Xabier Agirrezabala
xagirrezabala
Xabier Agirrezabala
SPECIALIST
CryoEM of Biological Macromolecules Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

The structural study of biological macromolecules is key to understand their functioning. By means of cryo-electron microscopy we can obtain 3D maps biological complexes under nearly physiological conditions, and the latest developments in the field allow for near-atomic resolution, providing detailed observation of molecules. The aim of the team is to describe the structure and the conformational changes associated with the biological function. We focus on motors involved in universal biological functions where interactions between protein and nucleic acids are essential. Structural studies of ribosomes during translation allow the understanding of the mechanisms which govern protein synthesis. In this process, interactions with translation factors and interference by several antibiotics are especially important. We also analyze the structure of flexible filamentous viruses, a group of plant pathogens, and large oligomeric enzymes such as pyruvate carboxylase.

Latest Publications

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase

Lopez-Alonso, JP;Lazaro, M;Gil-Carton, D;Choi, PH;Tong, L;Valle, M

NATURE COMMUNICATIONS

2022-10-19

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes

Ballesteros, U;Etxaniz, A;Iriondo, MN;Varela, YR;Lazaro, M;Viguera, AR;Montes, LR;Valle, M;Goni, FM;Alonso, A

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

2022-07-01

A switch from alpha-helical to beta-strand conformation during co-translational protein folding

Agirrezabala, X;Samatova, E;Macher, M;Liutkute, M;Maiti, M;Gil-Carton, D;Novacek, J;Valle, M;Rodnina, MV

EMBO JOURNAL

2022-01-07

3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme

Lazaro, M;Melero, R;Huet, C;Lopez-Alonso, JP;Delgado, S;Dodu, A;Bruch, EM;Abriata, LA;Alzari, PM;Valle, M;Lisa, MN

COMMUNICATIONS BIOLOGY

2021-06-03

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP;Oyenarte, I;Diercks, T;Quintana, JI;Gimeno, A;Coelho, H;Diniz, A;Peccati, F;Delgado, S;Bosch, A;Valle, M;Millet, O;Abrescia, NGA;Palazn, A;Marcelo, F;Jimnez-Oss, G;Jimnez-Barbero, ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis

Galisteo-Gonzalez, F;Monasterio, BG;Gil, D;Valle, M;Goni, FM

SCIENTIFIC REPORTS

2020-01-15

Structure of Turnip mosaic virus and its viral-like particles

Cuesta, R;Yuste-Calvo, C;Gil-Carton, D;Sanchez, F;Ponz, F;Valle, M

SCIENTIFIC REPORTS

2019-10-28

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Canal-Martin, A;Sastre, J;Sanchez-Barrena, MJ;Canales, A;Baldominos, S;Pascual, N;Martinez-Gonzalez, L;Molero, D;Fernandez-Valle, ME;Saez, E;Blanco-Gabella, P;Gomez-Rubio, E;Martin-Santamaria, ...

NATURE COMMUNICATIONS

2019-06-26

Structural Homology Between Nucleoproteins of ssRNA Viruses

Valle, M

Sub-cellular biochemistry

2018-01-01

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses

Zamora, M;Mendez-Lopez, E;Agirrezabala, X;Cuesta, R;Lavin, JL;Sanchez-Pina, MA;Aranda, MA;Valle, M

Science advances

2017-09-01