2017/03/23

Los grupos de investigación sobre exosomas en Euskadi se reúnen en CIC bioGUNE para compartir...

Estas vesículas secretadas al exterior celular son consideradas como importantes...

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2017/03/16

CIC bioGUNE, British Council y AECC continúan con el ciclo de conferencias divulgativas “Cáncer:...

El investigador Johan Hyllner, responsable científico de la Cell and Gene...

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2017/03/08

El consejero de Salud del Gobierno Vasco, Jon Darpón, visita las instalaciones de CIC bioGUNE

José María Mato, director general, y Jesús Jiménez, director científico, han...

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2017/02/23

Arkaitz Carracedo, galardonado con el premio Radio Bilbao a la Excelencia 2017 en la categoría...

El trabajo del investigador Ikerbasque en CIC bioGUNE ha sido reconocido por “seguir desentrañando los mecanismos del cáncer” (Bilbao, 23 de febrero de 2017). Arkaitz Carracedo, investigador Ikerbasque en CIC bioGUNE, ha sido galardonado en los premios Radio Bilbao a la Excelencia 2017 en la categoría de investigación. La entrega de esta primera edición de los premios organizados por Radio...

2017/02/22

La metabolómica puede mejorar el diagnóstico y el tratamiento de la enfermedad del hígado...

CIC bioGUNE y OWLMetabolomics identifican dos subtipos de NAFLD El estudio, realizado...

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2017/02/15

CIC bioGUNE, British Council y AECC organizan el ciclo de conferencias divulgativas “Cáncer:...

El investigador Bart Vanhaesebroeck, profesor del UCL Cancer Institute de Londres,...

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2017/02/10

Amelie Schober will defend her PhD thesis on February 13th

Amelie Schober will defend her PhD thesis, entitled "Establishment and characterisation of USP29 as a novel regulator of Hypoxia Inducible Factor α", on February 13th . The event will take place at University of Liverpool.

2017/02/07

CIC bioGUNE research on nerve regeneration after injury, selected as one of the most relevant...

The work of the Ikerbasque researcher Ashwin Woodhoo will be published in a collection...

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2017/02/02

Un proyecto de CIC bioGUNE sobre biomarcadores de detección del cáncer de próstata recibe...

El Consejo Europeo de Investigación apoya con 150.000 euros la investigación para...

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2017/01/25

CIC bioGUNE- CIBEREHD researchers describe for the first time the involvement of the nedd8-mediated...

Liver fibrosis is an integral part in the progression of chronic liver disease,...

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2017/01/20

A comprehensive biotin-based toolbox to study protein homeostasis: A community resource developed...

Protein homeostasis is at the heart of human wellbeing. Numerous diseases such...

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2017/01/19

La potente mirada de una Euskadi del futuro

El pasado Julio investigadores de la Universidad de Oxford (UK), del Instituto Nacional del Cáncer - NIH (US) y CIC bioGUNE (Spain) publicaron en la revista científica Nature Methods (Stuart, Subramanian, Abrescia,  ‘The democratization of cryo-EM’, Nat Methods. 2016 13:607-8- http://www.nature.com/nmeth/journal/v13/n8/full/nmeth.3946.html) una reflexión...

2017/01/17

Discovery of a new mechanism to understand certain interspecies prion transmission barriers

The article describes an alternative replicative process in which certain prion strains...

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2017/01/10

CIC bioGUNE researchers uncover the molecular mechanism of PCNA protein sliding on DNA

The work, published in the journal Nature Communications, suggests modulator molecules of...

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2016/12/05

CIC bioGUNE researchers discover a molecular recognition mechanism which enables certain proteins...

  The work, coordinated by the Ikerbasque researcher Aitor Hierro, has...

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2016/11/29

Multidisciplinary Research Training Program To Uncover Cellular Control Of Immuno-Metabolism...

The EU Marie Sklodowska-Curie Innovative Training Network (ITN) “TRAIN” (“Tribbles...

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2016/11/22

Deporte e investigación unidos para luchar a favor de la salud masculina

  El Getxo Errugbia, en colaboración con el grupo CAYSO (Cáncer Y Sociedad), organizará el próximo...

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2016/10/27

CIC bioGUNE statement on the use of research animals

CIC bioGUNE has joined the Agreement on Openness on Animal Research, promoted by the Federation of Scientific Societies in Spain (COSCE), with the collaboration of the European Association of Research Animals (EARA). This initiative was launched on September 20th, 2016.   An important part of the research undertaken at CIC bioGUNE...

2016/10/17

La marea rosa vuelve a Bilbao

Este domingo 16 de octubre se ha celebrado la 3ª Carrera solidaria contra el cáncer de mama en Bilbao organizada por la Asociación Acambi. Más...

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2016/10/13

Juan Manuel Ramírez will defend his PhD thesis on October 17th

Juan Manuel Ramírez will defend his PhD thesis, entitled "In vivo strategies for the study of ubiquitination and ubiquitin-related diseases: application to Angelman syndrome”, on October 17th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/10/06

Luca Unione will defend his PhD thesis on October 18th

Luca Unione will defend his PhD thesis, entitled "Sugars and Proteins: The Role of Dynamics in Molecular Interactions", on October 18th at 11.30H. The event will take place at the salón de actos "Colegio Oficial de Farmacéuticos", aulario de la Facultad de Farmacia de la Universidad Complutense de Madrid (Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid).

2016/10/05

Expertos internacionales se reúnen en Bilbao para discutir sobre cáncer

CIC bioGUNE organiza “Translational research in cancer cell metabolism”, un congreso sobre...

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2016/09/26

The University of the Basque Country has awarded Juan Luis García Rodríguez the Extraordinary...

The University of the Basque Country has awarded Juan Luis García Rodríguez the Extraordinary Doctoral Prize 2015-2016 for the thesis entitled “LKB1 in Liver Physiology”. His work, directed by Dr. Maria Luz Martinez Chantar at the Metabolomics Unit of CIC bioGUNE, was defended on January 31 of 2014 and is framed within the PhD Program of Molecular Biology and BioMedicine of UPV-EHU.The University...

2016/09/22

Assembly of large, salty and fat viruses: when a bit of grease helps

  The Structural Virology group led by Nicola Abrescia attended and contributed to the 10th...

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2016/09/12

New drug discovery company in the area of rare diseases

The new company, Atlas Molecular Pharma, aims to develop a technology capable of detecting molecules which stabilize proteins involved in the development of certain rare diseases The venture capital firm CRB Inverbío, Kereon Partners and other private investors also have a participating interest in the new company   CIC bioGUNE, the venture capital firm CRB Inverbío, Kereon Partners and private investors have jointly set up the company...

2016/09/06

Amaia Arruabarrena will defend her PhD thesis on September 16th

Amaia Arruabarrena will defend her PhD thesis, entitled "Metabolic Alterations in Prostate Cancer Pathogenesis”, on September 16th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencias y Tecnología de la UPV/ EHU.

2016/08/24

A new study sheds further light on vulnerabilities in aggressive breast cancer

Triple negative breast cancer is characterised by a lack of markers indicating the most effective treatment strategies A study led by the group of Dr. Arkaitz Carracedo in CIC bioGUNE identifies a protein which could be the subject of new treatments Research findings have been published in the prestigious journal Nature Communications. The study was mostly funded by social donations through...

2016/07/19

Translational research in cancer cell metabolism conference

Cancer metabolism is a rapidly evolving research area. The main aim of this conference is to bring together cancer researchers to present their work in the context of its monitoring or manipulating metabolic alterations in cancer.  This 3-day conference will cover established and emerging topics in the field, with an emphasis on translational research. A venue located in...

2016/07/05

Jesús Jiménez-Barbero has been appointed member of the Editorial Advisory Board of ACS Omega...

Jesús Jiménez-Barbero has been appointed member of the Editorial Advisory Board of ACS Omega, a new multidisciplinary, open access and online journal that represents a new approach from American Chemical Society Publications for chemists, materials scientists, biologists, physicists, engineers and other researchers, focused on research with connections to chemistry.

2016/06/30

Announcement of the 3rd PROTEOSTASIS Action Meeting: “Proteostasis and its Biological Implications”...

About the meeting The COST Action...

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2016/06/29

CIC bioGUNE inaugurates a Nuclear Magnetic Resonance spectrometer for the study of metabolic...

The innovative equipment has been acquired with financial support...

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2016/06/24

Lucia Mayela Gayosso will defend her PhD thesis on July 5th

Lucia Mayela Gayosso will defend her PhD thesis, entitled " Desarrollo de líneas celulares competentes para la replicación de priones humanos mediante la reprogramación de fibroblastos de pacientes genéticamente susceptibles”, on July 5th at 11.00H. The event will take place at the Sala Anexa al Paraninfo de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/06/21

Almudena Gerpe will defend her PhD thesis on July 6th

Almudena Gerpe will defend her PhD thesis, entitled "Estudio de la regulación de PHD1 y PHD3 por SUMO”, on July 6th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/06/21

La Academia de Ciencias Médicas de Bilbao nombra a Óscar Millet presidente de su sección...

La centenaria institución interrelaciona la sanidad con la...

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2016/06/17

Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing

  About this book: High throughput...

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2016/06/15

MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization...

  Aortic stenosis (AS) is the most...

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2016/06/10

CIC bioGUNE acoge una conferencia de Andrew Hessel, referente mundial en biología sintética

Es investigador de Autodesk Research San Francisco y...

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2016/05/25

CIC bioGUNE researchers identify immune cell checkpoints that regulate cell responsiveness...

The research describes the role of the mitochondrial MCJ protein...

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2016/05/23

The metabolism of prostate cancer cells is a determining factor for the development of metastasis...

The expression of a central regulator of cell metabolism,...

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2016/05/18

Estudio molecular de exosomas, sangre y microbioma en Fibromialgia

La Fibromialgia es una enfermedad crónica que cursa con dolor intenso en numerosos puntos del cuerpo, que se estima la padece un 3% de la población y para la cual no existe un diagnóstico eficaz. El gobierno Vasco ha concedido al Dr. Juan M Falcon-Perez un proyecto de Investigación en Salud para estudiar los exosomas, y analizar mediante tecnologías omicas la sangre y el microbioma de pacientes con fibromialgia. El objetivo del...

2016/05/16

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance...

Allergy may be combated by using Allergen immunotherapy (AIT). However, AIT displays...

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2016/05/16

The mechanism of sulfur transfer across protein-protein interfaces: the CSD model system

Cellular mobilization of elemental sulfur (S) is a crucial step for the biosynthesis of...

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2016/05/16

Our scientists develop a novel fragment-based combinatorial Nuclear Magnetic Resonance strategy...

One of the most expensive and time-consuming tasks in the drug discovery process...

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2016/05/16

Immunological adjuvants may help to stimulate the immune response to the co-administered antigens

Immunological adjuvants may help to stimulate the immune response to the co-administered...

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2016/04/12

CIC bioGUNE, only Spanish research centre selected in the latest call for applications of the...

The centre will research into the metabolism of hummingbirds, capable of storing and burning fat very rapidly The HFSPO will provide over one million euros in funds for the project   (Bilbao, 12 April 2016). CIC bioGUNE, the Centre for Cooperative Research in Biosciences, is the only Spanish scientific organisation selected in the 2016 call for applications of the Research Grant Program...

2016/03/17

Patricia Zuñiga will defend her PhD thesis on April 8th

Patricia Zuñiga will defend her PhD thesis, entitled "Implicación de LKB1 en la patogénesis y progresión del cáncer de próstata”, on April 8th at 12.30H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/02/15

Investigadores de CIC bioGUNE participan en el 2º Encuentro Industrias Bio-Salud Aquitania/Euskadi...

En el encuentro organizado por Basque Biocluster han intervenido la Dra. María Vivanco y el Dr. Joaquín Castilla(Bilbao, 12 de febrero de 2016). Los investigadores de CIC bioGUNE María Vivanco y Joaquín Castilla han participado en el 2º Encuentro de Industrias de Bio-Salud Aquitania/Euskadi, organizado por Basque Biocluster, asociación que aglutina...

2016/02/09

Observation at atomic resolution of an enzyme opens a pathway for inhibition of colon and liver...

A team of scientists from CIC bioGUNE, University of Liverpool and Cedars-Sinai...

