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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase fromMycobacterium tuberculosis

 

Mycobacterium tuberculosis is a human pathogen that causes tuberculosis, a disease that kills ca. 2 million people worldwide every year. The occurrence of multidrug and extensively drug-resistant strains of M. tuberculosis have...

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Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis for Assessing the Contribution of Electrostatics to the Stability of CH-pi Bonds in Water

 

The interactions between aromatic moieties and aliphatic entities are of paramount importance for essential molecular recognition events. In particular, CH-pi contacts are present in a variety of biomolecular complexes, and provide...

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Structure of a protein interaction key for microtubule elongation


Cell division involves the segregation of the genetic material into the daughter cells that, when not properly controlled, may produce aberrant chromosomes and lead to cancer. Microtubule elongation plays a key role in the machine that...

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S-adenosylmethionine levels regulate the Schwann cell DNA methylome

 

Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. Schwann cell myelination is a highly orchestrated...

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Sox2 promotes tamoxifen resistance in breast cancer cells

 

A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr Zabalza (Hospital of Galdakao) and Dr López-Ruiz (PreteImagen) has been published this week in the prestigious...

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Seminars

2015/03/27

Dimitris Xirodimas, PhD (CNRS-CRBM, Montpellier)

The ubiquitin-like molecule NEDD8 under stress

Cells constantly respond to cellular stress that causes protein or DNA/RNA damage. Defects in repair or elimination of the damage can lead to many diseases including neurodegeneration and cancer. To prevent this toxicity, cells have evolved many...

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