Juan Anguita | CIC bioGUNE | Center for Cooperative Research in Biosciences

Juan Anguita

PRINCIPAL INVESTIGATOR

Ikerbasque Research Professor

Inflammation and Macrophage Plasticity Lab & Animal Facility & Monoclonal Antibody Facility

Orcid:

0000-0003-2061-7182

Email: janguita@cicbiogune.es

Phone: 4211 / 944 061 311

Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Juan Anguita joined CIC bioGUNE as an Ikerbasque Professor in 2012. He has a BS degree in Biochemistry and Molecular Biology from the University of the Basque Country, and a PhD degree in Animal Health from the University of Leon. After 5 years as a postdoctoral fellow at Yale University School of medicine followed by 2 years as Associate Research Scientist (non-tenure faculty position) at the same institution, Dr. Anguita started his independent career fi rst as an Assistant Professor in the Department of Biology at the University of North Carolina at Charlotte, then as an Assistant and then Associate Professor with tenure in the Department of Veterinary and Animal Sciences at the University of Massachusetts at Amherst. Dr. Anguita´s laboratory is currently focused on the study of the mammalian host immune response to the spirochete that causes Lyme disease, Borrelia burgdorferi. His work is centered in the mechanisms of immune defense against infection, particularly focused on the phagocytosis of spirochetes and the activation of macrophages in the context of cardiac infection. His laboratory is also involved in the search of vaccine candidates to tick salivary antigens in order to prevent the transmission of several pathogens of medical importance, as part of international collaborative networks that include ANTIDotE, an European Commission funded consortium. Dr. Anguita’s group performs extensive –omic analysis relevant to his research interests, including phosphoproteomics, transcriptomics, proteomics and metabolomics.

Latest Publications

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen
Pifferi, C;Aguinagalde, L;Ruiz-de-Angulo, A;Sacristan, N;Baschirotto, PT;Poveda, A;Jimenez-Barbero, J;Anguita, J;Fernandez-Tejada, A
CHEMICAL SCIENCE
2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
Romerio, A;Gotri, N;Franco, AR;Artusa, V;Shaik, MM;Pasco, ST;Atxabal, U;Matamoros-Recio, A;Minguez-Toral, M;Zalamea, JD;Franconetti, A;Abrescia, NGA;Jimenez-Barbero, J;Anguita, J;Martin-Santamaria, ...
JOURNAL OF MEDICINAL CHEMISTRY
2023-02-02

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development
Rana, VS;Kitsou, C;Dutta, S;Ronzetti, MH;Zhang, M;Bernard, Q;Smith, AA;Tomas-Cortazar, J;Yang, XL;Wu, MJ;Kepple, O;Li, WZ;Dwyer, JE;Matias, J;Baljinnyam, B;Oliver, JD;Rajeevan, N;Pedra, JHF;Narasimhan, ...
SCIENCE
2023-01-12

2022

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
Gonzalez-Recio, I;Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Mercado-Gomez, M;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Gil-Pitarch, C;Fernandez-Rodriguez, C;Castellana, D;Latasa, MU;Abecia, ...
NATURE COMMUNICATIONS
2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...
HEPATOLOGY
2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis
Pena-Cearra, A;Pascual-Itoiz, MA;Lavin, JL;Fuertes, M;Martin-Ruiz, I;Castelo, J;Palacios, A;Barriales, D;Fullaondo, A;Aransay, AM;Rodriguez, H;Anguita, J;Abecia, L
SCIENTIFIC REPORTS
2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants
Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A
FRONTIERS IN IMMUNOLOGY
2022-05-06

Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of l-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease
Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V
FOOD & FUNCTION
2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15
Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022-03-01

2021

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Goikoetxea-Usandizaga, N;Serrano-Macia, M;Delgado, TC;Simon, J;Ramos, DF;Barriales, D;Cornide, ME;Jimenez, M;Perez-Redondo, M;Lachiondo-Ortega, S;Rodriguez-Agudo, R;Bizkarguenaga, M;Zalamea, ...
HEPATOLOGY
2021-12-15

BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis
Tomas-Cortazar, J;Bossi, L;Quinn, C;Reynolds, CJ;Butler, DK;Corcoran, N;Murchu, MO;McMahon, E;Singh, M;Rongkard, P;Anguita, J;Blanco, A;Dunachie, SJ;Altmann, D;Boyton, RJ;Arnold, J;Giltaire, ...
FRONTIERS IN IMMUNOLOGY
2021-12-13

Aspergillus fumigatus Fumagillin Contributes to Host Cell Damage
Guruceaga, X;Perez-Cuesta, U;Pellon, A;Cendon-Sanchez, S;Pelegri-Martinez, E;Gonzalez, O;Hernando, FL;Mayayo, E;Anguita, J;Alonso, RM;Keller, NP;Ramirez-Garcia, A;Rementeria, A
JOURNAL OF FUNGI
2021-11-01

Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics
Bizkarguenaga, M;Bruzzone, C;Gil-Redondo, R;SanJuan, I;Martin-Ruiz, I;Barriales, D;Palacios, A;Pasco, ST;Gonzalez-Valle, B;Lain, A;Herrera, L;Azkarate, A;Vesga, MA;Eguizabal, C;Anguita, J;Embade, ...
NMR IN BIOMEDICINE
2021-10-27

A Catalogus Immune Muris of the mouse immune responses to diverse pathogens
Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A
CELL DEATH & DISEASE
2021-08-17

Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model
Ladero-Aunon, I;Molina, E;Oyanguren, M;Barriales, D;Fuertes, M;Sevilla, IA;Luo, L;Arrazuria, R;De Buck, J;Anguita, J;Elguezabal, N
NPJ VACCINES
2021-08-12

Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
Trentelman, JJA;Tomas-Cortazar, J;Knorr, S;Barriales, D;Hajdusek, O;Sima, R;Ersoz, JI;Narasimhan, S;Fikrig, E;Nijhof, AM;Anguita, J;Hovius, JW
SCIENTIFIC REPORTS
2021-08-03

Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Iruzubieta, P;Goikoetxea-Usandizaga, N;Barbier-Torres, L;Serrano-Macia, M;Fernandez-Ramos, D;Fernandez-Tussy, P;Gutierrez-de-Juan, V;Lachiondo-Ortega, S;Simon, J;Bravo, M;Lopitz-Otsoa, F;Robles, ...
JHEP REPORTS
2021-06-01

Identification and Characterization of Immunodominant Proteins from Tick Tissue Extracts Inducing a Protective Immune Response against Ixodes ricinus in Cattle
Knorr, S;Reissert-Oppermann, S;Tomas-Cortazar, J;Barriales, D;Azkargorta, M;Iloro, I;Elortza, F;Pinecki-Socias, S;Anguita, J;Hovius, JW;Nijhof, AM
VACCINES
2021-06-01

Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernandez-Tussy, P;Rodriguez-Agudo, R;Fernandez-Ramos, D;Barbier-Torres, L;Zubiete-Franco, I;de Davalillo, SL;Herraez, E;Goikoetxea-Usandizaga, N;Lachiondo-Ortega, S;Simon, J;Lopitz-Otsoa, F;Gutierrez-de ...
CELL DEATH & DISEASE
2021-05-28

Peripheral blood mononuclear cells (PBMC) microbiome is not affected by colon microbiota in healthy goats
Pena-Cearra, A;Belanche, A;Gonzalez-Lopez, M;Lavin, JL;Pascual-Itoiz, MA;Jimenez, E;Rodriguez, H;Aransay, AM;Anguita, J;Yanez-Ruiz, DR;Abecia, L
ANIMAL MICROBIOME
2021-04-14

Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro
Ladero-Aunon, I;Molina, E;Holder, A;Kolakowski, J;Harris, H;Urkitza, A;Anguita, J;Werling, D;Elguezabal, N
FRONTIERS IN IMMUNOLOGY
2021-03-17

Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants
Fuentes, R;Ruiz-de-Angulo, A;Sacristan, N;Navo, CD;Jimenez-Oses, G;Anguita, J;Fernandez-Tejada, A
CHEMISTRY-A EUROPEAN JOURNAL
2021-02-04

