Kathrin Keim
Kathrin Keim
ASSISTANT TO SCIENTIFIC DIRECTOR OFFICE
General Director Office & Scientific Director Office & Cancer Cell Signaling And Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)
Latest Publications

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I

Gil-Martinez, J;Macias, I;Unione, L;Bernardo-Seisdedos, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Lain, A;Sanz-Parra, A;Mato, JM;Millet, O

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-02-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...

HEPATOLOGY

2020-11-13

S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes

Kilanczyk, E;Banales, JM;Wunsch, E;Barbier, O;Avila, MA;Mato, JM;Milkiewicz, M;Milkiewicz, P

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2020-11-01

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Bruzzone, C;Bizkarguenaga, M;Gil-Redondo, R;Diercks, T;Arana, E;de Vicuna, AG;Seco, M;Bosch, A;Palazon, A;San Juan, I;Lain, A;Gil-Martinez, J;Bernardo-Seisdedos, G;Fernandez-Ramos, D;Lopitz-Otsoa, ...

ISCIENCE

2020-10-23

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

Robinson, AE;Binek, A;Venkatraman, V;Searle, BC;Holewinski, RJ;Rosenberger, G;Parker, SJ;Basisty, N;Xie, XS;Lund, PJ;Saxena, G;Mato, JM;Garcia, BA;Schilling, B;Lu, SC;Van Eyk, JE

JOURNAL OF PROTEOME RESEARCH

2020-10-02

Reciprocal Regulation Between Forkhead Box M1/NF-kappa B and Methionine Adenosyltransferase 1A Drives Liver Cancer

Li, Y;Lu, LQ;Tu, J;Zhang, J;Xiong, T;Fan, W;Wang, JH;Li, M;Chen, YB;Steggerda, J;Peng, H;Chen, YH;Li, TWH;Zhou, ZG;Mato, JM;Seki, E;Liu, T;Yang, HP;Lu, SC

HEPATOLOGY

2020-10-01

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitisviaAMPK and mTOR regulation

Fernandez-Ramos, D;Lopitz-Otsoa, F;Delacruz-Villar, L;Bilbao, J;Pagano, M;Mosca, L;Bizkarguenaga, M;Serrano-Macia, M;Azkargorta, M;Iruarrizaga-Lejarreta, M;Sot, J;Tsvirkun, D;van Liempd, SM;Goni, ...

WORLD JOURNAL OF GASTROENTEROLOGY

2020-09-14

Abnormal concentration of porphyrins in serum from COVID-19 patients

San Juan, I;Bruzzone, C;Bizkarguenaga, M;Bernardo-Seisdedos, G;Lain, A;Gil-Redondo, R;Diercks, T;Gil-Martinez, J;Urquiza, P;Arana, E;Seco, M;de Vicuna, AG;Embade, N;Mato, JM;Millet, O

BRITISH JOURNAL OF HAEMATOLOGY

2020-08-29

PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks

Sundararaman, N;Go, J;Robinson, AE;Mato, JM;Lu, SC;Van Eyk, JE;Venkatraman, V

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

2020-07-01

Latest Publications

Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative

Miller, MC;Zheng, Y;Suylen, D;Ippel, H;Canada, FJ;Berbis, MA;Jimenez-Barbero, J;Tai, GH;Gabius, HJ;Mayo, KH

CHEMMEDCHEM

2020-12-01

Dissection of the key steps of amyloid-beta peptide 1-40 fibrillogenesis

Leite, JP;Gimeno, A;Taboada, P;Jimenez-Barbero, JJ;Gales, L

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

2020-12-01

Single-Step Glycosylations with C-13-Labelled Sulfoxide Donors: A Low-Temperature NMR Cartography of the Distinguishing Mechanistic Intermediates

Santana, AG;Montalvillo-Jimenez, L;Diaz-Casado, L;Mann, E;Jimenez-Barbero, J;Gomez, AM;Asensio, JL

CHEMISTRY-A EUROPEAN JOURNAL

2020-11-23

Insight into the Ferrier Rearrangement by Combining Flash Chemistry and Superacids

