Stress kinases – crossroad between obesity and liver cancer

2020/04/03 Atrio 800

Seminar

Stress kinases – crossroad between obesity and liver cancer

Prof. Guadalupe Sabio

Stress kinases – crossroad between obesity and liver cancer Obesity, a worldwide pandemic health condition, is involved in the development and progression of cardiovascular diseases, diabetes and cancer. One important common factor during obesity is the activation of stress kinases, p38 and JNK, in several organs, including adipose tissue, liver, muscle, immune and central nervous system. The correct activation in time, intensity and duration is crucial because it contributes to the metabolic cellular adaptation. In consequence, these pathways have been proposed as potential targets for the development of novel therapeutic approaches for the treatment of the metabolic syndrome. We will discuss the recent finding of the role of the stress kinases in the metabolic control and highlight our recent discoveries in the field.

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