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01

The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
Pellon, A;Barriales, D;Pena-Cearra, A;Castelo-Careaga, J;Palacios, A;Lopez, N;Atondo, E;Pascual-Itoiz, MA;Martin-Ruiz, I;Sampedro, L;Gonzalez-Lopez, M;Barcena, L;Martin-Mateos, T;Landete, JM;Prados-Rosales, ...
GUT MICROBES
2021-01-01

2020

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance
Mancheno, JM;Atondo, E;Tomas-Cortazar, J;Lavin, JL;Plaza-Vinuesa, L;Martin-Ruiz, I;Barriales, D;Palacios, A;Navo, CD;Sampedro, L;Pena-Cearra, A;Pascual-Itoiz, MA;Castelo, J;Carreras-Gonzalez, ...
MICROBIAL BIOTECHNOLOGY
2020-12-18

Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2)
Ingles-Ferrandiz, M;Martin-Inaraja, M;Herrera, L;Villaverde, M;Santos, S;Vesga, MA;Garreta, E;Martin-Ruiz, I;Aransay, AM;Anguita, J;Barrena, B;Allende, LM;Gonzalez-Granado, LI;Eguizabal, C
STEM CELL RESEARCH
2020-12-01

Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
Montalvo-Quiros, S;Vallet-Regi, M;Palacios, A;Anguita, J;Prados-Rosales, RC;Gonzalez, B;Luque-Garcia, JL
PHARMACEUTICS
2020-12-01

A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission
Trentelman, JJA;Sima, R;Krezdorn, N;Tomas-Cortazar, J;Barriales, D;Takumi, K;Butler, JM;Sprong, H;Klouwens, MJ;Urbanova, V;Mahmood, S;Winter, P;Kopacek, P;Anguita, J;Hajdusek, O;Hovius, JW
SCIENTIFIC REPORTS
2020-11-18

Lessons from Bacillus Calmette-Guerin: Harnessing Trained Immunity for Vaccine Development
Pasco, ST;Anguita, J
CELLS
2020-09-01

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier-Torres, L;Fortner, KA;Iruzubieta, P;Delgado, TC;Giddings, E;Chen, YDH;Champagne, D;Fernandez-Ramos, D;Mestre, D;Gomez-Santos, B;Varela-Rey, M;de Juan, VG;Fernandez-Tussy, P;Zubiete-Franco, ...
NATURE COMMUNICATIONS
2020-07-03

Editorial: Macrophage Metabolism and Immune Responses
Rodriguez, H;Prados-Rosales, R;Lavin, JL;Mazzone, M;Anguita, J
FRONTIERS IN IMMUNOLOGY
2020-05-29

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue
Pifferi, C;Ruiz-de-Angulo, A;Goyard, D;Tiertant, C;Sacristan, N;Barriales, D;Berthet, N;Anguita, J;Renaudet, O;Fernandez-Tejada, A
CHEMICAL SCIENCE
2020-05-07

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance
Narasimhan, S;Kurokawa, C;Diktas, H;Strank, NO;Cerny, J;Murfin, K;Cao, YG;Lynn, G;Trentleman, J;Wu, MJ;DePonte, K;Kantor, F;Anguita, J;Hovius, J;Fikrig, E
TICKS AND TICK-BORNE DISEASES
2020-05-01

Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis
Estevez, H;Palacios, A;Gil, D;Anguita, J;Vallet-Regi, M;Gonzalez, B;Prados-Rosales, R;Luque-Garcia, JL
FRONTIERS IN MICROBIOLOGY
2020-04-28

The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis
Pascual-Itoiz, MA;Pena-Cearra, A;Martin-Ruiz, I;Lavin, JL;Simo, C;Rodriguez, H;Atondo, E;Flores, JM;Carreras-Gonzalez, A;Tomas-Cortazar, J;Barriales, D;Palacios, A;Garcia-Canas, V;Pellon, A;Fullaondo, ...
SCIENTIFIC REPORTS
2020-01-17

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants
Ghirardello, M;Ruiz-de-Angulo, A;Sacristan, N;Barriales, D;Jimenez-Barbero, J;Poveda, A;Corzana, F;Anguita, J;Fernandez-Tejada, A
CHEMICAL COMMUNICATIONS
2020-01-16

