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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Evolution of SUMO function and chain formation in insects.

To understand the function and mechanisms of postranslational modification is crucial to understand protein function. Modifications by the Small Ubiquitin-like Modifier (SUMO) to target proteins are proven to be important in critical...


The quest of anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related monoclonal antibodies by combining microarray screening and STD-NMR

The expression of MUC1, a glycoprotein displaying complex oligosaccharides, is usually increased with aberrant glycosylation in tumour cells. In fact, the carbohydrate side chains are now incomplete and different epitopes, including the Tn antigen...


Designing a broad-spectrum integrative approach for cancer prevention and treatment.

While current therapies have achieved modest successes in some cancers, significant problems remain with most of our approaches to treatment. In particular, many newer targeted therapies are extremely expensive, highly toxic and not effective for...


The ubiquitin ligase TRAIP binds PCNA and protects the genome in response to replication stress.

The replication of the genetic material can be blocked or slowed down by different causes creating replication stress in the cell. This is the primary source of genome instability, and the cell triggers a replication stress response to prevent it....


Cellular and molecular heterogeneity in breast cancer


Breast cancer is a very heterogeneous disease. We now know that breast tumors contain cells with properties of stem cells (cancer stem cells, CSCs) that support tumor initiation and resistance to current therapies. Furthermore, the...




José Antonio Enríquez Domínguez, PhD (CNIC)

Are population variants of mtDNA physiologically relevant?

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability. We performed a comprehensive study on the physiological relevance of mtDNA sequence variability in mice. It understand the effects of mtDNA variants we...