The structural study of biological macromolecules is key to understand their functioning. By means of cryo-electron microscopy we can obtain 3D maps biological complexes under nearly physiological conditions, and the latest developments in the field allow for near-atomic resolution, providing detailed observation of molecules. The aim of the team is to describe the structure and the conformational changes associated with the biological function. We focus on motors involved in universal biological functions where interactions between protein and nucleic acids are essential. Structural studies of ribosomes during translation allow the understanding of the mechanisms which govern protein synthesis. In this process, interactions with translation factors and interference by several antibiotics are especially important. We also analyze the structure of flexible filamentous viruses, a group of plant pathogens, and large oligomeric enzymes such as pyruvate carboxylase.
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Principal Investigator
Mikel Valle
TECHNICIANS / DOCTORAL CANDIDATES -
Melisa Lázaro
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Aileen Santini Santiago
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Fernando Lamas Lopez
Members
Latest Publications
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation
Eraña, H; Díaz-Domínguez, CM; Charco, JM; Vidal, E; González-Miranda, E; Pérez-Castro, MA; Piñeiro, P; López-Moreno, R; Sampedro-Torres-Quevedo, C; Fernández-Veiga, L; Tasis-Galarza, J; Lorenzo, ...
ACTA NEUROPATHOLOGICA COMMUNICATIONS
2023-09-07
Genomic insights into metabolic flux in hummingbirds
Gershman, A; Hauck, Q; Dick, M; Jamison, JM; Tassia, M; Agirrezabala, X; Muhammad, S; Ali, R; Workman, RE; Valle, M; Wong, GW; Welch, KC; Timp, W;
GENOME RESEARCH
2023-05-01
Effect of ATG12-ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Iriondo, MN; Etxaniz, A; Varela, YR; Ballesteros, U; Lázaro, M; Valle, M; Fracchiolla, D; Martens, S; Montes, LR; Goñi, FM; Alonso, A;
CELLULAR AND MOLECULAR LIFE SCIENCES
2023-02-01
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
López-Alonso, JP; Lázaro, M; Gil-Cartón, D; Choi, PH; Tong, L; Valle, M;
NATURE COMMUNICATIONS
2022-10-19
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
Ballesteros, U; Etxaniz, A; Iriondo, MN; Varela, YR; Lazaro, M; Viguera, AR; Montes, LR; Valle, M; Goni, FM; Alonso, A;
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2022-05-26
A switch from α-helical to β-strand conformation during co-translational protein folding
Agirrezabala, X; Samatova, E; Macher, M; Liutkute, M; Maiti, M; Gil-Carton, D; Novacek, J; Valle, M; Rodnina, MV;
EMBO JOURNAL
2022-01-07
3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme
Lázaro, M; Melero, R; Huet, C; López-Alonso, JP; Delgado, S; Dodu, A; Bruch, EM; Abriata, LA; Alzari, PM; Valle, M; Lisa, MN;
COMMUNICATIONS BIOLOGY
2021-06-03
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazn, A; Marcelo, F; Jimnez-Oss, G; ...
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-10-22
Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis
Galisteo-González, F; Monasterio, BG; Gil, D; Valle, M; Goñi, FM;
SCIENTIFIC REPORTS
2020-01-15
Structure of Turnip mosaic virus and its viral-like particles
Cuesta, R; Yuste-Calvo, C; Gil-Cartón, D; Sánchez, F; Ponz, F; Valle, M;
SCIENTIFIC REPORTS
2019-10-28
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Canal-Martín, A; Sastre, J; Sánchez-Barrena, MJ; Canales, A; Baldominos, S; Pascual, N; Martínez-González, L; Molero, D; Fernández-Valle, ME; Sáez, E; Blanco-Gabella, P; Gómez-Rubio, E; Martín-Santamaría, ...
NATURE COMMUNICATIONS
2019-06-26
SUB CELL BIOCHEM
Valle, M; Harris Jr; Bhella, D;
VIRUS PROTEIN AND NUCLEOPROTEIN COMPLEXES
2018-01-01
Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses
Zamora, M; Méndez-López, E; Agirrezabala, X; Cuesta, R; Lavín, JL; Sánchez-Pina, MA; Aranda, MA; Valle, M;
SCIENCE ADVANCES
2017-09-01
Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism
Artetxe, I; Ugarte-Uribe, B; Gil, D; Valle, M; Alonso, A; García-Sáez, AJ; Goñi, FM;
BIOPHYSICAL JOURNAL
2017-08-22
Coating Graphene Oxide with Lipid Bilayers Greatly Decreases Its Hemolytic Properties
Monasterio, BG; Alonso, B; Sot, J; García-Arribas, AB; Gil-Cartón, D; Valle, M; Zurutuza, A; Goñi, FM;
LANGMUIR
2017-08-22
Ribosome rearrangements at the onset of translational bypassing
Agirrezabala, X; Samatova, E; Klimova, M; Zamora, M; Gil-Carton, D; Rodnina, MV; Valle, M;
SCIENCE ADVANCES
2017-06-01
SUB CELL BIOCHEM
Valle, M; Harris Jr; MarlesWright, J;
MACROMOLECULAR PROTEIN COMPLEXES: STRUCTURE AND FUNCTION
2017-01-01
Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins
Morante, K; Bellomio, A; Gil-Cartón, D; Redondo-Morata, L; Sot, J; Scheuring, S; Valle, M; González-Mañas, JM; Tsumoto, K; Caaveiro, JMM;
JOURNAL OF BIOLOGICAL CHEMISTRY
2016-09-09
Lipid Modulation of LC3/GABARAP-Mediated Autophagosomal Elongation
Alonso, A; Landajuela, A; Hervas, JH; Anton, Z; Montes, LR; Gil, D; Valle, M; Rodriguez, JF; Goni, FM;
BIOPHYSICAL JOURNAL
2016-02-16
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation
Landajuela, A; Hervás, JH; Antón, Z; Montes, LR; Gil, D; Valle, M; Rodriguez, JF; Goñi, FM; Alonso, A;
BIOPHYSICAL JOURNAL
2016-01-19