Activity Detail
Seminar
Decryption of microbial glycans unveils structure to function relationship
Alba Silipo
The evaluation of the structure and host recognition of glycoconjugates from microbial cell envelope is key to two interconnected pillars: i) to provide structural insights into the mechanisms governing microbial glycans’ recognition and binding by host cognate receptors and ii) to evaluate their contribute to the microbial cell survival as well as their interaction with host receptor(s). The combined use of complementary approaches, including NMR spectroscopy, computational techniques and biophysical methodologies is essential to unravel the structure, conformation and molecular recognition features of microbial glycoconjugates as well as their interaction with eukaryotic host.