Ikerbasque Research Professor
0000-0003-2061-7182Juan Anguita obtained his BSc in Biochemistry and Molecular Biology from the University of the Basque Country (UPV/EHU) and continued his scientific career by completing his PhD in Animal Health from the University of León, Spain.
In 1993, Dr. Anguita joined Yale University School of Medicine as a postdoctoral associate for 5 years followed by a 2-year non-tenured faculty position period at the same institution supported by NIH R03 and, Merck grants. In 2000, Dr. Anguita started his independent career, first as an Assistant Professor in the Department of Biology at the University of North Carolina at Charlotte, then as an Assistant and then Associate Professor with tenure in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst.
In 2012, Dr. Anguita joined CIC bioGUNE as an Ikerbasque Research Professor and Group Leader, leading the Inflammation and Macrophage Plasticity Lab. His laboratory is focused on the study of the mammalian host immune response to the spirochete that causes Lyme disease, Borrelia burgdorferi. The work is centered in the mechanisms of immune defense against infection, particularly focused on the phagocytosis of spirochetes and the activation of macrophages in the context of cardiac infection. His laboratory is also involved in the search of vaccine candidates to tick salivary antigens in order to prevent the transmission of several pathogens of medical importance, as part of international collaborative networks that include ANTIDotE, an European Commission funded consortium.
Awards & recognitions
Ikerbasque Research Professorship awarded by the Basque Foundation for Science (2012).
Latest Publications
2024
2023
2022
The work that our group has been conducting during the last decade has focused on the understanding of myeloid cell responses to microorganisms. Since our initial focus on inflammation induced by infection with the causative agent of Lyme borreliosis, our interest has broadened to the general mechanisms that drive both short and long-term monocyte/macrophage responses to diverse microorganisms, including pathogenic (systemic – Borrelia burgdorferi, Mycobacterium tuberculosis; or intestinal – Fusobacterium nucleatum, enteropathogenic E. coli) as well as symbiotic bacteria (Lactoplantibacillus plantarum, Akkermansia municipila).
Our goal is to identify general trends of innate immune memory responses and delineate specific regulatory networks that are associated with the overall activity of these cells. We have focused our efforts on live microorganisms and the specific responses that arise from the complex engagement of pattern recognition receptors and secondary responses resulting from metabolic changes, addressing the full functionality of innate immune cells, including internalization events (i.e. phagocytosis), transcriptional changes (mRNAseq, ATACseq, microRNAseq), their metabolic status, and the induction of soluble factors.
On the other hand, we have had a long interest on the mechanisms that drive inflammatory responses during murine Lyme borreliosis as well as the identification of therapeutic (vaccine candidates, small anti-inflammatory molecules, etc.) interventions against the bacterium and its arthropod vector (Ixodes spp. ticks).
Research line 1: Trained immune responses to pathogens and symbionts of diverse ecologies
Research line 2: Mechanisms of action and efficacy of novel vaccine adjuvants
Research line 3: Tick immunity and tick-specific vaccine formulations
Research line 4: Infection in the context of colorectal cancer
Research line 5: Microbiota and its associated metabolome in homeostasis and disease
Collaborations
Utpal Pal (University of Maryland College Park), Erol Fikrig (University of Yale School of Medicine), Francesco Peri & Siobhán McClean (BactiVax), Joppe Hovius & Boris Klempa (AntiDotE).
Links
BactiVax (https://www.bactivax.eu)
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Aize Pellón Rodríguez
MSCA-PF TECHNICIANS / DOCTORAL CANDIDATES -
Itziar Martín Ruíz
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Alba Mosteiro Couso
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Sarai Araujo Aris
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Naiara Gutiez García
AECC Predoctoral Felow -
Iratxe Seoane Alvarez
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Eneko Santos Fernández
Members
POSTDOCTORAL RESEARCHERLatest Publications
Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients
Martin-Inaraja, M; Romayor, I; de Cámara, AS; Herrera, L; Palacios, A; Villaverde, M; Santos, S; Vesga, MA; Barreña, B; Aransay, AM; Anguita, J; Solorzano, E; Prieto, MB; Matorras, R; Eguizabal, ...
