CIC bioGUNE

Research

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

The covalent attachment of adenosine monophosphate (AMP) to proteins, a process called AMPylation (adenylylation), has recently emerged as a novel theme in microbial pathogenesis. While AMPylases from various pathogenic microorganisms have...

Regulating the regulators: Steroid hormone synthesis is controlled by SUMO, Ftz-f1 and Scavenger Receptors.

Steroid hormones are cholesterol derivates that control many aspects of animal physiology, including development, growth, energy storage and reproduction. In insects, the main steroid hormone is ecdysone, which gets activated in pulses that precede...

Seminars

2013/06/14

Marc Claret, PhD (Institut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Barcelona, Spain.)

Mitochondrial fusion proteins in hypothalamic POMC neurons regulate whole-body energy homeostasis

In recent years, the mediobasal hypothalamus has been firmly established as a key area of the central nervous system implicated in the regulation of whole-body energy homeostasis. This is achieved through a complex sensing of hormones and...