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2016/02/08

CIC bioGUNE y la AECC celebran el 5º aniversario de su colaboración con un evento de...

El presente y el futuro en la investigación de cáncer de hígado...

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2016/02/04

La creación de REDiEX potenciará la medicina personalizada en España

 CIC bioGUNE participa en esta red que nace con la voluntad de potenciar las interacciones científicas La Red de Excelencia e Innovación en Exosomas aportará nuevas estrategias terapéuticas en enfermedades parasitarias y en cáncer(Bilbao, 4 de febrero de 2016). Diez centros españoles que estudian los exosomas en España, entre los que se encuentra...

2016/02/01

CIC bioGUNE celebra su undécimo aniversario con una conferencia científica a...

El premio Príncipe de Asturias de Investigación Científica y Técnica...

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2016/01/13

Lucia Pirone will defend her PhD thesis on February 18th

Lucia Pirone will defend her PhD thesis, entitled "Post-translational modifications by SUMO and ubiquitin-like proteins; role of sumoylation on SALL proteins", on February 18th at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/01/13

The ubiquitin ligase TRAIP binds PCNA and protects the genome in response to replication stress.

The replication of the genetic material can be blocked or slowed down by different...

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2016/01/12

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

While current therapies have achieved modest successes in some cancers, significant problems remain with most of our approaches to treatment. In particular, many newer targeted therapies are extremely expensive, highly toxic and not effective for rare types of cancer and advanced cancers. Even when they appear to work, a significant percentage of patients will experience a relapse after only a few months. Typically...

2016/01/11

Paulina Pluta will defend her PhD thesis on February 2nd

Paulina Pluta will defend her PhD thesis, entitled "Computational and biophysical methods for the characterization of protein-protein and protein-ligand interactions", on February 2nd at 11.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2016/01/11

David Gil will defend his PhD thesis on January 11th

David Gil will defend his PhD thesis, entitled "Automatización de la adquisición y procesamiento de datos en microscopía electrónica tridimensional", on January 11th at 12.00. The event will take place at the aula (Planta Baja), Escuela Universitaria de Ingeniería Técnica Industrial, Paseo Rafael Moreno "Pitxitxi" 3, BILBAO.

2015/12/22

Beca de investigación AECC Bizkaia

La mañana del 22 de diciembre tuvo lugar la firma de la última beca de investigación del año, concedida...

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2015/12/21

1st meeting of the Spanish Hypoxia Network (HypoxiaNet.es)

 HypoxiaNET.es is an open initiative to all researchers (basic, clinical and industrial) with a common interest in...

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2015/12/18

Highest resolution structure of a flexuous filamentous plant virus

 Flexible filamentous viruses are eukaryotic RNA viruses and economically important plant pathogens. Their viral particles contain several hundred copies of a helically arrayed coat protein (CP) protecting a (+)ssRNA. A research team from CICbioGUNE has described the structure of Pepino mosaic virus (PepMV) at 3.9 Å resolution by high-resolution electron cryo-electron microscopy. The work published in

2015/12/09

Hasier Eraña will defend his PhD thesis on December 21st

Hasier Eraña will defend his PhD thesis, entitled "Estudio de los determinantes moleculares que modulan la resistencia del conejo a la infección por priones utilizando un modelo de propagación in vitro", on December 21st at 12.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2015/12/09

Understanding proteins that only work with a pinch of salt

 Life on earth exhibits an enormous adaptive capacity and living organisms can be found even in extreme environments....

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2015/12/01

Ganeko Bernardo will defend his PhD thesis on December 15th

Ganeko Bernardo will defend his PhD thesis, entitled "Structural characterization of helices A and B of Kv7.2 channel bound to Calmodulin. The calcium effect.", on December 15th at 11.00H. The event will take place at the Salón de Grados de la Facultad de Ciencia y Tecnología de la UPV/ EHU.

2015/11/23

A key moment for science

- The Center for Cooperative Research in Biosciences CIC bioGUNE has managed to observe empirically for the first time a chemical species with a short lifetime that is generated during the formation and cleavage of sugars - The experimental demonstration of the existence of this chemical species, called intermediate "glycosyl oxocarbenium", helps to know more about the formation of carbohydrates - The study, which was presented in the prestigious...

2015/11/17

Evolution of SUMO function and chain formation in insects.

To understand the function and mechanisms of postranslational modification is crucial to understand protein function....

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2015/10/30

Carrera contra el Cáncer de Mama - Bilbao 2015

El pasado domingo 25, 10.000 camisetas rosas llenaron Bilbao de color y esperanza. Acambi (Asociación de Cáncer de Mama de Bizkaia) y el Gimnasio Urtzi organizaron por segundo año consecutivo la Carrera Solidaria contra el Cáncer de Mama. El corte de la cinta que daba inicio a la carrera fue cortado por la Dra Maria dM Vivanco, responsable del proyecto de investigación en el CIC bioGUNE, al que irá destinado...

2015/10/19

The CIC bioGUNE's International Scientific Board will meet to design the strategies of...

- The International Scientific Advisory Board, made up of leading international researchers, will hold its tri-annual meeting in order to analyse the research centre's scientific output in recent years and its projects for the future.- The sessions will take place on 19th and 20th October at the CIC bioGUNE headquarters - The group will disseminate the conclusions of its evaluation at the end of...

2015/10/08

The article "Insight into the Assembly of Viruses with Vertical Single β-barrel Major...

by Gil-CartonGil-Carton D, Jaakkola ST, Charro D, Peralta B, Castaño-Díez D, Oksanen HM, Bamford DH, Abrescia NG. Structure. 2015, 23:1866-1877. doi: 10.1016/j.str.2015.07.015. Epub 2015 Aug 27. Within an activity of 2 months the article has received 148 views and importantly it has been highlighted through the Previews section of the same issue of Structure: A Greasy...

2015/09/30

Gabriel Ortega will defend his PhD thesis on October 5th

Gabriel Ortega will defend his PhD thesis, entitled "Structural Studies of the Hypersaline Adaptation of Proteins belonging to Halophilic Archaea", on October 5th at 11.00H. The event will take place at the Salón de Grados of the Facultad de Ciencias (UPV/EHU).

2015/09/29

BM1307 PROTEOSTASIS Meeting in collaboration with EMBO (18th to 22nd September 2015). COST...

 About the meeting The COST Action BM1307 PROTEOSTASIS coordinated by Dr. Rosa Barrio (leader researcher at CIC bioGUNE) organized its third meeting in parallel with the EMBO Conference on "Ubiquitin and ubiquitin-like modifiers: from molecular mechanisms to human diseases" (18th-22nd September, Cavtat, Croatia). The meeting gathered together the members of the PROTEOSTASIS networking...

2015/09/16

Cellular and molecular heterogeneity in breast cancer

 Breast cancer is a very heterogeneous disease. We now know that breast tumors contain cells with properties of stem cells...

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2015/09/15

The quest of anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related...

The expression of MUC1, a glycoprotein displaying complex oligosaccharides, is usually...

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2015/09/03

A study shows the peripheral nervous system regeneration capacity after a lesion

- The project, led by CIC bioGUNE and University College London, has discovered a new mechanism that facilitates the regeneration of the layer that surrounds the neurons in the peripheral nervous system after suffering a lesion. - The loss of this insulating substance, called myelin, is involved in various severe neurodegenerative diseases.  - The research also shows that the cells that form myelin in...

2015/08/31

The unexplored archaeal domain and its viruses

Archaeal viruses represents one of the most challenging and yet unknown area of investigation. Archaeal viruses live in extreme...

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2015/08/07

A new study shows that rabbits are not resistant to infection by prions

 - A project led by CIC bioGUNE shows that rabbits are susceptible to spongiform encephalopathies, neurodegenerative diseases caused by prions.- The research, published in the journal PLOS Pathogens, used real prions regularly found in livestock species.- The conclusions from this study are useful for correctly assessing the risks faced by some species intended for human consumption. (Bilbao, 7 August...

2015/08/05

BRCA1, a breast cancer predisposition gene, a potential contributor in a human and animal model...

 Amyotrophic lateral sclerosis (ALS) is characterised by selective motoneuron degeneration in the spinal cord, brainstem and motor cortex leading to progressive muscle weakness, atrophy and paralysis. Growing evidence suggest that microglia are implicated in ALS through the release of both neuroprotective and neurotoxic factors. Analysis of the genetic profile of microglia in an animal model of...

2015/07/24

Steroids and Insulin pathways collaborate to promote tissue growth

How organisms reach their final size is a crucial question in Biology that is deeply related with the mechanisms...

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2015/07/20

Discovered the potential of a DNA regulator in the treatment of liver diseases

 - Research led by CIC-BioGUNE has achieved the remission of the biliary cirrhosis phenotype by controlling the activity of an epigenetic regulator. - The research, in which the University of California (UCLA) took part, was carried out using genetically modified mice.  (Bilbao, July 2015).- Center for Cooperative Research in Biosciences CIC bioGUNE is leading a study which has enabled the discovery...

2015/07/20

Cellular Uptake and Cytotoxic Effect of Epidermal Growth Factor Receptor Targeted and Plitidepsin...

Felipe Goñi-de-Cerio, Julie Thevenot, Hugo Oliveira, Encarnación...

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2015/07/15

Mammary Stem Cells

A book has recently been published on "Mammary Stem Cells", as part of the prestigious series on Methods in Molecular Biology from Springer. The book has been edited by Maria dM Vivanco, Group Leader at CIC bioGUNE, and includes cutting-edge methods and protocols to help members of the scientific community explore the behaviour of stem cells. Link

2015/07/15

Chafik Harrathi will defend his PhD thesis on July 28th

Chafik Harrathi will defend his PhD thesis, entitled "Estudio de la susceptibilidad/resistencia del ganado ovino a la infección por priones utilizando modelos de propagación in vitro", on July 28th at 12.00H. The event will take place in Salón de Grados, Facultad de Ciencia y Tecnología at the University of Basque Country.

2015/07/15

Molecular processes affecting mammary luminal progenitor fate

 In contrast to most mammalian organs, the mammary gland develops mostly after birth. Mammary epithelium is a...

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2015/07/15

Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag...

 Detection of molecular recognition processes requires robust, specific and easily...

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2015/07/14

Laura Palomo Díaz will defend her PhD thesis on July 28th

Laura Palomo Díaz will defend her PhD thesis, entitled "Metabolic implications and characterization of hepatic extracellular vesicles in drug-induced liver injury", on July 28th at 11.00H. The event will take place in Sala Anexa, Departamento de Genética, Antropología física y Fisiología Animal at the University of Basque Country.

2015/07/06

New pharmacological therapies for treating the most aggressive form of porphyria

- Research led by the Center for Cooperative Research in Biosciences seeks to obtain effective methods for changing the stability of the enzyme that causes development of congenital erythropoietic porphyria.- The research, which has received financial assistance from the multinational pharmaceutical company, Merck Serono, is focused on the use of pharmacological chaperones.   (Bilbao,...

2015/07/01

Prohibitins (PHBs) comprise an evolutionary conserved and ubiquitously expressed family of...

Prohibitins (PHBs) comprise an evolutionary conserved and ubiquitously expressed family...

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2015/06/29

The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated structures

 The Tn antigen (α-O-GalNAc-Ser/Thr) is one specific human tumor-associated...

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2015/06/22

Marie Skłodowska-Curie action awarded to carry out structure-function studies on Schmallenberg...

 Bilbao, June 15th, 2015: Virologist Dr. Hani Boshra has been awarded...

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2015/06/16

Healing tears

 - CIC bioGUNE and the company Bioftalmik have been working on a project that has identified a broad catalogue of endogenous peptides in human tears, and some...

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2015/06/09

The barrier preventing fatal disease transmission from deer to humans is identified

- Research by the University of California in co-operation with the Ikerbasque researcher...

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2015/05/21

Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and...

Endogenous peptides are valuable targets in the analysis of biological processes....

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2015/05/13

A new book on the role of carbohydrates in nature, with special emphasis on their roles in...

A new book on the role of carbohydrates in nature, with special emphasis on their roles in disease, is available. The book has been edited by J. Jiménez-Barbero, Scientific Director of CIC bioGUNE, together with two other scientific colleagues from CSIC  Details

2015/05/08

Defense of the PhD Thesis of Leire Herboso

Leire Herboso will defend her PhD thesis, entitled "El papel de los receptores SR-BI en la esteroidogénesis y de la Hormona Ecdisona en el crecimiento ", on May 12th at 12.00H. The event will take place in Salón de grados at the University of Basque Country.

