Mikel Pujana Vaquerizo
mpujana
Mikel Pujana Vaquerizo
EARLY STAGE RESEARCHER
Cancer Cell Signaling And Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, AM;Abaurrea, A;Azcoaga, P;Lopez-Velazco, JI;Manzano, S;Rodriguez, J;Rezola, R;Egia-Mendikute, L;Valdes-Mora, F;Flores, JM;Jenkins, L;Pulido, L;Osorio-Querejeta, I;Fernandez-Nogueira, ...

JOURNAL OF CLINICAL INVESTIGATION

2022-04-01

Angiocrine polyamine production regulates adiposity

Monelli, E;Villacampa, P;Zabala-Letona, A;Martinez-Romero, A;Llena, J;Beiroa, D;Gouveia, L;Chivite, I;Zagmutt, S;Gama-Perez, P;Osorio-Conles, O;Muixi, L;Martinez-Gonzalez, A;Castillo, SD;Martin-Martin, ...

NATURE METABOLISM

2022-03-14

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Zabala-Letona, A;Arruabarrena-Aristorena, A;Fernandez-Ruiz, S;Viera, C;Carlevaris, O;Ercilla, A;Mendizabal, I;Martin, T;Macchia, A;Camacho, L;Pujana-Vaquerizo, M;Sanchez-Mosquera, P;Torrano, ...

ONCOGENESIS

2022-02-23

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

Plou, J;Valera, PS;Garcia, I;de Albuquerque, CDL;Carracedo, A;Liz-Marzan, LM

ACS PHOTONICS

2022-02-16

Implication of Ceramide Kinase/C1P in Cancer Development and Progression

Camacho, L;Ouro, A;Gomez-Larrauri, A;Carracedo, A;Gomez-Munoz, A

CANCERS

2022-01-01

Identification of proximal SUMO-dependent interactors using SUMO-ID

Barroso-Gomila, O;Trulsson, F;Muratore, V;Canosa, I;Merino-Cacho, L;Cortazar, AR;Perez, C;Azkargorta, M;Iloro, I;Carracedo, A;Aransay, AM;Elortza, F;Mayor, U;Vertegaal, ACO;Barrio, R;Sutherland, ...

NATURE COMMUNICATIONS

2021-11-18

Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy

Plou, J;Molina-Martinez, B;Garcia-Astrain, C;Langer, J;Garcia, I;Ercilla, A;Perumal, G;Carracedo, A;Liz-Marzan, LM

NANO LETTERS

2021-10-27

Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens

Camacho, L;Zabala-Letona, A;Cortazar, AR;Astobiza, I;Dominguez-Herrera, A;Ercilla, A;Crespo, J;Viera, C;Fernandez-Ruiz, S;Martinez-Gonzalez, A;Torrano, V;Martin-Martin, N;Gomez-Munoz, A;Carracedo, ...

CANCERS

2021-09-01

FOXA1 mutations influence the therapeutic response of breast cancer by altering chromatin state

Arruabarrena-Aristorena, A;Toska, E

MOLECULAR & CELLULAR ONCOLOGY

2021-05-08

Selective modulation by PARP-1 of HIF-1 alpha-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Marti, JM;Garcia-Diaz, A;Delgado-Bellido, D;O'Valle, F;Gonzalez-Flores, A;Carlevaris, O;Rodriguez-Vargas, JM;Ame, JC;Dantzer, F;King, GL;Dziedzic, K;Berra, E;de Alava, E;Amaral, AT;Hammond, ...

REDOX BIOLOGY

2021-05-01