Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients

Martin-Inaraja, M; Romayor, I; de Cámara, AS; Herrera, L; Palacios, A; Villaverde, M; Santos, S; Vesga, MA; Barreña, B; Aransay, AM; Anguita, J; Solorzano, E; Prieto, MB; Matorras, R; Eguizabal, ...

STEM CELL RESEARCH

2025-03-01

Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis

Kioroglou, D; Peña-Cearra, A; Corraliza, AM; Seoane, I; Castelo, J; Panés, J; Gómez-Irwin, L; Rodríguez-Lago, I; de Zarate, JO; Fuertes, M; Martín-Ruiz, I; Gonzalez, M; Aransay, AM; Salas, A; ...

INFLAMMATORY BOWEL DISEASES

2025-02-13

The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation

Castelo, J; Araujo-Aris, S; Barriales, D; Pasco, ST; Seoane, I; Peña-Cearra, A; Palacios, A; Simó, C; Garcia-Cañas, V; Khamwong, M; Martín-Ruiz, I; Gonzalez-Lopez, M; Barcena, L; Rodríguez, ...

GUT MICROBES

2024-12-31

Development of a New Vaccine Adjuvant System Based on the Combination of the Synthetic TLR4 Agonist FP20 and a Synthetic QS-21 Variant

Shaik, MM; Pasco, S; Romerio, A; Pifferi, C; Sesana, S; Re, F; Bezuidenhout, CX; Bracco, S; Fernandez-Tejada, A; Anguita, J; Peri, F;

JOURNAL OF MEDICINAL CHEMISTRY

2024-12-08

The Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cell Secretome in Osteoarthritis: A Comprehensive Study

González-Cubero, E; González-Fernández, ML; Esteban-Blanco, M; Perez-Castrillo, S; Pérez-Fernández, E; Navasa, N; Aransay, AM; Anguita, J; Villar-Suárez, V;

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2024-10-01

Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists

Ami, D; Franco, AR; Artusa, V; Romerio, A; Shaik, MM; Italia, A; Anguita, J; Pasco, S; Mereghetti, P; Peri, F; Natalello, A;

TALANTA

2024-08-01

An in vitro analysis of the interaction between infliximab and granulocyte-monocyte apheresis

Rodríguez-Lago, I; Abecia, L; Seoane, I; Anguita, J; Cabriada, JL;

GASTROENTEROLOGIA Y HEPATOLOGIA

2024-04-01

Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies

Franco, AR; Sadones, O; Romerio, A; Artusa, V; Shaik, MM; Pasco, ST; Italia, A; DAmato, S; Anguita, J; Huebner, J; Romero-Saavedra, F; Peri, F;

JOURNAL OF MEDICINAL CHEMISTRY

2024-03-21

Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Peña-Cearra, A; Palacios, A; Pellon, A; Castelo, J; Pasco, ST; Seoane, I; Barriales, D; Martin, JE; Pascual-Itoiz, MA; Gonzalez-Lopez, M; Martín-Ruiz, I; Macías-Cámara, N; Gutiez, N; Araujo-Aris, ...

COMMUNICATIONS BIOLOGY

2024-02-16

IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation

Jiménez-Cabello, L; Utrilla-Trigo, S; Benavides-Silván, J; Anguita, J; Calvo-Pinilla, E; Ortego, J;

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

2024-01-01

Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Peña-Cearra, A; Castelo, J; Lavín, JL; Gonzalez-Lopez, M; Pascual-Itoiz, MA; Fuertes, M; de Juan, VG; Bárcena, L; Martín-Ruiz, I; Pellón, A; Seoane, I; Barriales, D; Palacios, A; Fullaondo, ...

GUT MICROBES

2023-12-18

Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

Pena-Cearra, A; Song, DG; Castelo, J; Palacios, A; Lavin, JL; Azkargorta, M; Elortza, F; Fuertes, M; Pascual-Itoiz, MA; Barriales, D; Martin-Ruiz, I; Fullaondo, A; Aransay, AM; Rodriguez, H; ...

NPJ BIOFILMS AND MICROBIOMES

2023-10-07

Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice

Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;

VACCINE

2023-05-12

The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine

Klouwens, MJ; Trentelman, JJA; Barriales, D; Ersoz, JI; Azkargorta, M; Elortza, F; Síma, R; Hajdusek, O; Cortazar, JT; Corcuera, IE; Colstrup, E; Nayak, A; Ruíz, IM; Rodriguez, H; Nijhof, AM; ...

VACCINE

2023-03-04

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-23

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

Rana, VS; Kitsou, C; Dutta, S; Ronzetti, MH; Zhang, M; Bernard, Q; Smith, AA; Tomás-Cortázar, J; Yang, XL; Wu, MJ; Kepple, O; Li, WZ; Dwyer, JE; Matias, J; Baljinnyam, B; Oliver, JD; Rajeevan, ...

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

González-Recio, I; Simón, J; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Mercado-Gómez, M; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Gil-Pitarch, C; Fernández-Rodríguez, C; Castellana, D; Latasa, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juárez-Fernández, M; Goikoetxea-Usandizaga, N; Porras, D; García-Mediavilla, MV; Bravo, M; Serrano-Maciá, M; Simón, J; Delgado, TC; Lachiondo-Ortega, S; Martínez-Flórez, S; Lorenzo, O; Rincón, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Peña-Cearra, A; Pascual-Itoiz, MA; Lavin, JL; Fuertes, M; Martín-Ruiz, I; Castelo, J; Palacios, A; Barriales, D; Fullaondo, A; Aransay, AM; Rodríguez, H; Anguita, J; Abecia, L;

SCIENTIFIC REPORTS

2022-06-15