Maria Camila Salazar Palacio
Maria Camila Salazar Palacio
LABORATORY TECHNICIAN
Cancer Cell Signaling And Metabolism Lab & Metabolomics Platform
Email: msalazar@cicbiogune.es
Phone: 4229 / 944 061 317
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

Metabolic alterations driven by PFKFB3 upregulation confer resistance to trastuzumab in HER2-positive breast cancer.

Vincken, Roos; Pasco, Samuel T; Steri, Veronica; Bozal-Basterra, Laura; van IJcken, Wilfred F J; Carracedo, Arkaitz; Huylebroeck, Danny; Moasser, Mark M; Ruiz-Saenz, Ana;

BIOMEDICINE & PHARMACOTHERAPY

2026-05-11

Polyamine-dependent metabolic shielding regulates alternative splicing

Zabala-Letona, A; Pujana-Vaquerizo, M; Martinez-Laosa, B; Ponce-Rodriguez, M; Garcia-Longarte, S; Mendizabal, I; Gimeno, A; Rogalska, M; Tan, J; Cabrera, D; Van Liempd, S; Ximenez-Embun, P; ...

NATURE

2026-01-14

Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential

Mercado-Gómez , M; Goikoetxea-Usandizaga, N; Giné, AE; Rodrigo, MAM; Afonso, MB; Azkargorta, M; Zapata-Pavas, LE; Rejano-Gordillo, CM; Romero, MR; Mendizabal, I; Rodrigues, PM; Wu, HH; Rodríguez-Agudo, ...

GUT

2025-08-05

Engineering a single-chain immunoglobulin scaffold loaded with a latent-releasable cytotoxic pore-forming peptide

Morillo, I; Zulaica, J; Caballero, AR; Auzmendi-Iriarte, J; Largo, E; Apellaniz, B; Carracedo, A; Piva, M; Nieva, JL; Rujas, E;

COMMUNICATIONS BIOLOGY

2025-11-25

Transcriptional network analysis of PTEN-protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Rondon-Lorefice, I; Lopez, JI; Ugalde-Olano, A; Zufiaurre, M; Astobiza, I; Martin-Martin, N; Bozal-Basterra, L; Garcia-Longarte, S; Zabala-Letona, A; Rey, S; Santos-Martin, A; Unda, M; Loizaga-Iriarte, ...

MOLECULAR ONCOLOGY

2025-11-17

Age-and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts

Conde, R; Gil-Redondo, R; Bizkarguenaga, M; Lodge, S; Nitschke, P; De Diego, A; González-Valle, B; Hui, JN; Hunter, ML; Yeap, BB; Cenarro, A; Lope, V; Habisch, H; Haudum, C; Verheyen, N; Obermayer-Pietsch, ...

EBIOMEDICINE

2025-11-08

Aggressive prostate cancer is associated with pericyte dysfunction

Martinez-Romero, A; Martinez-Larrinaga, A; Grego-Bessa, J; Garcia-Longarte, S; van Splunder, H; Astobiza, I; Ercilla, A; Bozal-Basterra, L; Mendizabal, I; Villacampa, P; Carracedo, A; Graupera, ...

MOLECULAR ONCOLOGY

2025-10-21

Unravelling the role of L-and Dalanine in prostate cancer: a Positron Emission Tomography study in a genetic mouse model

Castellnou, P; Gómez-Martínez, M; Gómez-Vallejo, V; Baz, Z; López-Gallego, F; Rondon-Lorefice, I; Zabala-Letona, A; Poot, AJ; Mendizabal, I; Carracedo, A; Rejc, L; Llop, J;

NUCLEAR MEDICINE AND BIOLOGY

2025-09-25

A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer

Ercilla, A; Crespo, JR; Garcia-Longarte, S; Fidalgo, M; del Palacio, S; Martin-Martin, N; Carlevaris, O; Astobiza, I; Fernández-Ruiz, S; Guiu, M; Bárcena, L; Mendizabal, I; Aransay, AM; Graupera, ...

MOLECULAR ONCOLOGY

2025-09-15

Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination

Martin-Martin, N; Garcia-Longarte, S; Corres-Mendizabal, J; Lazcano, U; Astobiza, I; Bozal-Basterra, L; Herranz, N; van Splunder, H; Carlevaris, O; Pujana-Vaquerizo, M; Blasco, MT; Aransay, ...

GENOME BIOLOGY

2025-06-03

Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer

Schaub-Clerigué, A; Hermanova, I; Pintor-Rial, A; Sydorenko, M; Valcarcel-Jimenez, L; Macchia, A; Lectez, B; Garcia-Longarte, S; Fagoaga-Eugui, M; Astobiza, I; Martín-Martín, N; Zabala-Letona, ...

CELL DEATH & DISEASE

2025-04-23

Syndecan-3 positively regulates the pro-inflammatory function of macrophages

Lee, SY; Prieto-Fernández, E; Egia-Mendikute, L; Antonaña-Vildosola, A; Velasco-Beltrán, P; Bosch, A; Jimenez-Lasheras, B; de Blas, A; de Durana, JED; Valdaliso-Díez, E; Bozal-Basterra, L; Ercilla, ...

