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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted and Plitidepsin Loaded Co-Polymeric Polymersomes on Colorectal Cancer Cell Lines

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa,
Blanca Suárez-Merino, Sébastien Lecommandoux, and Pedro Heredia. J. Biomed. Nanotechnol. 11,...


Evolution of SUMO function and chain formation in insects.

To understand the function and mechanisms of postranslational modification is crucial to understand protein function. Modifications by the Small Ubiquitin-like Modifier (SUMO) to target proteins are proven to be important in critical...


The unexplored archaeal domain and its viruses

Archaeal viruses represents one of the most challenging and yet unknown area of investigation. Archaeal viruses live in extreme environments (alkaline, acidic conditions, hyper-salinity and elevated temperature), conditions reminiscent of...


The quest of anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related monoclonal antibodies by combining microarray screening and STD-NMR

The expression of MUC1, a glycoprotein displaying complex oligosaccharides, is usually increased with aberrant glycosylation in tumour cells. In fact, the carbohydrate side chains are now incomplete and different epitopes, including the Tn antigen...


Steroids and Insulin pathways collaborate to promote tissue growth

How organisms reach their final size is a crucial question in Biology that is deeply related with the mechanisms involved in cell growth control and the pathologies associated to the misregulation of this process, such are cancer and...




Vadim Frolov (EHU- UPV)

Nanomechanics of membrane fission: lessons from dynamin

Morphological flexibility of cell membranes provides the foundation for the spatial organization of living cells. The signature morphologies of cellular endomembrane systems are created at the nanoscale where specialized proteolipid complexes...