0000-0002-5200-0905Tammo Diercks obtained his MSc in Chemistry from the University of Heidelberg and continued his scientific career with a PhD on NMR spectrostropic analyses of the structure and dynamics of proteins at the Institute for Organic Chemistry & Biochemistry, TU München, Germany.
From 2000 to 2001, Dr. Diercks continued working as a research scientist with Prof. Horst Kessler, focusing on the development of NMR methodology for protein structure analysis. During this time, he co-founded Novaspin Biotech in Freising, Germany, a company dedicated to NMR-based drug discovery and development. As a key player in the company's foundation, he was responsible for preparing the business plan, assembling the team, participating in the financing talks, and launching the first NMR projects for customers.
From 2001 to 2002, Dr. Diercks served as the Head of the NMR department at Novaspin Biotech where he developed, patented, and applied NMR screening techniques, conducted structural analyses of ligand-target complexes, and led various service-for-fee and in-house research projects.
In early 2003, Dr. Diercks returned to the academic world and expanded his expertise as a visiting scientist at the Swedish NMR Center in Göteborg, working with Profs. Vladislav Orekhov and Göran Carlsson on NMR binding studies of azurin and p53DBD. He also contributed to methodological developments aimed at enhancing NMR sensitivity for proteins. From 2003 to 2007, he continued his research at the Bijvoet Center for Biomolecular Research at Utrecht University in the Netherlands, collaborating with Profs. Rob Kaptein and Rolf Boelens. There, he served as an NMR spectroscopist for the Structural Proteomics in Europe (SPINE) consortium and the European NMR Large Scale Facility Utrecht, focusing on NMR structure determination of various proteins and developing further methodology to enhance and accelerate NMR experiments.
In 2007, Dr. Diercks joined CIC bioGUNE as the Nuclear Magnetic Resonance (NMR) Platform Manager, where he is in charge of the installation, maintenance, and scientific supervision of the NMR facility that now includes seven instruments ranging from 80 MHz to a 1 GHz spectrometer. His responsibilities also involve user training and support, the development, implementation, and optimization of NMR methods, and participation in both independent and collaborative research projects. Under his leadership the unit, certified as a Unique Scientific Technical Facility (ICTS) of the State, has become an international reference in NMR research, advancing personalized and precision medicine through drug design, biomarker identification, and the analysis of diseases and aging.
Awards & recognitions
Ph.D. Award of the Technical University of München for the best thesis in chemistry (2001).
Latest Publications
2024
2022
2021
2020
Latest Publications
Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma
Wist, J; Nitschke, P; Conde, R; de Diego, A; Bizkarguenaga, M; Lodge, S; Hall, D; Chai, ZL; Wang, WJ; Kowlessur, S; Cobo, MF; Pompe, N; Schütz, B; Schäfer, H; Spraul, M; Cannet, C; Diercks, ...
ANALYTICAL CHEMISTRY
2025-03-17
Exploring Glycan-Lectin Interactions in Natural-Like Environments: A View Using NMR Experiments Inside Cell and on Cell Surface
Bertuzzi, S; Lete, MG; Franconetti, A; Diercks, T; Delgado, S; Oyenarte, I; Moure, MJ; Nuñez-Franco, R; Valverde, P; Lenza, MP; Sobczak, K; Jiménez-Osés, G; Paulson, JC; Ardá, A; Ereño-Orbea, ...
CHEMISTRY-A EUROPEAN JOURNAL
2024-12-11
MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics
Gil-Redondo, R; Conde, R; Bruzzone, C; Seco, ML; Bizkarguenaga, M; González-Valle, B; de Diego, A; Lain, A; Habisch, H; Haudum, C; Verheyen, N; Obermayer-Pietsch, B; Margarita, S; Pelusi, S; ...
CARDIOVASCULAR DIABETOLOGY
2024-07-24
Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling
Unione, L; Ammerlaan, ANA; Bosman, GP; Uslu, E; Liang, RA; Broszeit, F; van der Woude, R; Liu, YY; Ma, SZ; Liu, L; Gomez-Redondo, M; Bermejo, IA; Valverde, P; Diercks, T; Arda, A; de Vries, ...
NATURE COMMUNICATIONS
2024-04-06
A glutamine-based single α-helix scaffold to target globular proteins
Escobedo, A; Piccirillo, J; Aranda, J; Diercks, T; Mateos, B; Garcia-Cabau, C; Sánchez-Navarro, M; Topal, B; Biesaga, M; Staby, L; Kragelund, BB; García, J; Millet, O; Orozco, M; Coles, M; Crehuet, ...
NATURE COMMUNICATIONS
2022-11-18
Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection
Masuda, R; Lodge, S; Whiley, L; Gray, N; Lawler, N; Nitschke, P; Bong, SH; Kimhofer, T; Loo, RL; Boughton, B; Zeng, AX; Hall, D; Schaefer, H; Spraul, M; Dwivedi, G; Yeap, BB; Diercks, T; Bernardo-Seisdedos, ...