2019

Adult peripheral blood and umbilical cord blood NK cells are good sources for effective CAR therapy against CD19 positive leukemic cells
Herrera, L;Santos, S;Vesga, MA;Anguita, J;Martin-Ruiz, I;Carrascosa, T;Juan, M;Eguizabal, C
SCIENTIFIC REPORTS
2019-12-10

Regulation of macrophage activity by surface receptors contained within Borrelia burgdorferi-enriched phagosomal fractions
Carreras-Gonzalez, A;Barriales, D;Palacios, A;Montesinos-Robledo, M;Navasa, N;Azkargorta, M;Pena-Cearra, A;Tomas-Cortazar, J;Escobes, I;Pascual-Itoiz, MA;Hradiska, J;Kopecky, J;Gil-Carton, D;Prados-Rosales, ...
PLOS PATHOGENS
2019-11-18

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernandez-Tussy, P;Fernandez-Ramos, D;Lopitz-Otsoa, F;Simon, J;Barbier-Torres, L;Gomez-Santos, B;Nunez-Garcia, M;Azkargorta, M;Gutierrez-de Juan, V;Serrano-Macia, M;Rodriguez-Agudo, R;Iruzubieta, ...
MOLECULAR METABOLISM
2019-11-01

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
Clos-Garcia, M;Andres-Marin, N;Fernandez-Eulate, G;Abecia, L;Lavin, JL;van Liempd, S;Cabrera, D;Royo, F;Valero, A;Errazquin, N;Vega, MCG;Govillard, L;Tackett, MR;Tejada, G;Gonzalez, E;Anguita, ...
EBIOMEDICINE
2019-08-01

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis
Kalscheuer, R;Palacios, A;Anso, I;Cifuente, J;Anguita, J;Jacobs, WR;Guerin, ME;Prados-Rosales, R
BIOCHEMICAL JOURNAL
2019-07-18

Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection
Palacios, A;Sampedro, L;Sevilla, IA;Molina, E;Gil, D;Azkargorta, M;Elortza, F;Garrido, JM;Anguita, J;Prados-Rosales, R
BMC VETERINARY RESEARCH
2019-06-07

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission
Rego, ROM;Trentelman, JJA;Anguita, J;Nijhof, AM;Sprong, H;Klempa, B;Hajdusek, O;Tomas-Cortazar, J;Azagi, T;Strnad, M;Knorr, S;Sima, R;Jalovecka, M;Havlikova, SF;Lickova, M;Slavikova, M;Kopacek, ...
PARASITES & VECTORS
2019-05-14

Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD
Ramos, DF;Tussy, PF;Otsoa, FL;Simon, J;Torres, LB;Santos, BG;Nunez, M;Azkargorta, M;de Juan, VG;Serrano-Macia, M;Agudo, RR;Champagne, DG;Iruzubieta, P;Anguita, J;Rincon, M;Elortza, F;Anita, ...
JOURNAL OF HEPATOLOGY
2019-04-01

Bacterial tannases: classification and biochemical properties
de las Rivas, B;Rodriguez, H;Anguita, J;Munoz, R
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2019-01-01

2018

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Fernandez-Ramos, D;Fernandez-Tussy, P;Lopitz-Otsoa, F;Gutierrez-de-Juan, V;Navasa, N;Barbier-Torres, L;Zubiete-Franco, I;Simon, J;Fernandez, AF;Arbelaiz, A;Aransay, AM;Lavin, JL;Beraza, N;Perugorria, ...
CELL DEATH & DISEASE
2018-09-20

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
Urquiza, P;Lain, A;Sanz-Parra, A;Moreno, J;Bernardo-Seisdedos, G;Dubus, P;Gonzalez, E;Gutierrez-de-Juan, V;Garcia, S;Erana, H;Juan, IS;Macias, I;Ben Bdira, F;Pluta, P;Ortega, G;Oyarzabal, J;Gonzalez-Muniz, ...
SCIENCE TRANSLATIONAL MEDICINE
2018-09-19

Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans
Pellon, A;Ramirez-Garcia, A;Guruceaga, X;Zabala, A;Buldain, I;Antoran, A;Anguita, J;Rementeria, A;Matute, C;Hernando, FL
CELLULAR MICROBIOLOGY
2018-08-01