2015/05/08

The scientific director of CIC biomaGUNE, Luis Liz-Marzán, elected member of the Royal...

 - Along with José María Mato and Soledad Penadés, three scientists from CIC bioGUNE and CIC biomaGUNE are now part of the scientific institution. - The researcher, doctor in chemistry from the University of Santiago de Compostela, is the scientific director of the research center in San Sebastian since early 2013.  (San Sebastián, May 2015)...

2015/04/21

Centros de investigación y empresas ‘bio' de Euskadi buscan estrechar lazos de...

- Los centros de investigación CIC biomaGUNE y CIC bioGUNE y el cluster de...

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2015/03/30

Protein homeostasis project brings researchers together

Intracellular proteolysis is critical to maintaining cellular homeostasis, and aberrations in this process play a central role in pathologies such as cancers, immune diseases and neurodegenerative conditions. The PROTEOSTASIS project aims to coordinate and integrate the work of research teams from across Europe in this area, as project chair Dr Rosa Barrio explains

2015/03/17

The oncogenic protein p15 binds and crosses the PCNA ring, suggesting a mechanism for regulation...

 PCNA forms a ring that encircles and slides on the DNA. It is an essential...

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2015/03/16

Revealing the mode of binding between the DNA repair machinery and a carcinogenic protein

 - A team from CIC bioGUNE led by Francisco J. Blanco has determined the structure of the complex formed by the p15 protein, present in several kinds of cancer and part of the cellular DNA repair machinery. - The structure reveals "a novel and unexpected mode of binding" that opens up the opportunity for designing selective inhibitors with anticancer therapeutic potential. - The study,...

2015/03/04

Ramón Areces Foundation funds research on therapeutic application of exosomes

 - The study is coordinated by CIC bioGUNE researcher Juan Manuel Falcón-Pérez,...

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2015/02/17

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

 Liver Cancer, the fifth most common cancer worldwide and the third leading cause of death, is a very complex and heterogeneous pathology with multiple and distinct signaling pathways that converge in the same malignant transformation. The laboratory of María Luz Martínez Chantar in the Metabolomics Unit at CIC bioGUNE has identified the effect of the post-translational modification NEDDylation...

2015/02/16

Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis for...

 The interactions between aromatic moieties and aliphatic entities are of paramount importance for essential molecular recognition events. In particular, CH-pi contacts are present in a variety of biomolecular complexes, and provide the impetus for different binding processes, including the recognition of glycans by proteins. Within a scientific collaboration leaded by CIB-CSIC (Asensio), with research...

2015/02/12

TV3 telethon funds Alzheimer's disease study by CIC bioGUNE and CIC biomaGUNE

- The project has secured 400,000 euros in funding from the telethon that the Catalan public TV channel organises every year, and which in 2013 raised money for neurodegenerative diseases.- The project focuses on the interaction of two proteins linked to Alzheimer's disease, with the aim of developing new therapies. (Bilbao/Donostia, February 2015).- Basque research centres CIC bioGUNE and CIC biomaGUNE...

2015/01/26

Ikerbasque researcher Jesús Jiménez Barbero is appointed new scientific director...

- A CSIC Research Professor and current president of the Spanish Royal Society...

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2015/01/26

Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase fromMycobacterium tuberculosis

 Mycobacterium tuberculosis is a human pathogen that causes tuberculosis, a...

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2015/01/22

Structure and interactions of a multifunctional domain of HuR protein

The human antigen R (HuR) is a powerful regulator of cancer. By binding and stabilizing certain messenger...

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2015/01/14

10º aniversario del Centro de Investigación Cooperativa en Biociencias

 Una década de biociencias en Euskadi- El centro vasco es hoy una realidad dentro...

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2014/12/23

Exosomes involved in tissue and organ formation

 - A study conducted by CIC bioGUNE, in collaboration with Severo Ochoa Molecular Biology Centre, shows that a Hedgehog protein...

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2014/12/16

Nora Bengoa will defend her PhD thesis on December 18th

Nora Bengoa will defend her PhD thesis, entitled "Noncanonical Wnts and their Receptors in Neural Differentiation", on December 18th at 4 pm. The event will take place in Salón de grados of the Faculty of Medicine at the University of Basque Country.

2014/12/12

Elisa Aida da Silva Ferrada will defend her PhD thesis on December 22nd

Elisa Aida da Silva Ferrada will defend her PhD thesis, entitled " Role of ubiquitin and SUMO molecules in the regulation of cellular factors", on December 22nd at 11.00H. The event will take place in Salón de grados at the University of Basque Country.

2014/12/10

One of our latest publications about Legionella appears as Scientific Highlight in Biostruct-X...

A long-standing question in the field of microbial pathogenesis is how virulence...

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2014/12/09

Exosomes participate in the Hedgehog gradient formation required in development

 Tissue and organ formation require a tight concerted coordination of many different cell types...

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2014/12/02

Marta Iruarrizaga will defend her PhD thesis on December 11th

Marta Iruarrizaga will defend her PhD thesis, entitled "Control of gene expression during schwann cell myelination and in pathological conditions", on December 11th at 10.30H. The event will take place in "Sala de Juntas de la Facultad de Medicina y Odontología" at the University of Basque Country

2014/11/19

Study discovers how rare disease causing cardiovascular and cognitive disorders is triggered

- This rare disease is homocystinuria, which affects 1 in every 250,000 children...

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2014/11/18

Structure of a protein interaction key for microtubule elongation

Cell division involves the segregation of the genetic material into the daughter cells that, when not properly...

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2014/10/28

The 7th Fero Grant is awarded to a study by Arkaitz Carracedo concerning new targets in aggressive...

- The CIC bioGUNE received the award from the cancer research foundation...

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2014/10/06

International experts in cell signalling and cancer metabolism gather at CIC bioGUNE

- From tomorrow until Thursday a congress will gather 120 scientists. - It is one of the most important European events in this field.- Its goal is to bring together the knowledge of basic science and clinical researchers  (Bilbao, October 2014) The Basque Center for Cooperative Research in Biosciences CIC bioGUNE will hold a scientific congress on cancer from tomorrow until the 9th. The title,...

2014/10/03

Resistir el déficit de oxígeno

 Ya lo dijo Darwin "no son las especies más fuertes las que sobreviven, ni las más inteligentes, sino aquellas...

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2014/10/01

The first non-invasive test to diagnose fatty liver disease is awarded two patents in the US

- The diagnostic test, which correctly categorises the disease in 94% of patients,...

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2014/09/22

Discovery of a new therapeutic target to fight against Legionella

- The bacteria releases a protein in human cells, called VipD, that facilitates its intracellular...

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2014/09/17

El Diputado de Promoción Económica visita bioGUNE para conocer su nuevo fermentador

- Imanol...

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2014/09/16

Scottish Ubiquigent will sell a product developed by CIC bioGUNE and Histocell to research...

 - The project is born from research projects undertaken in the CIC bioGUNE research...

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2014/08/12

A switch in Wnt signaling mediates early differentiation of human neural stem cells.

 A new study from the Cell Biology and Stem Cells Unit focuses on secreted proteins called...

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2014/07/30

US patent issued for a new CIC bioGUNE product to develop new cancer treatments

 - Tandem-repeated Ubiquitin Binding Entities (TUBEs) enable the identification of biomarkers,...

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2014/07/18

Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.

 During mitotic cell division chromosomes need to be repackaged into daughter cells,...

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2014/07/08

Discovery of a protein that allows brain stem cells to generate new neurons

 - A study conducted on mice, in which CIC bioGUNE is involved, has revealed that the MTP-MMP protein...

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2014/06/26

CIC bioGUNE's Animal Unit renews the accreditation that certifies the use of the highest...

 The Animal Unit of the CIC bioGUNE has renewed its "Full Accreditation"...

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2014/06/20

A possible pathway for inhibiting liver and colon cancer growth is found

 - A study by CIC bioGUNE, the University of Liverpool and the US research centre USC-UCLA has revealed...

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2014/06/16

Tuning intracellular homeostasis of human uroporphyrinogen III synthase by engineering a mutational...

 Congenital erythropoietic porphyria (CEP) results from a deficiency...

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2014/05/30

La química de carbohidratos rinde homenaje a la trayectoria científica de Manuel...

- El fundador y ex-director científico de CIC biomaGUNE es una de...

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2014/05/20

Medalla de la Real Sociedad Española de Química a la trayectoria científica...

 - Se trata del mayor reconocimiento que concede anualmente la RSEQ...

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2014/05/07

Cultivar para recoger, la inversión en investigación para el futuro de la innovación.

 La innovación es el futuro, y debe desempeñar una...

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2014/04/30

Ubiquitin profiling in liver using a transgenic mouse with biotinylated ubiquitin

 Ubiquitination is behind most cellular processes, with ubiquitin substrates being regulated...

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2014/03/31

Lysine Methylation Mapping of Crenarchaeal DNA-Directed RNA Polymerases by Collision-Induced...

 Enzymatic machineries fundamental for information processing (e.g. transcription,...

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2014/03/26

Abnormal levels of a molecule are associated with diabetic neuropathy

 - Researchers from CIC bioGUNE have revealed that the molecule SAMe causes changes in the genome...

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2014/03/13

S-adenosylmethionine levels regulate the Schwann cell DNA methylome

 Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation...

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2014/02/06

El investigador británico Mark Kearney
explica en Bilbao la relación entre...

 - El científico británico abrirá el jueves 6 de febrero (19.30 horas) la IX edición del ciclo de conferencias organizado por la Fundación BBVA y CIC bioGUNE - Ofrecerá una conferencia titulada 'Cómo promover la salud cardiovascular'- La diabetes es un trastorno crónico grave que afecta a más de 300 millones de personas en todo el...

2014/01/31

CIC bioGUNE celebra su noveno aniversario

- El centro vasco de investigación en biociencias ha celebrado su noveno aniversario con una conferencia a cargo del investigador...

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2014/01/14

Sox2 promotes tamoxifen resistance in breast cancer cells

 A study by the group of Maria Vivanco, in collaboration with the group of Robert Kypta (also at CIC bioGUNE), Dr...

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2014/01/10

European network to carry out research on protein life cycle

 - CIC bioGUNE leads the Proteostasis initiative, with more than 100 participant European laboratories.- Companies,...

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2014/01/07

SIRT1 controls liver regeneration by regulating BA metabolism through FXR and mTOR signaling

 Sirtuin 1 (SIRT1) is a class III histone deacetylase that tightly controls lipogenesis,...

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2013/12/23

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and...

 Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease...

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2013/12/18

The Movember Foundation has renewed by second year the EXOSOMES GAP1 project

Thanks to this award CIC bioGUNE researchers in close collaboration with the Basurto Hospital and the...

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2013/12/12

Rare disease that causes cardiovascular and mental disorders

3D structure of key protein...

 - CIC bioGUNE researchers have discovered the 3D structure of a protein (CBS),...

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2013/12/09

What goes wrong in Angelman Syndrome? Fruit flies give us the insight

 Angelman syndrome (AS) is a severe neurodevelopmental disorder related to autism, which presents also...

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2013/11/29

Structural basis for the allosteric regulation of human cystathionine beta synthase, the key...

 Cystathionine β-synthase (CBS) is the key enzyme in the transsulfuration...

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2013/11/11

A protein that 'rebels' against breast cancer treatment

- A study headed by the researcher María Vivanco, at CIC bioGUNE, has shown that the protein SOX2 makes...

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2013/10/30

Structural virology: making an impact in biology through hybrid methods

 The study of virus structures has contributed to structure biology methodological advances that go...

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2013/10/29

One of our groups opens the way to combatting dermatological disorders associated with Gunther's...

- The prestigious scientific journal PNAS has published a study from...

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2013/10/17

Mechanism of Membranous Tunnelling Nanotube Formation in Viral Genome Delivery

- The laboratory of Dr. Abrescia has described for the first time how the virus PRD1 uses...

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2013/10/16

CIC bioGUNE discovers a new form of virus reproduction

- The laboratory of Dr. Abrescia has described for the first time how the virus PRD1 uses lipids and proteins that are...

