecha-arriba

Competitiveness:

  • Leading infrastructures
  • Human Resources
  • Technical and administrative support
  • Competitive salaries
  • Goal-Fulfillment Incentives
flecha abajo-izquierda

Staff

Staff 2020.12.31: 0

FTE (2020): 0

Permanent Staff (FTE): 0 (43%)

Gender distribution

  • 0% Female
    121
  • 0% Male
    90
  • LISMI - Law of Social Integration of the Handicapped
    4
 

211 Total CIC bioGUNE Personnel

  • 0% Research
    177
  • 0% Administration and Services
    34

 

Researchers Distribution by Professional Category

    % Woman Man
  Researchers 136 76.8 67 69
  • Principal investigators/Platform Managers 28 15.8 7 21
  • Postdoctoral Researchers/Research Assistant/Specialist 47 26.6 26 21
  • PhD Students 61 34.5 34 27
  Technicians 41 23.2 31 10

Research Distribution by Geographic Origin

Research Distribution by Geographic Origin

Spain 174
Italy 12
Portugal 1
Austria 1
United Kingdom 1
The Netherlands 1
Germany 3
America 14
Asia 4
  • 0% Spain
    174 researchers
  • 0% Rest of Europe
    19 researchers
  • 0% America
    14 researchers
  • 0% Asia
    4 researchers

Funding

Total 2020 R&D Budget: 0 k€

Running R&D Projects: 0

New R&D Projects: 0

 
  • 0 % Basque Government Departments
    8.436 K€
  • 0 % MINECO & MEDC (Spanish Government)
    3.554 K€
  • 0 % R&D Contracts, Research Services & Others
    6.014 K€
  • 0 % EU & International Projects
    1750 K€

Technology Transfer and Innovation

Economic Activity: 5.077.212

  • Basque Country: 0%
  • National: 0%
  • International: 0%

New Research Contracts 0

0 New Patent Applications

0 new patent:

  • EPO: 3 532 058 B1

0 Licensing Agreement

 

Intellectual Property 2020

 
  • 0 European Patent Applications
  • 0 Trade Secret Application
  • 0 USPTO Patent Application
  • 0 Utility Model Application

Professional Career

  1. Motivation
  2. Management Career and Technical Staff
    • Level 1
    • Level 2A  Level 2B
    • Level 3
    • Level 4
    • Level 5
  3. Research Staff Career
    • Level G1A  Level G1B
    • Level G2
    • Level G3
    • Level G4
  4. Flow chart-Professional Career Level
  5. Evaluation procedure to Management and Technical Staff

Organization Chart-Professional Career Level

Click on the image to see it enlarged in pdf

Organigrama nivel carrera profesional

Equality Plan

Click on the image to see it enlarged in pdf

Competitive Funding

Private Funding

The new Scientific Advisory Board (SAB)

Strategic plan: Infrastructure

  • Camera K2 cryoEM
  • NMR 400 MHz
  • NMR 600 MHz
  • Vitrobot
  • Single Cell
  • Seahorse
  • Biosafety Cabins (3)
  • Plates reader
  • Small equipment for the center
  • Shaker-Incubator
  • Animal Facility Washing machine & cages
  • Flash chromatographer
  • Glass case
  • Nitrogen tank
  • Microscope & SW
  • New Brunswick Innova
  • Rotatory evaporator
  • Small equipment for the labs

IT servers, small computers, furniture for labs

Works at: Animal facility, Ground floor Labs at 801A

Renting for: Chromatograph, storage space for IT

Acquisition of 275 m2 at 800

Actions: New incorporation 2021

Mauro D'Amato
Monash University
Australia

Gastrointestinal Genomics lab

Genomic, computational and pre-clinical expertise to elucidate the pathogenetic mechanisms predisposing to gastrointestinal (GI) disease.

