Sarai Araujo Aris
Sarai Araujo Aris
DOCTORAL CANDIDATE
Inflammation and Macrophage Plasticity Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The macrophage and tick vaccine laboratory studies the interaction between athropod vectors, infectious microorganisms and their mammalian hosts. The laboratory is primarily focused on ticks of the genus Ixodes, which transmit several medically important pathogens, such as the causative agent of Lyme borreliosis, Borrelia burgdorferi.

The lab participates in a large multicenter project funded by the EU (ANTIDotE) that seeks to identify tick salivary antigens that could be used as potential vaccine candidates against tick bites and therefore, prevent the transmission of pathogens. They are also interested in the pharmacological activities exerted by tick saliva proteins, especially those that can modulate the immune response and that can have therapeutic applications in immune disorders.

Finally, the group is interested in understanding the regulation of the immune response pathways present in ticks that participate in the control of pathogens within the vector. On the other hand, the laboratory seeks to understand the response of macrophages to infectious agents, from Lyme borreliosis to inflammatory bowel disease to tuberculosis.

They are interested in understanding the metabolic control of macrophage responses through the specific mitochondrial complex I repressor, MCJ in different models of disease in which these cells participate, such as Lyme carditis and inflammatory bowel disease. Furthermore, the role of INFγ and other signals on the plasticity of the response of macrophages to infectious agents is another focus of the laboratory.

Finally, the group is interested in defining the phagocytic ‘ome’ that mediates the uptake, elimination and initiation of proinflammatory responses by macrophages. In this context, the group described the Complement Receptor (CR) 3 as a phagocytic receptor involved in the elimination of B. burgdorferi by macrophages. CR3 cooperates with the GPI-anchored protein, CD14, in the internalization of the spirochete, a novel mechanism that is independent of MyD88 signals.

Latest Publications

Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation.

Pena-Cearra, Ainize; Palacios, Ainhoa; Pellon, Aize; Castelo, Janire; Pasco, Samuel Tanner; Seoane, Iratxe; Barriales, Diego; Martin, Jose Ezequiel; Pascual-Itoiz, Miguel Angel; Gonzalez-Lopez, ...

Communications Biology

2024-02-16

Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Peña-Cearra, A; Castelo, J; Lavín, JL; Gonzalez-Lopez, M; Pascual-Itoiz, MA; Fuertes, M; de Juan, VG; Bárcena, L; Martín-Ruiz, I; Pellón, A; Seoane, I; Barriales, D; Palacios, A; Fullaondo, ...

GUT MICROBES

2023-12-18

Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

Pena-Cearra, A; Song, DG; Castelo, J; Palacios, A; Lavin, JL; Azkargorta, M; Elortza, F; Fuertes, M; Pascual-Itoiz, MA; Barriales, D; Martin-Ruiz, I; Fullaondo, A; Aransay, AM; Rodriguez, H; ...

NPJ BIOFILMS AND MICROBIOMES

2023-10-07

An in vitro analysis of the interaction between infliximab and granulocyte-monocyte apheresis.

Rodriguez-Lago, Iago; Abecia, Leticia; Seoane, Iratxe; Anguita, Juan; Cabriada, Jose Luis;

Gastroenterologia y hepatologia

2023-07-06

Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice

Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;

VACCINE

2023-05-12

Dynamin-like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis

Gupta, S; Bhagavathula, M; Sharma, V; Sharma, N; Sharma, N; Biswas, A; Palacios, A; Salgueiro, V; Lavín, JL; Dogra, N; Salgame, P; Prados-Rosales, R; Rodríguez, GM;

EMBO REPORTS

2023-04-20

The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine

Klouwens, MJ; Trentelman, JJA; Barriales, D; Ersoz, JI; Azkargorta, M; Elortza, F; Síma, R; Hajdusek, O; Cortazar, JT; Corcuera, IE; Colstrup, E; Nayak, A; Ruíz, IM; Rodriguez, H; Nijhof, AM; ...

VACCINE

2023-03-04

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-23

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

Rana, VS; Kitsou, C; Dutta, S; Ronzetti, MH; Zhang, M; Bernard, Q; Smith, AA; Tomás-Cortázar, J; Yang, XL; Wu, MJ; Kepple, O; Li, WZ; Dwyer, JE; Matias, J; Baljinnyam, B; Oliver, JD; Rajeevan, ...

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

González-Recio, I; Simón, J; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Mercado-Gómez, M; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Gil-Pitarch, C; Fernández-Rodríguez, C; Castellana, D; Latasa, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juárez-Fernández, M; Goikoetxea-Usandizaga, N; Porras, D; García-Mediavilla, MV; Bravo, M; Serrano-Maciá, M; Simón, J; Delgado, TC; Lachiondo-Ortega, S; Martínez-Flórez, S; Lorenzo, O; Rincón, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Peña-Cearra, A; Pascual-Itoiz, MA; Lavin, JL; Fuertes, M; Martín-Ruiz, I; Castelo, J; Palacios, A; Barriales, D; Fullaondo, A; Aransay, AM; Rodríguez, H; Anguita, J; Abecia, L;

SCIENTIFIC REPORTS

2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R; Aguinagalde, L; Pifferi, C; Plata, A; Sacristan, N; Castellana, D; Anguita, J; Fernandez-Tejada, A;

FRONTIERS IN IMMUNOLOGY

2022-05-06

Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of l-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease

Simó, C; Fornari, T; García-Risco, MR; Peña-Cearra, A; Abecia, L; Anguita, J; Rodríguez, H; García-Cañas, V;

FOOD & FUNCTION

2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

Chaves-Arquero, B; Persson, C; Merino, N; Tomás-Cortazar, J; Rojas, AL; Anguita, J; Blanco, FJ;

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-03-01

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Delgado, TC; Simón, J; Ramos, DF; Barriales, D; Cornide, ME; Jiménez, M; Pérez-Redondo, M; Lachiondo-Ortega, S; Rodríguez-Agudo, R; Bizkarguenaga, ...

HEPATOLOGY

2021-12-15

Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics

Bizkarguenaga, M; Bruzzone, C; Gil-Redondo, R; SanJuan, I; Martin-Ruiz, I; Barriales, D; Palacios, A; Pasco, ST; González-Valle, B; Laín, A; Herrera, L; Azkarate, A; Vesga, MA; Eguizabal, C; ...

NMR IN BIOMEDICINE

2021-10-27

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

Mancheño, JM; Atondo, E; Tomás-Cortázar, J; Lavín, JL; Plaza-Vinuesa, L; Martín-Ruiz, I; Barriales, D; Palacios, A; Navo, CD; Sampedro, L; Peña-Cearra, A; Pascual-Itoiz, MA; Castelo, J; Carreras-González, ...

MICROBIAL BIOTECHNOLOGY

2020-12-18

BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis

Tomás-Cortázar, J; Bossi, L; Quinn, C; Reynolds, CJ; Butler, DK; Corcoran, N; Murchú, MO; McMahon, E; Singh, M; Rongkard, P; Anguita, J; Blanco, A; Dunachie, SJ; Altmann, D; Boyton, RJ; Arnold, ...

FRONTIERS IN IMMUNOLOGY

2021-12-13