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2013/10/04

UPV/EHU awards one of our groups with the Special Doctoral Dissertation Award in Health Sciences...

 The Postgraduate Committee of the UPV/EHU awarded Dr. Nuria Martinez-Lopez with the Special Doctoral Dissertation Award in Health Sciences in the year 2010/2011 for her doctoral thesis entitled, "THE ROLE OF THE SERINE/THREONINE KINASE LKB1 IN THE PROLIFERATION OF HEPATOCELLULAR CARCINOMAS DERIVED FROM NON-ALCOHOLIC STEATOHEPATITIS (NASH)". Dr. Nuria Martinez-Lopez's research work...

2013/10/01

"Ayuda a investigación Oncológica 2013" grant awarded to one our groups...

 After studying the evaluation report by the A.N.E.P. (Agencia Nacional de...

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2013/09/19

The Spanish Association Against Cancer (AECC) awards one of our groups with a three year PhD...

Pablo Fernadez Tussy, from

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2013/09/18

Best poster presentation award in The Metabolic Regulation section of the XXXVI Congreso de...

 

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2013/09/11

EU allocates €1.5m funding to Arkaitz Carracedo's prostate cancer research project

- The European...

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2013/09/09

Ceramide-1-phosphate trafficking regulates intracellular eicosanoic lipid levels and the inflammation...

 In the presence of harmful stimuli, intracellular production of eicosanoids triggers the pro-inflammatory response. However, chronic inflammation has obvious deleterious effects and it has been associated with different pathologies including asthma and cancer. For this reason, the precursor of eicosanoids, the arachidonic acid, is tightly regulated by several signalling molecules...

2013/09/03

European project searches for tick-borne disease antidote

- CIC bioGUNE is taking part in the European project ANTIDotE, which aims to find components in the arthropod's...

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2013/09/03

Structural Basis for the Interaction of the Golgi-Associated Retrograde Protein Complex with...

Fusion of transport vesicles with the appropriate target compartment is a tightly...

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2013/07/29

Sensing low amino acids levels on the ribosome explored by cryoEM

In some bacteria the scarcity of amino acids is sensed on the ribosome, where RelA, the stringent factor,...

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2013/07/22

Abren un nuevo frente en la lucha contra
el cáncer de hígado

 - Una investigación del director de CIC bioGUNE, José María Mato, pone las bases para una nueva aproximación al tratamiento del cáncer de hígado más común, el Carcinoma Hepatocelular (HCC, en sus siglas en inglés) - El estudio, realizado en colaboración con la investigadora de la University of Southern California, Shelly Lu, demuestra...

2013/07/08

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma:...

 MAT1A is the main gene involved in the hepatic synthesis of S-adenosylmethionine (SAMe), the principal biological methyl donor and a precursor of polyamines and glutathione synthesis. We have previously shown that the disruption of MAT1A in mice induces a reduction in hepatic SAMe content, the spontaneous development of nonalcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC) (Mato...

2013/06/20

Abrescia's group has recently published its new book-chapter: Combined Approaches to Study...

Nicola Abrescia, Ikerbasque Research Professor and PI at the Structural Biology Unit at CIC bioGUNE has led the accomplishment of an exhaustive book-chapter on the hybridization of methods to determine the three-dimensional structure of viruses. This book-chapter has benefited from the contributions of Dr. Hanna M. Oksanen (Institute of Biotechnology and Department of Biosciences, University of...

2013/06/14

The eBook "Bioinformatics for High Throughput Sequencing" is one of the highly accessed...

 Since its online publication on Oct 25, 2011, there has been a total of 10268 chapter downloads for the book "Bioinformatics for High Throughput Sequencing" (edited by Naiara Rodriguez-Ezpeleta, Michael Hackenberg and Ana M. Aransay) on SpringerLink. This means that this book was one of the top 25% most downloaded eBooks in the relevant Springer eBook Collection in 2012.  Details...

2013/06/12

Nanoparticles for controlled drug release

 - Researchers from CIC bioGUNE are participating in the study of a novel technique that allows medicines to be transported...

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2013/05/16

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

The covalent attachment of adenosine monophosphate (AMP) to proteins, a process called...

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2013/04/29

Ikerbasque y CIC bioGUNE convierten euskadi en un referente internacional en biociencias

 o Los 12 investigadores Ikerbasque en CIC bioGUNE han captado más de 3 millones...

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2013/04/24

Discovery of a gene involved in fatty liver disease

  - An international research consortium led by CIC bioGUNE has found that the gene SLC2A1 is associated with non-alcoholic...

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2013/04/22

Regulating the regulators: Steroid hormone synthesis is controlled by SUMO, Ftz-f1 and Scavenger...

Steroid hormones are cholesterol derivates that control many aspects of animal...

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2013/04/19

New insight into the regulation of prostate gland morphogenesis

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE, Imperial College London and DKFZ Heidelberg...

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2013/04/08

Shedding light on new metabolic pathways implicated in cancer

The group of Arkaitz Carracedo at CIC bioGUNE has corresponded a review article in the prestigious journal Nature Reviews...

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2013/02/25

The great human protein 'encyclopaedia'

 - The Basque research centre CIC bioGUNE is participating in one of the largest international science projects after the Human...

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2013/02/21

CIC bioGUNE researchers to take part in the Basque Network of Food Safety Experts

 - This network will support the Food Safety Scientific Committee who advise the Basque Government(Bilbao, 21 february 2013).- CIC bioGUNE researchers -Mikel Valle, Nicola Abrescia, Juan Anguita and Jokin Castilla- will join an expert network providing advice to the Basque Foundation for Agro-food Safety (Elika) to share their knowledge with this Basque public body when needed. The expert network which...

2013/02/14

Novel designed molecules could stop colon cancer metastasis

 - A Basque research consortium has carried out a study in mice showing that novel synthetic molecules stop the...

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2013/02/13

Novel antagonists in early and late stages of cancer development.

 A multidisciplinary research team led by groups from CIC bioGUNE and the University of the Basque Country...

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2013/02/12

Proteomics Platform at CIC bioGUNE participates in the Chromosome Centric Project (C-HPP) within...

 With the generation of a well characterized human genome map together with...

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2013/02/06

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver...

 Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathologies...

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2013/01/17

Eight years of biosciences

 - Research centre CIC bioGUNE is celebrating its eighth anniversary with a conference by Catalan researcher Modesto OrozcoThe Basque Center...

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2013/01/09

Analía Núñez-O'Mara defends her PhD thesis on January 16th, 2013

 Analía Núñez-O'Mara will defend her PhD thesis, entitled " HIF Prolil Hidroxilasa 3 (PHD3), un doble centinela en la regulación de HIF: Implicación de la modificación por SUMO ", on January 16th, at 11.30h. The event will take place in "Salón de Grados de la Facultad de Ciencia y Tecnología", at the University of Basque Country. ...

2013/01/03

A new path for the future generation of glucose-measuring biosensors

- CIC bioGUNE researchers have proven the close connection between proteins that were thought...

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2012/12/11

Famelab, el certamen internacional de monólogos científicos, llega a España...

FameLab nació en 2005 gracias a una idea original del Festival de Cheltenham, cuyo principal objetivo era fomentar la divulgación de la ciencia identificando, formando y dando a conocer nuevos talentos entre los que trabajan en ciencia a través de un formato innovador, el monólogo científico.

2012/12/11

S-adenosylmethionine in Liver Health, Injury, and Cancer

 In this article, published in Physiological Reviews, Shelly Lu, from the Keck School of Medicine at the USC in Los Angeles and José Mato, from bioGUNE, review the work they have carried out in collaboration during the last 15 years on S-adenosylmethionine (AdoMet) and its role in liver health, injury, and cancer. Their research has unquestionably shown that normal AdoMet level is necessary to maintain liver health and prevent...

2012/12/10

LKB1: Friend or foe?

- Researchers from CIC bioGUNE have found that LKB1 protein, which is commonly used to inhibit the proliferation of breast, lung and cervical cancers, stimulates the growth of liver cancers in mice.- This discovery may lead to therapeutic applications in the fight against this type of cancer, which is one of the most dangerous and difficult to treat.(Bilbao,...

2012/12/05

A joint study between the CNIO and CIC bioGUNE identifies metabolomic biomarkers that could...

 - These findings were obtained in a study of 1500 metabolites in blood, thus making it the most in-depth analysis to date in this research field.- The work, which is published today in the on-line version of the journal Aging Cell, is an important breakthrough in the field of preventive molecular medicine and the identification of new biomarkers for early detection of...

2012/12/05

A metabolic signature predicts the biological age in mice

It is the metabolism, not the genes or the proteins, what defines better the phenotype of an organism. Consequently, the...

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2012/11/30

Jevgenia Tamjar defends his PhD thesis on December 3th, 2012

Jevgenia Tamjar will defend his PhD thesis, on December 3th, at 11:30 o'clock. The event will take place in "Sala anexa al Paraninfo", at the University of Basque Country (Leioa).

2012/11/29

David Fernández Ramos defends his PhD thesis on December 5th, 2012

 David Fernández Ramos will defend his PhD thesis, entitled "New Oncogenic Drivers in Hepatocellular Carcinoma: Role of the RNA Binding Protein Hu Antigen R", on December 5th, at 12 o'clock. The event will take place in "Salón de grados de la facultad de medicina", at the University of Basque Country.

2012/11/21

Algunos de los retos pasados y futuros de la Virología Estructural

Los virus se extienden por toda la biosfera. Algunos de ellos son patógenos para los seres humanos y los animales; otros son nuestros aliados al infectar y controlar la proliferación de bacterias indeseadas. Indudablemente estas maquinarias miniaturizadas e ingeniosas comparten nuestra existencia probablemente desde antes de que ocurriera la división en los tres dominios de la vida: Bacteria, Eukarya y Archaea....

2012/11/20

¿Podemos poner a dieta el cáncer?

Arkaitz Carracedo de la Unidad de Proteómica nos explica en una entrevista en Radio Euskadi, cómo se produce y desarrolla el cáncer, y cómo las investigaciones sobre el metabolismo de las células tumorales lo señala como un método de detección de tumores y el origen de posibles tratamientos.Audio: http://t.co/r9kzfrFb

2012/11/16

Glucose-galactose binding protein: e pur si muove.

 Protein function is often coupled to internal dynamics. Periplasmic binding proteins are bi-domain bacterial proteins that...

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2012/11/15

Jornada de divulgación: Alimenta tus emociones.

 En la jornada se abordará la relación existente entre la alimentación y la felicidad, así...

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2012/10/11

CIC NETWORK reúne a representantes políticos para debatir sobre política...

Racionalizar el sistema vasco de ciencia, tecnología e innovación...

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2012/10/05

Forum on Scientific Policy this October 11th at 11:00am

Con motivo de la próxima convocatoria de elecciones al Parlamento Vasco, el próximo día 21 de octubre, la revista CIC Network -impulsada por la red de Centros de Investigación Cooperativa (CIC) de Euskadi- ha convocado un Fórum sobre política científica, en la que participarán representantes de las principales fuerzas políticas que concurrirán a dicha convocatoria electoral...

2012/10/01

First symposium of leading Spanish scientists who use Drosophila in their biomedical studies...

 More than 40 scientists from 11 centres, including CIC bioGUNE, bear out the strength of the science performed with the fruit fly in Spain.CIC bioGUNE scientists David Gubb and

2012/10/01

First 1st Board Meeting of the UPStream Consortium organized by CIC bioGUNE in Bilbao

 CIC bioGUNE leads the UPStream project, an excellence training program for young scientists investigating the biochemical process of ubiquitylation and other related modifications. The 1st Supervisory Board Meeting will take place in the

2012/10/01

Metabolomics and proteomics, two key technologies in modern biology

 - International experts will discuss recent technological advances and the applications of these...

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2012/09/19

LKB1 drives Ras activation in bad prognosis hepatocellular carcinoma: A new axis in liver tumorigenesis....

 Hepatocellular carcinoma (HCC) accounts for more than 90% of liver...

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2012/09/18

CIC bioGUNE y CIC biomaGUNE, dos centros, un objetivo

- Ambos centros de investigación en biociencias y biomateriales cuentan con más de 200 investigadores y han acometido inversiones por valor de 75 M€ desde 2005.- Han obtenido 158 M€ procedentes de programas competitivos de ayuda a la investigación, fundaciones y contratos de investigación con empresas.- Presentarán sus credenciales...

