Ander Vidaurrazaga
avidaurrazaga
Ander Vidaurrazaga
LABORATORY TECHNICIAN
Structure and Cell Biology of Viruses Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

The past years (2020-2021) have underscored the critical importance of research in virology and immunology. Rapid responses to pandemic events depend on years of accumulated basic knowledge and ongoing technological advancements. Studying viruses that infect Bacteria, Archaea, or Eukaryotes—whether from basic, clinical, or translational perspectives—ultimately benefits society. The Abrescia Lab focuses on understanding the molecular mechanisms governing viral pathogenesis through structural methods. Our research areas include virus assembly, virus cell entry, and virus-antibody recognition mechanisms.

By deciphering the principles of virus assembly, we aim to develop strategies to interfere with viral morphogenesis. Expanding our structural knowledge of the viral world (virosphere) helps uncover viral relationships that are not apparent at the sequence level. Understanding virus cell entry processes enables us to disrupt this key-lock mechanism, often using antibodies. By studying recognition and neutralization processes, we increase the potential for fine-tuning these mechanisms.

We employ an integrative approach based on X-ray crystallography and Electron Microscopy (EM) techniques, complemented by functional studies. Our access to high-end electron microscopy and crystallographic infrastructure allows us to resolve viral and viral protein structures at atomic detail. This knowledge helps elucidate molecular mechanisms and translates into molecular tools such as drugs, diagnostics, and vaccines to improve human and animal health.

Our group combines electron microscopy and tomography, X-ray crystallography, and biophysical methods with expertise in molecular and cell biology. Our structural studies are complemented by functional data. Our targets include:

Research line 1: Viruses with internal membranes and medically relevant human and animal enveloped viruses
Research line 2: Viral vectors for gene therapy, such as AAV
Research line 3: Prototype vaccines within the ONE HEALTH framework

Collaborations
Hanna M Oksanen (University of Finland). Alejandro Brun (CISA-INIA, Madrid). David I Stuart (University of Oxford). Santiago Elena (I2SysBio, CSIC – Universitat de València). Javier Ortego (CISA-INIA, Madrid). Viralgen biotech (San Sebastian). VIVEbiotech (San Sebastian).

Links
https://www.deia.eus/opinion/tribuna-abierta/2017/01/19/potente-mirada-euskadi-futuro/551456.html

Latest Publications

Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors

López-Estévez, AM; Sanjurjo, L; Turrero, A; Arriaga, I; Abrescia, NGA; Poveda, A; Jimenez-Barbero, J; Vidal, A; Torres, D; Alonso, MJ;

JOURNAL OF CONTROLLED RELEASE

2024-07-15

Seroprevalence of adeno-associated virus types 1, 2, 3, 4, 5, 6, 8, and 9 in a Basque cohort of healthy donors

Navarro-Oliveros, M; Vidaurrazaga, A; Guerra, GS; Castellana, D; Embade, N; Millet, O; Marigorta, UM; Abrescia, NGA;

SCIENTIFIC REPORTS

2024-07-10

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Lachiondo-Ortega, S; Rejano-Gordillo, CM; Simon, J; Lopitz-Otsoa, F; Delgado, TC; Mazan-Mamczarz, K; Goikoetxea-Usandizaga, N; Zapata-Pavas, LE; García-del Río, A; Guerra, P; Peña-Sanfélix, ...

CELL REPORTS

2024-03-26

Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection

Stagnoli, S; Macari, G; Corsi, P; Capone, B; Vidaurrazaga, A; Ereño-Orbea, J; Ardá, A; Polticelli, F; Jiménez-Barbero, J; Abrescia, NGA; Coluzza, I;

ACS OMEGA

2023-11-13

Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption

Berrecoso, G; Bravo, SB; Arriaga, I; Abrescia, N; Crecente-Campo, J; Alonso, MJ;

DRUG DELIVERY AND TRANSLATIONAL RESEARCH

2023-10-08

Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice

Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;

VACCINE

2023-05-12

Molecular Recognition of Glycan-Bearing Glycomacromolecules Presented at Membrane Surfaces by Lectins: An NMR View

