The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:
- Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
- Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
- Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
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Group Leader
Isabel Mendizabal
Ikerbasque Research Fellow - Ramón y Cajal Programme -
Edurne Berra
Emerging Scientist -
Amaia Ercilla Eguiarte
Ikerbasque Research Fellow - Juan de la Cierva Fellow -
Marco Piva
Ikerbasque Research Fellow - Ramón y Cajal (RyC) Programme IKERBASQUE RESEARCH FELLOW -
Oihana Iriondo Martinez de Zuazo
Ikerbasque Research Fellow RESEARCH ASSISTANT -
Natalia Martín Martín
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Amaia Zabala Letona
AECC Researcher POSTDOCTORAL RESEARCHER -
Mikel Pujana Vaquerizo
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Blanca Calle Ciborro
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Laura Bozal Basterra
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Jaione Auzmendi Iriarte
Juan de la Cierva Fellow TECHNICIANS / DOCTORAL CANDIDATES -
Maria Camila Salazar Palacio
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Kathrin Keim
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Victoria Cid I Centelles
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Candela Gerediaga Ruiz de Velasco
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Belén Martínez La Osa
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Alex Rodríguez Alonso
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Onintza Carlevaris
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Saioa García Longarte
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Mikel Arana Castañares
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Encarnación Pérez Andrés
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Irati Aguirre Vicente
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María Ponce Rodríguez
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Uxue Lazcano Dobao
AECC Predoctoral Fellow -
Adrián Vicente Barrueco
Members
Arkaitz Carracedo
ERC Consolidator Grant - Ikerbasque Research ProfessorLatest Publications
Aggressive prostate cancer is associated with pericyte dysfunction
Martinez-Romero, A; Martinez-Larrinaga, A; Grego-Bessa, J; Garcia-Longarte, S; van Splunder, H; Astobiza, I; Ercilla, A; Bozal-Basterra, L; Mendizabal, I; Villacampa, P; Carracedo, A; Graupera, ...
Molecular Oncology
2025-11-03
Unravelling the role of L-and Dalanine in prostate cancer: a Positron Emission Tomography study in a genetic mouse model
Castellnou, P; Gómez-Martínez, M; Gómez-Vallejo, V; Baz, Z; López-Gallego, F; Rondon-Lorefice, I; Zabala-Letona, A; Poot, AJ; Mendizabal, I; Carracedo, A; Rejc, L; Llop, J;
NUCLEAR MEDICINE AND BIOLOGY
2025-09-25
A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer
Ercilla, A; Crespo, JR; Garcia-Longarte, S; Fidalgo, M; del Palacio, S; Martin-Martin, N; Carlevaris, O; Astobiza, I; Fernández-Ruiz, S; Guiu, M; Bárcena, L; Mendizabal, I; Aransay, AM; Graupera, ...
MOLECULAR ONCOLOGY
2025-09-15
Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential
Mercado-Gómez , M; Goikoetxea-Usandizaga, N; Giné, AE; Rodrigo, MAM; Afonso, MB; Azkargorta, M; Zapata-Pavas, LE; Rejano-Gordillo, CM; Romero, MR; Mendizabal, I; Rodrigues, PM; Wu, HH; Rodríguez-Agudo, ...
GUT
2025-08-05
Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination
Martin-Martin, N; Garcia-Longarte, S; Corres-Mendizabal, J; Lazcano, U; Astobiza, I; Bozal-Basterra, L; Herranz, N; van Splunder, H; Carlevaris, O; Pujana-Vaquerizo, M; Blasco, MT; Aransay, ...
GENOME BIOLOGY
2025-06-03
Precision proteogenomics reveals pan-cancer impact of germline variants
Rodrigues, FM; Terekhanova, NV; Imbach, KJ; Clauser, KR; Selvan, ME; Mendizabal, I; Geffen, Y; Akiyama, Y; Maynard, M; Yaron, TM; Li, YZ; Cao, S; Storrs, EP; Gonda, OS; Gaite-Reguero, A; Govindan, ...
CELL
2025-05-01
Asymmetrical Evolution of Promoter Methylation of Mammalian Genes after Duplication
de la Fuente, M; Mendizabal, I; Han, M; Yi, S; Alvarez-Ponce, D;
MOLECULAR BIOLOGY AND EVOLUTION
2024-12-30
Human brain aging is associated with dysregulation of cell type epigenetic identity
Jeong, H; Mendizabal, I; Yi, SV;
GEROSCIENCE
2024-12-27
The PP2A regulator IER5L supports prostate cancer progression
Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...
CELL DEATH & DISEASE
2024-07-18
Human Brain Aging is Associated with Dysregulation of Cell-Type Epigenetic Identity.
Jeong, Hyeonsoo; Mendizabal, Isabel; Yi, Soojin V;
bioRxiv : the preprint server for biology
2024-06-03
DNA methylation differences between the female and male X chromosomes in human brain.
Morgan, Robert; Loh, Eddie; Singh, Devika; Mendizabal, Isabel; Yi, Soojin V;
bioRxiv : the preprint server for biology
2024-04-17
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...
MOLECULAR CANCER
2023-07-29
Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer
Santasusagna, S; Zhu, S; Jawalagatti, V; Carceles-Cordon, M; Ertel, A; Garcia-Longarte, S; Song, WM; Fujiwara, N; Li, P; Mendizabal, I; Petrylak, DP; Kelly, WK; Reddy, EP; Wang, L; Schiewer, ...
CANCER DISCOVERY
2023-01-01
RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress
Feu, S; Unzueta, F; Ercilla, A; Pérez-Venteo, A; Jaumot, M; Agell, N;
PLOS ONE
2022-08-15
Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer
Arruabarrena-Aristorena, A; Toska, E;
FRONTIERS IN ONCOLOGY
2022-06-14
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Zabala-Letona, A; Arruabarrena-Aristorena, A; Fernandez-Ruiz, S; Viera, C; Carlevaris, O; Ercilla, A; Mendizabal, I; Martin, T; Macchia, A; Camacho, L; Pujana-Vaquerizo, M; Sanchez-Mosquera, ...
ONCOGENESIS
2022-02-23
Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients
Rodriguez, RM; Hernández-Fuentes, MP; Corte-Iglesias, V; Saiz, ML; Lozano, JJ; Cortazar, AR; Mendizabal, I; Suarez-Fernandez, ML; Coto, E; López-Vázquez, A; Díaz-Corte, C; Aransay, AM; López-Larrea, ...
FRONTIERS IN IMMUNOLOGY
2021-08-20
Evolution of DNA methylation in the human brain
Jeong, H; Mendizabal, I; Berto, S; Chatterjee, P; Layman, T; Usui, N; Toriumi, K; Douglas, C; Singh, D; Huh, I; Preuss, TM; Konopka, G; Yi, S;
NATURE COMMUNICATIONS
2021-04-01
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P; Astobiza, I; Cortazar, AR; Torrano, V; Macchia, A; Flores, JM; Niespolo, C; Mendizabal, I; Caloto, R; Ercilla, A; Camacho, L; Arreal, L; Bizkarguenaga, M; Martinez-Chantar, ML; ...
CANCERS
2020-09-01