COVID Projects
Regional Funding

Desarrollo de herramientas analíticas para el diagnóstico serológico de la población general frente al SARS-CoV-2

Grant Amount 0

Desarrollo y validación de tests serológicos escalables para la identificación seropositivos frente COVID-19

Grant Amount 0

Desarrollo de un test rápido para la detección de anticuerpos frente a COVID-19 por sobreexpresión del antígeno inmunogénico viral (ARINTEST)

Grant Amount 0

Group Leaders

Nicola Abrescia, Oscar Millet, Asís Palazón, Juan Anguita, Jesús Jiménez-Barbero, Mikel Valle

Ramón y Cajal Program
Competitive Funding

Asís Palazón
Group Leader

Cancer Immunology and Immunotherapy Lab

Marco Piva
Ramón y Cajal Researcher

Cancer Cell Signaling & Metabolism Lab

IKERBASQUE
Competitive Funding

Ikerbasque Research Fellow

Marco Piva

Cancer Cell Signaling & Metabolism Lab

Isabel Mendizabal

Cancer Cell Signaling & Metabolism Lab

Ikerbasque Research Associates

Gonzalo Jiménez-Osés

Computational Chemistry Lab

Ana Ardá

Chemical Glycobiology Lab

International Foundations

Investigator: Gonzalo Jiménez-Osés

Addressing Enthalpy - Entropy Compensation in Carbohydrates Binding by Computation

European Funding

Juan Manuel Falcón


Plasma extracellular vesicles (EVs): the key for precision medicine in Glioblastoma - EV-glio

Coordinator
Italy

Rosa Barrio


PROTEOblood - Red cooperativa franco-española para el análisis de proteinopatías y el desarrollo de terapias individualizadas en cánceres hematológicos

Coordinator
Spain

Alfonso Martínez De La Cruz


 

For improving diagnostics and Grasping the disease mechanisms of rare Hypomagnesemia in patients with CNNM2 mutations - FIGHT - CNNM2

Coordinator
Netherlands

Ashwin Woodhoo


ERC Consolidator Grant

MyeRIBO: Deconstructing the Translational Control of Myelination by Specialized Ribosomes

Applications

Funding
Entity
Applications
19 Dec 2019
Applications
16 Dec 2020
Basque Government 17 17
Ikerbasque 3 5
Spanish Ministry 44 31
ISCII 4 2
H2020 21 25
National Entities 52 78
International Entities 17 20
Other International Calls 7 3
TOTAL 165 181

2019

"

2020

"

Singular Projects

International

Special Networks

H2020: ERC

1 Advanced Grant

3 Starting Grants

2 Consolidator Grants

Publications

 

 

 

Citations

76
h-index

Scientific Highlights

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives.

Linclau B, Ardá, Reichardt NC, Sollogoub M, Unione L, Vincent SP, Jiménez- Barbero J.

Chem Soc Rev. 2020 Jun 22,49(12):3863-3888. doi: 10.1039/c9cs00099b. PMID: 32520059.

Read the article

The future of Extracellular Vesicles as Theranostics – an ISEV meeting report

Soekmadji C, Li B, Huang Y, Wang H, An T, Liu C, Pan W, Chen J, Cheung L, Falcon-Perez JM, Gho YS, Holthofer HB, Le MTN, Marcilla A, O'Driscoll L, Shekari F, Shen TL, Torrecilhas AC, Yan X, Yang F, Yin H, Xiao Y, Zhao Z, Zou X, Wang Q, Zheng L.

J Extracell Vesicles. 2020 Sep 4;9(1):1809766. doi: 10.1080/20013078.2020.1809766. PMID: 33144926; PMCID: PMC7580849.

Read the article

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M.

Circulation. 2020 Aug 18,142(7):688-704. doi: 10.1161/CIRCULATIONAHA.119.042354. Epub 2020 May 29. PMID: 32466671.

Read the article

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Plou, J , Garcia, I, Charconnet, M, Astobiza, I, Garcia-Astrain, C , Matricardi, C, Mihi, A, Carracedo, A, Liz-Marzan, LM.

