Structural analysis of intracellular transport, nuclear entry and egress in the Herpes Simplex Virus 1 (HSV-1) 'life' cycle

 

Seminar

Structural analysis of intracellular transport, nuclear entry and egress in the Herpes Simplex Virus 1 (HSV-1) 'life' cycle

Iosune Ibiricu, PhD

Structural analysis of intracellular transport, nuclear entry and egress in the Herpes Simplex Virus 1 (HSV-1) 'life' cycle

 

Cryo-electron tomography (cryo-ET), in combination with fluorescence microscopy, was applied to structurally analyze different stages of the HSV-1 'life’ cycle in situ under close-to native conditions and without any chemical fixation. The focus of this study was on intracellular viral transport, attachment of capsids to nuclear pores and viral egress from cells.