CIC bioGUNE

Research

Structure of the Tumor Suppressor ING4

The tumor suppressor ING4 regulates gene transcription by recruiting chromatin remodeling complexes to active promoters. A team of CIC bioGUNE researchers has investigated the structure of ING4 and found that it forms dimers in vitro and in vivo....

HOXB9 promotes breast cancer progression

Aberrant expression of transcription factors has been implicated in tumorigenesis. Investigators from the Cell Biology and Stem Cells Unit at CIC bioGUNE and groups at Massachusetts General Hospital and Harvard Medical School have shown that...

Seminars

2010/02/19

Radu Aricescu, PhD (Division of Structural Biology. Wellcome Trust Centre for Human Genetics. University of Oxford. (UK))

The molecular architecture of ionotropic glutamate receptors

L-Glutamate is the major mediator of excitatory synaptic transmission the vertebrate central nervous system. Its receptors are either ligand-gated ion channels ( the AMPA, kainite and NMDA subtypes) or G-protein coupled receptors (metabotropic,...