Encarnación Pérez Andrés
eperez
Encarnación Pérez Andrés
LABORATORY TECHNICIAN
Cancer Cell Signaling And Metabolism Lab
Email: eperez@cicbiogune.es
Phone: 4234 / 944 061 323
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

FOXA1 mutations influence the therapeutic response of breast cancer by altering chromatin state

Arruabarrena-Aristorena, A;Toska, E

MOLECULAR & CELLULAR ONCOLOGY

2021-05-08

Selective modulation by PARP-1 of HIF-1 alpha-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Marti, JM;Garcia-Diaz, A;Delgado-Bellido, D;O'Valle, F;Gonzalez-Flores, A;Carlevaris, O;Rodriguez-Vargas, JM;Ame, JC;Dantzer, F;King, GL;Dziedzic, K;Berra, E;de Alava, E;Amaral, AT;Hammond, ...

REDOX BIOLOGY

2021-05-01

LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton

Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Martin-Martin, N;Ercilla, A;Rodriguez, JA;Carracedo, A;Sutherland, JD;Barrio, R

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2021-04-01

Oligometastatic Prostate Adenocarcinoma. Clinical-Pathologic Study of a Histologically Under-Recognized Prostate Cancer

Manini, C;Gonzalez, A;Buchser, D;Garcia-Olaverri, J;Urresola, A;Ezquerro, A;Fernandez, I;Llarena, R;Zabalza, I;Pulido, R;Carracedo, A;Gomez-Iturriaga, A;Lopez, JI

JOURNAL OF PERSONALIZED MEDICINE

2020-12-01

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...

CANCERS

2020-09-01

Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling

Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M

CIRCULATION

2020-08-18

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Bermejo-Arteagabeitia, A;Da Fonseca, C;Barroso-Gomila, O;Azkargorta, M;Iloro, I;Pampliega, O;Andrade, R;Martin-Martin, N;Branon, TC;Ting, ...

ELIFE

2020-06-18

H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...

JOURNAL OF PROTEOME RESEARCH

2020-06-05

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...

JOURNAL OF EXPERIMENTAL MEDICINE

2020-06-01

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N

FASEB JOURNAL

2020-05-01