STEM CELL RESEARCH
2025-03-01
Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis
Kioroglou, D; Peña-Cearra, A; Corraliza, AM; Seoane, I; Castelo, J; Panés, J; Gómez-Irwin, L; Rodríguez-Lago, I; de Zarate, JO; Fuertes, M; Martín-Ruiz, I; Gonzalez, M; Aransay, AM; Salas, A; ...
INFLAMMATORY BOWEL DISEASES
2025-02-13
The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation
Castelo, J; Araujo-Aris, S; Barriales, D; Pasco, ST; Seoane, I; Peña-Cearra, A; Palacios, A; Simó, C; Garcia-Cañas, V; Khamwong, M; Martín-Ruiz, I; Gonzalez-Lopez, M; Barcena, L; Rodríguez, ...
GUT MICROBES
2024-12-31
Development of a New Vaccine Adjuvant System Based on the Combination of the Synthetic TLR4 Agonist FP20 and a Synthetic QS-21 Variant
Shaik, MM; Pasco, S; Romerio, A; Pifferi, C; Sesana, S; Re, F; Bezuidenhout, CX; Bracco, S; Fernandez-Tejada, A; Anguita, J; Peri, F;
JOURNAL OF MEDICINAL CHEMISTRY
2024-12-08
The Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cell Secretome in Osteoarthritis: A Comprehensive Study
González-Cubero, E; González-Fernández, ML; Esteban-Blanco, M; Perez-Castrillo, S; Pérez-Fernández, E; Navasa, N; Aransay, AM; Anguita, J; Villar-Suárez, V;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024-10-01
Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists
Ami, D; Franco, AR; Artusa, V; Romerio, A; Shaik, MM; Italia, A; Anguita, J; Pasco, S; Mereghetti, P; Peri, F; Natalello, A;
TALANTA
2024-08-01
An in vitro analysis of the interaction between infliximab and granulocyte-monocyte apheresis
Rodríguez-Lago, I; Abecia, L; Seoane, I; Anguita, J; Cabriada, JL;
GASTROENTEROLOGIA Y HEPATOLOGIA
2024-04-01
Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies
Franco, AR; Sadones, O; Romerio, A; Artusa, V; Shaik, MM; Pasco, ST; Italia, A; DAmato, S; Anguita, J; Huebner, J; Romero-Saavedra, F; Peri, F;
JOURNAL OF MEDICINAL CHEMISTRY
2024-03-21
Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation
Peña-Cearra, A; Palacios, A; Pellon, A; Castelo, J; Pasco, ST; Seoane, I; Barriales, D; Martin, JE; Pascual-Itoiz, MA; Gonzalez-Lopez, M; Martín-Ruiz, I; Macías-Cámara, N; Gutiez, N; Araujo-Aris, ...
COMMUNICATIONS BIOLOGY
2024-02-16
IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation
Jiménez-Cabello, L; Utrilla-Trigo, S; Benavides-Silván, J; Anguita, J; Calvo-Pinilla, E; Ortego, J;
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2024-01-01
Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis
Peña-Cearra, A; Castelo, J; Lavín, JL; Gonzalez-Lopez, M; Pascual-Itoiz, MA; Fuertes, M; de Juan, VG; Bárcena, L; Martín-Ruiz, I; Pellón, A; Seoane, I; Barriales, D; Palacios, A; Fullaondo, ...
GUT MICROBES
2023-12-18
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
Pena-Cearra, A; Song, DG; Castelo, J; Palacios, A; Lavin, JL; Azkargorta, M; Elortza, F; Fuertes, M; Pascual-Itoiz, MA; Barriales, D; Martin-Ruiz, I; Fullaondo, A; Aransay, AM; Rodriguez, H; ...