Advanced Functional Materials. 2020 Mar 5, 30 (17): 1910335   doi: 10.1002/adfm.201910335.

Read the article

The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development

Qureshi R, Picon-Ruiz M, Aurrekoetxea-Rodriguez I, Nunes de Paiva V, D'Amico M, Yoon H, Radhakrishnan R, Morata-Tarifa C, Ince T, Lippman ME, Thaller SR, Rodgers SE, Kesmodel S, Vivanco MDM, Slingerland JM. .

Cell Metab. 2020 Jun 2,31(6):1154-1172.e9. doi: 10.1016/j.cmet.2020.05.008. PMID: 32492394.

Read the article

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano- Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. issmeyer, N; Coux, O; Rodriguez, MS; Barrio, R.

Cell Metab. 2020 Mar 3,31(3):605-622.e10. doi: 10.1016/j.cmet.2020.01.013. Epub 2020 Feb 21. PMID: 32084378, PMCID: PMC7259377.

Read the article

Metabolic Landscape of the Mouse Liver by Quantitative 31P Nuclear Magnetic Resonance Analysis of the Phosphorome

Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O.

Hepatology. 2020 Dec 7. doi: 10.1002/hep.31676. Epub ahead of print. PMID: 33284502.

Read the article

Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC.

Hepatology. 2020 Nov;72(5):1682-1700. doi: 10.1002/hep.31196. Epub 2020 Oct 1. PMID: 32080887; PMCID: PMC7442711.

Read the article

The L-α-Lysophosphatidylinositol/G Protein–Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R.

Hepatology. 2021 Feb;73(2):606-624. doi: 10.1002/hep.31290. Epub 2020 Nov 13. PMID: 32329085; PMCID: PMC7894478.

Read the article

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Compañón I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernadó P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R.

Nat Chem Biol. 2020 Mar;16(3):351-360. doi: 10.1038/s41589-019-0444-x. Epub 2020 Jan 13. PMID: 31932717; PMCID: PMC7923394.  

Read the article

Dissecting the Essential Role of Anomeric β-Triflates in Glycosylation Reactions

Santana AG, Montalvillo-Jiménez L, Díaz-Casado L, Corzana F, Merino P, Cañada FJ, Jiménez-Osés G, Jiménez-Barbero J, Gómez AM, Asensio JL.

J Am Chem Soc. 2020 Jul 15;142(28):12501-12514. doi: 10.1021/jacs.0c05525. Epub 2020 Jul 6. PMID: 32579343.

Read the article

Complete Dynamic Reconstruction of C60, C70, and (C59N)2 Encapsulation into an Adaptable Supramolecular Nanocapsule

García-Simón C, Colomban C, Çetin YA, Gimeno A, Pujals M, Ubasart E, Fuertes- Espinosa C, Asad K, Chronakis N, Costas M, Jiménez-Barbero J, Feixas F, Ribas X.

J Am Chem Soc. 2020 Sep 16;142(37):16051-16063. doi: 10.1021/jacs.0c07591. Epub 2020 Sep 3. PMID: 32822170.

Read the article

Discovering Biomolecules with Huisgenase Activity: Designed Repeat Proteins as Biocatalysts for (3 + 2) Cycloadditions

Rivilla I, Odriozola-Gimeno M, Aires A, Gimeno A, Jiménez-Barbero J, Torrent- Sucarrat M, Cortajarena AL, Cossío FP.

J Am Chem Soc. 2020 Jan 15;142(2):762-776. doi: 10.1021/jacs.9b06823. Epub 2019 Dec 26. PMID: 31829573.8b13503  

Read the article

An Epoxide Intermediate in Glycosidase Catalysis

Sobala LF, Speciale G, Zhu S, Raich L, Sannikova N, Thompson AJ, Hakki Z, Lu D, Shamsi Kazem Abadi S, Lewis AR, Rojas-Cervellera V, Bernardo-Seisdedos G, Zhang Y, Millet O, Jiménez-Barbero J, Bennet AJ, Sollogoub M, Rovira C, Davies GJ, Williams SJ.

