Ikerbasque Research Professor
0000-0003-2061-7182Juan Anguita joined CIC bioGUNE as an Ikerbasque Professor in 2012. He has a BS degree in Biochemistry and Molecular Biology from the University of the Basque Country, and a PhD degree in Animal Health from the University of Leon. After 5 years as a postdoctoral fellow at Yale University School of medicine followed by 2 years as Associate Research Scientist (non-tenure faculty position) at the same institution, Dr. Anguita started his independent career fi rst as an Assistant Professor in the Department of Biology at the University of North Carolina at Charlotte, then as an Assistant and then Associate Professor with tenure in the Department of Veterinary and Animal Sciences at the University of Massachusetts at Amherst. Dr. Anguita´s laboratory is currently focused on the study of the mammalian host immune response to the spirochete that causes Lyme disease, Borrelia burgdorferi. His work is centered in the mechanisms of immune defense against infection, particularly focused on the phagocytosis of spirochetes and the activation of macrophages in the context of cardiac infection. His laboratory is also involved in the search of vaccine candidates to tick salivary antigens in order to prevent the transmission of several pathogens of medical importance, as part of international collaborative networks that include ANTIDotE, an European Commission funded consortium. Dr. Anguita’s group performs extensive –omic analysis relevant to his research interests, including phosphoproteomics, transcriptomics, proteomics and metabolomics.
Latest Publications
2020
2019
2018
2017
2016
2015
2014
2013
2012
The macrophage and tick vaccine laboratory studies the interaction between athropod vectors, infectious microorganisms and their mammalian hosts. The laboratory is primarily focused on ticks of the genus Ixodes, which transmit several medically important pathogens, such as the causative agent of Lyme borreliosis, Borrelia burgdorferi.
The lab participates in a large multicenter project funded by the EU (ANTIDotE) that seeks to identify tick salivary antigens that could be used as potential vaccine candidates against tick bites and therefore, prevent the transmission of pathogens. They are also interested in the pharmacological activities exerted by tick saliva proteins, especially those that can modulate the immune response and that can have therapeutic applications in immune disorders.
Finally, the group is interested in understanding the regulation of the immune response pathways present in ticks that participate in the control of pathogens within the vector. On the other hand, the laboratory seeks to understand the response of macrophages to infectious agents, from Lyme borreliosis to inflammatory bowel disease to tuberculosis.
They are interested in understanding the metabolic control of macrophage responses through the specific mitochondrial complex I repressor, MCJ in different models of disease in which these cells participate, such as Lyme carditis and inflammatory bowel disease. Furthermore, the role of INFγ and other signals on the plasticity of the response of macrophages to infectious agents is another focus of the laboratory.
Finally, the group is interested in defining the phagocytic ‘ome’ that mediates the uptake, elimination and initiation of proinflammatory responses by macrophages. In this context, the group described the Complement Receptor (CR) 3 as a phagocytic receptor involved in the elimination of B. burgdorferi by macrophages. CR3 cooperates with the GPI-anchored protein, CD14, in the internalization of the spirochete, a novel mechanism that is independent of MyD88 signals.
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Hector Rodriguez
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TECHNICIANS / EARLY STAGE RESEARCHER
Julen Tomás Cortazar
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Diego Barriales
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Janire Castelo Careaga
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Estíbaliz Atondo Gondra
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Samuel Tanner Pasco
MSCA-ITN Fellow -
Ainhoa Palacios
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Sarai Araujo Aris
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Itziar Martín Ruíz
Members
POST DOCTORAL RESEARCHERLatest Publications
A Catalogus Immune Muris of the mouse immune responses to diverse pathogens
Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A
CELL DEATH & DISEASE
2021-08-17
Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model
Ladero-Aunon, I;Molina, E;Oyanguren, M;Barriales, D;Fuertes, M;Sevilla, IA;Luo, L;Arrazuria, R;De Buck, J;Anguita, J;Elguezabal, N
NPJ VACCINES
2021-08-12
Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
Trentelman, JJA;Tomas-Cortazar, J;Knorr, S;Barriales, D;Hajdusek, O;Sima, R;Ersoz, JI;Narasimhan, S;Fikrig, E;Nijhof, AM;Anguita, J;Hovius, JW
SCIENTIFIC REPORTS
2021-08-03
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Iruzubieta, P;Goikoetxea-Usandizaga, N;Barbier-Torres, L;Serrano-Macia, M;Fernandez-Ramos, D;Fernandez-Tussy, P;Gutierrez-de-Juan, V;Lachiondo-Ortega, S;Simon, J;Bravo, M;Lopitz-Otsoa, F;Robles, ...