2012/09/13

Iñigo Urkullu visita las instalaciones de CIC bioGUNE

 El Presidente del Partido Nacionalista Vasco (EAJ-PNV) y candidato a Lehendakari en las próximas elecciones...

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2012/09/12

Pubmed ratings place the CIC bioGUNE Animal Unit's work in the top 10

 The publication "Clinical biochemistry parameters in C57BL/6J mice after blood collection from the submandibular vein and retroorbital plexus" (Fernandez et al., 2010), was the third most downloaded article (1903 hits) of the Journal of the American Association of Laboratory Animal Science (JAALAS) from Pubmed Central in 2011 (see table 5 in page 247 in reader survey). JAALAS is recognized as one of the top international...

2012/09/04

The therapeutic potential of cellular fat oxidation in bone-marrow transplants and breast cancer

 - Dr. Arkaitz Carracedo of Biogune takes part in two studies which...

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2012/08/20

Burning fat for cellular fitness: friend or foe?

 Fat accumulation and elimination in developed societies is an increasing health and aesthetic concern. But there is more to...

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2012/08/02

Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA

 Multi-subunit RNA polymerases (RNAPs) in all three domains of life share a common...

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2012/07/13

HuR plays a critical role in liver fibrosis development

 Hepatic fibrosis is the common consequence of chronic liver diseases such as viral and autoimmune hepatitis, alcohol...

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2012/07/10

Synthetic solutions to combat infections

Biogune researcher, Juan Anguita, in collaboration with scientists of the University of Massachusetts, has proven the efficiency of...

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2012/06/27

Viruses find new ancestors

 - Biogune researchers and scientists from the Universities of Oxford and Helsinki propose a radically different structure-based classification...

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2012/06/26

CIC bioGUNE to hold exosome expert meeting

 - The meeting will gather the Spanish work group that studies exosomes, formed after the last conference in Gothenburg...

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2012/06/04

When fat meets inflammation: NK cells are to blame

 - Researchers from the Center for Cooperative Research in Biosciences, CIC bioGUNE (Bizkaia), led by Dr. Naiara...

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2012/06/04

NK cells are the main contributors to the chronification of liver inflammation in the absence...

 Glycine N-methyltransferase (GNMT) is the key enzyme that catabolizes S-adenosylmethionine...

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2012/05/24

Ugo Mayor, from Funcional Genomic Unit, have collaborated in the book "Ubiquitin Family...

 Ugo Mayor, from Laboratory 4 at Functional Genomics Unit, have collaborated in the book "Ubiquitin Family Modifiers and the Proteasome" with the chapter titled "Deciphering tissue-specific ubiquitylation by mass spectrometry". Abstract Protein ubiquitylation is a highly conserved, central mechanism to regulate cellular events in all eukaryotes, such as...

2012/05/22

New non-invasive test for fatty liver disease diagnosis developed

 - Researchers at Biogune, in collaboration with OWL Genomics, CIBERehd and eleven hospitals...

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2012/05/07

Post-transcriptional regulation of Schwann cell development

 Schwann cells are the dominant glia cells in the peripheral nervous system (PNS) and associate with axons...

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2012/04/16

NASH predictive test

 In collaboration with OWL Genomics, CIBERehd,...

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2012/03/20

CIC bioGUNE leads European researcher training project

 - The Basque research Centre is coordinating UPStream, an excellence training programme for young scientists...

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2012/03/19

Our researchers from Laboratory 3 at Proteomics Research Unit, have collaborated in the book...

 Researchers from Laboratory 3 at Proteomics Research Unit, have collaborated...

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2012/03/13

Mad rabbit disease

 - Our scientists have shown that rabbits, which were previously thought to be resistant to prion diseases, can also develop such infections....

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2012/03/13

Mad rabbit disease

 The ability of prions to infect some species and not others is determined by the transmission barrier. This unexplained phenomenon led to the belief...

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2012/03/07

Metabolomics as a Tool for Preclinical Studies.

 Juan Manuel Falcón will participate in the MS Technology Days organized by Waters Corporation between the days 20th and 21st of March that will take place in Madrid and Barcelona with the speach "Metabolomics as a Tool for Preclinical Studies". Link to the program here. ...

2012/03/01

Extracellular Microvesicles as Biological Source for Biomarker Discovery

Juan Manuel Falcón has participated in the conference "Extracellular Microvesicles as Biological Source for Biomarker Discovery", organized by the Luxembourg Center for System Biology, University of Luxembourg the 29th of February and hosted by Karsten Killer and Rudi Balling.

2012/02/27

Valentine Comaills will defend her PhD thesis on March 2nd

 Valentine Comaills will defend her PhD thesis, entitled "Retinoic acid and estrogen signalling pathways in tamoxifen resistant breast cancer cells", on March 2nd, at 13.00H. The event will take place in 'Salón de grados de la Facultad de Ciencias', at the University of Basque Country.

2012/02/27

Women and science

Our research, Edurne Berra, will participate in the fisrt edition of the conference "Women and science".

2012/02/27

The structure of the dimerization domain of the tumor suppressor ING4 reveals the functional...

 A collaborative work between the groups of Ignacio Palmero (CSIC), Guillermo...

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2012/02/13

A prestigious American foundation will fund research at Biogune into Angelman Syndrome

 The group led by Dr. Ugo Mayor aims to identify the protein substrates responsible...

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2012/01/31

Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities...

 According to a study carried out by researchers at CIC bioGUNE (Proteomics...

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2012/01/31

New mechanism involved in the development of hepatocellular carcinoma and colon cancer.

 Hepatocellular carcinoma (HCC) is a neoplasm with poor prognosis and represents...

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2012/01/13

New therapeutic target to fight liver cancer discovered

 Researchers from the Center for Cooperative Research in Biosciences, CIC bioGUNE (Bizkaia), led by Dr. Maria...

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2012/01/11

Recently, researchers from the Metabolomics Unit have collaborated in the new book Methods...

 Hepatic differentiation is a complex process that requires the balanced regulation...

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2012/01/11

Arkaitz Carracedo: searching the keys of cancer

Small interview to one of our researchers in Teknopolis TV show

2011/12/21

CIC bioGUNE researchers, Mikel Valle and Xabier Agirrezabala, have collaborated in the new...

 Mikel Valle and Xabier Agirrezabala have collaborated in the new book edited...

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2011/12/19

First Engineered Human GLTP

 The rational engineering of proteins with desirable properties is an emerging field that relies on structural studies. A research team of...

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2011/12/12

Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice

 Very-low-density lipoprotein (VLDL) secretion provides a mechanism to export triglycerides...

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2011/11/04

CIC bioGUNE researchers, Ana María Aransay and Naiara Rodríguez-Ezpeleta, have...

 Ana María Aransay and Naiara Rodríguez-Ezpeleta,

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2011/10/27

Researchers, doctors and health managers analyse prevention challenges in Bilbao

 The conference took place on Thursday 27 October, at the Basque Government's...

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2011/10/18

The second health innovation cycle will take place on the 27th of october, 2011

The second health innovation cycle, conducted by Fundación Ciencias de la Salud, will take place on the 27th of october, 2011.

2011/10/10

Discovery of a cell mechanism that reduces effectiveness of breast cancer treatment

 - Researchers from Massachusetts General Hospital, Harvard Medical School and CIC...

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2011/10/10

De novo induction of amyloid-β deposition in vivo

 Alzheimer's disease (AD), the most common type of senile dementia, is associated to the buildup of misfolded...

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2011/10/05

A new study attributes infectivity to Alzheimer's disease

 - It is still...

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2011/09/30

CIC bioGUNE welcomes the presentation of the new season of Teknopolis television show

 This Sunday, October 2, starts the fourteenth season of the science and technology show...

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2011/09/26

A consortium of Basque institutions patents a product to foretell drug-related hepatic toxicity

- The project, named LIVERTOX, involves the research centre CIC bioGUNE...

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2011/09/14

The Center for Cooperative Research in Biosciences, CIC bioGUNE, hosts from 12 to 14 September...

  - Leading researchers, including President of the Metabolomics...

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2011/08/16

Alternate Models of RNA Looping on Nova-1 Protein in Splicing

 Nova proteins are implicated in alternate splicing regulation of specific neuronal genes and expressed...

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2011/07/29

José M Mato appointed as a member of the new Society of CSIC Presidents

 Prof. José M Mato, General Director of CIC bioGUNE and CIC biomaGUNE, has become part...

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2011/07/18

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli...

 Researchers from CICbioGUNE in collaboration with the Max Planck Institute for Biophysical Chemistry have described the first initiation complex for E. coli ribosomes during translation.  The selection of mRNA, of the correct start codon, and of the initiator fMet-tRNAfMet requires the presence of three initiation factors (IF1, IF2, IF3). By cryoEM and classification techniques the structure...

2011/07/14

Prof. Neil Kaplowitz's special lecture available in our Video section

 Interplay of Stress Signaling and Mitochondria in Hepatotoxicity: watch it!

2011/07/07

The activity of SALL transcriptional repressors depends on their HDAC and their SUMOylation...

 The SALL (Spalt-like) family of zinc finger transcription factors is conserved...

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2011/07/01

Rapid identification of fluorochrome modification sites in proteins

 Conjugation of a fluorescent dye to the ε-amino groups of protein lysine residues maximizes the detection...

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2011/06/15

Marco Piva will defend his PhD thesis on June 16, 2011 at 11:00, in Salón de Grados...

The thesis is entitled: "Implication of breast cancer stem cells in tamoxifen...

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2011/06/13

La aecc concede 300.000€ a CIC bioGUNE para impulsar la investigación contra el...

  - La Asociación Española Contra el Cáncer (aecc)...

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2011/05/19

José M Mato receives the prestigious "XLIII Jímenez Díaz Memorial...

 -> The award was granted by the Conchita Rábado de Jiménez...

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2011/05/19

Macromolecular crowding fails to fold a globular halophilic protein in cells

 Scientists from the Structural Biology Unit in collaboration with researchers of the University...

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2011/05/02

The metabolism of cancer: Warburg effect mediated by ROS and HIF

 In Cancer cells, the reprogramming of cellular metabolism requires a glycolitic shift that provides the source of lipids, amino acids and nucleic acids needed for tumor progression and proliferation. Critical roles for posttranslational modifications of proteins have emerged in cancer. Among them, histone deacetylase SIRT3 has been recently identified as a genomically expressed, mitochondria-localized tumor suppressor (Kim et...

2011/04/29

miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing...

 We present a new version of miRanalyzer, a web server and stand-alone tool for the detection of known and prediction of new microRNAs in highthroughput sequencing experiments. The new version has been notably improved regarding speed, scope and available features. Alignments are now based on the ultrafast short-read aligner Bowtie (granting also colour space support, allowing mismatches and improving...

2011/04/13

Intracellular Rescue of the Uroporphyrinogen III Synthase Activity in Enzymes Carrying the...

 In a collaborative effort between the Metabolomics Unit and the Structural Biology...

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2011/04/01

Discovery of a protein that alters the nutrition of breast cancer cells

A study published in the prestigious journal Cancer Cell in March gives us a better understanding of the...

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2011/03/31

Series of Lectures 2011: Prof. Sir Tom Blundell

Sir Tom Blundell, Professor and Director of Investigation in the Department of Biochemistry of the University of Cambridge (United...

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2011/03/18

Series of Lectures 2011: Peter H. Seeberger

A bottle of refreshment, a remote control and four dolls are the means that Swiss chemistry Peter Seeberger uses to explain the importance...

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2011/03/17

Nuria Martínez defends her PhD thesis on March 22, 2011

Nuria Martínez will defend her PhD thesis on March 22, 2011, in Salón de Grados de la Facultad de Medicina at University of Basque Country. The thesis is entitled: The Role of Serine/Threonine Kinase Lkb1 In The Proliferation Of Hepatocellular Carcinomas Derived From Non-Alcoholic Steatohepatitis (NASH).

2011/03/17

The sirtuin SIRT3 counteracts HIF1A-mediated metabolic reprogramming in cancer

 Researchers at Harvard Medical School in collaboration with a group from CIC bioGUNE reveal...