ACS Cent Sci. 2020 May 27;6(5):760-770. doi: 10.1021/acscentsci.0c00111. Epub 2020 Apr 16. PMID: 32490192; PMCID: PMC7256955.

Read the article

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

Gil de Montes E, Istrate A, Navo CD, Jiménez-Moreno E, Hoyt EA, Corzana F, Robina I, Jiménez-Osés G, Moreno-Vargas AJ, Bernardes GJL.

Angew Chem Int Ed Engl. 2020 Apr 6;59(15):6196-6200. doi: 10.1002/anie.201914529. Epub 2020 Feb 18. PMID: 31981460.

Read the article

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS- CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza MP, Oyenarte I, Diercks T, Quintana JI, Gimeno A, Coelho H, Diniz A, Peccati F, Delgado S, Bosch A, Valle M, Millet O, Abrescia NGA, Palazón A, Marcelo F, Jiménez-Osés G, Jiménez-Barbero J, Ardá A, Ereño-Orbea J.

Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23763-23771. doi: 10.1002/anie.202011015. Epub 2020 Oct 22. PMID: 32915505; PMCID: PMC7894318.

Read the article

Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans Featuring α-Galactose, α-Galactosamine and α-N-Acetyl Galactosamine Linkages

Zhang Y, Gómez-Redondo M, Jiménez-Osés G, Arda A, Overkleeft HS, van der Marel GA, Jiménez-Barbero J, Codée JDC.

Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12746-12750. doi: 10.1002/anie.202003951. Epub 2020 May 20. PMID: 32342633.

Read the article

Non-Stationary Complementary Non-Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data.

Romero JA, Nawrocka EK, Shchukina A, Blanco FJ, Diercks T, Kazimierczuk K.

Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23496-23499. doi: 10.1002/anie.202009479. Epub 2020 Sep 29. PMID: 32852098; PMCID: PMC7756666.

Read the article

Structure of the processive human Pol δ holoenzyme

Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A.

Nat Commun. 2020 Feb 28;11(1):1109. doi: 10.1038/s41467-020-14898-6. PMID: 32111820; PMCID: PMC7048817.

Read the article

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

Trastoy B, Naegeli A, Anso I, Sjögren J, Guerin ME.

Nat Commun. 2020 Sep 24;11(1):4844. doi: 10.1038/s41467-020-18696-y. PMID: 32973204; PMCID: PMC7518263.

Read the article

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Barbier-Torres L, Fortner KA, Iruzubieta P, Delgado TC, Giddings E, Chen Y, Champagne D, Fernández-Ramos D, Mestre D, Gomez-Santos B, Varela-Rey M, de Juan VG, Fernández-Tussy P, Zubiete-Franco I, García-Monzón C, González-Rodríguez Á, Oza D, Valença-Pereira F, Fang Q, Crespo J, Aspichueta P, Tremblay F, Christensen BC, Anguita J, Martínez-Chantar ML, Rincón M.

Nat Commun. 2020 Jul 3;11(1):3360. doi: 10.1038/s41467-020-16991-2. PMID: 32620763; PMCID: PMC7334216.

Read the article

Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides

Trastoy B, Du JJ, Klontz EH, Li C, Cifuente JO, Wang LX, Sundberg EJ, Guerin ME.

Nat Commun. 2020 Feb 14;11(1):899. doi: 10.1038/s41467-020-14754-7. PMID: 32060313; PMCID: PMC7021837.

Read the article

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D, Fernández-Ramos D, Lozano JJ, Okawa S, Lavín JL, Martín-Martín N, Sutherland JD, de Juan VG, Gonzalez-Lopez M, Macías-Cámara N, Mosén-Ansorena D, Laraba L, Hanemann CO, Ercolano E, Parkinson DB, Schultz CW, Araúzo-Bravo MJ, Ascensión AM, Gerovska D, Iribar H, Izeta A, Pytel P, Krastel P, Provenzani A, Seneci P, Carrasco RD, Del Sol A, Martinez-Chantar ML, Barrio R, Serra E, Lazaro C, Flanagan AM, Gorospe M, Ratner N, Aransay AM, Carracedo A, Varela-Rey M, Woodhoo A.