NPJ BIOFILMS AND MICROBIOMES
2023-10-07
Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice
Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;
VACCINE
2023-05-12
Dynamin-like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis
Gupta, S; Bhagavathula, M; Sharma, V; Sharma, N; Sharma, N; Biswas, A; Palacios, A; Salgueiro, V; Lavín, JL; Dogra, N; Salgame, P; Prados-Rosales, R; Rodríguez, GM;
EMBO REPORTS
2023-04-20
The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine
Klouwens, MJ; Trentelman, JJA; Barriales, D; Ersoz, JI; Azkargorta, M; Elortza, F; Síma, R; Hajdusek, O; Cortazar, JT; Corcuera, IE; Colstrup, E; Nayak, A; Ruíz, IM; Rodriguez, H; Nijhof, AM; ...
VACCINE
2023-03-04
Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen
Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;
CHEMICAL SCIENCE
2023-03-01
New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...
JOURNAL OF MEDICINAL CHEMISTRY
2023-02-23
Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development
Rana, VS; Kitsou, C; Dutta, S; Ronzetti, MH; Zhang, M; Bernard, Q; Smith, AA; Tomás-Cortázar, J; Yang, XL; Wu, MJ; Kepple, O; Li, WZ; Dwyer, JE; Matias, J; Baljinnyam, B; Oliver, JD; Rajeevan, ...
SCIENCE
2023-01-12
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
González-Recio, I; Simón, J; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Mercado-Gómez, M; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Gil-Pitarch, C; Fernández-Rodríguez, C; Castellana, D; Latasa, ...
NATURE COMMUNICATIONS
2022-11-25
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Juárez-Fernández, M; Goikoetxea-Usandizaga, N; Porras, D; García-Mediavilla, MV; Bravo, M; Serrano-Maciá, M; Simón, J; Delgado, TC; Lachiondo-Ortega, S; Martínez-Flórez, S; Lorenzo, O; Rincón, ...
HEPATOLOGY
2022-09-12
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Itziar Fernández Domínguez
TECHNICIANS / DOCTORAL CANDIDATES -
Nahia Del Teso
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Ainhoa Otero Garcia
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Estíbaliz Atondo Gondra
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Adrián Iturriaga Sámano
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Leticia Sampedro de la Fuente
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Ion Iñaki Zendoia Beaumont
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Iker Rodríguez Bolaños
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Virginia Pérez Luena
Members
SPECIALISTLatest Publications
Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients
Martin-Inaraja, M; Romayor, I; de Cámara, AS; Herrera, L; Palacios, A; Villaverde, M; Santos, S; Vesga, MA; Barreña, B; Aransay, AM; Anguita, J; Solorzano, E; Prieto, MB; Matorras, R; Eguizabal, ...
STEM CELL RESEARCH
2025-03-01
Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis
Kioroglou, D; Peña-Cearra, A; Corraliza, AM; Seoane, I; Castelo, J; Panés, J; Gómez-Irwin, L; Rodríguez-Lago, I; de Zarate, JO; Fuertes, M; Martín-Ruiz, I; Gonzalez, M; Aransay, AM; Salas, A; ...
INFLAMMATORY BOWEL DISEASES
2025-02-13
The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation
Castelo, J; Araujo-Aris, S; Barriales, D; Pasco, ST; Seoane, I; Peña-Cearra, A; Palacios, A; Simó, C; Garcia-Cañas, V; Khamwong, M; Martín-Ruiz, I; Gonzalez-Lopez, M; Barcena, L; Rodríguez, ...
