Seminar

Tumour initiating cells in human prostate cancers: can we translate genomic data into novel therapies?

Prof. Norman Maitland

While little is known of the risk factors involved in prostate carcinogenesis, current studies modelling human cancer in vivo and in vitro have provided new insights into tumour origins and resistance to treatment. A novel "gene signature" for cancer stem cells has been generated and these data have been ’mined’ for biologically significant genes, whose expression is linked to either carcinogenic change or stemness. This has resulted in a refined target list for the development of therapies against tumour initiating cells.