CELLULAR AND MOLECULAR LIFE SCIENCES

2025-04-07

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Conduit, SE; Pearce, W; Bhamra, A; Bilanges, B; Bozal-Basterra, L; Foukas, LC; Cobbaut, M; Castillo, SD; Danesh, MA; Adil, M; Carracedo, A; Graupera, M; McDonald, NQ; Parker, PJ; Cutillas, PR; ...

NATURE COMMUNICATIONS

2024-08-21

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics

Gil-Redondo, R; Conde, R; Bruzzone, C; Seco, ML; Bizkarguenaga, M; González-Valle, B; de Diego, A; Lain, A; Habisch, H; Haudum, C; Verheyen, N; Obermayer-Pietsch, B; Margarita, S; Pelusi, S; ...

CARDIOVASCULAR DIABETOLOGY

2024-07-24

Metastatic hormone-naïve prostate cancer: a distinct biological entity

Corres-Mendizabal, J; Zacchi, F; Martín-Martín, N; Mateo, J; Carracedo, A;

TRENDS IN CANCER

2024-07-23

The PP2A regulator IER5L supports prostate cancer progression

Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...

CELL DEATH & DISEASE

2024-07-18

Metabolic adaptations in prostate cancer

Pujana-Vaquerizo, M; Bozal-Basterra, L; Carracedo, A;

BRITISH JOURNAL OF CANCER

2024-07-05

SERS analysis of cancer cell- secreted purines reveals a unique paracrine crosstalk in MTAP- deficient tumors

Valera, PS; Plou, J; Garcia, I; Astobiza, I; Viera, C; Aransay, AM; Martin, JE; Sasselli, IR; Carracedo, A; Liz-Marzan, LM;

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2023-12-26

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Pencik, J; Philippe, C; Schlederer, M; Atas, E; Pecoraro, M; Grund-Gröchke, S; Li, W; Tracz, A; Heidegger, I; Lagger, S; Trachtová, K; Oberhuber, M; Heitzer, E; Aksoy, O; Neubauer, HA; Wingelhofer, ...

MOLECULAR CANCER

2023-08-12

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...

MOLECULAR CANCER

2023-07-29

Latest Publications

Defining the reference proteomes for small extracellular vesicles and non-vesicular components

Morales-Sanfrutos, J; Etxeberria-Ugartemendia, J; Barroso-Gomila, O; González, E; Sendino, M; Ximénez-Embún, P; García, F; Zarzuela, E; Falcón-Pérez, JM; Peinado, H; Muñoz, J;

NATURE CELL BIOLOGY

2026-02-13

Updating MISEV: When, What, How, and Why?

Akbar, N; Burger, D; Bussolati, B; Buzás, EI; Carney, RP; Cho, Y-; Driedonks, TAP; Falcon-Perez, JM; Fujita, Y; Goberdhan, DC; Hendrix, A; Huang, YY; Mathivanan, S; Mahoney, MG; Mohanty, S; ...

JOURNAL OF EXTRACELLULAR VESICLES

2026-01-29

Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis

Guinart-Cuadra, A; Brujats, A; Szafranska, J; Guerrero, R; Dinamarca, F; Cantó, E; Poca, M; Román, E; Sánchez-Ardid, E; Fajardo, J; Camps, M; Mulet, M; Soriano, G; Escorsell, A; Falcon-Perez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2026-01-27

From Lab to Industry: Advancing the Translational Potential of Extracellular Vesicles Through the ISEV Translation, Regulation and Advocacy Committee (ISEV-TRA)

Gurriaran-Rodriguez, U; Bussolati, B; Gimona, M; Glebov, K; Fujita, Y; Marcilla, A; Neri, C; Fu, QL; Das, S; Pluchino, S; Zarovni, N; Salomon, C; Witwer, K; Falcon-Perez, JM;

JOURNAL OF EXTRACELLULAR VESICLES

2026-01-14

Polyamine-dependent metabolic shielding regulates alternative splicing

Zabala-Letona, A; Pujana-Vaquerizo, M; Martinez-Laosa, B; Ponce-Rodriguez, M; Garcia-Longarte, S; Mendizabal, I; Gimeno, A; Rogalska, M; Tan, J; Cabrera, D; Van Liempd, S; Ximenez-Embun, P; ...

NATURE

2026-01-14

Deciphering the dialogue between the bovine blastocyst and the uterus: embryo-induced alterations in extracellular vesicle protein content from an ex vivo model and the in vivo environment

Mazzarella, R; Sánchez, JM; Egido, SG; McDonald, M; Alvarez-Barrientos, A; González, E; Falcón-Pérez, JM; Azkargorta, M; Elortza, F; González, ME; Lonergan, P; Rizos, D; Fernandez-Fuertes, B; ...

