At the Precision Cancer Multiomics Lab, we study the molecular, cellular, and tissue-level processes that shape prostate cancer development and clinical behavior. By combining multiomic profiling, computational analysis, and imaging approaches, we aim to better understand why tumors differ so widely and how this diversity can inform diagnosis and patient care.
Research line 1: Regulatory programs shaping prostate cancer progression
We study genomic, epigenomic, and transcriptional programs that contribute to how prostate tumors arise and progress. This line focuses on understanding the regulatory mechanisms and cellular interactions that influence tumor behavior.
Research line 2: Comparative profiling of prostate disease states
Our group examines shared and distinct molecular features across prostate conditions. By placing prostate cancer in the broader context of prostate disease, we seek to clarify biological relationships that help explain clinical heterogeneity.
Research line 3: Computational mapping of tumor diversity
We use advanced computational approaches, including AI, to study tumor architecture and microenvironmental patterns. These tools help us identify features linked to tumor heterogeneity and clinical outcomes, complementing our multiomic research.
Collaborations
We maintain close collaborations with a number of clinical and research partners who play a key role in our work, including Ainara Azueta and Ana Loizaga-Iriarte (Basurto University Hospital, Pathology and Urology departments, respectively), Enrique González-Billalabeitia (Hospital 12 de Octubre, Oncology), Mariona Graupera and Eduard Porta-Pardo (Josep Carreras Leukemia Research Institute), and Arkaitz Carracedo (CIC bioGUNE). We have also contributed to the European PIPgen Network (MSCA-ITN) on PI3K/PTEN-related diseases, as well as to collaborative publications with the Clinical Proteomic Tumor Analysis Consortium (National Cancer Institute, USA).
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Group Leader
Isabel Mendizabal
Ikerbasque Research Fellow - Ramón y Cajal Programme TECHNICIANS / DOCTORAL CANDIDATES -
Uxue Lazcano Dobao
AECC Predoctoral Fellow
Members
Latest Publications
Transcriptional network analysis of PTEN-protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Rondon-Lorefice, I; Lopez, JI; Ugalde-Olano, A; Zufiaurre, M; Astobiza, I; Martin-Martin, N; Bozal-Basterra, L; Garcia-Longarte, S; Zabala-Letona, A; Rey, S; Santos-Martin, A; Unda, M; Loizaga-Iriarte, ...
MOLECULAR ONCOLOGY
2025-11-17
Aggressive prostate cancer is associated with pericyte dysfunction
Martinez-Romero, A; Martinez-Larrinaga, A; Grego-Bessa, J; Garcia-Longarte, S; van Splunder, H; Astobiza, I; Ercilla, A; Bozal-Basterra, L; Mendizabal, I; Villacampa, P; Carracedo, A; Graupera, ...
MOLECULAR ONCOLOGY
2025-10-21
Unravelling the role of L-and Dalanine in prostate cancer: a Positron Emission Tomography study in a genetic mouse model
Castellnou, P; Gómez-Martínez, M; Gómez-Vallejo, V; Baz, Z; López-Gallego, F; Rondon-Lorefice, I; Zabala-Letona, A; Poot, AJ; Mendizabal, I; Carracedo, A; Rejc, L; Llop, J;
NUCLEAR MEDICINE AND BIOLOGY
2025-09-25
A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer
Ercilla, A; Crespo, JR; Garcia-Longarte, S; Fidalgo, M; del Palacio, S; Martin-Martin, N; Carlevaris, O; Astobiza, I; Fernández-Ruiz, S; Guiu, M; Bárcena, L; Mendizabal, I; Aransay, AM; Graupera, ...
MOLECULAR ONCOLOGY
2025-09-15
Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential
Mercado-Gómez , M; Goikoetxea-Usandizaga, N; Giné, AE; Rodrigo, MAM; Afonso, MB; Azkargorta, M; Zapata-Pavas, LE; Rejano-Gordillo, CM; Romero, MR; Mendizabal, I; Rodrigues, PM; Wu, HH; Rodríguez-Agudo, ...
