Activities

The role of K-homology Splicing Recognition Protein

 

Seminar

The role of K-homology Splicing Recognition Protein

Irene Díaz Moreno, PhD

The role of K-homology Splicing Recognition Protein K-homology Splicing Regulator Protein (KSRP) is a multi-domain RNA-binding proteininvolved in gene regulation by promoting adenosine-uridine-rich element (ARE)-mediated mRNA decay (AMD). Post-translationally modified KSRP by phosphorylation of a serine residue from the first RNA-binding domain (KH1) becomes unfolded and transiently recognised by the 14-3-3ζ protein, which efficiently discriminates between phosphorylated and unphosphosrylated KSRP-KH1, driving the nuclear localization of KSRP. In addition, the arrangement of the two central KSRP RNA-binding domains (KH2-KH3) by the linker between them has important implications for discriminating between KSRP's RNA targets.