2009/06/19

A multidisciplinary approach using a combination of biophysical techniques reveals unexpected structural features in an archaeal CBS-domain containing protein.

A multidisciplinary approach using a combination of biophysical techniques, applied by researchers from the CIC bioGUNE's Structural Biology Unit, has recently revealed unexpected structural features in an archaeal CBS-domain containing protein. CBS domains are small protein motifs, usually associated in tandems, involved in adenosyl group binding. In humans, several genetic diseases have been associated with mutations in CBS domains. They can be expected to become promising targets for the rational design of new drugs. The report was published in Biochemistry journal (Martínez-Cruz et al, 2009, 48(12):2760-2776) and is a result of a collaboration with University Miguel Hernández, University of the Basque country, University of Zaragoza and CNIO.