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR(-/-) Mice
Marin-Lopez, A;Calvo-Pinilla, E;Barriales, D;Lorenzo, G;Brun, A;Anguita, J;Ortego, J
JOURNAL OF VIROLOGY
2018-08-01

Plasticity in early immune evasion strategies of a bacterial pathogen
Bernard, Q;Smith, AA;Yang, XL;Koci, J;Foor, SD;Cramer, SD;Zhuang, X;Dwyer, JE;Lin, YP;Mongodin, EF;Marques, A;Leong, JM;Anguita, J;Pal, U
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2018-04-17

The liver-specific deletion of the respiratory chain inhibitor MCJ attenuates NAFLD progression by enhancing hepatic beta-oxidation
Barbier-Torres, L;Delgado, TC;Iruzubieta, P;Ramos, DF;de Juan, VG;Varela-Rey, M;Tussy, PF;Zubiete-Franco, I;Simon, J;Otsoa, FL;Congregado, DM;Santos, BG;Buque, X;Crespo, J;Lu, SC;Matos, J;Aspichueta, ...
JOURNAL OF HEPATOLOGY
2018-04-01

A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi
Carreras-Gonzalez, A;Navasa, N;Martin-Ruiz, I;Lavin, JL;Azkargorta, M;Atondo, E;Barriales, D;Macias-Camara, N;Pascual-Itoiz, MA;Sampedro, L;Tomas-Cortazar, J;Pena-Cearra, A;Pellon, A;Prados-Rosales, ...
EMERGING MICROBES & INFECTIONS
2018-03-07

Quantum DNA Sequencing: A Peek Into a Dystopic Future?
Lavin, JL;Anguita, J
BIOESSAYS : NEWS AND REVIEWS IN MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY
2018-03-01

Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp polymorphum
Tomas-Cortazar, J;Plaza-Vinuesa, L;de las Rivas, B;Lavin, JL;Barriales, D;Abecia, L;Mancheno, JM;Aransay, AM;Munoz, R;Anguita, J;Rodriguez, H
MICROBIAL CELL FACTORIES
2018-02-26

Phagocytosis Assays for Borrelia burgdorferi
Anguita, J;Carreras-Gonzalez, A;Navasa, N
METHODS IN MOLECULAR BIOLOGY
2018-01-01

Preliminary Evaluation of Tick Protein Extracts and Recombinant Ferritin 2 as Anti-tick Vaccines Targeting lxodes ricinus in Cattle
Knorr, S;Anguita, J;Cortazar, JT;Hajdusek, O;Kopacek, P;Trentelman, JJ;Kershaw, O;Hovius, JW;Nijhof, AM
FRONTIERS IN PHYSIOLOGY
2018-01-01

2017

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Barbier-Torres, L;Iruzubieta, P;Fernandez-Ramos, D;Delgado, TC;Taibo, D;Guitierrez-de-Juan, V;Varela-Rey, M;Azkargorta, M;Navasa, N;Fernandez-Tussy, P;Zubiete-Franco, I;Simon, J;Lopitz-Otsoa, ...
NATURE COMMUNICATIONS
2017-12-12

Role of Aramchol in Steatohepatitis and Fibrosis in Mice
Iruarrizaga-Lejarreta, M;Varela-Rey, M;Fernandez-Ramos, D;Martinez-Arranz, I;Delgado, TC;Simon, J;Gutierrez-de Juan, V;delaCruz-Villar, L;Azkargorta, M;Lavin, JL;Mayo, R;van Liempd, SM;Aurrekoetxea, ...
HEPATOLOGY COMMUNICATIONS
2017-11-01

Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes
Johnson, BB;Brena, M;Anguita, J;Heuck, AP
SCIENTIFIC REPORTS
2017-10-23

The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant
Tomas-Cortazar, J;Martin-Ruiz, I;Barriales, D;Pascual-Itoiz, MA;de Juan, VG;Caro-Maldonado, A;Merino, N;Marina, A;Blanco, FJ;Flores, JM;Sutherland, JD;Barrio, R;Rojas, A;Martinez-Chantar, ML;Carracedo, ...
SCIENTIFIC REPORTS
2017-09-06

