Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity

Díaz-Domínguez, CM; Eraña, H; Peccati, F; Vidal, E; Charco, JM; Sampedro-Torres-Quevedo, C; Pérez-Castro, MA; Lorenzo, NL; Giler, S; Tellingg, GC; Geijo, M; Requena, JR; Jiménez-Osés, G; Castilla, ...

NEUROBIOLOGY OF DISEASE

2025-09-01

Glycans and Chirality: Stereoselectivity at the Core of DC-SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

Martínez, JD; Núñez-Franco, R; Valverde, P; Delgado, S; Ardá, A; Jiménez-Barbero, J; Jiménez-Oses, G; Cañada, FJ;

CHEMISTRY-A EUROPEAN JOURNAL

2025-05-22

The disease-linked R336C mutation in cystathionine β-synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

Conter, C; Núñez-Franco, R; Al-Sadeq, DW; Fernández-Rodríguez, C; Goikoetxea-Usandizaga, N; Nasrallah, GK; Nomikos, M; Martinez-Chantar, ML; Astegno, A; Jiménez-Osés, G; Martínez-Cruz, LA;

FEBS JOURNAL

2025-05-06

Bis-CF3-bipyridine Ligands for the Iridium-Catalyzed Borylation of N-Methylamides

Marcos-Atanes, D; Jiménez-Osés, G; Mascareñas, JL;

ACS CATALYSIS

2025-04-16

Host-Guest Dynamic Behavior of Melatonin Encapsulated in β-Cyclodextrin Nanosponges

Ferrero, R; Pantaleone, S; Brunella, V; Corno, M; Jiménez-Osés, G; Peccati, F;

ACS OMEGA

2025-01-28

Doublet Spin State Mediated Photoluminescence Upconversion in Organic Radical Donor-Triplet Acceptor Dyads

OShea, JM; Yun, YJ; Jamhawi, AM; Peccati, F; Jiménez-Osés, G; Ayitou, AJL;

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2024-12-19

Exploring Glycan-Lectin Interactions in Natural-Like Environments: A View Using NMR Experiments Inside Cell and on Cell Surface

Bertuzzi, S; Lete, MG; Franconetti, A; Diercks, T; Delgado, S; Oyenarte, I; Moure, MJ; Nuñez-Franco, R; Valverde, P; Lenza, MP; Sobczak, K; Jiménez-Osés, G; Paulson, JC; Ardá, A; Ereño-Orbea, ...

CHEMISTRY-A EUROPEAN JOURNAL

2024-12-11

Mechanistic Insights into Chloride-Dependent Uncaging Reaction of Propargyl and Allene-Protected Substrates by Pd-Complexes

Ferreira, TM; Navo, CD; Agnes, JP; Cardozo, F; de Oliveira, DC; Zanotto, A; Jimenez-Osés, G; Domingos, JB;

CHEMISTRY-A EUROPEAN JOURNAL

2024-12-10

Unveiling the GT114 family: Structural characterization of A075L, a glycosyltransferase from Paramecium bursaria chlorella virus-1 (PBCV-1)

Laugieri, ME; Speciale, I; Gimeno, A; Lin, SC; Byers, BW; Poveda, A; Nunez-Franco, R; Iturrioz, I; Moure, MJ; Jimenez-Oses, G; Russo-Krauss, I; Notaro, A; Van Etten, JL; Lowary, TL; Jimenez-Barbero, ...

PROTEIN SCIENCE

2024-12-01

Enriching productive mutational paths accelerates enzyme evolution

Patsch, D; Schwander, T; Voss, M; Schaub, D; Hüppi, S; Eichenberger, M; Stockinger, P; Schelbert, L; Giger, S; Peccati, F; Jiménez-Osés, G; Mutny, M; Krause, A; Bornscheuer, UT; Hilvert, D; ...

NATURE CHEMICAL BIOLOGY

2024-09-11

AlphaFold2 Predicts Alternative Conformation Populations in Green Fluorescent Protein Variants

Núñez-Franco, R; Muriel-Olaya, MM; Jiménez-Osés, G; Peccati, F;

JOURNAL OF CHEMICAL INFORMATION AND MODELING

2024-09-03

Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution

Unnikrishnan, VB; Sabatino, V; Amorim, F; Estrada, MF; Navo, CD; Jimenez-Oses, G; Fior, R; Bernardes, GJL;

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2024-08-08

Different roles of the heterodimer architecture of galectin-4 in selective recognition of oligosaccharides and lipopolysaccharides having ABH antigens

Quintana, JI; Massaro, M; Cagnoni, AJ; Nuñez-Franco, R; Delgado, S; Jiménez-Osés, G; Mariño, KV; Rabinovich, GA; Jiménez-Barbero, J; Ardá, A;

JOURNAL OF BIOLOGICAL CHEMISTRY

2024-08-01

Interplay Between Substrate Polarity and Protein Dynamics in Evolved Kemp Eliminases

Peccati, F; Noey, EL; Houk, KN; Osuna, S; Jiménez-Osés, G;

CHEMCATCHEM

2024-06-05

Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C-C Bond Formation

Woodard, AM; Peccati, F; Navo, CD; Jiménez-Osés, G; Mitchell, DA;

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2024-05-10

Interplay of chloride levels and palladium(ii)-catalyzed O-deallenylation bioorthogonal uncaging reactions

Dal Forno, GM; Latocheski, E; Navo, CD; Albuquerque, BL; St John, AL; Avenier, F; Jiménez-Osés, G; Domingos, JB;

CHEMICAL SCIENCE

2024-03-20

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Erana, H; Sampedro-Torres-Quevedo, C; Charco, JM; Diaz-Dominguez, CM; Peccati, F; San-Juan-Ansoleaga, M; Vidal, E; Goncalves-Anjo, N; Perez-Castro, MA; Gonzalez-Miranda, E; Pineiro, P; Fernandez-Veiga, ...

NATURE COMMUNICATIONS

2024-03-08

Improving Protein Expression, Stability, and Function with ProteinMPNN

Sumida, KH; Núñez-Franco, R; Kalvet, I; Pellock, SJ; Wicky, BIM; Milles, LF; Dauparas, J; Wang, J; Kipnis, Y; Jameson, N; Kang, AL; De La Cruz, J; Sankaran, B; Bera, AK; Jiménez-Osés, G; Baker, ...

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2024-01-09

Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes

Carranza, M; Carmona, AT; Navo, CD; Robina, I; Fratta, S; Newburn, C; Jiménez-Osés, G; Moreno-Vargas, AJ;

ORGANIC LETTERS

2023-10-10

Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process

Méndez, Y; Vasco, AV; Ivey, G; Dias, AL; Gierth, P; Sousa, BB; Navo, CD; Torres-Mozas, A; Rodrigues, T; Jiménez-Osés, G; Bernardes, GJL;

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2023-09-20