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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures


The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures. This molecule is expressed in ca. 90 % of carcinomas, and there is a direct correlation between the aggressiveness of the carcinoma and...


Protein homeostasis project brings researchers together

Intracellular proteolysis is critical to maintaining cellular homeostasis, and aberrations in this process play a central role in pathologies such as cancers, immune diseases and neurodegenerative conditions. The PROTEOSTASIS project aims to...


Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer


Liver Cancer, the fifth most common cancer worldwide and the third leading cause of death, is a very complex and heterogeneous pathology with multiple and distinct signaling pathways that converge in the same malignant transformation....


Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis for Assessing the Contribution of Electrostatics to the Stability of CH-pi Bonds in Water


The interactions between aromatic moieties and aliphatic entities are of paramount importance for essential molecular recognition events. In particular, CH-pi contacts are present in a variety of biomolecular complexes, and provide...


Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase fromMycobacterium tuberculosis


Mycobacterium tuberculosis is a human pathogen that causes tuberculosis, a disease that kills ca. 2 million people worldwide every year. The occurrence of multidrug and extensively drug-resistant strains of M. tuberculosis have...




José Manuel Andreu, PhD (CIB-CSIC)

Targeting bacterial cell division protein FtsZ with assembly inhibitors and fluorescent probes