J Clin Invest. 2020 Jul 1;130(7):3848-3864. doi: 10.1172/JCI130379. PMID: 32315290; PMCID: PMC7324187.

Read the article

CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo

Alajati A, D'Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, Revandkar A, Bolis M, Theurillat JP, Guccini I, Losa M, Calcinotto A, De Bernardis G, Pasquini E, D'Antuono R, Sharp A, Figueiredo I, Nava Rodrigues D, Welti J, Gil V, Yuan W, Vlajnic T, Bubendorf L, Chiorino G, Gnetti L, Torrano V, Carracedo A, Camplese L, Hirabayashi S, Canato E, Pasut G, Montopoli M, Rüschoff JH, Wild P, Moch H, De Bono J, Alimonti A.

J Clin Invest. 2020 May 1;130(5):2435-2450. doi: 10.1172/JCI131133. PMID: 32250342; PMCID: PMC7190998.

Read the article

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez- Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.

J Exp Med. 2020 Jun 1;217(6):e20191787. doi: 10.1084/jem.20191787. PMID: 32219437; PMCID: PMC7971141.

Read the article

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Schijns V, Fernández-Tejada A, Barjaktarović Ž, Bouzalas I, Brimnes J, Chernysh S, Gizurarson S, Gursel I, Jakopin Ž, Lawrenz M, Nativi C, Paul S, Pedersen GK, Rosano C, Ruiz-de-Angulo A, Slütter B, Thakur A, Christensen D, Lavelle EC.

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. Immunol Rev. 2020 Jul;296(1):169-190. doi: 10.1111/imr.12889. Epub 2020 Jun 28. PMID: 32594569; PMCID: PMC7497245.

Read the article

OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

Fabre M, Ferrer C, Domínguez-Hormaetxe S, Bockorny B, Murias L, Seifert O, Eisler SA, Kontermann RE, Pfizenmaier K, Lee SY, Vivanco MD, López-Casas PP, Perea S, Abbas M, Richter W, Simon L, Hidalgo M.

Clin Cancer Res. 2020 Jul 1;26(13):3420-3430. doi: 10.1158/1078-0432.CCR-19-2238. Epub 2020 Mar 11. PMID: 32161121.

Read the article

COVID-19 Publications

Abnormal concentration of porphyrins in serum from COVID-19 patient

San Juan I, Bruzzone C, Bizkarguenaga M, Bernardo-Seisdedos G, Laín A, Gil- Redondo R, Diercks T, Gil-Martínez J, Urquiza P, Arana E, Seco M, García de Vicuña A, Embade N, Mato JM, Millet O.

Br J Haematol. 2020 Sep;190(5):e265-e267. doi: 10.1111/bjh.17060. Epub 2020 Aug 29. Erratum in: Br J Haematol. 2021 Apr;193(2):429. PMID: 32745239; PMCID: PMC7436216.

Read the article

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Bruzzone C, Bizkarguenaga M, Gil-Redondo R, Diercks T, Arana E, García de Vicuña A, Seco M, Bosch A, Palazón A, San Juan I, Laín A, Gil-Martínez J, Bernardo-Seisdedos G, Fernández-Ramos D, Lopitz-Otsoa F, Embade N, Lu S, Mato JM, Millet O.

iScience. 2020 Oct 23;23(10):101645. doi: 10.1016/j.isci.2020.101645. Epub 2020 Oct 5. PMID: 33043283; PMCID: PMC7534591.

Read the article

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS- CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza MP, Oyenarte I, Diercks T, Quintana JI, Gimeno A, Coelho H, Diniz A, Peccati F, Delgado S, Bosch A, Valle M, Millet O, Abrescia NGA, Palazón A, Marcelo F, Jiménez-Osés G, Jiménez-Barbero J, Ardá A, Ereño-Orbea J.

Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23763-23771. doi: 10.1002/anie.202011015. Epub 2020 Oct 22. PMID: 32915505; PMCID: PMC7894318.

Read the article

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Fondevila MF, Mercado-Gómez M, Rodríguez A, Gonzalez-Rellan MJ, Iruzubieta P, Valentí V, Escalada J, Schwaninger M, Prevot V, Dieguez C, Crespo J, Frühbeck G, Martinez-Chantar ML, Nogueiras R.

J Hepatol. 2021 Feb;74(2):469-471. doi: 10.1016/j.jhep.2020.09.027. Epub 2020 Oct 20. PMID: 33096086; PMCID: PMC7574841.

Read the article

Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity

Millet O, Cortajarena AL, Salvatella X, Kiessling LL, Jiménez-Barbero J.

ACS Chem Biol. 2020 Jul 17;15(7):1722-1723. doi: 10.1021/acschembio.0c00496. Epub 2020 Jun 25. PMID: 32584537; PMCID: PMC7323048.

Read the article

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute L, Bosch A, Prieto-Fernández E, Lee SY, Jiménez-Lasheras B, García Del Río A, Antoñana-Vildosola A, Bruzzone C, Bizkarguenaga M, Embade N, Gil-Redondo R, Martínez-Chantar ML, López-Hoyos M, Abrescia NGA, Mato JM, Millet Ó, Palazón A.

Commun Biol. 2021 Apr 20;4(1):486. doi: 10.1038/s42003-021-02011-6. PMID: 33879833; PMCID: PMC8058339.

Read the article

Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19

Jung S, Potapov I, Chillara S, Del Sol A.

Sci Adv. 2021 Feb 3;7(6):eabe5735. doi: 10.1126/sciadv.abe5735. PMID: 33536217.

Read the article

Editorial Activity

  • Joaquín Castilla
    Advisory Board

  • Óscar Millet
    Associate Editor

  • Juan Anguita
    Editor Board

  • Óscar Millet
    Editor Board

  • Juan Anguita
    Editor Board

  • Antonio Del Sol
    Editor Board

  • Óscar Millet
    Associate Editor

  • Óscar Millet
    Editor Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Félix Elortza
    Editor Board

  • Juan M. Falcón
    Review Editor

  • Rosa Barrio
    Review Editor

  • Juan Anguita
    Guest Associate Editor
    Review Editor

  • Juan Anguita
    Review Editor

  • Rosa Barrio
    Associate Editor

  • Jesús Jiménez-Barbero
    Associate Editor

  • Jesús Jiménez-Barbero
    Advisory Board

  • Rosa Barrio
    Editor Board

  • Juan Anguita
    Senior Editor

  • Óscar Millet
    Associate Editor

  • Félix Elortza
    Editor Board

  • María Vivanco
    Editor Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Jesús Jiménez-Barbero
    Advisory Board

  • Óscar Millet
    Editor Board

  • Joaquín Castilla
    Editor Board

  • Joaquín Castilla
    Editor Board

  • Juan Anguita
    Editor Board

PhD Thesis

0 in progress

Collaboration RVCTI

0 RVCTI

Accredited Centers Scientific Foundation AECC

Scientific Excellence

Quality, Impact and Leadership

PHASE I: Documentation

PHASE II: Visit to CIC bioGUNE

Telematics Assessment

October 14th and 15th, 2020

PHASE III: Membership of the Programme

Click on the image to see it enlarged in pdf

AAALAC Acreditation

AAALAC accredited Animal Facility

2008 AAALAC Accreditation

2011
2014
2017
2020

AAALAC Renewal of accreditation

Basque Research Alliance

Provincial council of

Scientific-technological commission

Socio-economic challenges: Personalized health (coordination)

Degree in Medicine.
University of Deusto

Battalion of the imposition of robes. 1st Student Promotion.

