Activity Detail
Seminar
Lipidomics in Cell Biology: How lipid composition leads to function at the subcellular scale
Noemí Jiménez-Rojo
Why has nature evolved such a vast repertoire of lipids? Theoretically, a single glycerophospholipid could be sufficient to form a bilayer that fulfills basic barrier functions. Yet, biological membranes contain an astonishing diversity of lipid species, which are heterogeneously distributed across the evolutionary tree, with lipidomes evolving alongside organismal complexity.
In this talk, I will explore the significance of lipid diversity in biology across different scales. I will focus on our recent findings on how lipids and membrane mechanics regulate protein export from the endoplasmic reticulum, particularly in collagen secretion pathways. Using a combination of siRNA screening and lipidomics analysis, we have identified a potential role for specific sphingolipid species in this process, shedding light on the intricate interplay between membrane composition and cellular function.