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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Structure and interactions of a multifunctional domain of HuR protein


The human antigen R (HuR) is a powerful regulator of cancer. By binding and stabilizing certain messenger RNA molecules, it promotes the production of other proteins related to cell proliferation, survival, angiogenesis and metastasis, and...

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Structure of a protein interaction key for microtubule elongation


Cell division involves the segregation of the genetic material into the daughter cells that, when not properly controlled, may produce aberrant chromosomes and lead to cancer. Microtubule elongation plays a key role in the machine that...

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Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.

 

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic...

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Lysine Methylation Mapping of Crenarchaeal DNA-Directed RNA Polymerases by Collision-Induced and Electron-Transfer Dissociation Mass Spectrometry

 

Enzymatic machineries fundamental for information processing (e.g. transcription, replication, translation) in Archaea are simplified versions of their eukaryotic counterparts. This is clearly noticeable in the conservation of...

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SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling

 

Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis. Hence, SIRT1 is considered as a key regulator of cell metabolism. Previous...

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Seminars

2015/03/27

Dimitris Xirodimas, PhD (CNRS-CRBM, Montpellier)

TBA

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