Alba Mosteiro Couso
Alba Mosteiro Couso
LABORATORY TECHNICIAN
Inflammation and Macrophage Plasticity Lab & Chemical Immunology Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The work that our group has been conducting during the last decade has focused on the understanding of myeloid cell responses to microorganisms. Since our initial focus on inflammation induced by infection with the causative agent of Lyme borreliosis, our interest has broadened to the general mechanisms that drive both short and long-term monocyte/macrophage responses to diverse microorganisms, including pathogenic (systemic – Borrelia burgdorferi, Mycobacterium tuberculosis; or intestinal – Fusobacterium nucleatum, enteropathogenic E. coli) as well as symbiotic bacteria (Lactoplantibacillus plantarum, Akkermansia municipila).

Our goal is to identify general trends of innate immune memory responses and delineate specific regulatory networks that are associated with the overall activity of these cells. We have focused our efforts on live microorganisms and the specific responses that arise from the complex engagement of pattern recognition receptors and secondary responses resulting from metabolic changes, addressing the full functionality of innate immune cells, including internalization events (i.e. phagocytosis), transcriptional changes (mRNAseq, ATACseq, microRNAseq), their metabolic status, and the induction of soluble factors.

On the other hand, we have had a long interest on the mechanisms that drive inflammatory responses during murine Lyme borreliosis as well as the identification of therapeutic (vaccine candidates, small anti-inflammatory molecules, etc.) interventions against the bacterium and its arthropod vector (Ixodes spp. ticks).

Research line 1: Trained immune responses to pathogens and symbionts of diverse ecologies
Research line 2: Mechanisms of action and efficacy of novel vaccine adjuvants
Research line 3: Tick immunity and tick-specific vaccine formulations
Research line 4: Infection in the context of colorectal cancer
Research line 5: Microbiota and its associated metabolome in homeostasis and disease

Collaborations
Utpal Pal (University of Maryland College Park), Erol Fikrig (University of Yale School of Medicine), Francesco Peri & Siobhán McClean (BactiVax), Joppe Hovius & Boris Klempa (AntiDotE).

Links
BactiVax (https://www.bactivax.eu)

Latest Publications

An in vitro analysis of the interaction between infliximab and granulocyte-monocyte apheresis.

Rodriguez-Lago, Iago; Abecia, Leticia; Seoane, Iratxe; Anguita, Juan; Cabriada, Jose Luis;

Gastroenterologia y hepatologia

2024-04-01

Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies

Franco, AR; Sadones, O; Romerio, A; Artusa, V; Shaik, MM; Pasco, ST; Italia, A; DAmato, S; Anguita, J; Huebner, J; Romero-Saavedra, F; Peri, F;

JOURNAL OF MEDICINAL CHEMISTRY

2024-03-21

Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Peña-Cearra, A; Palacios, A; Pellon, A; Castelo, J; Pasco, ST; Seoane, I; Barriales, D; Martin, JE; Pascual-Itoiz, MA; Gonzalez-Lopez, M; Martín-Ruiz, I; Macías-Cámara, N; Gutiez, N; Araujo-Aris, ...

COMMUNICATIONS BIOLOGY

2024-02-16

Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Peña-Cearra, A; Castelo, J; Lavín, JL; Gonzalez-Lopez, M; Pascual-Itoiz, MA; Fuertes, M; de Juan, VG; Bárcena, L; Martín-Ruiz, I; Pellón, A; Seoane, I; Barriales, D; Palacios, A; Fullaondo, ...

GUT MICROBES

2023-12-18

Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

Pena-Cearra, A; Song, DG; Castelo, J; Palacios, A; Lavin, JL; Azkargorta, M; Elortza, F; Fuertes, M; Pascual-Itoiz, MA; Barriales, D; Martin-Ruiz, I; Fullaondo, A; Aransay, AM; Rodriguez, H; ...

NPJ BIOFILMS AND MICROBIOMES

2023-10-07

Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice

Guerra, GS; Barriales, D; Lorenzo, G; Moreno, S; Anguita, J; Brun, A; Abrescia, NGA;

VACCINE

2023-05-12

Dynamin-like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis

Gupta, S; Bhagavathula, M; Sharma, V; Sharma, N; Sharma, N; Biswas, A; Palacios, A; Salgueiro, V; Lavín, JL; Dogra, N; Salgame, P; Prados-Rosales, R; Rodríguez, GM;

EMBO REPORTS

2023-04-20

The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine

Klouwens, MJ; Trentelman, JJA; Barriales, D; Ersoz, JI; Azkargorta, M; Elortza, F; Síma, R; Hajdusek, O; Cortazar, JT; Corcuera, IE; Colstrup, E; Nayak, A; Ruíz, IM; Rodriguez, H; Nijhof, AM; ...

VACCINE

2023-03-04

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;

CHEMICAL SCIENCE

2023-03-01

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Romerio, A; Gotri, N; Franco, AR; Artusa, V; Shaik, MM; Pasco, ST; Atxabal, U; Matamoros-Recio, A; Mínguez-Toral, M; Zalamea, JD; Franconetti, A; Abrescia, NGA; Jimenez-Barbero, J; Anguita, ...

