Research in the Gastrointestinal Genetics Lab is geared towards a translational application for therapeutic precision in gastroenterology. The team combines leading expertise in genomic, computational and pre-clinical research to identify causative genes and pathogenetic mechanisms influencing gastrointestinal (GI) disease risk and human microbiome composition. The druggable genome and nutrigenetics are also new research lines of high interest, especially in relation to the possibility to treat GI conditions and dysbiosis.
Our current research in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), microscopic colitis (MC), gastroparesis (Gp) and other GI diseases is at the scientific forefront in the field, and takes advantage of an extremely large network of international collaboration (>60 research groups and institutions across EU, USA and Australasia).
We serve as analytical hub for several coordinated efforts aimed to exploit big data from large-scale, population-based cohorts and biobanks including more than 1 million people across the world (UK Biobank, LifeLines, EGCUT, Mayo GC, MGI, KPRB, HUNT, FGFP, Genes for Good, TWIBS, PopCol, and many others).
Our research contributes to the activities of multiple consortia including the bellygenes inititative we coordinate on the genetics of IBS, the International IBD Genetics Consortium (IIBDGC), the European Microscopic Colitis Group (EMCG), the Gastroparesis Clinical Research Consortium (NIDDK-GpCRC), the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), and others.
Research from the Gastrointestinal Genetics Lab has received and receives funding from national and international agencies (Spanish Ministry for Science and Innovation, the Basque Government, Swedish Research Council, Swedish Foundation for Strategic Research, EU-FP7-HEALTH) and the pharma sector (AstraZeneca, Almirall, Medical Need, QOL Medical).
-
Principal Investigator
Mauro D'Amato
Ikerbasque Research Professor POSTDOCTORAL RESEARCHER -
Leire Torices Cabarcos
-
Cristina Esteban Blanco
-
Cristian Díaz Muñoz
TECHNICIANS / DOCTORAL CANDIDATES -
Andreea Zamfir Taranu
Members
Latest Publications
Juzenas, S; Ellinghaus, D; Sanna, S; Franke, A; DAmato, M;
GUT
2023-10-09
Thomas, M; Su, YR; Rosenthal, EA; Sakoda, LC; Schmit, SL; Timofeeva, MN; Chen, Z; Fernandez-Rozadilla, C; Law, PJ; Murphy, N; Carreras-Torres, R; Diez-Obrero, V; van Duijnhoven, FJB; Jiang, ...
NATURE COMMUNICATIONS
2023-10-02
Garcia-Etxebarria, K; Etxart, A; Barrero, M; Nafria, B; Merino, NM; Romero-Garmendia, I; Goel, A; Franke, A; DAmato, M; Bujanda, L;
CANCERS
2023-10-01
Zheng, TH; Roda, G; Zabana, Y; Escudero-Hernández, C; Liu, XR; Chen, Y; Tavares, LC; Bonfiglio, F; Mellander, MR; Janczewska, I; Vigren, L; Sjöberg, K; Ohlsson, B; Almer, S; Halfvarson, J; Miehlke, ...
JOURNAL OF CROHNS & COLITIS
2023-09-28
Tavares, LC; Zheng, TH; Kwicklis, M; Mitchell, E; Pandit, A; Pullapantula, S; Bernard, C; Teder-Laving, M; Marques, FZ; Esko, T; Kuo, BD; Shulman, RJ; Chumpitazi, BP; Koch, KL; Sarosiek, I; ...
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
2023-09-08
Constantinescu, AE; Bull, CJ; Jones, N; Mitchell, R; Burrows, K; Dimou, N; Bézieau, S; Brenner, H; Buchanan, DD; DAmato, M; Jenkins, MA; Moreno, V; Pai, RK; Um, CY; White, E; Murphy, N; Gunter, ...
INTERNATIONAL JOURNAL OF CANCER
2023-08-14
Zamfir-Taranu, A; Löcher, BS; Husein, DM; Hoter, A; Garcia-Etxebarria, K; Etxeberria, U; Gayoso, L; Mayr, G; Nilholm, C; Gustafsson, RJ; Ozaydin, O; Zheng, TH; Esteban-Blanco, C; Bozzarelli, ...
GUT
2023-03-06
Mathisen, CBW; Nyström, N; Bazov, I; Andersen, S; Olbjorn, C; Perminow, G; Kristensen, VA; Opheim, R; Ricanek, P; DAmato, M; Carlson, M; Hedin, CR; Keita, AV; Kruse, R; Lindqvist, CM; Magnusson, ...
JOURNAL OF CROHNS & COLITIS
2023-02-01
Gayoso, L; Garcia-Etxebarria, K; Arzallus, T; Montalvo, I; Lizasoain, J; DAmato, M; Etxeberria, U; Bujanda, L;
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
2023-01-01
Fritz, N; Berens, S; Dong, YJ; Martínez, C; Schmitteckert, S; Houghton, LA; Goebel-Stengel, M; Wahl, V; Kabisch, M; Götze, D; DAmato, M; Zheng, TH; Röth, R; Mönnikes, H; Tesarz, J; Engel, F; ...
JOURNAL OF MOLECULAR MEDICINE-JMM
2022-09-19
Garcia-Etxebarria, K; Etxart, A; Barrero, M; Nafria, B; Merino, NMS; Romero-Garmendia, I; Franke, A; DAmato, M; Bujanda, L;
CANCERS
2022-09-01
Kalla, R; Adams, AT; Nowak, JK; Bergemalm, D; Vatn, S; Ventham, NA; Kennedy, NA; Ricanek, P; Lindstrom, J; Söderholm, J; Pierik, M; DAmato, M; Gomollón, F; Olbjorn, C; Richmond, R; Relton, CL; ...
JOURNAL OF CROHNS & COLITIS
2022-08-27
Husein, DM; Rizk, S; Hoter, A; Wanes, D; DAmato, M; Naim, HY;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
2022-08-19
Camilleri, M; Zhernakova, A; Bozzarelli, S; DAmato, M;
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
2022-08-10
Berens, S; Dong, YJ; Fritz, N; Walstab, J; DAmato, M; Zheng, TH; Wahl, V; Boekstegers, F; Bermejo, JL; Martinez, C; Schmitteckert, S; Clevers, E; Engel, F; Gauss, A; Herzog, W; Spiller, R; Goebel-Stengel, ...
WORLD JOURNAL OF GASTROENTEROLOGY
2022-06-07
Svensson, A; Garcia-Etxebarria, K; Åkesson, A; Borgfeldt, C; Roth, B; Ek, M; DAmato, M; Ohlsson, B;
BMC WOMENS HEALTH
2022-06-03
Roth, B; Myllyvainio, J; DAmato, M; Larsson, E; Ohlsson, B;
NUTRIENTS
2022-05-01
Nilholm, C; Manoharan, L; Roth, B; DAmato, M; Ohlsson, B;
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
2022-04-28
Garcia-Etxebarria, K; Merino, O; Gaite-Reguero, A; Rodrigues, PM; Herrarte, A; Etxart, A; Ellinghaus, D; Alonso-Galan, H; Franke, A; Marigorta, UM; Bujanda, L; DAmato, M;
SCIENTIFIC REPORTS
2022-03-01
Zabana, Y; Tontini, G; Hultgren-Hörnquist, E; Skonieczna-Zydecka, K; Latella, G; Ostvik, AE; Marlicz, W; DAmato, M; Arias, A; Mielhke, S; Münch, A; Fernández-Bañares, F; Lucendo, AJ; European ...
JOURNAL OF CROHNS & COLITIS
2022-01-28