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The goal of CIC bioGUNE is to bring discoveries to the society by partnering with industry.


Structure and interactions of a multifunctional domain of HuR protein

The human antigen R (HuR) is a powerful regulator of cancer. By binding and stabilizing certain messenger RNA molecules, it promotes the production of other proteins related to cell proliferation, survival, angiogenesis and metastasis, and...


The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation of DNA replication and repair.


PCNA forms a ring that encircles and slides on the DNA. It is an essential factor in replication and repair that recruits DNA-modifying enzymes and regulatory proteins to the replication fork. The regulatory protein p15 is...


Protein homeostasis project brings researchers together

Intracellular proteolysis is critical to maintaining cellular homeostasis, and aberrations in this process play a central role in pathologies such as cancers, immune diseases and neurodegenerative conditions. The PROTEOSTASIS project aims to...


The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures


The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures. This molecule is expressed in ca. 90 % of carcinomas, and there is a direct correlation between the aggressiveness of the carcinoma and...


Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

Endogenous peptides are valuable targets in the analysis of biological processes. The tear film contains proteins and peptides released by the tear duct mucosal cells, including antimicrobial peptides involved in the protection against...




José Manuel Andreu, PhD (CIB-CSIC)

Targeting bacterial cell division protein FtsZ with assembly inhibitors and fluorescent probes