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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Sox2 promotes tamoxifen resistance in breast cancer cells


A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr Zabalza (Hospital of Galdakao) and Dr López-Ruiz (PreteImagen) has been published this week in the prestigious...


The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation of DNA replication and repair.


PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is...


Lysine Methylation Mapping of Crenarchaeal DNA-Directed RNA Polymerases by Collision-Induced and Electron-Transfer Dissociation Mass Spectrometry


Enzymatic machineries fundamental for information processing (e.g. transcription, replication, translation) in Archaea are simplified versions of their eukaryotic counterparts. This is clearly noticeable in the conservation of...


A switch in Wnt signaling mediates early differentiation of human neural stem cells.


A new study from the Cell Biology and Stem Cells Unit focuses on secreted proteins called Wnts, which are particularly important for tissue development and morphogenesis. Purified proteins and small molecules that regulate Wnt...


Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.


Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, being frequently associated with obesity, dyslipidemia and insulin resistance, a group of disorders that constitute the metabolic...




3rd Anniversary Lecture Prof. Arun Sanyal (Virginia Commonwealth University (VCU) Richmond, Virginia)

"Evolving trends in diagnosis and management

Dr. Arun J. Sanyal, M.D., has been Global Principal Investigator of Immuron Limited since May 24, 2011. Dr. Sanyal is a Professor of Medicine and Chairman of Gastroenterology Division at Virginia Commonwealth University (VCU) Medical Center in...