Start in January:
24 Teachers

MATERIA M3

Chemistry Applied to Life Sciences

 

MATERIA M4

Homeostasis and Regulation

 

Health Crisis: COVID-19

ISCIII validation for performing PCR tests

Click on the image to see it enlarged in pdf

COVID-19 research projects

The first aims to validate and develop rapid virological diagnostic techniques for SARS-CoV-2. Different spike protein antigens have been generated, which have been validated in ELISA tests. Monoclonal antibodies are being generated.

  • Nicola Abrescia
    Structure & Cell Biology of Viruses

  • Óscar Millet
    Precision Medicine & Metabolism

  • Juan Anguita
    Inflammation & Macrophage Plasticity

  • Mikel Valle
    CryoEM of Biological Macromolecules

  •    
  • June Ereño-Orbea & Jesús Jiménez-Barbero
    Chemical Glycobiology

  • Asís Palazón
    Cancer Immunology & Immunotherapy

An effective process has been developed for sample processing, RNA purification and detection of the RNA of the virus by PCR. Various laboratory procedures have been validated for automated RNA extraction in human samples, as well as virus RNA detection procedures using PCR, in collaboration with the Arquimea group (webcovid19). Saliva from positive individuals also works with the antigen test (Abbott). The sample left after this test can be used to extract RNA and detect SARS-CoV-2 with the bioGUNE CIC procedure.

  • Ana M. Aransay
    Genome Analysis Platform

  • Arkaitz Carracedo
    Cancer Cell Signaling & Metabolism

  • Joaquín Castilla
    Prion Research

Metabolic disorders affecting the composition of lipoproteins and metabolites have been identified in the serum of COVID-19 patients

  • Óscar Millet
    Precision Medicine & Metabolism

A fourth project is aimed at the application of new computational methods to characterize the immune response that defines this pathology and to propose strategies and treatments that are able to modulate the corresponding severe inflammatory cascade.

  • Antonio del Sol
    Computational Biology

Another project, led by CIMUS with the participation of bioGUNE, has determined that the fatty liver with inflammation (NASH) favors the entry of coronavirus into this organ in obese people.

  • Malu Martínez-Chantar
    Liver Disease

These projects are being developed in collaboration with different Institutions and agents:

Health Crisis:
CIC bioGUNE in COVID-19

Click on the image to see it enlarged in pdf

News Special Covid

Business Development Activity

R&D agreements with companies

COVID 19

Production of Antigens and Monoclonal Antibodies for rapid and effective diagnosis of COVID-19

Collaboration agreement

Technology Transfer and Innovation

Business Development

Business Leads generation:

  • 0 new business leads
  • 0 MTA
  • 0 CDA signed with companies
  • 0 Collaborative Agreements
  • 0 Sponsorship Agreements
  • 0 Licenses Options
  • 0 Industrial Doctorate

Training

InnoBerrIkasi

BioBridge

The program provides PhD and MBA students a vehicle toward entrepreneurship through learn-by-doing methodology, at the intersection of Life Sciences, Engineering and Business.

TechBoost

We continuously screen for technologies with high exploitation values for society and scientists are immersed in the development and evaluation of the idea and the generation of models to allow commercialization.

Technology Certifications

NMR-based Diagnostics
ISO 9001 obtained

Diagnostic analysis of metabolites from blood and urine. Capacity 15.000 samples/year. Collaboration with Bruker.

New Spin-Off Company:

Akribea 6174 S.L.

September 18th, 2020

  • Acquisition and filtering of databases in the context of precision medicine
  • Statistical data processing and processing to establish tools to support the diagnosis of pathologies
  • Acquisition and processing of NMR data and their applications

Society Outreach

Approach Civil Society

Collaboration Agreements

AECC contra el cáncer

British Council

Enhance External Visibility

News Special Covid19
Scientific Annual Review 2019
Social Media

Create an Alumni Network

In collaboration with Bizkaia Talent:
The talent attraction /retention arm of Basque Country
Bizkaia Talent

Highlights

CIC bioGUNE investigators publish more than 160 publications in 2020. More than 30 % of them display an Impact factor above 10. CIC publications are cited more than 7400 times in 2020.

