DNA changes behind irritable bowel syndrome (IBS): state-of-the-art

Publication in Nature Reviews Gastroenterology and Hepatology by researchers at CIC bioGUNE

Irritable bowel syndrome is a common condition characterized by recurrent abdominal pain, constipation and diarrhea without an apparent underlying organic cause. The pathophysiology of IBS is mostly unknown and hope has been put into genetic research for revealing therapeutically actionable pathways, though with very limited success. Recent large-scale studies in population-based cohorts and biobanks have contributed major breakthroughs, from the analysis of thousands of patients and the adoption of novel approaches using stool endophenotypes to studying gut dysmotility. A team of experts, including Isotta Bozzarelli and corresponding author Mauro D’Amato from the Gastrointestinal Genetics Laboratory at CIC bioGUNE, provide a state-of-the-art overview in an article now published in Nature Reviews Gastroenterology and Hepatology.

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