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2011/03/11

Jose Luis Bilbao receives in Leasehold Palace 71 people and 40 companies that participated...

The General Deputy of Bizkaia, Jose Luis Bilbao, has received in the Leasehold Palace...

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2011/03/03

Series of Lectures 2011: José Elguero

First day of Center's Series of Lectures 2011: Química y Salud

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2011/02/11

Structural studies of a eukaryotic pore-forming toxin.

 Collaboration between the University of the Basque Country and the Structural Biology Unit in CIC bioGUNE brought some...

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2011/02/10

Designed endonucleases in gene therapy for the Bubble Boy syndrome

 A collaborative work from research groups at CIC bioGUNE, CNIO, CRG and Cellectis shows how meganucleases...

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2011/02/08

Oestrogen reduces the aggressiveness of breast cancer

According to a study carried out by researchers at CIC bioGUNE, led by Dr. María Vivanco, oestrogen reduces the proportion...

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2011/02/03

CIC bioGUNE celebrates its sixth anniversary with a special lecture by Professor Jesús...

(Bilbao, 29 January 2011).- On 28th of January, the Centre for Cooperative Research...

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2011/01/26

Javier Conde Vancells defends his PhD thesis on February 2nd, 2011

Javier Conde Vancells will defend his PhD thesis, entitled "Molecular and Functional Study of Exosome-like Vesicles as a New Source of Non-invasive Biomarkers for Liver Disease", on February 2nd, at 12 o'clock. The event will take place in 'Salón de grados de la Facultad de Ciencias', at the University of Basque Country.

2011/01/20

Prohibiting hepatocytes to lose control

  Hepatocellular carcinoma (HCC) is the most frequent primary malignant tumor type in the liver. Whereas the etiology frequently involves viral infection or alcoholic cirrhosis, it can often be preceded by non-alcoholic steatohepatitis (NASH). Critically, Non-Alcoholic Fatty Liver Disease (NAFLD) is present in up to a third of the general population. It is therefore of tremendous interest to characterise the biological factors that affect the...

2011/01/20

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and...

 Prohibitin 1 is a highly conserved, ubiquitously expressed protein that participates...

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2011/01/19

Different DNA binding modes for p53 tumor suppressor

 Tumor suppressor p53 is a transcription factor that plays a central role in cell cycle control, and mutations in the protein...

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2011/01/11

New insight into the regulation of neuronal differentiation by Wnt proteins

Researchers from the Cell Biology and Stem Cells Unit and the Genome Analysis Group at CIC bioGUNE have...

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2011/01/11

Two recent publications reveal how cancer-associated mutations in ING1 and ING4 genes impair...

 Collaborative work between the groups of Ignacio Palmero (Instituto de Investigaciones...

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2011/01/04

'Teknopolis': De cerca: Ugo Mayor

Aparición en Teknopolis de Ugo Mayor. Teknopolis, programa de divulgación científica emitido en ETB. Teknopolis pretende difundir contenidos científicos de carácter general y realizaciones científico-tecnológicas del País Vasco.Video en Castellano Video en Euskera  

2010/12/21

The workshop on patents and their role in knowledge and technology transfer.

The workshop on patents and their role in knowledge and technology transfer took place in CIC bioGUNE...

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2010/11/29

The First National Conference on Prion Diseases takes place in CIC bioGUNE

Over a hundred experts attended the First National Conference on Prion Diseases which took place in CIC...

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2010/11/16

From the lab to the market: patents as vehicles of knowledge's transfer

On the 17th of December, 2010, CIC bioGUNE will host a half day seminar on patents as vehicles of knowledge's transfer. The seminar opens at 9:30 in Atrio of the building 800. Available downloads:1.- Manuel Illescas2.- Manuel Martín-Lomas 3.-...

2010/11/16

CIC bioGUNE patents a new system to treat Günter's disease

CIC bioGUNE has patented a new system that can help alleviate the symptoms of a rare, aggressive disease, congenital erythropoietic porphyria, more commonly known as Gunther's disease. The Centre is examining the possibility of developing a new drug that improves the quality of life for patients suffering from this disorder.

2010/10/29

Ubiquitination during neural development

Ubiquitination of neuronal proteins is an essential regulatory mechanism of brain function. The failure of this process has been associated...

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2010/10/18

A novel strategy to isolate ubiquitin conjugates reveals a role of ubiquitination in neural...

Ubiquitination of neuronal proteins is an essential regulatory mechanism of brain...

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2010/10/06

Joint Workshop UPV/EHU - CIC bioGUNE: Introduction to Tomography Techniques in TEM

UPV/EHU - CIC bioGUNE Joint Workshop on tomography techniques in TEM will take place on 6th of October, at Joxe Mari Korta building, Donostia, and on 7th of October, in building 801's atrium, CIC bioGUNE, Derio. Please see attached files for more information.

2010/10/05

Estrogen affects the proportion of stem cells in the breast

Researchers from Maria Vivanco's laboratory at Cell Biology and Stem Cells Unit of CIC bioGUNE, in collaboration with...

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2010/10/01

Blood test developed for non-alcoholic fatty liver disease diagnosis

Researchers from the Metabolomics unit at CICbioGUNE-CIBERehd and OWL Genomics Ltd. (Bilbao, Spain) have used...

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2010/09/29

Expertos internacionales en Resonancia Magnética Nuclear se dan cita en CIC bioGUNE

Centro de Investigación Cooperativa en Biociencias, CIC bioGUNE, acoge estos días...

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2010/09/27

A consortium of Biscayan entities will develop an innovative computer tool to predict hepatic...

Participating in the project, called LIVERTOX, are the research centreCIC bioGUNE, the companies Owl Genomics, MD Renal and FaesFarma, which is financed by the Provincial Council of Biscay.Apart from the clinical importance of the project, hepatotoxicity is themost frequent reason for removing a medicine from the market.

2010/09/27

Blood test developed for non-alcoholic fatty liver disease diagnosis

The metabolomics-based blood test developed by OWL Genomics andCIC bioGUNE will contribute to the early diagnosis of NASH, whichaffects up to 24% of the US and European population. "This is the first application of a novel experimental approach for bloodmetabolomic profiling that can identify biomarkers for potentially anyliver disease", says professor José Mato.OWL Genomics is beginning to commercialise...

2010/09/23

Open Day Presentation for MSc students

On Thursday, 23rd of September, CIC bioGUNE will be hosting a group of Master's students from the UPV and University of Cantabria Molecular Biology and Biomedicine course. The students will attend a short talk and will be given a guided tour of CIC bioGUNE laboratories.

2010/09/22

Critical role of LKB1-Akt pathway activation in the proliferation of hepatocellular carcinoma...

Researchers from the Metabolomics unit at CICbioGUNE-CIBERehd have recently observed...

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2010/09/10

Mutations That Cause Neurodegenerative Disorders

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a progressive neuromuscular disease that weakens and eventually destroys motor neurons (components of the nervous system that connect the brain with the skeletal muscles). 4-8 per 1000,000 people suffer from ALS worldwide, with 5000 new cases occurring in the United States and 900 in Spain each year. In collaborative effort with Juan S. Bonifacino from National Institute of...

2010/09/01

Structural Basis for the Wobbler Mouse Neurodegenerative Disorder

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the...

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2010/07/28

Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Fibroblast growth factor 21 (FGF21) is a hepatic protein that plays a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat. Its systemic administration to obese rodents and diabetic monkeys leads to improved glucose homeostasis and weight loss. In rodents, FGF21 increases with fasting and consumption of a ketogenic diet (KD). In humans, FGF21 correlates with body mass index (BMI),...

2010/07/12

Work-shop Consorcio SICI-Consolider (Spanish Initiative on Ion Channels)

Expertos internacionales debaten en Bilbao sobre los avancesen la investigación en canales iónicos, proteínas que tienen unpapel clave en enfermedades como epilepsia, arritmia,trastornos mentales o cáncer

2010/07/01

Xavier Tadeo Campillo defends his PhD thesis

On 01/07/2010, Xavier Tadeo Campillo from Oscar Millet's lab defended his PhD thesis: CStructural basis for the aminoacids composition of halophilic proteins and its relationship with enzimatic activity and stability. The event took place in Aula Magna Enric Casassas aulario de Química, Planta 0.

2010/06/24

Advisory Board visits CIC bioGUNE

The Scientific Advisory Board visited the centre between June 16th and 18th, marking the 5th anniversary of the CIC bioGUNE Research Centre's...

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2010/06/24

Novel Function and Intracellular Localization of Methionine Adenosyltransferase 2β Splicing...

Human methionine adenosyltransferase 2B (MAT2B) gene encodes two major splicing variants, V1 and V2, which are differentially expressed in normal tissues. Both variants are induced in human liver cancer and regulate growth. Researchers from the Division of Gastroenterology and Liver Diseases, University of Southern California (USC) and from CIC bioGUNE have shown, using proteomics analysis, that HuR...

2010/06/23

Liher Imaz presented his Ph.D. thesis on Wednesday, 23rd of June.

Liher Imaz successfully defended his Ph.D. thesis on Wednesday, 23rd of June, at 12 o'clock, in the "Sala Anexa al Paraninfo" at the School of Science and Technology at the Basque Country University (Leioa). The thesis title: Estudio de asociación de genoma completo en enfermedad de Alzheimer.

2010/06/23

Post-translational modification by sumoylation is crucial to the activity of the Spalt-like...

The Spalt-like (Sall) family of zinc finger transcription factors is conserved throughout...

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2010/06/22

The Long History of the European People

    A large proportion of diseases that affect the welfare of human populations have a genetic component. Researchers have put in a vast effort in order to correlate the incidence of a particular disease with a particular gene. Those efforts have been unsuccessful in many cases, particularly with diseases considered multi-causal, where there could be a strong environmental component or where several genes could be implicated. Under this scenario, genetically...

2010/06/01

The structure of the cellular stress sensor Gadd45α has been determined by NMR

The Gadd45 nuclear proteins modulate the response of mammalian cells to genetoxic and physiological...

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2010/05/25

Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary...

The mechanism underlying prion strain mutation in the absence of nucleic acids remains unresolved. Using susceptible transgenic mice, two prevalent chronic wasting disease (CWD) prion strains were identified - with divergent biological properties but composed of PrPSc with indistinguishable biochemical characteristics.The study, performed at the University of Kentucky Medical Center, was published in the...

2010/05/19

Harvard University and the Pasteur Institute will use CIC bioGUNE technology for the research...

Several international scientific institutions of wide renown, such as Harvard University...

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2010/05/18

CIC bioGUNE researchers take part in a project to control the prion epidemic affecting deer...

(Bilbao, 13 May 2010).- Researchers at the Centre for Cooperative Research in Bioscience,...

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2010/05/11

A large-scale genetic study confirms that Basque people are a homogeneous group distinguishable...

(Bilbao, May 10, 2010).- A new population genetics study coordinated by the Centre...

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2010/05/07

High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms...

Researchers from the Co-operative Research Center, CIC bioGUNE, from the Basque Foundation...

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2010/05/06

The Crystal Structure of Protein MJ1225 from Methanocaldococcus jannaschii Shows Strong Conservation...

In mammals, 5′-AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic serine/threonine kinase subunit (alpha) and two regulatory subunits (beta and gamma). The gamma-subunit senses the intracellular energy status by competitively binding AMP and ATP and is thought to be responsible for allosteric regulation of the whole complex which is thought to exist only...

2010/04/28

Interacting Pathologies

Workers in Texas and Chile, including Joachin Castilla (who is now at the CIC bioGUNE Institute), have shown a link between the pathological mechanisms of Alzheimer's disease and Prion disease in a mouse model system. A group of human diseases is associated with the accumulation of misfolded proteins. These diseases tend to develop late in life, strike without warning and are progressive, causing tremendous suffering both to patients and their immediate families. The nervous...

2010/04/23

CIC bioGUNE y el Instituto Tomás Pascual firman un convenio de colaboración dirigido...

(Bilbao, 22 de abril de 2010).- El Centro de Investigación Cooperativa en Biociencias, CIC bioGUNE, y el Instituto Tomás Pascual han firmado un convenio de colaboración con el objetivo de fomentar la formación y difusión del conocimiento científico durante el presente año 2010.

