Adrián Vicente Barrueco
Adrián Vicente Barrueco
DOCTORAL CANDIDATE
Cancer Cell Signaling And Metabolism Lab
Orcid: 0000-0002-9660-1315
Email: avicente@cicbiogune.es
Phone: 4234 / 944 061 323
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

Aggressive prostate cancer is associated with pericyte dysfunction

Martinez-Romero, A; Martinez-Larrinaga, A; Grego-Bessa, J; Garcia-Longarte, S; van Splunder, H; Astobiza, I; Ercilla, A; Bozal-Basterra, L; Mendizabal, I; Villacampa, P; Carracedo, A; Graupera, ...

Molecular Oncology

2025-11-03

Unravelling the role of L-and Dalanine in prostate cancer: a Positron Emission Tomography study in a genetic mouse model

Castellnou, P; Gómez-Martínez, M; Gómez-Vallejo, V; Baz, Z; López-Gallego, F; Rondon-Lorefice, I; Zabala-Letona, A; Poot, AJ; Mendizabal, I; Carracedo, A; Rejc, L; Llop, J;

NUCLEAR MEDICINE AND BIOLOGY

2025-09-25

A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer

Ercilla, A; Crespo, JR; Garcia-Longarte, S; Fidalgo, M; del Palacio, S; Martin-Martin, N; Carlevaris, O; Astobiza, I; Fernández-Ruiz, S; Guiu, M; Bárcena, L; Mendizabal, I; Aransay, AM; Graupera, ...

MOLECULAR ONCOLOGY

2025-09-15

Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential

Mercado-Gómez , M; Goikoetxea-Usandizaga, N; Giné, AE; Rodrigo, MAM; Afonso, MB; Azkargorta, M; Zapata-Pavas, LE; Rejano-Gordillo, CM; Romero, MR; Mendizabal, I; Rodrigues, PM; Wu, HH; Rodríguez-Agudo, ...

GUT

2025-08-05

Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination

Martin-Martin, N; Garcia-Longarte, S; Corres-Mendizabal, J; Lazcano, U; Astobiza, I; Bozal-Basterra, L; Herranz, N; van Splunder, H; Carlevaris, O; Pujana-Vaquerizo, M; Blasco, MT; Aransay, ...

GENOME BIOLOGY

2025-06-03

Precision proteogenomics reveals pan-cancer impact of germline variants

Rodrigues, FM; Terekhanova, NV; Imbach, KJ; Clauser, KR; Selvan, ME; Mendizabal, I; Geffen, Y; Akiyama, Y; Maynard, M; Yaron, TM; Li, YZ; Cao, S; Storrs, EP; Gonda, OS; Gaite-Reguero, A; Govindan, ...

CELL

2025-05-01

Asymmetrical Evolution of Promoter Methylation of Mammalian Genes after Duplication

de la Fuente, M; Mendizabal, I; Han, M; Yi, S; Alvarez-Ponce, D;

MOLECULAR BIOLOGY AND EVOLUTION

2024-12-30

Human brain aging is associated with dysregulation of cell type epigenetic identity

Jeong, H; Mendizabal, I; Yi, SV;

GEROSCIENCE

2024-12-27

The PP2A regulator IER5L supports prostate cancer progression

Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...

CELL DEATH & DISEASE

2024-07-18

Human Brain Aging is Associated with Dysregulation of Cell-Type Epigenetic Identity.

Jeong, Hyeonsoo; Mendizabal, Isabel; Yi, Soojin V;

bioRxiv : the preprint server for biology

2024-06-03

DNA methylation differences between the female and male X chromosomes in human brain.

Morgan, Robert; Loh, Eddie; Singh, Devika; Mendizabal, Isabel; Yi, Soojin V;

bioRxiv : the preprint server for biology

2024-04-17

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...

MOLECULAR CANCER

2023-07-29

Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Santasusagna, S; Zhu, S; Jawalagatti, V; Carceles-Cordon, M; Ertel, A; Garcia-Longarte, S; Song, WM; Fujiwara, N; Li, P; Mendizabal, I; Petrylak, DP; Kelly, WK; Reddy, EP; Wang, L; Schiewer, ...

CANCER DISCOVERY

2023-01-01

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

Feu, S; Unzueta, F; Ercilla, A; Pérez-Venteo, A; Jaumot, M; Agell, N;

PLOS ONE

2022-08-15

Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer

Arruabarrena-Aristorena, A; Toska, E;

FRONTIERS IN ONCOLOGY

2022-06-14

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Zabala-Letona, A; Arruabarrena-Aristorena, A; Fernandez-Ruiz, S; Viera, C; Carlevaris, O; Ercilla, A; Mendizabal, I; Martin, T; Macchia, A; Camacho, L; Pujana-Vaquerizo, M; Sanchez-Mosquera, ...

ONCOGENESIS

2022-02-23

Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients

Rodriguez, RM; Hernández-Fuentes, MP; Corte-Iglesias, V; Saiz, ML; Lozano, JJ; Cortazar, AR; Mendizabal, I; Suarez-Fernandez, ML; Coto, E; López-Vázquez, A; Díaz-Corte, C; Aransay, AM; López-Larrea, ...

FRONTIERS IN IMMUNOLOGY

2021-08-20

Evolution of DNA methylation in the human brain

Jeong, H; Mendizabal, I; Berto, S; Chatterjee, P; Layman, T; Usui, N; Toriumi, K; Douglas, C; Singh, D; Huh, I; Preuss, TM; Konopka, G; Yi, S;

NATURE COMMUNICATIONS

2021-04-01

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, P; Astobiza, I; Cortazar, AR; Torrano, V; Macchia, A; Flores, JM; Niespolo, C; Mendizabal, I; Caloto, R; Ercilla, A; Camacho, L; Arreal, L; Bizkarguenaga, M; Martinez-Chantar, ML; ...

CANCERS

2020-09-01