Lete, MG; Hoffmann, M; Schomann, N; Martínez-Castillo, A; Peccati, F; Konietzny, PB; Delgado, S; Snyder, NL; Jiménez-Oses, G; Abrescia, NGA; Ardá, A; Hartmann, L; Jiménez-Barbero, J;

ACS OMEGA

2023-05-03

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-23

Cellular and Structural Characterization of VP1 and VP2 Knockout Mutants of AAV3B Serotype and Implications for AAV Manufacturing

Arriaga, I; Navarro, A; Etxabe, A; Trigueros, C; Samulski, RJ; Moullier, P; François, A; Abrescia, NGA;

HUMAN GENE THERAPY

2022-11-01

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Stagnoli, S; Peccati, F; Connell, SR; Martinez-Castillo, A; Charro, D; Millet, O; Bruzzone, C; Palazon, A; Arda, A; Jimenez-Barbero, J; Ereno-Orbea, J; Abrescia, NGA; Jimenez-Oses, G;

FRONTIERS IN MICROBIOLOGY

2022-04-15

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Delgado, TC; Simón, J; Ramos, DF; Barriales, D; Cornide, ME; Jiménez, M; Pérez-Redondo, M; Lachiondo-Ortega, S; Rodríguez-Agudo, R; Bizkarguenaga, ...

HEPATOLOGY

2021-12-15

Bacteriophage PRD1 as a nanoscaffold for drug loading

Duyvesteyn, HME; Santos-Pérez, I; Peccati, F; Martinez-Castillo, A; Walter, TS; Reguera, D; Goñi, FM; Jiménez-Osés, G; Oksanen, HM; Stuart, DI; Abrescia, NGA;

NANOSCALE

2021-12-01

Chemoenzymatic Synthesis of Complex N-Glycans of the Parasite S. mansoni to Examine the Importance of Epitope Presentation on DC-SIGN recognition

Srivastava, AD; Unione, L; Bunyatov, M; Gagarinov, IA; Delgado, S; Abrescia, NGA; Ardá, A; Boons, GJ;

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2021-07-16

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

Bertuzzi, S; Gimeno, A; Martinez-Castillo, A; Lete, MG; Delgado, S; Airoldi, C; Tavares, MR; Bláhová, M; Chytil, P; Kren, V; Abrescia, NGA; Ardá, A; Bojarová, P; Jiménez-Barbero, J;

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021-06-01

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Robakiewicz, S; Bridot, C; Serna, S; Gimeno, A; Echeverria, B; Delgado, S; de Ruyck, J; Semwal, S; Charro, D; Dansercoer, A; Verstraete, K; Azkargorta, M; van Noort, K; Wilbers, RHP; Savvides, ...

GLYCOBIOLOGY

2021-04-28

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Egia-Mendikute, L; Bosch, A; Prieto-Fernández, E; Lee, SY; Jiménez-Lasheras, B; del Río, AG; Antoñana-Vildosola, A; Bruzzone, C; Bizkarguenaga, M; Embade, N; Gil-Redondo, R; Martínez-Chantar, ...

COMMUNICATIONS BIOLOGY

2021-04-20

A novel Schmallenberg virus subunit vaccine candidate protects IFNAR-/- mice against virulent SBV challenge

Boshra, H; Lorenzo, G; Charro, D; Moreno, S; Guerra, GS; Sanchez, I; Garrido, JM; Geijo, M; Brun, A; Abrescia, NGA;

SCIENTIFIC REPORTS

2020-11-23

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazn, A; Marcelo, F; Jiménez-Osés, G; ...

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020-10-22

Superimposition of Viral Protein Structures: A Means to Decipher the Phylogenies of Viruses

Ravantti, JJ; Martinez-Castillo, A; Abrescia, NGA;

VIRUSES-BASEL

2020-10-01

The cryo-EM structure of African swine fever virus unravels a unique architecture comprising two icosahedral protein capsids and two lipoprotein membranes.

Andres, German; Charro, Diego; Matamoros, Tania; Dillard, Rebecca S; Abrescia, Nicola G A;

The Journal of biological chemistry

2020-01-03