ANALYTICAL CHEMISTRY
2022-03-15
J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum
Nitschke, P; Lodge, S; Kimhofer, T; Masuda, R; Bong, SH; Hall, D; Schäfer, H; Spraul, M; Pompe, N; Diercks, T; Bernardo-Seisdedos, G; Mato, JM; Millet, O; Susic, D; Henry, A; El-Omar, EM; Holmes, ...
ANALYTICAL CHEMISTRY
2022-01-05
What is the Sugar Code?
Gabius, HJ; Cudic, M; Diercks, T; Kaltner, H; Kopitz, J; Mayo, KH; Murphy, PV; Oscarson, S; Roy, R; Schedlbauer, A; Toegel, S; Romero, A;
CHEMBIOCHEM
2021-09-22
A molecular signature for the metabolic syndrome by urine metabolomics
Bruzzone, C; Gil-Redondo, R; Seco, M; Barragán, R; de la Cruz, L; Cannet, C; Schäfer, H; Fang, F; Diercks, T; Bizkarguenaga, M; González-Valle, B; Laín, A; Sanz-Parra, A; Coltell, O; de Letona, ...
CARDIOVASCULAR DIABETOLOGY
2021-07-28
Unambiguous Tracking of Protein Phosphorylation by Fast High-Resolution FOSY NMR**
Lesovoy, DM; Georgoulia, PS; Diercks, T; Matecko-Burmann, I; Burmann, BM; Bocharov, EV; Bermel, W; Orekhov, VY;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021-07-13
Selective 13C-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins
Moure, MJ; Gimeno, A; Delgado, S; Diercks, T; Boons, GJ; Jiménez-Barbero, J; Ardá, A;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021-07-13
Metabolic Landscape of the Mouse Liver by Quantitative 31P Nuclear Magnetic Resonance Analysis of the Phosphorome
Bernardo-Seisdedos, G; Bilbao, J; Fernández-Ramos, D; Lopitz-Otsoa, F; de Juan, VG; Bizkarguenaga, M; Mateos, B; Fondevila, MF; Abril-Fornaguera, J; Diercks, T; Lu, SC; Nogueiras, R; Mato, JM; ...
HEPATOLOGY
2021-06-15
A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit
Schedlbauer, A; Iturrioz, I; Ochoa-Lizarralde, B; Diercks, T; López-Alonso, JP; Lavin, JL; Kaminishi, T; Çapuni, R; Dhimole, N; de Astigarraga, E; Gil-Carton, D; Fucini, P; Connell, SR;
SCIENCE ADVANCES
2021-06-01
Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange
Schedlbauer, A; Gilles, U; Ludwig, AK; Adler, A; Kaltner, H; Lindner, I; Mayo, KH; Diercks, T; Reusch, D; Gabius, HJ;
BIOCHIMIE
2021-05-26
Galectin-Glycan Interactions: Guidelines for Monitoring by 77Se NMR Spectroscopy, and Solvent (H2O/D2O) Impact on Binding
Diercks, T; Medrano, FJ; FitzGerald, FG; Beckwith, D; Pedersen, MJ; Reihill, M; Ludwig, AK; Romero, A; Oscarson, S; Cudic, M; Gabius, HJ;
CHEMISTRY-A EUROPEAN JOURNAL
2020-12-02
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum
Bruzzone, C; Bizkarguenaga, M; Gil-Redondo, R; Diercks, T; Arana, E; de Vicuña, AG; Seco, M; Bosch, A; Palazón, A; San Juan, I; Laín, A; Gil-Martínez, J; Bernardo-Seisdedos, G; Fernández-Ramos, ...
ISCIENCE
2020-10-23
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazn, A; Marcelo, F; Jiménez-Osés, G; ...
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-10-22
Non-Stationary Complementary Non-Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data
Romero, JA; Nawrocka, EK; Shchukina, A; Blanco, FJ; Diercks, T; Kazimierczuk, K;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-09-29
Abnormal concentration of porphyrins in serum from COVID-19 patients
San Juan, I; Bruzzone, C; Bizkarguenaga, M; Bernardo-Seisdedos, G; Laín, A; Gil-Redondo, R; Diercks, T; Gil-Martínez, J; Urquiza, P; Arana, E; Seco, M; de Vicuña, AG; Embade, N; Mato, JM; Millet, ...
BRITISH JOURNAL OF HAEMATOLOGY
2020-08-29
The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations
Martínez, JD; Infantino, AS; Valverde, P; Diercks, T; Delgado, S; Reichardt, NC; Ardá, A; Canada, FJ; Oscarson, S; Jiménez-Barbero, J;
PHARMACEUTICALS
2020-08-01