GUT
2025-08-05
Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination
Martin-Martin, N; Garcia-Longarte, S; Corres-Mendizabal, J; Lazcano, U; Astobiza, I; Bozal-Basterra, L; Herranz, N; van Splunder, H; Carlevaris, O; Pujana-Vaquerizo, M; Blasco, MT; Aransay, ...
GENOME BIOLOGY
2025-06-03
Precision proteogenomics reveals pan-cancer impact of germline variants
Rodrigues, FM; Terekhanova, NV; Imbach, KJ; Clauser, KR; Selvan, ME; Mendizabal, I; Geffen, Y; Akiyama, Y; Maynard, M; Yaron, TM; Li, YZ; Cao, S; Storrs, EP; Gonda, OS; Gaite-Reguero, A; Govindan, ...
CELL
2025-05-01
Asymmetrical Evolution of Promoter Methylation of Mammalian Genes after Duplication
de la Fuente, M; Mendizabal, I; Han, M; Yi, S; Alvarez-Ponce, D;
MOLECULAR BIOLOGY AND EVOLUTION
2024-12-30
Human brain aging is associated with dysregulation of cell type epigenetic identity
Jeong, H; Mendizabal, I; Yi, SV;
GEROSCIENCE
2024-12-27
The PP2A regulator IER5L supports prostate cancer progression
Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...
CELL DEATH & DISEASE
2024-07-18
Human Brain Aging is Associated with Dysregulation of Cell-Type Epigenetic Identity.
Jeong, Hyeonsoo; Mendizabal, Isabel; Yi, Soojin V;
bioRxiv : the preprint server for biology
2024-06-03
DNA methylation differences between the female and male X chromosomes in human brain.
Morgan, Robert; Loh, Eddie; Singh, Devika; Mendizabal, Isabel; Yi, Soojin V;
bioRxiv : the preprint server for biology
2024-04-17
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...
MOLECULAR CANCER
2023-07-29
Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer
Santasusagna, S; Zhu, S; Jawalagatti, V; Carceles-Cordon, M; Ertel, A; Garcia-Longarte, S; Song, WM; Fujiwara, N; Li, P; Mendizabal, I; Petrylak, DP; Kelly, WK; Reddy, EP; Wang, L; Schiewer, ...
CANCER DISCOVERY
2023-01-01
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Zabala-Letona, A; Arruabarrena-Aristorena, A; Fernandez-Ruiz, S; Viera, C; Carlevaris, O; Ercilla, A; Mendizabal, I; Martin, T; Macchia, A; Camacho, L; Pujana-Vaquerizo, M; Sanchez-Mosquera, ...
ONCOGENESIS
2022-02-23
Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients
Rodriguez, RM; Hernández-Fuentes, MP; Corte-Iglesias, V; Saiz, ML; Lozano, JJ; Cortazar, AR; Mendizabal, I; Suarez-Fernandez, ML; Coto, E; López-Vázquez, A; Díaz-Corte, C; Aransay, AM; López-Larrea, ...
FRONTIERS IN IMMUNOLOGY
2021-08-20
Evolution of DNA methylation in the human brain
Jeong, H; Mendizabal, I; Berto, S; Chatterjee, P; Layman, T; Usui, N; Toriumi, K; Douglas, C; Singh, D; Huh, I; Preuss, TM; Konopka, G; Yi, S;
NATURE COMMUNICATIONS
2021-04-01
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P; Astobiza, I; Cortazar, AR; Torrano, V; Macchia, A; Flores, JM; Niespolo, C; Mendizabal, I; Caloto, R; Ercilla, A; Camacho, L; Arreal, L; Bizkarguenaga, M; Martinez-Chantar, ML; ...
CANCERS
2020-09-01