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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.

 

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic...

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SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling

 

Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous...

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Sox2 promotes tamoxifen resistance in breast cancer cells

 

A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr Zabalza (Hospital of Galdakao) and Dr López-Ruiz (PreteImagen) has been published this week in the prestigious...

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Tuning intracellular homeostasis of human uroporphyrinogen III synthase by engineering a mutational hotspot found in congenital erythropoietic porphyria

 

Congenital erythropoietic porphyria (CEP) results from a deficiency in uroporphyrinogen III synthase enzyme (UROIIIS) activity that ultimately stems from deleterious mutations in the uroS gene. CEP presents with a plethora of...

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S-adenosylmethionine levels regulate the Schwann cell DNA methylome

 

Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. Schwann cell myelination is a highly orchestrated...

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Seminars

2015/03/27

Dimitris Xirodimas, PhD (CNRS-CRBM, Montpellier)

TBA

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Events