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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Molecular processes affecting mammary luminal progenitor fate

 

In contrast to most mammalian organs, the mammary gland develops mostly after birth. Mammary epithelium is a bilayered structure formed by luminal and myoepithelial cells. Luminal cells are responsible for producing milk. When the...

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Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.


Endogenous peptides are valuable targets in the analysis of biological processes. The tear film contains proteins and peptides released by the tear duct mucosal cells, including antimicrobial peptides involved in the protection against...

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The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation of DNA replication and repair.

 

PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is...

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Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions

 

Detection of molecular recognition processes requires robust, specific and easily implementable sensing methods, especially for screening applications related to the drug discovery process. Within a collaborative project between the...

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Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted and Plitidepsin Loaded Co-Polymeric Polymersomes on Colorectal Cancer Cell Lines

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa,
Blanca Suárez-Merino, Sébastien Lecommandoux, and Pedro Heredia. J. Biomed. Nanotechnol. 11,...

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Seminars

2015/09/01

Paula Saá, PhD (American Red Cross Holland Laboratory, Rockville, Maryland)

Exploring plasma extracellular vesicles as carriers of infectious prion proteins in blood

Extracellular vesicles (EVs) were originally considered to be a cellular mechanism to eliminate unwanted proteins. Recent investigations however, have attributed new roles to these vesicles including intercellular communication and infectious agent...

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