Nonalcoholic fatty liver disease cardiovascular risk by metabolic subtype

2021/02/05 ON LINE

Seminar

Nonalcoholic fatty liver disease cardiovascular risk by metabolic subtype

Prof. José María Mato

Nonalcoholic fatty liver disease cardiovascular  risk by metabolic subtype Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of adult population with the associated metabolic abnormalities conferring increased risk of cardiovascular disease (CVD). NAFLD is a complex heterogenous disease with histological features reflecting an imbalance in hepatic lipid metabolism (de novo lipogenesis, fatty acid (FA) uptake, oxidation and very low-density lipoprotein (VLDL) secretion) caused by multiple nutritional and environmental factors acting on a susceptible genetic background. Metabolomic signatures obtained by analyzing an international cohort of 1099 patients identify 3 NAFLD subgroups based on lipid profile. These are independent of histological disease severity but align to known CVD risk factors that may account for the observed inter-patient variation in hepatic vs. cardiovascular outcomes. If validated, it provides a novel, clinically relevant, risk stratification.

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