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso, C;Fernandez-Ramos, D;Varela-Rey, M;Martinez-Arranz, I;Navasa, N;Van Liempd, SM;Trueba, JLL;Mayo, R;Ilisso, CP;de Juan, VG;Iruarrizaga-Lejarreta, M;delaCruz-Villar, L;Minchole, I;Robinson, ...
GASTROENTEROLOGY
2017-05-01

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine
Prados-Rosales, R;Carreno, L;Cheng, TT;Blanc, C;Weinrick, B;Malek, A;Lowary, TL;Baena, A;Joe, M;Bai, Y;Kalscheuer, R;Batista-Gonzalez, A;Saavedra, NA;Sampedro, L;Tomas, J;Anguita, J;Hung, SC;Tripathi, ...
PLOS PATHOGENS
2017-03-01

Aramchol reduces established fibrosis in MCD diet animal model
Varela-Rey, M;Fernandez-Ramos, D;Iruarrizaga-Lejarreta, M;Van Liempd, SM;DelaCruz-Villar, L;de Davalillo, SL;Martin-Ruiz, I;Aurrekoetxea, I;Buque, X;Lavin, JL;Aransay, AM;Hayardeny, L;Alonso, ...
JOURNAL OF HEPATOLOGY
2017-01-01

2016

Characterization of a Chikungunya virus strain isolated from banked patients' sera
Chalaem, P;Chusri, S;Fernandez, S;Chotigeat, W;Anguita, J;Pal, U;Promnares, K
VIROLOGY JOURNAL
2016-09-02

Stratification and therapeutic potential of PML in metastatic breast cancer
Martin-Martin, N(Martin-Martin, Natalia);Piva, M(Piva, Marco);Urosevic, J(Urosevic, Jelena);Aldaz, P(Aldaz, Paula);Sutherland, JD(Sutherland, James D.);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Arreal, ...
NATURE COMMUNICATIONS
2016-08-01

Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector
Smith, AA;Navasa, N;Yang, XL;Wilder, CN;Buyuktanir, O;Marques, A;Anguita, J;Pal, U
CELL HOST & MICROBE
2016-07-13

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
Champagne, DP;Hatle, KM;Fortner, KA;D'Alessandro, A;Thornton, TM;Yang, R;Torralba, D;Tomas-Cortazar, J;Jun, YW;Ahn, KH;Hansen, KC;Haynes, L;Anguita, J;Rincon, M
IMMUNITY
2016-06-21

2015

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1
Barbier-Torres, L;Beraza, N;Fernandez-Tussy, P;Lopitz-Otsoa, F;Fernandez-Ramos, D;Zubiete-Franco, I;Varela-Rey, M;Delgado, TC;Gutierrez, V;Anguita, J;Pares, A;Banales, JM;Villa, E;Caballeria, ...
HEPATOLOGY
2015-10-01

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages
Navasa, N;Martin-Ruiz, I;Atondo, E;Sutherland, JD;Pascual-Itoiz, MA;Carreras-Gonzalez, A;Izadi, H;Tomas-Cortazar, J;Ayaz, F;Martin-Martin, N;Torres, IM;Barrio, R;Carracedo, A;Olivera, ER;Rincon, ...
SCIENTIFIC REPORTS
2015-09-30

Regulation of Oxidative Stress by Methylation-Controlled J Protein Controls Macrophage Responses to Inflammatory Insults
Navasa, N;Martin, I;Iglesias-Pedraz, JM;Beraza, N;Atondo, E;Izadi, H;Ayaz, F;Fernandez-Alvarez, S;Hatle, K;Som, A;Dienz, O;Osborne, BA;Martinez-Chantar, ML;Rincon, M;Anguita, J
THE JOURNAL OF INFECTIOUS DISEASES
2015-01-01

Serum C3 Enhances Complement Receptor 3-Mediated Phagocytosis of Borrelia burgdorferi
Hawley, KL;Olson, CM;Carreras-Gonzalez, A;Navasa, N;Anguita, J
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2015-01-01

