2010/04/16

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases.

The work whose results suggest an interaction between Alzheimer's and prion pathologies has been published in the March edition of The Journal of Neuroscience, with Joaquín Castilla, the head of CIC bioGUNE's Prion Lab, as one of the authors.

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein. Despite the diversity of clinical symptoms associated with different PMDs, many similarities in their mechanism suggest that distinct pathologies may cross talk at the molecular level.