Alexandre Bosch Martínez
Alexandre Bosch Martínez
DOCTORAL CANDIDATE
AECC Predoctoral Felow
AECC Predoctoral Felow
Cancer Immunology and Immunotherapy Lab
Email: abosch@cicbiogune.es
Phone: 4225 / 944 061 304
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

It is well recognised that the clinical response of immunotherapies depends on the ability of T-cells to mount an effective effector response, persist in treated patients and avoid exhaustion and toxicities. Several approaches to immunotherapy have shown promise in clinical trials, especially the use of immune checkpoint inhibitors and, more recently, autologous adoptive T-cell therapies. However, current state-of-the-art immunotherapies are only effective in a small fraction of patients, offering a medical need to be addressed in several cancer types.

Importantly, the tumor microenvironment has specific features that impact the immune response, including decreased oxygenation, aberrant vascularization and altered nutrient availability; all these influence the success of immunotherapies.

Our research is focused on elucidating the role of the oxygen sensing machinery in T cell function, and the link of hypoxia-driven metabolism and epigenetic modifications with T cell differentiation into effector and memory T cells within the context of cancer immunotherapy. Our current aims are to exploit these findings with a multi-disciplinary strategy, to deliver several early-stage drug discovery outputs. Our main objectives are:

1. Development of novel small molecule inhibitors to modulate the hypoxic response in T cells.
2. Therapeutic target discovery in T cells, focused on hypoxia-driven epigenetic modifications.
3. Development of hypoxia-responsive approaches for adoptive T cell therapy.

Successful completion of these aims will allow us to further innovate, harness this pathway for therapeutic potential and explore potential combinatorial approaches.

Latest Publications

An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study

Gil-Redondo, R;Conde, R;Bizkarguenaga, M;Bruzzone, C;Lain, A;Gonzalez-Valle, B;Iriberri, M;Ramos-Acosta, C;Anguita, E;Lariz, JIA;Yandiola, PPE;Moran, MA;Jimenez-Mercado, ME;Egia-Mendikute, L;Seco, ...

METABOLITES

2022-12-01

A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants

Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Vila-Vecilla, L;Zanetti, SR;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;de Blas, A;Velasco-Beltran, P;Serrano-Macia, M;Iruzubieta, ...

FRONTIERS IN IMMUNOLOGY

2022-11-24

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Mercado-Gomez, M;Prieto-Fernandez, E;Goikoetxea-Usandizaga, N;Vila-Vecilla, L;Azkargorta, M;Bravo, M;Serrano-Macia, M;Egia-Mendikute, L;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Lee, SY;Gine, AE;Gil-Pitarch, ...

COMMUNICATIONS BIOLOGY

2022-08-17

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients

Serrano-Macia, M;Lachiondo-Ortega, S;Iruzubieta, P;Goikoetxea-Usandizaga, N;Bosch, A;Egia-Mendikute, L;Jimenez-Lasheras, B;Azkargorta, M;Elortza, F;Martinez-Redondo, D;Castro, B;Lozano, JJ;Nogueiras, ...

CELL DEATH DISCOVERY

2022-07-12

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Stagnoli, S;Peccati, F;Connell, SR;Martinez-Castillo, A;Charro, D;Millet, O;Bruzzone, C;Palazon, A;Arda, A;Jimenez-Barbero, J;Ereno-Orbea, J;Abrescia, NGA;Jimenez-Oses, G

FRONTIERS IN MICROBIOLOGY

2022-04-15

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, AM;Abaurrea, A;Azcoaga, P;Lopez-Velazco, JI;Manzano, S;Rodriguez, J;Rezola, R;Egia-Mendikute, L;Valdes-Mora, F;Flores, JM;Jenkins, L;Pulido, L;Osorio-Querejeta, I;Fernandez-Nogueira, ...

JOURNAL OF CLINICAL INVESTIGATION

2022-04-01

Enabling CAR-T cells for solid tumors: Rage against the suppressive tumor microenvironment

Antonana-Vildosola, A;Zanetti, SR;Palazon, A

ADOPTIVE CELL TRANSFER

2022-01-01

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;Bruzzone, C;Bizkarguenaga, M;Embade, N;Gil-Redondo, R;Martinez-Chantar, ML;Lopez-Hoyos, ...

COMMUNICATIONS BIOLOGY

2021-04-20

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Prieto-Fernandez, E;Egia-Mendikute, L;Vila-Vecilla, L;Bosch, A;Barreira-Manrique, A;Lee, SY;Garcia-del Rio, A;Antonana-Vildosola, A;Jimenez-Lasheras, B;Moreno-Cugnon, L;Jimenez-Barbero, J;Berra, ...

EMERGING MICROBES & INFECTIONS

2021-01-01

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Bruzzone, C;Bizkarguenaga, M;Gil-Redondo, R;Diercks, T;Arana, E;de Vicuna, AG;Seco, M;Bosch, A;Palazon, A;San Juan, I;Lain, A;Gil-Martinez, J;Bernardo-Seisdedos, G;Fernandez-Ramos, D;Lopitz-Otsoa, ...

ISCIENCE

2020-10-23