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CIC bioGUNE

CIC bioGUNE

The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Research

Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions

 

Detection of molecular recognition processes requires robust, specific and easily implementable sensing methods, especially for screening applications related to the drug discovery process. Within a collaborative project between the...

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Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.


Endogenous peptides are valuable targets in the analysis of biological processes. The tear film contains proteins and peptides released by the tear duct mucosal cells, including antimicrobial peptides involved in the protection against...

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Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted and Plitidepsin Loaded Co-Polymeric Polymersomes on Colorectal Cancer Cell Lines

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa,
Blanca Suárez-Merino, Sébastien Lecommandoux, and Pedro Heredia. J. Biomed. Nanotechnol. 11,...

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The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures

 

The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures. This molecule is expressed in ca. 90 % of carcinomas, and there is a direct correlation between the aggressiveness of the carcinoma and...

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BRCA1, a breast cancer predisposition gene, a potential contributor in a human and animal model of amyotrophic lateral sclerosis

 

Amyotrophic lateral sclerosis (ALS) is characterised by selective motoneuron degeneration in the spinal cord, brainstem and motor cortex leading to progressive muscle weakness, atrophy and paralysis. Growing evidence suggest that...

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Seminars

2015/09/11

José Manuel Andreu, PhD (Centro de Investigaciones Biológicas, CSIC, Madrid )

Targeting bacterial cell division protein FtsZ with assembly inhibitors and fluorescent probes

Assembly machines from the tubulin-FtsZ superfamily of GTPases are essential for most cells to segregate DNA or to divide. Their different polymers can do work even without the assistance of motor proteins. FtsZ forms the Z-ring that coordinates the...

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