JHEP REPORTS
2021-06-01
Identification and Characterization of Immunodominant Proteins from Tick Tissue Extracts Inducing a Protective Immune Response against Ixodes ricinus in Cattle
Knorr, S;Reissert-Oppermann, S;Tomas-Cortazar, J;Barriales, D;Azkargorta, M;Iloro, I;Elortza, F;Pinecki-Socias, S;Anguita, J;Hovius, JW;Nijhof, AM
VACCINES
2021-06-01
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...
CELL DEATH & DISEASE
2021-05-28
Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro
Ladero-Aunon, I;Molina, E;Holder, A;Kolakowski, J;Harris, H;Urkitza, A;Anguita, J;Werling, D;Elguezabal, N
FRONTIERS IN IMMUNOLOGY
2021-03-17
Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants
Fuentes, R;Ruiz-de-Angulo, A;Sacristan, N;Navo, CD;Jimenez-Oses, G;Anguita, J;Fernandez-Tejada, A
CHEMISTRY-A EUROPEAN JOURNAL
2021-02-04
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
Pellon, A;Barriales, D;Pena-Cearra, A;Castelo-Careaga, J;Palacios, A;Lopez, N;Atondo, E;Pascual-Itoiz, MA;Martin-Ruiz, I;Sampedro, L;Gonzalez-Lopez, M;Barcena, L;Martin-Mateos, T;Landete, JM;Prados-Rosales, ...
GUT MICROBES
2021-01-01
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TECHNICIANS / EARLY STAGE RESEARCHER
Itziar Fernández Domínguez
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María Vicario
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Nahia Del Teso
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Iker Rodríguez Bolaños
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Virginia Pérez Luena
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Leticia Sampedro de la Fuente
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Arantza Peña
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Sergio Lozano Román
Members
SPECIALISTLatest Publications
A Catalogus Immune Muris of the mouse immune responses to diverse pathogens
Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A
CELL DEATH & DISEASE
2021-08-17
Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model
Ladero-Aunon, I;Molina, E;Oyanguren, M;Barriales, D;Fuertes, M;Sevilla, IA;Luo, L;Arrazuria, R;De Buck, J;Anguita, J;Elguezabal, N
NPJ VACCINES
2021-08-12
Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
Trentelman, JJA;Tomas-Cortazar, J;Knorr, S;Barriales, D;Hajdusek, O;Sima, R;Ersoz, JI;Narasimhan, S;Fikrig, E;Nijhof, AM;Anguita, J;Hovius, JW
SCIENTIFIC REPORTS
2021-08-03
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Iruzubieta, P;Goikoetxea-Usandizaga, N;Barbier-Torres, L;Serrano-Macia, M;Fernandez-Ramos, D;Fernandez-Tussy, P;Gutierrez-de-Juan, V;Lachiondo-Ortega, S;Simon, J;Bravo, M;Lopitz-Otsoa, F;Robles, ...
JHEP REPORTS
2021-06-01
Identification and Characterization of Immunodominant Proteins from Tick Tissue Extracts Inducing a Protective Immune Response against Ixodes ricinus in Cattle
Knorr, S;Reissert-Oppermann, S;Tomas-Cortazar, J;Barriales, D;Azkargorta, M;Iloro, I;Elortza, F;Pinecki-Socias, S;Anguita, J;Hovius, JW;Nijhof, AM
VACCINES
2021-06-01
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...
