Alfonso Martínez de la Cruz
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Alfonso Martínez de la Cruz
ASSOCIATE PRINCIPAL INVESTIGATOR
Liver Disease Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Alfonso Martínez de la Cruz got his undergraduate degree in Chemistry from the Universidad Autónoma de Madrid, Spain (1992). He finished his PhD work at the Department of Crystallography of Institute Rocasolano (1997) under a FPI fellowship from the Spanish Ministry of Science. Afterwards, he held three post doctoral positions, first at the Max Planck Institute Für Medizinische Forschung in Heidelberg, Germany in the lab of Professors Ken Holmes and Wolfgang Kabsch, where he carried out structural studies of proteins involved in Chagas disease (March-October, 1997). His work there was done in collaboration with Prof. Luise Krauth-Siegel, at the Department of Biochemistry of the University of Heidelberg. In October 1997 he moved to USA to join Sung-Hou Kim´s lab at Univ. of California, Berkeley, granted by a Fulbright Fellowship and later by a postdoctoral contract at the Department of Chemistry of this University. His work at Berkeley focused on the nascent Structural Genomics Initiative, aimed to perform high-throughput structure determination of proteins to setup the limits of the protein fold universe. In September 2000, he returned to Spain and joined the lab of Prof. José María Mato at the Univ. of Navarra, in Pamplona, granted first by a postdoctoral fellowship and later under a contract as a Scientist at the Center for Applied Medical Research (CIMA). During his stay in Pamplona he performed structural studies on enzymes regulated by S-adenosylmethionine (AdoMet), a hub molecule of the methionine cycle, that regulates the activity of several metabolic enzymes linked to the development of human liver diseases, including liver cancer and several rare pathologies. The biological relevance and complex regulation of one of this enzymes, cystathionine beta-synthase (CBS), which is key in regulating the transsulfuration pathway in mammals, focused his attention for future studies. In January 2005, he joined CIC bioGUNE, in Bilbao, as Principal Investigator.

Latest Publications

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Latest Publications

The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2)

Franken, GAC;Muller, D;Mignot, C;Keren, B;Levy, J;Tabet, AC;Germanaud, D;Tejada, MI;Kroes, HY;Nievelstein, RAJ;Brimble, E;Ruzhnikov, M;Claverie-Martin, F;Szczepanska, M;Cuk, M;Latta, F;Konrad, ...

HUMAN MUTATION

2021-03-01

Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease

Martinez-Chantar, ML;Delgado, TC;Beraza, N

FRONTIERS IN IMMUNOLOGY

2021-02-18

Glutamine, fatty liver disease and aging

Simon, J;Martinez-Chantar, ML;Delgado, TC

AGING-US

2021-02-15

Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models

Lee-Law, PY;Olaizola, P;Caballero-Camino, FJ;Izquierdo-Sanchez, L;Rodrigues, PM;Santos-Laso, A;Azkargorta, M;Elortza, F;Martinez-Chantar, ML;Perugorria, MJ;Aspichueta, P;Marzioni, M;LaRusso, ...

JOURNAL OF HEPATOLOGY

2021-02-01

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Fondevila, MF;Mercado-Gomez, M;Rodriguez, A;Gonzalez-Rellan, MJ;Iruzubieta, P;Valenti, V;Escalada, J;Schwaninger, M;Prevot, V;Dieguez, C;Crespo, J;Fruhbeck, G;Martinez-Chantar, ML;Nogueiras, ...

JOURNAL OF HEPATOLOGY

2021-02-01

Magnesium, Little Known But Possibly Relevant: A Link between NASH and Related Comorbidities

Simon, J;Delgado, TC;Martinez-Cruz, LA;Martinez-Chantar, ML

BIOMEDICINES

2021-02-01

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...

PLOS BIOLOGY

2021-01-01

NFATc4: New hub in NASH development

Martinez-Chantar, ML;Foti, M

JOURNAL OF HEPATOLOGY

2020-12-01

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Mercado-Gomez, M;Lopitz-Otsoa, F;Azkargorta, M;Serrano-Maci, M;Lachiondo-Ortega, S;Goikoetxea-Usandizaga, N;Rodriguez-Agudo, R;Fernandez-Ramos, D;Bizkarguenaga, M;Gutierrez-de Juan, V;Lectez, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020-12-01

The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis

Fondevila, MF;Fernandez, U;Gonzalez-Rellan, MJ;Lima, ND;Buque, X;Gonzalez-Rodriguez, A;Alonso, C;Iruarrizaga-Lejarreta, M;Delgado, TC;Varela-Rey, M;Senra, A;Garcia-Outeiral, V;Novoa, E;Iglesias, ...

HEPATOLOGY

2020-11-13