2010/04/22

Researchers from CIC bioGUNE take part in SYSGENET European Network

(Bilbao, 23rd April 2010) - The European Science Foundation (ESF), which belongs to the European Union, with...

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2010/04/21

Sorting of the Alzhermer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex.

A new Signal-Adaptor Interaction between Alzheimer's Disease Amyloid Precursor Protein...

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2010/04/20

A new link between Alzheimer's and prion diseases.

(Bilbao, March 2010). Researchers from the Co-operative Research Center, CIC bioGUNE, and from the University of Texas Medical...

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2010/04/16

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion...

The work whose results suggest an interaction between Alzheimer's and prion...

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2010/04/01

Bruno Sergio Mafra Simoes defends his PhD thesis.

On 01/04/2010, Bruno Sergio Mafra Simoes from María dM Vivanco's lab defended his PhD thesis: Characterisation of human breast stem/progenitor cells. The event took place in Sala Anexa al Paraninfo, Facultad de Ciencias y Tecnología, UPV/EHU.

2010/03/30

Ciclo en Tierra de Nadie: Conversaciones sobre Ciencias y Letras

El discurso científico se rige, esencialmente por la razón; el humanístico, por el sentimiento....

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2010/03/26

New insight into the role of Wnt-11 in prostate cancer

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE and Imperial College London have studied the function...

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2010/03/24

Encuentros científicos Eureka Café - Alimentos transgénicos: pros y contras...

(Bilbao, 22 de marzo de 2010).- La catedrática de Bioquímica y...

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2010/03/24

Advances in protein quantitation using iTRAQ labeling

Proteomics Platform group at CIC bioGUNE has recently published two papers focused on the methodological aspects of protein...

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2010/03/22

Basque Business Association's President visits CIC bioGUNE

Mr. Miguel Lazpiur, President of the Basque Business Confederation (Confebask), visited today, 22nd of March, CIC bioGUNE's...

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2010/03/18

Timing is everything

Current estimates by the World Health Organization indicate that, worldwide, about 1.6 billion (BMI >25 kg/m2) adults are overweight and 400 million are obese (BMI >30 kg/m2), and in developed countries with a westernized style of life about two-thirds of the adults are overweight or obese. Although the majority of these individuals may have fatty liver, luckily, only a small fraction of these will develop hepatocellular carcinoma (HCC). Nevertheless, hepatosteatosis, together...

2010/03/17

Diagonal-free signals

Members of the NMR Platform and the Structural Biology Unit lead by Tammo Diercks have developed a new pulse sequence that improves the acquisition of spatial...

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2010/03/15

To mutate or not to mutate: that's the question

Palms, fingers and thumbs are not just parts of the human body. They are also terms used to describe the structural elements that make up the catalytic core of fundamental enzymes such as DNA polymerases. These enzymes are present across the three kingdoms of life, Eukarya, Archaea and Bacteria (but also encoded by some viruses), and are involved in DNA replication, a process that allows the polymerisation of a new DNA fragment by the readout of a DNA...

2010/03/05

Bypass of an aromatic amine lesion by Y-family polymerase Dpo4.

An international team of researchers from MSKCC (USA), NYU (USA) and CICbioGUNE reported a detailed insight into...

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2010/03/03

Novel properties of LDL atherogenic particles uncovered by NMR

A team of researchers from CIC bioGUNE and the Hospital de la Santa Creu i Sant Pau, in Barcelona, have measured 2D-NMR...

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2010/02/24

A new laboratory at CIC bioGUNE will research the mad cow disease

The Prion Laboratory of the Proteomics Unit of CIC bioGUNE has started its work in the Building 502 in the Bizkaia...

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2010/02/23

DNA replication with a polymerase of Y-family can cause new mutations.

Researchers from CIC bioGUNE, the Spanish Center for Co-operative Research in Biosciences(laboratory of Lucy...

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2010/02/16

CIC bioGUNE's 5th Anniversary Presentation file now available

CIC bioGUNE's 5th Anniversary Presentation file is now available for your perusal or download.

2010/02/11

Diagonal-Free 3D/4D HN,HN-TROSY-NOESY-TROSY.

Researchers at the CIC bioGUNE NMR facility have developed a novel NMR method for measuring crucial atomic distances for protein structure...

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2010/02/05

Nota de Prensa: CIC bioGUNE, 'buque insignia' de la apuesta vasca por las biociencias

(Derio, 29 de enero de 2010).- El centro de Investigación Cooperativa en Biociencias,...

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2010/02/05

Structure of the Tumor Suppressor ING4

The tumor suppressor ING4 regulates gene transcription by recruiting chromatin remodeling complexes to active promoters. A team of CIC bioGUNE...

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2010/02/02

5th Anniversary videos

Compilation of short videos from different televisions about our 5th anniversary special conference and also about what's being done in our scientific groups.January 28thOn TVE (TeleNorte)

2010/01/27

Minister of Industry and Minister of Health visit CIC bioGUNE

Basque Minister of Industry (Bernabé Unda), Vice-minister of Industry (Juan Goicolea), Minister of Health (Rafael...

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2010/01/27

HOXB9 promotes breast cancer progression

Aberrant expression of transcription factors has been implicated in tumorigenesis. Investigators from the Cell Biology and Stem...

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2010/01/22

CIC bioGUNE Platforms Brochure 2009

CIC bioGUNE Platforms Brochure 2009 is now vailable for your perusal. Please see the Press Area or the pdf file below.

2010/01/20

New insight into the regulation of axon growth by GSK-3, a protein kinase implicated in neurodegenerative...

Researchers from the Cell Biology and Stem Cells Unit at CIC bioGUNE...

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2010/01/19

New insights into the regulation of liver de-differentiation, development and human HCC progression.

HuR/Methyl-HuR and AUF1 provide a post-transcriptional regulatory mechanism...

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2010/01/04

CIC bioGUNE Annual Report 2009

CIC bioGUNE Annual Report 2009 is now available for download: please see Press Area menu entry or click here to see the pdf file.

2009/12/16

Proteins that 'resist' salt.

Structural Basis for the Aminoacid Composition of Proteins from Halophilic Archea.A group of researchers from CIC bioGUNE,...

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2009/12/11

Protein MJ0100: an open-to-closed conformational change in its CBS motif pair.

Binding of 5'-methylthioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed...

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2009/12/04

BCAM - CIC bioGUNE Workshop on Cell Population Dynamics takes place on the 4th of December....

Cell Population Dynamics - laboratory analysis and mathematical modelling.The workshop, to take place on the 4th of December in BCAM (Basque Center For Applied Mathematics, Bizkaia Technology Park, Building 500) is to bring together some experimental and mathematical biologists working in the field of cell population dynamics. In particular, we would like to strengthen the existing links and stimulate new...

2009/12/03

The Minister of Health visits CIC bioGUNE's Technological Platforms.

Yesterday, December the 2nd, the Minister of Health in the Basque Government, Rafael Bengoa, visited CIC...

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2009/11/18

Illumina workshop at CIC bioGUNE on November 25th.

Illumina workshop will take place in CIC bioGUNE on November 25th ( Atrio 800, 10.30- 13.30 ). Please see the pdf file for the progamme and further information.

2009/11/10

Symantec workshop takes place in CIC bioGUNE on the 10th of November

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2009/11/09

Basque Government's Minister of Industry and Innovation Visits CIC bioGUNE

The Minister of Industry and Innovation of the Basque Government, Bernabé Unda, visited today...

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2009/11/03

The role of surface tension in protein stability

The group of Oscar Millet from the Structural Biology Unit of CIC bioGUNE has recently published a study on the influence of the...

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2009/10/28

CIC bioGUNE and Proteomika create the largest catalogue of proteins from endometrial fluid...

Researchers from the Cooperative Research Centre in Biosciences CIC bioGUNE and from...

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2009/10/27

Researchers from CIC bioGUNE identify a risk gene that affects regeneration of the liver

Researchers from the Biosciences Co-operative Research Centre, CIC bioGUNE, and the Centre for Networked Biomedical Research into Hepatic and Digestive Diseases (CIBERehd) have discovered that the deficiency of the GNMT gene affects regeneration of the liver and causes uncontrolled proliferation, whilst causing greater susceptibility to liver damage. This discovery was recently published in the prestigious journal...

2009/10/21

The Deputy Minister of Industry and Innovation Visits CIC bioGUNE

The Deputy Minister for Industry and Innovation in the Basque Government, Pedro Hernandez, visited today the facilities...

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2009/10/07

SGI Roadshow 2009 seminar took place in CIC bioGUNE on the 7th October, 2009

SGI Roadshow 2009 seminar took place in CIC bioGUNE on the 7th October, 2009 between 9:30 and 13:00....

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2009/10/02

EMBO Reports describes the new tool for capturing ubiquitylated proteins (TUBEs), developed...

On October the 2nd EMBO Reports published a

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2009/09/30

CIC bioGUNE- VICOMTECH joint workshop took place on the 2nd of October, 2009

CIC bioGUNE- VICOMTECH joint workshop held at CIC bioGUNE, on the 2nd of October, 2009.

2009/09/25

Ane Fullaondo defended her doctoral thesis on September 29th, 2009.

Ane Fullaondo from D. Gubb's lab presented her doctoral thesis entitled "The role of Spn42Dd serpin in the innate immune response" on September 29th, 2009. The event took place at UPV/ EHU, Campus Leioa, in the room adjoining 'Paraninfo'.

2009/09/21

Comprehensive proteomic analysis of human endometrial fluid aspirate published by CIC bioGUNE's...

The group of Felix Elortza at the Proteomics Platform of CIC bioGUNE has recently...

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2009/09/15

CIC bioGUNE Laboratories are offering the opportunity to undertake Master/PhD studies with...

2009/09/15

CIC bioGUNE open day for PhD students took place on September 21st.

Open day for potential PhD students took place in CIC bioGUNE on the 21st of September. After a series of talks delivered by the heads of several of the CIC bioGUNE's laboratories the students took part in a tour of the center's facilities.

2009/09/14

Alzheimer Research Project: sample collection notes

Alzheimer Disease Research Project Sample Collection.We thank all the people who have shown interest in the research project related to Alzheimer Disease carried out by several medical groups (coordinated by the BIOEFFoundation) and CIC bioGUNE. Please note that the collection of samples has to be performed by specialized healthcare personnel: anyone planning to contribute their samples should contact the Basque Biobank for Research (Tel. 944 536...

2009/09/10

CIC bioGUNE - FAES FARMA Joint Workshop took place in CIC bioGUNE on September 8th.

FAES FARMA presentations and and CIC bioGUNE presentations were given by the scientists from both centers, following the general introduction talks by José M Mato and María Luisa Lucero. The talks, on variety of topics, were followed by disscusion. For details please see the pdf file containing the conference programme.

2009/09/07

Detection of protein SUMOylation in vivo

The group of Manuel S. Rodríguez from the Proteomics Unit of CIC bioGUNE, working in collaboration with Prof. R.T. Hay from the University...

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2009/08/13

Loss of GNMT impairs liver regeneration

Researchers at the CICbioGUNE-CIBERedh led by José Maria Mato and M-Luz Martínez-Chantar, in collaboration with investigators...

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2009/08/06

Adriana Rojas Cardona joins CIC bioGUNE as the leader of X-ray Crystallography Platform.

Researcher Adriana Rojas Cardona has taken up the position of manageress at the X-ray Crystallography platform of CIC bioGUNE's Structural Biology Unit, where she joins the four other crystallographers already working in the unit: Alfonso Martínez, Aitor Hierro, Nicola G. A. Abrescia and Lucy Malinina.

2009/07/27

Joaquín Castilla joins the Proteomic Unit at CIC bioGUNE to research prions, the agents...

Thanks to the Basque Government's Ikerbasque Programme, CIC bioGUNE's Proteomic Unit has just gained a new Group Leader, Joaquín Castilla, who will focus his research on the study of the molecular mechanisms involved in the transmission of prions between different species. The laboratory directed by Castilla aims to gain a better understanding of why prions are able to infect some species...

2009/07/23

A North American bio-company to market a CIC bioGUNE product for developing anti-cancer drugs...

The CIC bioGUNE Biosciences Research Centre has reached an agreement with the North American biotechnology firm LifeSensors to license them to market a product (TUBEs) which will enable the development of drugs for pathologies involving protein metabolism problems, such as cancer and neurodegenerative diseases. The product, called TUBEs (Tandem-repeated Ubiquitin Binding Entities), was entirely developed...