JOURNAL OF MEDICINAL CHEMISTRY

2023-02-23

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

Rana, VS; Kitsou, C; Dutta, S; Ronzetti, MH; Zhang, M; Bernard, Q; Smith, AA; Tomás-Cortázar, J; Yang, XL; Wu, MJ; Kepple, O; Li, WZ; Dwyer, JE; Matias, J; Baljinnyam, B; Oliver, JD; Rajeevan, ...

SCIENCE

2023-01-12

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

González-Recio, I; Simón, J; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Mercado-Gómez, M; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Gil-Pitarch, C; Fernández-Rodríguez, C; Castellana, D; Latasa, ...

NATURE COMMUNICATIONS

2022-11-25

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Juárez-Fernández, M; Goikoetxea-Usandizaga, N; Porras, D; García-Mediavilla, MV; Bravo, M; Serrano-Maciá, M; Simón, J; Delgado, TC; Lachiondo-Ortega, S; Martínez-Flórez, S; Lorenzo, O; Rincón, ...

HEPATOLOGY

2022-09-12

Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Peña-Cearra, A; Pascual-Itoiz, MA; Lavin, JL; Fuertes, M; Martín-Ruiz, I; Castelo, J; Palacios, A; Barriales, D; Fullaondo, A; Aransay, AM; Rodríguez, H; Anguita, J; Abecia, L;

SCIENTIFIC REPORTS

2022-06-15

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R; Aguinagalde, L; Pifferi, C; Plata, A; Sacristan, N; Castellana, D; Anguita, J; Fernandez-Tejada, A;

FRONTIERS IN IMMUNOLOGY

2022-05-06

Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of l-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease

Simó, C; Fornari, T; García-Risco, MR; Peña-Cearra, A; Abecia, L; Anguita, J; Rodríguez, H; García-Cañas, V;

FOOD & FUNCTION

2022-04-12

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

Chaves-Arquero, B; Persson, C; Merino, N; Tomás-Cortazar, J; Rojas, AL; Anguita, J; Blanco, FJ;

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-03-01

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Delgado, TC; Simón, J; Ramos, DF; Barriales, D; Cornide, ME; Jiménez, M; Pérez-Redondo, M; Lachiondo-Ortega, S; Rodríguez-Agudo, R; Bizkarguenaga, ...

HEPATOLOGY

2021-12-15

Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics

Bizkarguenaga, M; Bruzzone, C; Gil-Redondo, R; SanJuan, I; Martin-Ruiz, I; Barriales, D; Palacios, A; Pasco, ST; González-Valle, B; Laín, A; Herrera, L; Azkarate, A; Vesga, MA; Eguizabal, C; ...

NMR IN BIOMEDICINE

2021-10-27

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

Mancheño, JM; Atondo, E; Tomás-Cortázar, J; Lavín, JL; Plaza-Vinuesa, L; Martín-Ruiz, I; Barriales, D; Palacios, A; Navo, CD; Sampedro, L; Peña-Cearra, A; Pascual-Itoiz, MA; Castelo, J; Carreras-González, ...

MICROBIAL BIOTECHNOLOGY

2020-12-18

The clinical success of anticancer and antiviral vaccines often requires co-administration of an adjuvant, a substance that enhances the immunogenicity of the antigen and potentiates the immune response. However, few adjuvants exhibit sufficient potency and negligible toxicity to be suitable for clinical use; moreover, their mechanisms of action are generally not fully understood. Current subunit vaccines based on weakly immunogenic carbohydrate and glycopeptide antigens are not being very successful in eliciting a strong immune response against cancer, and no such carbohydrate-based anticancer vaccine has yet been approved for humans despite extensive research efforts and several clinical trials. In this context, building upon the PI's previous background and expertise in the area, the research program in the Fernández-Tejada Group has a double, ultimate goal based on applying chemistry to address the above clear gaps in the adjuvant/vaccine field. With this idea in mind, the Chemical Immunology Lab established by Dr. Fernández-Tejada at CIC bioGUNE will develop new improved adjuvants and novel chemical strategies towards more effective, self-adjuvanting synthetic vaccines. Moreover, leveraging the extraordinary facilities and scientific expertise available at CIC bioGUNE, we will also focus on investigating the molecular mechanisms of the synthetic constructs by combining extensive immunological evaluations with molecular target identification studies and detailed conformational analysis. Thus, the Fernández-Tejada Group builds upon a highly multidisciplinary program integrating ambitious objectives and complementary approaches at the chemistry-biology frontier. Research in the Chemical Immunology Lab connects chemical synthesis and chemical/structural biology with cellular and molecular immunology to explore key unresolved mechanistic questions in the adjuvant/vaccine arena with extraordinary chemical precision.

