2014/12/10

One of our latest publications about Legionella appears as Scientific Highlight in Biostruct-X newsletter

A long-standing question in the field of microbial pathogenesis is how virulence factors are regulated within host cells and how their activity is specifically directed toward a particular host cell compartment.

Now, Legionella pneumophila resolves this dilemma by tightly coupling the phospholipase A1 activity of one of its effectors, vacuolar protein sorting inhibitor protein D (VipD), to this protein's interaction with endosomal host GTPases... read full text in the newsletter.