2014

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe
Sprong, H;Trentelman, J;Seemann, I;Grubhoffer, L;Rego, ROM;Hajdusek, O;Kopacek, P;Sima, R;Nijhof, AM;Anguita, J;Winter, P;Rotter, B;Havlikova, S;Klempa, B;Schetters, TP;Hovius, JWR
PARASITES & VECTORS
2014-02-21

2013

MCJ/DnaJC15, an Endogenous Mitochondrial Repressor of the Respiratory Chain That Controls Metabolic Alterations
Hatle, KM;Gummadidala, P;Navasa, N;Bernardo, E;Dodge, J;Silverstrim, B;Fortner, K;Burg, E;Suratt, BT;Hammer, J;Radermacher, M;Taatjes, DJ;Thornton, T;Anguita, J;Rincon, M
MOLECULAR AND CELLULAR BIOLOGY
2013-06-01

CD14 Targets Complement Receptor 3 to Lipid Rafts during Phagocytosis of Borrelia burgdorferi
Hawley, KL;Martin-Ruiz, I;Iglesias-Pedraz, JM;Berwin, B;Anguita, J
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2013-01-01

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector
Kung, F;Anguita, J;Pal, U
FUTURE MICROBIOLOGY
2013-01-01

2012

Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and Anti-Inflammatory Activities
Som, A;Navasa, N;Percher, A;Scott, RW;Tew, GN;Anguita, J
CLINICAL AND VACCINE IMMUNOLOGY
2012-11-01

Macrophage p38 Mitogen-Activated Protein Kinase Activity Regulates Invariant Natural Killer T-Cell Responses During Borrelia burgdorferi Infection
Hawley, Kelly; Navasa, Nicolas; Olson, Chris M., Jr.; Bates, Tonya C.; Garg, Renu; Hedrick, Michael N.; Conze, Dietrich; Rincon, Mercedes; Anguita, Juan
JOURNAL OF INFECTIOUS DISEASES
2012-07-15

Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses
Thaker, Hitesh D.; Som, Abhigyan; Ayaz, Furkan; Lui, Dahui; Pan, Wenxi; Scott, Richard W.; Anguita, Juan; Tew, Gregory N.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2012-07-11

Multiserotype Protection Elicited by a Combinatorial Prime-Boost Vaccination Strategy against Bluetongue Virus
Calvo-Pinilla, Eva; Navasa, Nicolas; Anguita, Juan; Ortego, Javier
PLOS ONE
2012-04-13

CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi
Hawley, Kelly L.; Olson, Chris M., Jr.; Iglesias-Pedraz, Juan M.; Navasa, Nicolas; Cervantes, Jorge L.; Caimano, Melissa J.; Izadi, Hooman; Ingalls, Robin R.; Pal, Utpal; Salazar, Juan C.; Radolf, ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2012-01-24

The macrophage and tick vaccine laboratory studies the interaction between athropod vectors, infectious microorganisms and their mammalian hosts. The laboratory is primarily focused on ticks of the genus Ixodes, which transmit several medically important pathogens, such as the causative agent of Lyme borreliosis, Borrelia burgdorferi.

The lab participates in a large multicenter project funded by the EU (ANTIDotE) that seeks to identify tick salivary antigens that could be used as potential vaccine candidates against tick bites and therefore, prevent the transmission of pathogens. They are also interested in the pharmacological activities exerted by tick saliva proteins, especially those that can modulate the immune response and that can have therapeutic applications in immune disorders.

Finally, the group is interested in understanding the regulation of the immune response pathways present in ticks that participate in the control of pathogens within the vector. On the other hand, the laboratory seeks to understand the response of macrophages to infectious agents, from Lyme borreliosis to inflammatory bowel disease to tuberculosis.

They are interested in understanding the metabolic control of macrophage responses through the specific mitochondrial complex I repressor, MCJ in different models of disease in which these cells participate, such as Lyme carditis and inflammatory bowel disease. Furthermore, the role of INFγ and other signals on the plasticity of the response of macrophages to infectious agents is another focus of the laboratory.

Finally, the group is interested in defining the phagocytic ‘ome’ that mediates the uptake, elimination and initiation of proinflammatory responses by macrophages. In this context, the group described the Complement Receptor (CR) 3 as a phagocytic receptor involved in the elimination of B. burgdorferi by macrophages. CR3 cooperates with the GPI-anchored protein, CD14, in the internalization of the spirochete, a novel mechanism that is independent of MyD88 signals.

