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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

 

Liver Cancer, the fifth most common cancer worldwide and the third leading cause of death, is a very complex and heterogeneous pathology with multiple and distinct signaling pathways that converge in the same malignant transformation....

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Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted and Plitidepsin Loaded Co-Polymeric Polymersomes on Colorectal Cancer Cell Lines

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa,
Blanca Suárez-Merino, Sébastien Lecommandoux, and Pedro Heredia. J. Biomed. Nanotechnol. 11,...

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The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures

 

The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures. This molecule is expressed in ca. 90 % of carcinomas, and there is a direct correlation between the aggressiveness of the carcinoma and...

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Protein homeostasis project brings researchers together

Intracellular proteolysis is critical to maintaining cellular homeostasis, and aberrations in this process play a central role in pathologies such as cancers, immune diseases and neurodegenerative conditions. The PROTEOSTASIS project aims to...

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The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation of DNA replication and repair.

 

PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is...

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Seminars

2015/09/01

Paula Saá, PhD (American Red Cross, Washington D.C., USA)

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