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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling

 

Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous...

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Exosomes participate in the Hedgehog gradient formation required in development

 

Tissue and organ formation require a tight concerted coordination of many different cell types that have to proliferate and differentiate in the right place and moment. For proper development, the organism establishes a...

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Structure and interactions of a multifunctional domain of HuR protein


The human antigen R (HuR) is a powerful regulator of cancer. By binding and stabilizing certain messenger RNA molecules, it promotes the production of other proteins related to cell proliferation, survival, angiogenesis and metastasis, and...

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A switch in Wnt signaling mediates early differentiation of human neural stem cells.

 

A new study from the Cell Biology and Stem Cells Unit focuses on secreted proteins called Wnts, which are particularly important for tissue development and morphogenesis. Purified proteins and small molecules that regulate Wnt...

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Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase fromMycobacterium tuberculosis

 

Mycobacterium tuberculosis is a human pathogen that causes tuberculosis, a disease that kills ca. 2 million people worldwide every year. The occurrence of multidrug and extensively drug-resistant strains of M. tuberculosis have...

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Seminars

2015/03/27

Dimitris Xirodimas, PhD (CNRS-CRBM, Montpellier)

TBA

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