CELL DEATH & DISEASE
2021-05-28
Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro
Ladero-Aunon, I;Molina, E;Holder, A;Kolakowski, J;Harris, H;Urkitza, A;Anguita, J;Werling, D;Elguezabal, N
FRONTIERS IN IMMUNOLOGY
2021-03-17
Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants
Fuentes, R;Ruiz-de-Angulo, A;Sacristan, N;Navo, CD;Jimenez-Oses, G;Anguita, J;Fernandez-Tejada, A
CHEMISTRY-A EUROPEAN JOURNAL
2021-02-04
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
Pellon, A;Barriales, D;Pena-Cearra, A;Castelo-Careaga, J;Palacios, A;Lopez, N;Atondo, E;Pascual-Itoiz, MA;Martin-Ruiz, I;Sampedro, L;Gonzalez-Lopez, M;Barcena, L;Martin-Mateos, T;Landete, JM;Prados-Rosales, ...
GUT MICROBES
2021-01-01
-
Leticia Sampedro de la Fuente
Members
TECHNICIANS / EARLY STAGE RESEARCHERLatest Publications
A Catalogus Immune Muris of the mouse immune responses to diverse pathogens
Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A
CELL DEATH & DISEASE
2021-08-17
Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model
Ladero-Aunon, I;Molina, E;Oyanguren, M;Barriales, D;Fuertes, M;Sevilla, IA;Luo, L;Arrazuria, R;De Buck, J;Anguita, J;Elguezabal, N
NPJ VACCINES
2021-08-12
Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
Trentelman, JJA;Tomas-Cortazar, J;Knorr, S;Barriales, D;Hajdusek, O;Sima, R;Ersoz, JI;Narasimhan, S;Fikrig, E;Nijhof, AM;Anguita, J;Hovius, JW
SCIENTIFIC REPORTS
2021-08-03
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Iruzubieta, P;Goikoetxea-Usandizaga, N;Barbier-Torres, L;Serrano-Macia, M;Fernandez-Ramos, D;Fernandez-Tussy, P;Gutierrez-de-Juan, V;Lachiondo-Ortega, S;Simon, J;Bravo, M;Lopitz-Otsoa, F;Robles, ...
JHEP REPORTS
2021-06-01
Identification and Characterization of Immunodominant Proteins from Tick Tissue Extracts Inducing a Protective Immune Response against Ixodes ricinus in Cattle
Knorr, S;Reissert-Oppermann, S;Tomas-Cortazar, J;Barriales, D;Azkargorta, M;Iloro, I;Elortza, F;Pinecki-Socias, S;Anguita, J;Hovius, JW;Nijhof, AM
VACCINES
2021-06-01
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...
CELL DEATH & DISEASE
2021-05-28
Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro
Ladero-Aunon, I;Molina, E;Holder, A;Kolakowski, J;Harris, H;Urkitza, A;Anguita, J;Werling, D;Elguezabal, N
FRONTIERS IN IMMUNOLOGY
2021-03-17
Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants
Fuentes, R;Ruiz-de-Angulo, A;Sacristan, N;Navo, CD;Jimenez-Oses, G;Anguita, J;Fernandez-Tejada, A
CHEMISTRY-A EUROPEAN JOURNAL
2021-02-04
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
Pellon, A;Barriales, D;Pena-Cearra, A;Castelo-Careaga, J;Palacios, A;Lopez, N;Atondo, E;Pascual-Itoiz, MA;Martin-Ruiz, I;Sampedro, L;Gonzalez-Lopez, M;Barcena, L;Martin-Mateos, T;Landete, JM;Prados-Rosales, ...
GUT MICROBES
2021-01-01