Members

RESEARCH ASSISTANT

Hector Rodriguez

TECHNICIANS / DOCTORAL CANDIDATES

Janire Castelo Careaga
Sarai Araujo Aris
Naiara Gutiez García

AECC Predoctoral Felow
Itziar Martín Ruíz
Iratxe Seoane Alvarez
Samuel Tanner Pasco

MSCA-ITN Fellow
Alba Mosteiro Couso
Ainhoa Palacios

Latest Publications

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C;Aguinagalde, L;Ruiz-de-Angulo, A;Sacristan, N;Baschirotto, PT;Poveda, A;Jimenez-Barbero, J;Anguita, J;Fernandez-Tejada, A

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Romerio, A;Gotri, N;Franco, AR;Artusa, V;Shaik, MM;Pasco, ST;Atxabal, U;Matamoros-Recio, A;Minguez-Toral, M;Zalamea, JD;Franconetti, A;Abrescia, NGA;Jimenez-Barbero, J;Anguita, J;Martin-Santamaria, ...

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

Rana, VS;Kitsou, C;Dutta, S;Ronzetti, MH;Zhang, M;Bernard, Q;Smith, AA;Tomas-Cortazar, J;Yang, XL;Wu, MJ;Kepple, O;Li, WZ;Dwyer, JE;Matias, J;Baljinnyam, B;Oliver, JD;Rajeevan, N;Pedra, JHF;Narasimhan, ...

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

Gonzalez-Recio, I;Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Mercado-Gomez, M;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Gil-Pitarch, C;Fernandez-Rodriguez, C;Castellana, D;Latasa, MU;Abecia, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Pena-Cearra, A;Pascual-Itoiz, MA;Lavin, JL;Fuertes, M;Martin-Ruiz, I;Castelo, J;Palacios, A;Barriales, D;Fullaondo, A;Aransay, AM;Rodriguez, H;Anguita, J;Abecia, L

SCIENTIFIC REPORTS

2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A

FRONTIERS IN IMMUNOLOGY

2022-05-06

Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V

FOOD & FUNCTION

2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-03-01

Members

SPECIALIST

Itziar Fernández Domínguez

TECHNICIANS / DOCTORAL CANDIDATES

Latest Publications

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C;Aguinagalde, L;Ruiz-de-Angulo, A;Sacristan, N;Baschirotto, PT;Poveda, A;Jimenez-Barbero, J;Anguita, J;Fernandez-Tejada, A

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

Gonzalez-Recio, I;Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Mercado-Gomez, M;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Gil-Pitarch, C;Fernandez-Rodriguez, C;Castellana, D;Latasa, MU;Abecia, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Pena-Cearra, A;Pascual-Itoiz, MA;Lavin, JL;Fuertes, M;Martin-Ruiz, I;Castelo, J;Palacios, A;Barriales, D;Fullaondo, A;Aransay, AM;Rodriguez, H;Anguita, J;Abecia, L

SCIENTIFIC REPORTS

2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A

FRONTIERS IN IMMUNOLOGY

2022-05-06

Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V

FOOD & FUNCTION

2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-03-01

Members

TECHNICIANS / DOCTORAL CANDIDATES

Estíbaliz Atondo Gondra

Latest Publications

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C;Aguinagalde, L;Ruiz-de-Angulo, A;Sacristan, N;Baschirotto, PT;Poveda, A;Jimenez-Barbero, J;Anguita, J;Fernandez-Tejada, A

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-02

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

Gonzalez-Recio, I;Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Mercado-Gomez, M;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Gil-Pitarch, C;Fernandez-Rodriguez, C;Castellana, D;Latasa, MU;Abecia, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Pena-Cearra, A;Pascual-Itoiz, MA;Lavin, JL;Fuertes, M;Martin-Ruiz, I;Castelo, J;Palacios, A;Barriales, D;Fullaondo, A;Aransay, AM;Rodriguez, H;Anguita, J;Abecia, L

SCIENTIFIC REPORTS

2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A

FRONTIERS IN IMMUNOLOGY

2022-05-06

Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V

FOOD & FUNCTION

2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-03-01