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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling


Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous...


Tuning intracellular homeostasis of human uroporphyrinogen III synthase by engineering a mutational hotspot found in congenital erythropoietic porphyria


Congenital erythropoietic porphyria (CEP) results from a deficiency in uroporphyrinogen III synthase enzyme (UROIIIS) activity that ultimately stems from deleterious mutations in the uroS gene. CEP presents with a plethora of...


The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation of DNA replication and repair.


PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is...


A switch in Wnt signaling mediates early differentiation of human neural stem cells.


A new study from the Cell Biology and Stem Cells Unit focuses on secreted proteins called Wnts, which are particularly important for tissue development and morphogenesis. Purified proteins and small molecules that regulate Wnt...


Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.


Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic...




Alejandro Mira, PhD (Center for Advanced Research in Public Health (CSISP))

Alex Mira obtained an honour distinction for his BSc in Biology at the University of Alicante, Spain, in 1994. He then obtained a British Council scholarship to do a Master of Science degree at Oxford University (UK), and was the first Spanish...