Kathrin Keim
Kathrin Keim
ASSISTANT TO SCIENTIFIC DIRECTOR OFFICE
General Director Office & Scientific Director Office & Cancer Cell Signaling And Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)
Latest Publications

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan, MJ;Fondevila, MF;Fernandez, U;Rodriguez, A;Varela-Rey, M;Veyrat-Durebex, C;Seoane, S;Bernardo, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Bilbao, J;Iglesias, C;Novoa, E;Ameneiro, ...

NATURE COMMUNICATIONS

2021-08-20

Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts

Masuda, R;Lodge, S;Nitschke, P;Spraul, M;Schaefer, H;Bong, SH;Kimhofer, T;Hall, D;Loo, RL;Bizkarguenaga, M;Bruzzone, C;Gil-Redondo, R;Embade, N;Mato, JM;Holmes, E;Wist, J;Millet, O;Nicholson, ...

JOURNAL OF PROTEOME RESEARCH

2021-08-06

Deregulated 14-3-3 zeta and methionine adenosyltransferase alpha 1 interplay promotes liver cancer tumorigenesis in mice and humans

Lu, LQ;Zhang, J;Fan, W;Li, Y;Wang, JH;Li, TWH;Torres, LB;Mato, JM;Liu, T;Seki, E;Matsuda, M;Tomasi, ML;Bhowmick, NA;Yang, HP;Lu, SC

ONCOGENE

2021-08-04

A molecular signature for the metabolic syndrome by urine metabolomics

Bruzzone, C;Gil-Redondo, R;Seco, M;Barragan, R;de la Cruz, L;Cannet, C;Schafer, H;Fang, F;Diercks, T;Bizkarguenaga, M;Gonzalez-Valle, B;Lain, A;Sanz-Parra, A;Coltell, O;de Letona, AL;Spraul, ...

CARDIOVASCULAR DIABETOLOGY

2021-07-28

Metabolic Landscape of the Mouse Liver by Quantitative P-31 Nuclear Magnetic Resonance Analysis of the Phosphorome

Bernardo-Seisdedos, G;Bilbao, J;Fernandez-Ramos, D;Lopitz-Otsoa, F;de Juan, VG;Bizkarguenaga, M;Mateos, B;Fondevila, MF;Abril-Fornaguera, J;Diercks, T;Lu, SC;Nogueiras, R;Mato, JM;Millet, O

HEPATOLOGY

2021-06-15

Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

Bhattacharya, D;Basta, B;Mato, JM;Craig, A;Fernandez-Ramos, D;Lopitz-Otsoa, F;Tsvirkun, D;Hayardeny, L;Chandar, V;Schwartz, RE;Villanueva, A;Friedman, SL

JHEP REPORTS

2021-06-01

Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...

CELL DEATH & DISEASE

2021-05-28

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute, L;Bosch, A;Prieto-Fernandez, E;Lee, SY;Jimenez-Lasheras, B;del Rio, AG;Antonana-Vildosola, A;Bruzzone, C;Bizkarguenaga, M;Embade, N;Gil-Redondo, R;Martinez-Chantar, ML;Lopez-Hoyos, ...

COMMUNICATIONS BIOLOGY

2021-04-20

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I

Gil-Martinez, J;Macias, I;Unione, L;Bernardo-Seisdedos, G;Lopitz-Otsoa, F;Fernandez-Ramos, D;Lain, A;Sanz-Parra, A;Mato, JM;Millet, O

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-02-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

Latest Publications

Selective C-13-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

Moure, MJ;Gimeno, A;Delgado, S;Diercks, T;Boons, GJ;Jimenez-Barbero, J;Arda, A

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2021-07-13

Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease**

Zhu, S;Jagadeesh, Y;Tran, AT;Imaeda, S;Boraston, A;Alonzi, DS;Poveda, A;Zhang, YM;Desire, J;Charollais-Thoenig, J;Demotz, S;Kato, A;Butters, TD;Jimenez-Barbero, J;Sollogoub, M;Bleriot, Y

CHEMISTRY-A EUROPEAN JOURNAL

2021-07-02

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

Bertuzzi, S;Gimeno, A;Martinez-Castillo, A;Lete, MG;Delgado, S;Airoldi, C;Tavares, MR;Blahova, M;Chytil, P;Kren, V;Abrescia, NGA;Arda, A;Bojarova, P;Jimenez-Barbero, J