GUT MICROBES
2024-12-31
Development of a New Vaccine Adjuvant System Based on the Combination of the Synthetic TLR4 Agonist FP20 and a Synthetic QS-21 Variant
Shaik, MM; Pasco, S; Romerio, A; Pifferi, C; Sesana, S; Re, F; Bezuidenhout, CX; Bracco, S; Fernandez-Tejada, A; Anguita, J; Peri, F;
JOURNAL OF MEDICINAL CHEMISTRY
2024-12-08
The Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cell Secretome in Osteoarthritis: A Comprehensive Study
González-Cubero, E; González-Fernández, ML; Esteban-Blanco, M; Perez-Castrillo, S; Pérez-Fernández, E; Navasa, N; Aransay, AM; Anguita, J; Villar-Suárez, V;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024-10-01
Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists
Ami, D; Franco, AR; Artusa, V; Romerio, A; Shaik, MM; Italia, A; Anguita, J; Pasco, S; Mereghetti, P; Peri, F; Natalello, A;
TALANTA
2024-08-01
An in vitro analysis of the interaction between infliximab and granulocyte-monocyte apheresis
Rodríguez-Lago, I; Abecia, L; Seoane, I; Anguita, J; Cabriada, JL;
GASTROENTEROLOGIA Y HEPATOLOGIA
2024-04-01
Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies
Franco, AR; Sadones, O; Romerio, A; Artusa, V; Shaik, MM; Pasco, ST; Italia, A; DAmato, S; Anguita, J; Huebner, J; Romero-Saavedra, F; Peri, F;
JOURNAL OF MEDICINAL CHEMISTRY
2024-03-21
Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation
Peña-Cearra, A; Palacios, A; Pellon, A; Castelo, J; Pasco, ST; Seoane, I; Barriales, D; Martin, JE; Pascual-Itoiz, MA; Gonzalez-Lopez, M; Martín-Ruiz, I; Macías-Cámara, N; Gutiez, N; Araujo-Aris, ...
COMMUNICATIONS BIOLOGY
2024-02-16
IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation
Jiménez-Cabello, L; Utrilla-Trigo, S; Benavides-Silván, J; Anguita, J; Calvo-Pinilla, E; Ortego, J;
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2024-01-01
Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis
Peña-Cearra, A; Castelo, J; Lavín, JL; Gonzalez-Lopez, M; Pascual-Itoiz, MA; Fuertes, M; de Juan, VG; Bárcena, L; Martín-Ruiz, I; Pellón, A; Seoane, I; Barriales, D; Palacios, A; Fullaondo, ...
GUT MICROBES
2023-12-18
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
Pena-Cearra, A; Song, DG; Castelo, J; Palacios, A; Lavin, JL; Azkargorta, M; Elortza, F; Fuertes, M; Pascual-Itoiz, MA; Barriales, D; Martin-Ruiz, I; Fullaondo, A; Aransay, AM; Rodriguez, H; ...
NPJ BIOFILMS AND MICROBIOMES
2023-10-07
Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice
Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;
VACCINE
2023-05-12
The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine
Klouwens, MJ; Trentelman, JJA; Barriales, D; Ersoz, JI; Azkargorta, M; Elortza, F; Síma, R; Hajdusek, O; Cortazar, JT; Corcuera, IE; Colstrup, E; Nayak, A; Ruíz, IM; Rodriguez, H; Nijhof, AM; ...
VACCINE
2023-03-04
Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen
Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;
CHEMICAL SCIENCE
2023-03-01
New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...
JOURNAL OF MEDICINAL CHEMISTRY
2023-02-23
Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development
Rana, VS; Kitsou, C; Dutta, S; Ronzetti, MH; Zhang, M; Bernard, Q; Smith, AA; Tomás-Cortázar, J; Yang, XL; Wu, MJ; Kepple, O; Li, WZ; Dwyer, JE; Matias, J; Baljinnyam, B; Oliver, JD; Rajeevan, ...
SCIENCE
2023-01-12
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
González-Recio, I; Simón, J; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Mercado-Gómez, M; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Gil-Pitarch, C; Fernández-Rodríguez, C; Castellana, D; Latasa, ...
NATURE COMMUNICATIONS
2022-11-25
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Juárez-Fernández, M; Goikoetxea-Usandizaga, N; Porras, D; García-Mediavilla, MV; Bravo, M; Serrano-Maciá, M; Simón, J; Delgado, TC; Lachiondo-Ortega, S; Martínez-Flórez, S; Lorenzo, O; Rincón, ...
HEPATOLOGY
2022-09-12
Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis
Peña-Cearra, A; Pascual-Itoiz, MA; Lavin, JL; Fuertes, M; Martín-Ruiz, I; Castelo, J; Palacios, A; Barriales, D; Fullaondo, A; Aransay, AM; Rodríguez, H; Anguita, J; Abecia, L;
SCIENTIFIC REPORTS
2022-06-15