Latest Publications
2019
2018
2013
The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:
- Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
- Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
- Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
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Principal Investigator
Arkaitz Carracedo
ERC Consolidator Grant - Ikerbasque Research Professor -
Associate Principal Investigator
Edurne Berra
IKERBASQUE RESEARCH FELLOW -
Marco Piva
Ikerbasque Research Fellow -
RESEARCH ASSISTANT
Isabel Mendizabal
Ikerbasque Research Fellow -
Natalia Martín Martín
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POST DOCTORAL RESEARCHER
Amaia Zabala Letona
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Amaia Arruabarrena Aristorena
Juan de la Cierva Fellow -
Laura Bozal Basterra
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Verónica Torrano
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Amaia Ercilla Eguiarte
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Laura Camacho
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Leire Moreno Cugnon
Juan de la Cierva Fellow -
Ana Talamillo
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TECHNICIANS / EARLY STAGE RESEARCHER
Ianire Astobiza
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Ana R Cortazar
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Maider Fagoaga Eugui
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Ainara Martinez Gonzalez
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Cristina Viera Bardon
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Lucía Fadón
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Kathrin Keim
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Alice Macchia
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Sonia Fernández Ruiz
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Mikel Pujana Vaquerizo
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Jon Corres Mendizabal
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Onintza Carlevaris
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Pilar Castellnou Arenas
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Nerea Sahuquillo Virtus
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Laura Martínez Pérez
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Jana Crespo Trives
Members
Latest Publications
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...
CANCERS
2020-09-01
Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling
Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M
CIRCULATION
2020-08-18
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome
Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Bermejo-Arteagabeitia, A;Da Fonseca, C;Barroso-Gomila, O;Azkargorta, M;Iloro, I;Pampliega, O;Andrade, R;Martin-Martin, N;Branon, TC;Ting, ...
ELIFE
2020-06-18
H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer
Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...
JOURNAL OF PROTEOME RESEARCH
2020-06-05
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...
JOURNAL OF EXPERIMENTAL MEDICINE
2020-06-01
OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress
Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N
FASEB JOURNAL
2020-05-01
CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo
Alajati, A;D'Ambrosio, M;Troiani, M;Mosole, S;Pellegrini, L;Chen, JJ;Revandkar, A;Bolis, M;Theurillat, JP;Guccini, I;Losa, M;Calcinotto, A;De Bernardis, G;Pasquini, E;D'Antuono, R;Sharp, ...
JOURNAL OF CLINICAL INVESTIGATION
2020-05-01
Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media
Plou, J;Garcia, I;Charconnet, M;Astobiza, I;Garcia-Astrain, C;Matricardi, C;Mihi, A;Carracedo, A;Liz-Marzan, LM
ADVANCED FUNCTIONAL MATERIALS
2020-03-05
The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer
Sole, C;Goicoechea, I;Goni, A;Schramm, M;Armesto, M;Arestin, M;Manterola, L;Tellaetxe, M;Alberdi, A;Nogueira, L;Roumiguie, M;Lopez, JI;Jaka, JPS;Urruticoechea, A;Vergara, I;Loizaga-Iriarte, ...
CANCERS
2020-02-22
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Ercilla, A;Benada, J;Amitash, S;Zonderland, G;Baldi, G;Somyajit, K;Ochs, F;Costanzo, V;Lukas, J;Toledo, L
CELL REPORTS
2020-02-18