CIC bioGUNE

Research

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

The covalent attachment of adenosine monophosphate (AMP) to proteins, a process called AMPylation (adenylylation), has recently emerged as a novel theme in microbial pathogenesis. While AMPylases from various pathogenic microorganisms have...

Regulating the regulators: Steroid hormone synthesis is controlled by SUMO, Ftz-f1 and Scavenger Receptors.

Steroid hormones are cholesterol derivates that control many aspects of animal physiology, including development, growth, energy storage and reproduction. In insects, the main steroid hormone is ecdysone, which gets activated in pulses that precede...

Seminars

2013/06/07

Jesús Rodríguez Requena, PhD (CIMUS Biomedical Research Institute, University of Santiago de Compostela, Spain)

The structure of PrPSc in search of the 'double helix' of prions

Prions are infectious proteins that transmit deadly neurodegenerative diseases. More broadly, prions are proteins that store and transmit information, a property previously thought to be exclusive of nucleic acids. Prion-like information transmission...