Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody

Soares, CO; Laugieri, ME; Grosso, AS; Natale, M; Coelho, H; Behren, S; Yu, J; Cai, H; Franconetti, A; Oyenarte, I; Magnasco, M; Gimeno, A; Ramos, N; Chai, WA; Corzana, F; Westerlind, U; Jiménez-Barbero, ...

JACS AU

2024-12-16

Exploring Glycan-Lectin Interactions in Natural-Like Environments: A View Using NMR Experiments Inside Cell and on Cell Surface

Bertuzzi, S; Lete, MG; Franconetti, A; Diercks, T; Delgado, S; Oyenarte, I; Moure, MJ; Nuñez-Franco, R; Valverde, P; Lenza, MP; Sobczak, K; Jiménez-Osés, G; Paulson, JC; Ardá, A; Ereño-Orbea, ...

CHEMISTRY-A EUROPEAN JOURNAL

2024-12-11

NMR investigations of glycan conformation, dynamics, and interactions

Angulo, J; Ardá, A; Bertuzzi, S; Canales, A; Ereño-Orbea, J; Gimeno, A; Gomez-Redondo, M; Muñoz-García, JC; Oquist, P; Monaco, S; Poveda, A; Unione, L; Jiménez-Barbero, J;

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

2024-10-18

Insights into the recognition of hypermucoviscous Klebsiella pneumoniae clinical isolates by innate immune lectins of the Siglec and galectin families

Campanero-Rhodes, MA; Martí, S; Hernández-Ortiz, N; Cubero, M; Ereño-Orbea, J; Ardá, A; Jiménez-Barbero, J; Ardanuy, C; Solís, D;

FRONTIERS IN IMMUNOLOGY

2024-08-01

Quantifying Siglec-sialylated ligand interactions: a versatile 19F-T2 CPMG filtered competitive NMR displacement assay

Atxabal, U; Fernández, A; Moure, MJ; Sobczak, K; Nycholat, C; Almeida-Marrero, V; Oyenarte, I; Paulson, JC; de la Escosura, A; Torres, T; Reichardt, NC; Jiménez-Barbero, J; Ereño-Orbea, J;

CHEMICAL SCIENCE

2024-06-07

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Lachiondo-Ortega, S; Rejano-Gordillo, CM; Simon, J; Lopitz-Otsoa, F; Delgado, TC; Mazan-Mamczarz, K; Goikoetxea-Usandizaga, N; Zapata-Pavas, LE; García-del Río, A; Guerra, P; Peña-Sanfélix, ...

CELL REPORTS

2024-03-26

Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling

Atxabal, U; Nycholat, C; Pröpster, JM; Fernández, A; Oyenarte, I; Lenza, MP; Franconetti, A; Soares, CO; Coelho, H; Marcelo, F; Schubert, M; Paulson, JC; Jiménez-Barbero, J; Ereño-Orbea, J;

ACS CHEMICAL BIOLOGY

2024-02-16

Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection

Stagnoli, S; Macari, G; Corsi, P; Capone, B; Vidaurrazaga, A; Ereño-Orbea, J; Ardá, A; Polticelli, F; Jiménez-Barbero, J; Abrescia, NGA; Coluzza, I;

ACS OMEGA

2023-11-13

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Sauve, F; Nampoothiri, S; Clarke, SA; Fernandois, D; Coêlho, CFF; Dewisme, J; Mills, EG; Ternier, G; Cotellessa, L; Iglesias-Garcia, C; Mueller-Fielitz, H; Lebouvier, T; Perbet, R; Florent, ...

EBIOMEDICINE

2023-10-01

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Lenza, MP; Egia-Mendikute, L; Antoñana-Vildosola, A; Soares, CO; Coelho, H; Corzana, F; Bosch, A; Manisha, P; Quintana, JI; Oyenarte, I; Unione, L; Moure, MJ; Azkargorta, M; Atxabal, U; Sobczak, ...

NATURE COMMUNICATIONS

2023-06-13

Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

Lenza, MP; Atxabal, U; Nycholat, C; Oyenarte, I; Franconetti, A; Quintana, JI; Delgado, S; Núñez-Franco, R; Marroquin, CTG; Coelho, H; Unione, L; Jiménez-Oses, G; Marcelo, F; Schubert, M; Paulson, ...

JACS AU

2023-01-23

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Mercado-Gómez, M; Prieto-Fernández, E; Goikoetxea-Usandizaga, N; Vila-Vecilla, L; Azkargorta, M; Bravo, M; Serrano-Maciá, M; Egia-Mendikute, L; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Lee, ...

COMMUNICATIONS BIOLOGY

2022-08-17

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Stagnoli, S; Peccati, F; Connell, SR; Martinez-Castillo, A; Charro, D; Millet, O; Bruzzone, C; Palazon, A; Arda, A; Jimenez-Barbero, J; Ereno-Orbea, J; Abrescia, NGA; Jimenez-Oses, G;

FRONTIERS IN MICROBIOLOGY

2022-04-15

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Unione, L; Moure, MJ; Lenza, MP; Oyenarte, I; Ereño-Orbea, J; Ardá, A; Jiménez-Barbero, J;

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2022-03-07

Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling

Soares, CO; Grosso, AS; Ereno-Orbea, J; Coelho, H; Marcelo, F;

FRONTIERS IN MOLECULAR BIOSCIENCES

2021-11-15

Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains

Nilvebrant, J; Ereño-Orbea, J; Gorelik, M; Julian, MC; Tessier, PM; Julien, JP; Sidhu, SS;

JOURNAL OF MOLECULAR BIOLOGY

2021-09-22

Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22

Ereño-Orbea, J; Liu, XL; Sicard, T; Kucharska, I; Li, W; Borovsky, D; Cui, H; Feng, Y; Dimitrov, DS; Julien, JP;

JOURNAL OF BIOLOGICAL CHEMISTRY

2021-08-01

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Prieto-Fernández, E; Egia-Mendikute, L; Vila-Vecilla, L; Bosch, A; Barreira-Manrique, A; Lee, SY; García-del Río, A; Antoñana-Vildosola, A; Jiménez-Lasheras, B; Moreno-Cugnon, L; Jiménez-Barbero, ...

EMERGING MICROBES & INFECTIONS

2021-01-01

Current Status on Therapeutic Molecules Targeting Siglec Receptors

Lenza, MP; Atxabal, U; Oyenarte, I; Jiménez-Barbero, J; Ereño-Orbea, J;

CELLS

2020-12-01

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazn, A; Marcelo, F; Jiménez-Osés, G; ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22