Sascha Jung
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Sascha Jung
POST DOCTORAL RESEARCHER
Computational Biology Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The main goal of the Computational Biology Group is to develop computational models at different scales of biological organization, including cellular, tissue and organ level, to address challenges in stem cell research and disease modeling. Among these challenges, our research focuses on improving the regenerative capacity of stem cells in old tissues, identifying lineage-specifying transcription factors involved in organ-level developmental disorders, and modulating the dysregulated hyperinflammatory response associated to various infectious and autoimmune diseases. Moreover, our computational models employ methodologies from different areas of mathematics, engineering, and physics, and integrate multiple sources of biological information (e.g. transcriptomics, epigenomics, proteomics) to study biological processes at different levels of organization. Importantly, the development of these models aims at generating predictions to guide stem cell researchers in the design of novel regenerative medicine therapies, and to assist clinical researchers to design new therapeutic intervention strategies to revert disease phenotypes.

Latest Publications

ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells

Zheng, ML;Okawa, S;Bravo, M;Chen, F;Martinez-Chantar, ML;Del Sol, A

NUCLEIC ACIDS RESEARCH

2022-10-06

Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages

Hu, YZ;Jiang, YW;Behnan, J;Ribeiro, MM;Kalantzi, C;Zhang, MD;Lou, DH;Haring, M;Sharma, N;Okawa, S;Del Sol, A;Adameyko, I;Svensson, M;Persson, O;Ernfors, P

SCIENCE ADVANCES

2022-06-10

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Capelle, CM;Cire, S;Domingues, O;Ernens, I;Hedin, F;Fischer, A;Snoeck, CJ;Ammerlaan, W;Konstantinou, M;Grzyb, K;Skupin, A;Carty, CL;Hilger, C;Gilson, G;Celebic, A;Wilmes, P;Del Sol, A;Kaplan, ...

CELL REPORTS MEDICINE

2022-04-19

Fostering experimental and computational synergy to modulate hyperinflammation

Potapov, I;Kanneganti, TD;del Sol, A

TRENDS IN IMMUNOLOGY

2022-01-01

Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

Han, SS;Okawa, S;Wilkinson, GA;Ghazale, H;Adnani, L;Dixit, R;Tavares, L;Faisal, I;Brooks, MJ;Cortay, V;Zinyk, D;Sivitilli, A;Li, SQ;Malik, F;Ilnytskyy, Y;Angarica, VE;Gao, JH;Chinchalongporn, ...

NEURON

2021-09-15

A Catalogus Immune Muris of the mouse immune responses to diverse pathogens

Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A

CELL DEATH & DISEASE

2021-08-17

FunRes: resolving tissue-specific functional cell states based on a cell-cell communication network model

Jung, S;Singh, K;del Sol, A

BRIEFINGS IN BIOINFORMATICS

2021-07-01

Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach

Giovagnoni, C;Ali, M;Eijssen, LMT;Maes, R;Choe, K;Mulder, M;Kleinjans, J;del Sol, A;Glaab, E;Mastroeni, D;Delvaux, E;Coleman, P;Losen, M;Pishva, E;Martinez-Martinez, P;van den Hove, DLA

NEUROBIOLOGY OF AGING

2021-06-01

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

Goncalves, CA;Larsen, M;Jung, SC;Stratmann, J;Nakamura, A;Leuschner, M;Hersemann, L;Keshara, R;Perlman, S;Lundvall, L;Thuesen, LL;Hare, KJ;Amit, I;Jorgensen, A;Kim, YH;del Sol, A;Grapin-Botton, ...

NATURE COMMUNICATIONS

2021-05-25

Computational modelling of stem cell-niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing

Potapov, I;Garcia-Prat, L;Ravichandran, S;Munoz-Canoves, P;del Sol, A

FEBS JOURNAL

2021-05-14