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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Designing a broad-spectrum integrative approach for cancer prevention and treatment.

While current therapies have achieved modest successes in some cancers, significant problems remain with most of our approaches to treatment. In particular, many newer targeted therapies are extremely expensive, highly toxic and not effective for...


Highest resolution structure of a flexuous filamentous plant virus


Flexible filamentous viruses are eukaryotic RNA viruses and economically important plant pathogens. Their viral particles contain several hundred copies of a helically arrayed coat protein (CP) protecting a (+)ssRNA. A research team...


The unexplored archaeal domain and its viruses

Archaeal viruses represents one of the most challenging and yet unknown area of investigation. Archaeal viruses live in extreme environments (alkaline, acidic conditions, hyper-salinity and elevated temperature), conditions reminiscent of...


Cellular and molecular heterogeneity in breast cancer


Breast cancer is a very heterogeneous disease. We now know that breast tumors contain cells with properties of stem cells (cancer stem cells, CSCs) that support tumor initiation and resistance to current therapies. Furthermore, the...


The ubiquitin ligase TRAIP binds PCNA and protects the genome in response to replication stress.

The replication of the genetic material can be blocked or slowed down by different causes creating replication stress in the cell. This is the primary source of genome instability, and the cell triggers a replication stress response to prevent it....




José Antonio Enríquez Domínguez, PhD (CNIC)

Are population variants of mtDNA physiologically relevant?

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability. We performed a comprehensive study on the physiological relevance of mtDNA sequence variability in mice. It understand the effects of mtDNA variants we...