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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.

Series of Lectures 2014


Lysine Methylation Mapping of Crenarchaeal DNA-Directed RNA Polymerases by Collision-Induced and Electron-Transfer Dissociation Mass Spectrometry


Enzymatic machineries fundamental for information processing (e.g. transcription, replication, translation) in Archaea are simplified versions of their eukaryotic counterparts. This is clearly noticeable in the conservation of...


S-adenosylmethionine levels regulate the Schwann cell DNA methylome


Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. Schwann cell myelination is a highly orchestrated...


Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.


Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic...


SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling


Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous...


Sox2 promotes tamoxifen resistance in breast cancer cells


A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr Zabalza (Hospital of Galdakao) and Dr López-Ruiz (PreteImagen) has been published this week in the prestigious...




Mikel García-Marcos, PhD (Boston University School of Medicine)

Trimeric G protein signaling beyond GPCRs: teaching new tricks to an old dog

Dysregulation of trimeric G protein signaling is the cause of major diseases that represent a huge burden for public health such as cancer, cardiovascular diseases, neurological malfunction, inflammation or metabolic disorders, among others. In the...





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