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-06-01

Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions

Franconetti, A;Arda, A;Asensio, JL;Bleriot, Y;Thibaudeau, S;Jimenez-Barbero, J

ACCOUNTS OF CHEMICAL RESEARCH

2021-06-01

NMR of glycoproteins: profiling, structure, conformation and interactions

Unione, L;Arda, A;Jimenez-Barbero, J;Millet, O

CURRENT OPINION IN STRUCTURAL BIOLOGY

2021-06-01

Enzymatic Synthesis of Phloretin alpha-Glucosides Using a Sucrose Phosphorylase Mutant and its Effect on Solubility, Antioxidant Properties and Skin Absorption

Gonzalez-Alfonso, JL;Ubiparip, Z;Jimenez-Ortega, E;Poveda, A;Alonso, C;Coderch, L;Jimenez-Barbero, J;Sanz-Aparicio, J;Ballesteros, AO;Desmet, T;Plou, FJ

ADVANCED SYNTHESIS & CATALYSIS

2021-05-06

Trimethylamine N-oxide is a new plant molecule that promotes abiotic stress tolerance

Catala, R;Lopez-Cobollo, R;Berbis, MA;Jimenez-Barbero, J;Salinas, J

SCIENCE ADVANCES

2021-05-01

Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins

Lima, CDL;Coelho, H;Gimeno, A;Trovao, F;Diniz, A;Dias, JS;Jimenez-Barbero, J;Corzana, F;Carvalho, AL;Cabrita, EJ;Marcelo, F

CHEMISTRY-A EUROPEAN JOURNAL

2021-04-30

Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations

Quintana, JI;Delgado, S;Nunez-Franco, R;Canada, FJ;Jimenez-Oses, G;Jimenez-Barbero, J;Arda, A

FRONTIERS IN CHEMISTRY

2021-04-21

The two domains of human galectin-8 bind sialyl- and fucose-containing oligosaccharides in an independent manner. A 3D view by using NMR

Gomez-Redondo, M;Delgado, S;Nunez-Franco, R;Jimenez-Oses, G;Arda, A;Jimenez-Barbero, J;Gimeno, A

RSC CHEMICAL BIOLOGY

2021-04-12

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

FOXA1 mutations influence the therapeutic response of breast cancer by altering chromatin state

Arruabarrena-Aristorena, A;Toska, E

MOLECULAR & CELLULAR ONCOLOGY

2021-05-08

Selective modulation by PARP-1 of HIF-1 alpha-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Marti, JM;Garcia-Diaz, A;Delgado-Bellido, D;O'Valle, F;Gonzalez-Flores, A;Carlevaris, O;Rodriguez-Vargas, JM;Ame, JC;Dantzer, F;King, GL;Dziedzic, K;Berra, E;de Alava, E;Amaral, AT;Hammond, ...

REDOX BIOLOGY

2021-05-01

LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton

Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Martin-Martin, N;Ercilla, A;Rodriguez, JA;Carracedo, A;Sutherland, JD;Barrio, R

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2021-04-01

Oligometastatic Prostate Adenocarcinoma. Clinical-Pathologic Study of a Histologically Under-Recognized Prostate Cancer

Manini, C;Gonzalez, A;Buchser, D;Garcia-Olaverri, J;Urresola, A;Ezquerro, A;Fernandez, I;Llarena, R;Zabalza, I;Pulido, R;Carracedo, A;Gomez-Iturriaga, A;Lopez, JI

JOURNAL OF PERSONALIZED MEDICINE

2020-12-01

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...

CANCERS

2020-09-01

Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling

Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M

CIRCULATION

2020-08-18

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Bermejo-Arteagabeitia, A;Da Fonseca, C;Barroso-Gomila, O;Azkargorta, M;Iloro, I;Pampliega, O;Andrade, R;Martin-Martin, N;Branon, TC;Ting, ...

ELIFE

2020-06-18

H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...

JOURNAL OF PROTEOME RESEARCH

2020-06-05

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...

JOURNAL OF EXPERIMENTAL MEDICINE

2020-06-01

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N

FASEB JOURNAL

2020-05-01