Bhuma, N;Lebedel, L;Yamashita, H;Shimizu, Y;Abada, Z;Arda, A;Desire, J;Michelet, B;Martin-Mingot, A;Abou-Hassan, A;Takumi, M;Marrot, J;Jimenez-Barbero, J;Nagaki, A;Bleriot, Y;Thibaudeau, S

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-11-23

An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act as Chaperones of the Transthyretin and Amyloid-beta Peptides Interaction

Cotrina, EY;Gimeno, A;Llop, J;Jimenez-Barbero, J;Quintana, J;Prohens, R;Cardoso, I;Arsequell, G

CHEMISTRY-A EUROPEAN JOURNAL

2020-11-19

Isolation and characterization of an exopolymer produced by Bacillus licheniformis: In vitro antiviral activity against enveloped viruses

Sanchez-Leon, E;Bello-Morales, R;Lopez-Guerrero, JA;Poveda, A;Jimenez-Barbero, J;Girones, N;Abrusci, C

CARBOHYDRATE POLYMERS

2020-11-15

Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1

Bertuzzi, S;Gimeno, A;Nunez-Franco, R;Bernardo-Seisdedos, G;Delgado, S;Jimenez-Oses, G;Millet, O;Jimenez-Barbero, J;Arda, A

CHEMISTRY-A EUROPEAN JOURNAL

2020-10-29

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP;Oyenarte, I;Diercks, T;Quintana, JI;Gimeno, A;Coelho, H;Diniz, A;Peccati, F;Delgado, S;Bosch, A;Valle, M;Millet, O;Abrescia, NGA;Palazon, A;Marcelo, F;Jimenez-Oses, G;Jimenez-Barbero, ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Mono- and Di-Fucosylated Glycans of the Parasitic WormS. mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN

Srivastava, AD;Unione, L;Wolfert, MA;Valverde, P;Arda, A;Jimenez-Barbero, J;Boons, GJ

CHEMISTRY-A EUROPEAN JOURNAL

2020-10-22

Synthesis of long-chain alkyl glucosides via reverse hydrolysis reactions catalyzed by an engineered beta-glucosidase

Thenchartanan, P;Pitchayatanakorn, P;Wattana-Amorn, P;Arda, A;Svasti, J;Jimenez-Barbero, J;Kongsaeree, PT

ENZYME AND MICROBIAL TECHNOLOGY

2020-10-01

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...

CANCERS

2020-09-01

Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling

Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M

CIRCULATION

2020-08-18

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Bermejo-Arteagabeitia, A;Da Fonseca, C;Barroso-Gomila, O;Azkargorta, M;Iloro, I;Pampliega, O;Andrade, R;Martin-Martin, N;Branon, TC;Ting, ...

ELIFE

2020-06-18

H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...

JOURNAL OF PROTEOME RESEARCH

2020-06-05

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...

JOURNAL OF EXPERIMENTAL MEDICINE

2020-06-01

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N

FASEB JOURNAL

2020-05-01

CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo

Alajati, A;D'Ambrosio, M;Troiani, M;Mosole, S;Pellegrini, L;Chen, JJ;Revandkar, A;Bolis, M;Theurillat, JP;Guccini, I;Losa, M;Calcinotto, A;De Bernardis, G;Pasquini, E;D'Antuono, R;Sharp, ...

JOURNAL OF CLINICAL INVESTIGATION

2020-05-01

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Plou, J;Garcia, I;Charconnet, M;Astobiza, I;Garcia-Astrain, C;Matricardi, C;Mihi, A;Carracedo, A;Liz-Marzan, LM

ADVANCED FUNCTIONAL MATERIALS

2020-03-05

The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer

Sole, C;Goicoechea, I;Goni, A;Schramm, M;Armesto, M;Arestin, M;Manterola, L;Tellaetxe, M;Alberdi, A;Nogueira, L;Roumiguie, M;Lopez, JI;Jaka, JPS;Urruticoechea, A;Vergara, I;Loizaga-Iriarte, ...

CANCERS

2020-02-22

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

Ercilla, A;Benada, J;Amitash, S;Zonderland, G;Baldi, G;Somyajit, K;Ochs, F;Costanzo, V;Lukas, J;Toledo, L

CELL REPORTS

2020-02-18