Samuel Tanner Pasco
Samuel Tanner Pasco
EARLY STAGE RESEARCHER
MSCA-ITN Fellow
MSCA-ITN Fellow
Inflammation and Macrophage Plasticity Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The macrophage and tick vaccine laboratory studies the interaction between athropod vectors, infectious microorganisms and their mammalian hosts. The laboratory is primarily focused on ticks of the genus Ixodes, which transmit several medically important pathogens, such as the causative agent of Lyme borreliosis, Borrelia burgdorferi.

The lab participates in a large multicenter project funded by the EU (ANTIDotE) that seeks to identify tick salivary antigens that could be used as potential vaccine candidates against tick bites and therefore, prevent the transmission of pathogens. They are also interested in the pharmacological activities exerted by tick saliva proteins, especially those that can modulate the immune response and that can have therapeutic applications in immune disorders.

Finally, the group is interested in understanding the regulation of the immune response pathways present in ticks that participate in the control of pathogens within the vector. On the other hand, the laboratory seeks to understand the response of macrophages to infectious agents, from Lyme borreliosis to inflammatory bowel disease to tuberculosis.

They are interested in understanding the metabolic control of macrophage responses through the specific mitochondrial complex I repressor, MCJ in different models of disease in which these cells participate, such as Lyme carditis and inflammatory bowel disease. Furthermore, the role of INFγ and other signals on the plasticity of the response of macrophages to infectious agents is another focus of the laboratory.

Finally, the group is interested in defining the phagocytic ‘ome’ that mediates the uptake, elimination and initiation of proinflammatory responses by macrophages. In this context, the group described the Complement Receptor (CR) 3 as a phagocytic receptor involved in the elimination of B. burgdorferi by macrophages. CR3 cooperates with the GPI-anchored protein, CD14, in the internalization of the spirochete, a novel mechanism that is independent of MyD88 signals.

Latest Publications

Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro

Ladero-Aunon, I;Molina, E;Holder, A;Kolakowski, J;Harris, H;Urkitza, A;Anguita, J;Werling, D;Elguezabal, N

FRONTIERS IN IMMUNOLOGY

2021-03-17

Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Fuentes, R;Ruiz-de-Angulo, A;Sacristan, N;Navo, CD;Jimenez-Oses, G;Anguita, J;Fernandez-Tejada, A

CHEMISTRY-A EUROPEAN JOURNAL

2021-02-04

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...

PLOS BIOLOGY

2021-01-01

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

Mancheno, JM;Atondo, E;Tomas-Cortazar, J;Lavin, JL;Plaza-Vinuesa, L;Martin-Ruiz, I;Barriales, D;Palacios, A;Navo, CD;Sampedro, L;Pena-Cearra, A;Pascual-Itoiz, MA;Castelo, J;Carreras-Gonzalez, ...

MICROBIAL BIOTECHNOLOGY

2020-12-18

A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission

Trentelman, JJA;Sima, R;Krezdorn, N;Tomas-Cortazar, J;Barriales, D;Takumi, K;Butler, JM;Sprong, H;Klouwens, MJ;Urbanova, V;Mahmood, S;Winter, P;Kopacek, P;Anguita, J;Hajdusek, O;Hovius, JW

SCIENTIFIC REPORTS

2020-11-18

Lessons from Bacillus Calmette-Guerin: Harnessing Trained Immunity for Vaccine Development

Pasco, ST;Anguita, J

CELLS

2020-09-01

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Barbier-Torres, L;Fortner, KA;Iruzubieta, P;Delgado, TC;Giddings, E;Chen, YDH;Champagne, D;Fernandez-Ramos, D;Mestre, D;Gomez-Santos, B;Varela-Rey, M;de Juan, VG;Fernandez-Tussy, P;Zubiete-Franco, ...

NATURE COMMUNICATIONS

2020-07-03

Editorial: Macrophage Metabolism and Immune Responses

Rodriguez, H;Prados-Rosales, R;Lavin, JL;Mazzone, M;Anguita, J

FRONTIERS IN IMMUNOLOGY

2020-05-29

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Pifferi, C;Ruiz-de-Angulo, A;Goyard, D;Tiertant, C;Sacristan, N;Barriales, D;Berthet, N;Anguita, J;Renaudet, O;Fernandez-Tejada, A

CHEMICAL SCIENCE

2020-05-07

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

Narasimhan, S;Kurokawa, C;Diktas, H;Strank, NO;Cerny, J;Murfin, K;Cao, YG;Lynn, G;Trentleman, J;Wu, MJ;DePonte, K;Kantor, F;Anguita, J;Hovius, J;Fikrig, E

TICKS AND TICK-BORNE DISEASES

2020-05-01