CIC bioGUNE investigators file 7 EPO and 1 PCT applications.

CIC bioGUNE researchers are awarded with 28 new competitive R+D projects, funded by public and private institutions. 85 R+D projects are running along 2020.

Gonzalo Jiménez-Osés (Group Leader, Computational Chemistry Lab) and Ana Ardá (Associated Principal Investigator, Chemical Glycobiology lab) are promoted to Ikerbasque Research Associates.

CIC bioGUNE is recognized as "Centro de la RED de Centros FAECC”, by the Foundation of the Spanish Association Against Cancer".

CIC bioGUNE keeps its position within the top 100 NPO/NGO Institutions worldwide (position 48) in Life Sciences, according to Nature Index.

The External Scientific Advisory Board visits virtually CIC bioGUNE to carry out the corresponding evaluation of the Center and the Research Groups. Drs. Marisol Soengas (CNIO, Madrid), Caroline Dive (Cancer Research UK, Manchester), and María José Alonso (Santiago de Compostela, CIMUS) join the SAB by the end of the year.

17 PhD Thesis are presented by CIC bioGUNE ESRs along 2020.

CIC bioGUNE continues with its strategic plan to keep the key infrastructures: new actions in the NMR, proteomics, and cryoEM platforms are carried out, together with the update of the animal facility and the establishment of a life-cell image facility.

Competitive funding at CIC bioGUNE reaches 67,6% of total funding. Private funding goes beyond 30% of total funding.

CIC bioGUNE keeps its working capacity during the pandemic, establishing a specific plan that combines responsibility, safety, and focused research. Five specific collaborative projects on COVID-19, integrating 12 CIC bioGUNE research groups and different institutions and agents, are developed during 2020.

Despite the pandemic, the introductory week (October 5-9) for the new Early Stage Researchers(ESR) at CIC bioGUNE is delivered on line with great success. funding.

A new Equality Plan is established.

A new spin-off company, Akribea 6174 SL, is launched by CIC bioGUNE investigators, in the context of NMR and precision medicine.

Video Outreach

Follow the series Drops of Science

Training – ESR

The CIC bioGUNE Advanced Training Program

Introductory week: 5-9 October

Recognitions

Press

Radio & TV

  • 20.06.02 Interview with Oscar Millet and June Ereño-Orbea on new therapeutic strategies for autoimmune diseases and cancer.
  • 20.09.08 Interview with Jose M. Mato, Oscar Millet, Ana María Aransay and Arkaitz Carracedo on COVID-19.
  • 20.11.16 Interview with José M. Mato and Oscar Millet on patronage activities and ongoing investigations.
  • 20.07.07 Interview with Malu Martínez Chantar on the GalNAC-MCJ molecule.
  • 20.08.19 Interview with Oscar Millet on publication in the British Journal of Hematology.
  • 20.11.10 Interview with Donatello Castellana on statement of patronage activities.
  • 20.06.30 Interview with Ashwin Woodhoo on research that opens pathways to treat nervous system cancer.
  • 20.11.17 Interview with Arkaitz Carracedo on statement of patronage activities.
  • 20.08.14 Interview with Oscar Millet on publication in the British Journal of Hematology.
  • 20.11.05 Interview with Oscar Millet on research at COVID-19.
  • 20.11.10 Interview with Oscar Millet on statement of patronage activities.
  • 20.06.30 Interview with Ashwin Woodhoo on research that opens pathways to treat nervous system cancer.
  • 20.10.21 Interview with Oscar Millet on the publication on COVID-19.
  • 20.09.24 Interview with Arkaitz Carracedo on World Cancer Day.

Activities

3rd Glycobasque Meeting

Euromar 2020

SEBD

Ubicode

Outreach

Download PDF version Previous Report (2019)