Antonio Del Sol Mesa
adelsol
Antonio Del Sol Mesa
PRINCIPAL INVESTIGATOR
Ikerbasque Research Professor
Ikerbasque Research Professor
Computational Biology Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The main goal of the Computational Biology Group is to develop computational models at different scales of biological organization, including cellular, tissue and organ level, to address challenges in stem cell research and disease modeling. Among these challenges, our research focuses on improving the regenerative capacity of stem cells in old tissues, identifying lineage-specifying transcription factors involved in organ-level developmental disorders, and modulating the dysregulated hyperinflammatory response associated to various infectious and autoimmune diseases. Moreover, our computational models employ methodologies from different areas of mathematics, engineering, and physics, and integrate multiple sources of biological information (e.g. transcriptomics, epigenomics, proteomics) to study biological processes at different levels of organization. Importantly, the development of these models aims at generating predictions to guide stem cell researchers in the design of novel regenerative medicine therapies, and to assist clinical researchers to design new therapeutic intervention strategies to revert disease phenotypes.

Latest Publications

Epi-Impute: Single-Cell RNA-seq Imputation via Integration with Single-Cell ATAC-seq

Raevskiy, M;Yanvarev, V;Jung, SS;Del Sol, A;Medvedeva, YA

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2023-04-01

Measuring biological age using a functionally interpretable multi-tissue RNA clock

Jung, SS;Hodar, JA;del Sol, A

AGING CELL

2023-03-16

Transcriptional and Chromatin Accessibility Profiling of Neural Stem Cells Differentiating into Astrocytes Reveal Dynamic Signatures Affected under Inflammatory Conditions

Pavlou, MAS;Singh, K;Ravichandran, S;Halder, R;Nicot, N;Birck, C;Grandbarbe, L;del Sol, A;Michelucci, A

CELLS

2023-03-01

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Moiseeva, V;Cisneros, A;Sica, V;Deryagin, O;Lai, YW;Jung, SC;Andres, E;An, J;Segales, J;Ortet, L;Lukesova, V;Volpe, G;Benguria, A;Dopazo, A;Aznar-Benitah, S;Urano, Y;del Sol, A;Esteban, MA;Ohkawa, ...

NATURE

2022-12-21

ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells

Zheng, ML;Okawa, S;Bravo, M;Chen, F;Martinez-Chantar, ML;Del Sol, A

NUCLEIC ACIDS RESEARCH

2022-10-06

Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages

Hu, YZ;Jiang, YW;Behnan, J;Ribeiro, MM;Kalantzi, C;Zhang, MD;Lou, DH;Haring, M;Sharma, N;Okawa, S;Del Sol, A;Adameyko, I;Svensson, M;Persson, O;Ernfors, P

SCIENCE ADVANCES

2022-06-10

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Capelle, CM;Cire, S;Domingues, O;Ernens, I;Hedin, F;Fischer, A;Snoeck, CJ;Ammerlaan, W;Konstantinou, M;Grzyb, K;Skupin, A;Carty, CL;Hilger, C;Gilson, G;Celebic, A;Wilmes, P;Del Sol, A;Kaplan, ...

CELL REPORTS MEDICINE

2022-04-19

Fostering experimental and computational synergy to modulate hyperinflammation

Potapov, I;Kanneganti, TD;del Sol, A

TRENDS IN IMMUNOLOGY

2022-01-01

Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

Han, SS;Okawa, S;Wilkinson, GA;Ghazale, H;Adnani, L;Dixit, R;Tavares, L;Faisal, I;Brooks, MJ;Cortay, V;Zinyk, D;Sivitilli, A;Li, SQ;Malik, F;Ilnytskyy, Y;Angarica, VE;Gao, JH;Chinchalongporn, ...

NEURON

2021-09-15

A Catalogus Immune Muris of the mouse immune responses to diverse pathogens

Barlier, C;Barriales, D;Samosyuk, A;Jung, S;Ravichandran, S;Medvedeva, YA;Anguita, J;del Sol, A

CELL DEATH & DISEASE

2021-08-17