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY

2025-10-24

To a liquid brain biopsy of people with multiple sclerosis: extracellular vesicles as circulating biomarkers

Bravo-Miana, RD; Arizaga-Echebarria, JK; Azkargorta, M; Ascensión, AM; Velasco, HC; González, E; Falcón-Pérez, JM; Triviño, TC; Elortza, F; Pérez-González, R; Otaegui, D;

MULTIPLE SCLEROSIS JOURNAL

2025-09-01

Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic

Droste, M; Puhka, M; van Royen, ME; Ng, MSY; Blijdorp, C; Alvarez-Llamas, G; Borras, FE; Buescher, AK; Bussolati, B; Dear, JW; Falcon-Perez, JM; Giebel, B; Grange, C; Hoorn, EJ; Leivo, J; Lenassi, ...

JOURNAL OF EXTRACELLULAR VESICLES

2025-07-17

Metabolic Signature in Combination with Fecal Immunochemical Test as a Non-Invasive Tool for Advanced Colorectal Neoplasia Diagnosis

Albóniga, OE; Cubiella, J; Bujanda, L; Aspichueta, P; Blanco, ME; Lanza, BR; Alonso, C; Falcón-Pérez, JM;

CANCERS

2025-07-15

Embryo-Induced Changes in the Protein Profile of Bovine Oviductal Extracellular Vesicles

Mazzarella, R; Sánchez, J; Fernandez-Fuertes, B; Egido, SG; McDonald, M; Alvarez-Barrientos, A; González, E; Falcón-Pérez, JM; Azkargorta, M; Elortza, F; González, ME; Lonergan, P; Rizos, D; ...

MOLECULAR & CELLULAR PROTEOMICS

2025-04-01

Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes

Lago-Baameiro, N; Camino, T; Vazquez-Durán, A; Sueiro, A; Couto, I; Santos, F; Baltar, J; Falcón-Pérez, JM; Pardo, M;

JOURNAL OF TRANSLATIONAL MEDICINE

2025-02-20

Metabolic Profiling of Brain Tissue and Brain-Derived Extracellular Vesicles in Alzheimer's Disease

Hernandez, P; Rackles, E; Alboniga, OE; Martínez-Lage, P; Camacho, EN; Onaindia, A; Fernandez, M; Talamillo, A; Falcon-Perez, JM;

JOURNAL OF EXTRACELLULAR VESICLES

2025-02-01

Reproducibility of extracellular vesicle research

Crescitelli, R; Falcon-Perez, J; Hendrix, A; Lenassi, M; Minh, LN; Ochiya, T; Hooten, NN; Sandau, U; Théry, C; Nieuwland, R;

JOURNAL OF EXTRACELLULAR VESICLES

2025-01-01

Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates

Córdoba, KM; Jericó, D; Jiang, L; Collantes, M; Alegre, M; García-Ruiz, L; Manzanilla, O; Sampedro, A; Herranz, JM; Insausti, I; de la Cuesta, AM; Urigo, F; Alcaide, P; Morán, M; Martín, MA; ...

GUT

2025-01-17

Beyond basic characterization and omics: Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Palviainen, M; Puutio, J; Ostergaard, RH; Eble, JA; Maaninka, K; Butt, U; Ndika, J; Kari, OK; Kamali-Moghaddam, M; Kjaer-Sorensen, K; Oxvig, C; Aransay, AM; Falcon-Perez, JM; Federico, A; Greco, ...

JOURNAL OF EXTRACELLULAR VESICLES

2024-10-01

Extracellular vesicles in tumor-adipose tissue crosstalk: key drivers and therapeutic targets in cancer cachexia

Ramos, CC; Pires, J; Gonzalez, E; Garcia-Vallicrosa, C; Reis, CA; Falcon-Perez, JM; Freitas, D;

EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS

2024-09-01

Increased levels of circulating cell-free double-stranded nucleic acids in the plasma of glioblastoma patients

Rackles, E; Zaccheroni, E; Lopez, PH; Faletti, S; Del Bene, M; DiMeco, F; Pelicci, G; Falcon-Perez, JM;

JOURNAL OF EXTRACELLULAR BIOLOGY

2024-08-02

Cryogenic electron microscopy reveals morphologically distinct subtypes of extracellular vesicles among porcine ejaculate fractions

Parra, A; Barranco, I; Martínez-Díaz, P; González, E; Albóniga, OE; Cabrera, D; Falcón-Pérez, JM; Roca, J;

SCIENTIFIC REPORTS

2024-07-13

Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma

Royo, F; Garcia-Vallicrosa, C; Azparren-Angulo, M; Bordanaba-Florit, G; Lopez-Sarrio, S; Falcon-Perez, JM;

BIOMEDICINES

2024-05-28

Integration of proteomic and metabolomic analysis reveal distinct metabolic alterations of prostate cancer-associated fibroblasts compared to normal fibroblasts from patient's stroma samples

Bordanaba-Florit, G; Royo, F; Albóniga, OE; Clayton, A; Falcón-Pérez, JM; Webber, J;

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2024-05-10