The Fernández-Tejada Lab is funded primarily by the European Research Council through an ERC Starting Grant, which provides €1.5 million funding for a transformative and timely research program aimed at developing novel synthetic self-adjuvanting vaccines with improved properties and efficacy, as well as unraveling the molecular basis and three-dimensional structure underlying the biological activity of these constructs.

Latest Publications

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Pifferi, C; Aguinagalde, L; Ruiz-de-Angulo, A; Sacristán, N; Baschirotto, PT; Poveda, A; Jiménez-Barbero, J; Anguita, J; Fernández-Tejada, A;

CHEMICAL SCIENCE

2023-03-01

Chemical biology tools to interrogate the roles of O-GlcNAc in immunity

Saha, A; Fernández-Tejada, A;

FRONTIERS IN IMMUNOLOGY

2023-01-26

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Fuentes, R; Aguinagalde, L; Pifferi, C; Plata, A; Sacristan, N; Castellana, D; Anguita, J; Fernandez-Tejada, A;

FRONTIERS IN IMMUNOLOGY

2022-05-06

Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

Fuentes, R; Aguinagalde, L; Sacristán, N; Fernández-Tejada, A;

CHEMICAL COMMUNICATIONS

2021-10-14

Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms

Saha, A; Bello, D; Fernández-Tejada, A;

CHEMICAL SOCIETY REVIEWS

2021-08-02

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

Schijns, V; Majhen, D; van der Ley, P; Thakur, A; Summerfield, A; Berisio, R; Nativi, C; Fernández-Tejada, A; Alvarez-Dominguez, C; Gizurarson, S; Zamyatina, A; Molinaro, A; Rosano, C; Jakopin, ...

PHARMACEUTICS

2021-04-01

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action.

Pifferi, Carlo; Fuentes, Roberto; Fernandez-Tejada, Alberto;

Nature Reviews Chemistry

2021-03-01

Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Fuentes, R; Ruiz-de-Angulo, A; Sacristán, N; Navo, CD; Jiménez-Osés, G; Anguita, J; Fernández-Tejada, A;

CHEMISTRY-A EUROPEAN JOURNAL

2021-02-04

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action.

Pifferi, Carlo; Fuentes, Roberto; Fernandez-Tejada, Alberto;

Nature reviews. Chemistry

2021-01-25

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

Pifferi, C; Fuentes, R; Fernández-Tejada, A;

NATURE REVIEWS CHEMISTRY

2021-01-25

Synthetic carbohydrate-based HIV-1 vaccines.

Bastida, Inaki; Fernandez-Tejada, Alberto;

Drug discovery today. Technologies

2020-12-01

Therapeutic Pretargeting with Gold Nanoparticles as Drug Candidates for Boron Neutron Capture Therapy

Feiner, IVJ; Pulagam, KR; Gómez-Vallejo, V; Zamacola, K; Baz, Z; Caffarel, MM; Lawrie, CH; Ruiz-de-Angulo, A; Carril, M; Llop, J;

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

2020-09-23

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Schijns, V; Fernández-Tejada, A; Barjaktarovic, Z; Bouzalas, I; Brimnes, J; Chernysh, S; Gizurarson, S; Gursel, I; Jakopin, Z; Lawrenz, M; Nativi, C; Paul, S; Pedersen, GK; Rosano, C; Ruiz-de-Angulo, ...

IMMUNOLOGICAL REVIEWS

2020-06-28

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Pifferi, C; Ruiz-de-Angulo, A; Goyard, D; Tiertant, C; Sacristán, N; Barriales, D; Berthet, N; Anguita, J; Renaudet, O; Fernández-Tejada, A;

CHEMICAL SCIENCE

2020-05-07

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Ghirardello, M; Ruiz-de-Angulo, A; Sacristan, N; Barriales, D; Jiménez-Barbero, J; Poveda, A; Corzana, F; Anguita, J; Fernández-Tejada, A;

CHEMICAL COMMUNICATIONS

2020-01-16

β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Wang, HX; Yang, B; Wang, YL; Liu, F; Fernández-Tejada, A; Dong, SW;

CHEMICAL COMMUNICATIONS

2019-01-07

Design, synthesis and evaluation of optimized saponin variants derived from the vaccine adjuvant QS-21

Fernández-Tejada, A;

PURE AND APPLIED CHEMISTRY

2017-09-01

Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth

Rao, TD; Fernández-Tejada, A; Axelrod, A; Rosales, N; Yan, XJ; Thapi, S; Wang, A; Park, KJ; Nemieboka, B; Xiang, JY; Lewis, JS; Olvera, N; Levine, DA; Danishefsky, SJ; Spriggs, DR;

ACS CHEMICAL BIOLOGY

2017-08-01

Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Walkowicz, WE; Fernández-Tejada, A; George, C; Corzana, F; Jiménez-Barbero, J; Ragupathi, G; Tan, DS; Gin, DY;

CHEMICAL SCIENCE

2016-01-01

Glycans in Medicinal Chemistry: An Underexploited Resource

Fernández-Tejada, A; Cañada, FJ; Jiménez-Barbero, J;

CHEMMEDCHEM

2015-08-01