2009/07/23

PHDs silencing promotes therapeutic revascularisation

Therapeutic neovascularisation represents an alternative treatment modality for patients with advanced ischemic coronary or peripheral artery occlusive disease. The hypoxia-inducible transcription factor (HIF) is a master regulator controlling genes involved in several processes that promote neovascularisation, making modulation of HIF activity an attractive approach for the treatment of ischemic diseases. The O2-dependent hydroxylase domain proteins...

2009/07/22

Researchers from CIC bioGUNE find a way to treat ischemic pathologies

A team of researchers from CIC bioGUNE, led by Dr Edurne Berra from the Cellular Biology and Stem Cell Unit,...

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2009/07/21

Necrotic serpin, the protein that checks fungal growth.

A group of researchers from CIC bioGUNE and the Andalusian Developmental Biology Centre, led by the head of the Functional Genomics Unit - Laboratory 3, David Gubb from the U.K., has found the regulating mechanism of the serum protein Serpin (SERin Protease INhibitor) thanks to the fruit fly, Drosophila melanogaster. The research project has been published in the prestigious scientific journal PLoS Genetics. Serpins are a numerous group of proteins...

2009/07/21

Researchers from CIC bioGUNE and Columbia University conduct joint research into a metabolic...

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the prestigious scientific journal 'Structure', to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state). Pyruvate carboxylase is a metabolic enzyme that plays a fundamental role in...

2009/07/15

Luis Espinosa Hevia presented his doctoral thesis on July 17th

Luis Espinosa Hevia from Luis Parada's lab defended his doctoral thesis entitled "Organización del genoma durante hepatocarcinogénesis" on July 17th, 2009, at 11:30 am at the University of the Basque Country - campus de Leioa, Faculty of Medicine, "Salon de Grados".

2009/07/14

CIC bioGUNE & FAES FARMA special conference to be held on September 8th

CIC bioGUNE & FAES FARMA joint workshop is to be held on September 8th, 2009 in CIC bioGUNE, building 800. The conference will start with general introductory talks given by Jose M. Mato of CIC bioGUNE and María Luisa Lucero from FAES FARMA. Short presentations by scientists from both centers will follow. Please see the pdf file for more information.

2009/07/10

CIC bioGUNE scientists give talks in the summer conference in Convento de Santo Domingo in...

The summer conference entitled "CUANDO LA QUÍMICA SE HACE BIOLOGÍA Y VICEVERSA" took place in Convento de Santo Domingo in Ronda between 6th and 10th of July, 2009. The conference was organised by the University of Malaga. Several of the CIC bioGUNe scientists gave talks on variety of related subjects in the two sessions: "Genomas y proteomas" and "Cuando la Química...

2009/07/06

Mikel Valle, a CIC bioGUNE researcher, wins the 2009 EBSA Prize

Mikel Valle, head of one of the research groups at the CIC bioGUNE Structural Biology Unit, has won the 2009 EBSA Prize, an award granted by the European Biophysical Societies Association, which recognises the work carried out by researchers aged under 40 who work in Europe and have made an important contribution to biophysics.

2009/07/06

Miriam Hernando Rodríguez from José Luis Zugaza's lab defended her doctoral thesis...

Miriam Hernando Rodríguez from José Luis Zugaza's lab, defended her doctoral thesis entitled "Implicación de la GTPase Rac1 en la señalización y muerte celular por el péptido 1-42 β-Amiloide" on July 6, 2009 at 12:00 o'clock in the "Salón de grados de la Facultad de Ciencias y Tecnología, UPV/EHU".

2009/06/29

Researchers from CIC bioGUNE develop a bioinformatics tool for interpreting the results of...

 A team of researchers from the Functional Genomic Unit of CIC bioGUNE, led by Ana María Aransay, have developed a bioinformatics tool capable of analysing and interpreting the results of microRNA (or small, non-coding RNA) sequencing. The tool is a free-access, free-of-charge web tool called "miRanalyzer" (http://web.bioinformatics.cicbiogune.es/microRNA/miRanalyser.php),...

2009/06/29

The site of the uptake and degradation of the Necrotic serpin in Drosophila melanogaster identified.

A new study of the uptake and degradation of the Necrotic serpin in Drosophila...

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2009/06/26

Onetsine Arrizabalaga de Mingo from José Luis Zugaza's lab defended her doctoral thesis...

Onetsine Arrizabalaga de Mingo from José Luis Zugaza's lab defended her doctoral thesis entitled "Papel de las GTPasas de la familia Rho y la glucógeno fosforilasa en la proliferación linfocitaria" on June 26, 2009 at 12:00 o'clock in the 'sala anexa al paraninfo', Facultad de Ciencia y Tecnología, UPV-EHU.

2009/06/22

CIC bioGUNE and the Biophysics Unit at the UPV/EHU to perform research at the ESRF in Grenoble

The European Synchrotron Radiation Facility (ESRF) has awarded a Block Allocation...

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2009/06/22

Sergio Hernández from Jim Sutherland's lab defends his doctoral thesis

Sergio Hernández from Jim Sutherland's lab defends his doctoral thesis entitled "Functional and molecular characterisation of LMO6, a PET-LIM protein" on Monday June 22, 2009 at 12 noon at the University of the Basque Country (Campus de Leioa, Faculty of Science and Technology, "Salon de Grados".

2009/06/19

A multidisciplinary approach using a combination of biophysical techniques reveals unexpected...

A multidisciplinary approach using a combination of biophysical techniques, applied...

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2009/06/17

The joint CIC bioGUNE - CIC microGUNE workshop on July 13th, 2009

The joint CIC bioGUNE - CIC microGUNE workshop will take place at CIC bioGUNE's building 800 in Derio, on July 13th, 2009. Following general introductory talks by Carlos Luri of CIC microGUNE and José M. Mato of CIC bioGUNE, several short seminars will be given by the scientists from both centers.

2009/06/17

Pyruvate carboxylase structural studies

Researchers from the CICbioGUNE's Structural Biology Unit have recently resolved the three-dimensional structure for pyruvate carboxylase...

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2009/06/03

miRanalyzer, a new web server tool for smallRNAs deep-sequencing analysis, has been developed...

A paper by Michael Hackenberg et al, presenting miRanalyzer, a microRNA detection and analysis tool, was published in May's Web Server issue of Nucleic Acid Research journal. The project was completed in collaboration with bioinformatics experts from the Institute for Bioinformatics and Systems Biology at the German Research Center for Environmental Health. While next generation sequencing...

2009/06/01

Sandra Soukup from David Gubb's lab presented her PhD thesis on June the 5th, 2009

Sandra Soukup from David Gubb's lab defended her doctoral thesis entitled "Degradation of the Necrotic serpin in Drosophila" on June the 5th, 2009 at 12:00 o'clock at the University of the Basque Country - campus de Leioa, Faculty of Science and Technology, "Salon de Grados".

2009/05/28

Roland Hjerpe defended his PhD thesis on June 3rd, 2009

Roland Hjerpe from Manuel Rodríguez's lab defended his doctoral thesis entitled "p53, a crucial target of Mdm2 and the UPS: studies of specificity and method development for the purificiation of endogenously ubiquitylated proteins" on June 3rd, 2009, at 11:00 o'clock at the University of the Basque Country - campus de Leioa, Faculty of Science and Technology, "Salon de Grados".

2009/05/28

Ricardo Sánchez Pérez from Francisco Blanco's lab presented his PhD thesis on...

Ricardo Sánchez Pérez from Francisco Blanco's lab defended his doctoral thesis titled "Análisis por RMN de las proteínas PCNA y Gadd45alfa, y sus interacciones en la reparación del ADN y el control del ciclo celular" on June 12th, 2009. The event took place at 12:00 o'clock in the Seminario I, Edificio Decanato, Facultad de Medicina, Universidad Autónoma...

2009/05/20

Jonatan Sánchez García and Mercedes Vázquez Chantada presented their doctoral...

Two PhD students from CIC bioGUNE presented their doctoral theses on June the 1st, 2009, at 12 o'clock, at Facultad de Ciencias y Tecnología, UPV/EHU. Jonatan Sánchez García from Rosa Barrio's lab defended his thesis entitled "Mecanismo de acción de las proteínas Spalt durante el desarrollo de Drosophila melanogaster". Mercedes Vázquez Chantada...

2009/05/07

CIC bioGUNE - BCAM Joint Workshop took place in CIC bioGUNE on May 11th.

CIC bioGUNE and BCAM (Basque Center for Applied Mathematics) have organized a joint workshop where scientists from both centers presented their work. It is hoped that the conference will contribute to interdisciplinary work involving life sciences researchers and mathematicians. Such collaborations can provide new strategies to comprehend crucial questions about life and improve understanding and treatment of disease. The workshop...

2009/05/07

PLoS BIOLOGY publishes new work from a team of researchers led by Dr. Abrescia, investigating...

Acid-loving Archaeon Reads DNA with Enzyme Strikingly Similar to Our Own.Some...

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2009/05/06

Researchers at CIC bioGUNE reveal evolution of prehistoric protein in the human body.

Research carried out by the Basque Centre for Biosciences, CIC bioGUNE, and the universities of Yale, Harvard and Oxford, published in this May's edition of PLoS Biology, shows that the enzyme that converts DNA into RNA has been conserved in the human body, surprisingly, since appearing in ancestral unicellular organisms, despite an evolutionary gulf of 2 billion years. These organisms, called Sulfolobus, live in...

2009/04/29

CIC bioGUNE researcher contributes to the scientific magazine Investigación y Ciencia....

A scientific report by CIC bioGUNE researcher Oscar Millet dedicated to protein motion as studied by NMR spectroscopy has been published in the April's issue of the scientific journal Investigación y Ciencia.Proteins are intrinsically flexible and their motion is often related to the cellular function of the biomolecule. A detailed characterisation of protein dynamics is often elusive and NMR...

2009/04/29

A round table discussion "MUJER Y CIENCIA" at the University Rey Juan Carlos in Madrid....

A round table discussion entitled "Mujer y Ciencia" has taken place today at the University Rey Juan Carlos in Madrid, within the cycle of conferences "La Mujer en la España de Hoy". The discussion was moderated by Carmen Iglesias, a distinguished linguist and historian. The participants included Inés Fernández-Ordóñez, Mª Teresa Miras, Flora...

2009/03/23

El País reports on Ana M. Aransay's talk in Eureka Cafe

'What do we know about ourselves?' was the title of the talk, with an invitation to disscussion, which...

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2009/02/18

Evidence for LKB1/AMPK/eNOS cascade regulated by HGF, S-adenosylmethionine, and NO in hepatocyte...

Researchers at the CIC bioGUNE, in Bilbao, and colleagues at the Keck School...

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2009/02/11

CIC Network Forum 2009 held on February 19th, in CIC bioGUNE

CIC Network Forum 2009 took place on February 19th, in CIC bioGUNE, Technological Park of Bizkaia, Derio.

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2009/01/12

CICbioGUNE held an open day for potential PhD students on 22nd of January, 2009

On the 22nd of January, 2009, CIC bioGUNE held an open day aimed at potential PhD students interested in participating in a research project in the centre. All the laboratories planning to take on a PhD student presented the different research areas/projects developed in their groups and discussed them with the interested candidates. The full day visit will included a tour of our infrastructure facilities and discussion...

2008/12/05

Custom meganucleases induce chromosomal gene repair without detectable genotoxicity.

Custom meganucleases that recognize and cleave a specific sequence of the human xeroderma pigmentosum...

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2008/12/03

URBE (Usuarios Resonancia Bruker Española) 2008 conference takes place in CIC bioGUNE....

On 27th and 28th of November, CICBiogune and Bruker Española organized the URBE (Usuarios Resonancia Bruker Española) 2008 conference. More than 60 people from all parts of Spain as well as some participants from Germany and France, attended the conference. URBE conferences are a meeting point for NMR spectroscopists, to share experiences, create new collaborations and discuss the latest...

2008/12/01

Atos Origin collaborates with CIC bioGUNE designing a grid-based solution to achieve a performance...

One of the latest's challenges for CIC bioGUNE is to deal with the increasing computing power required to analyze huge amounts of genetic data, to find patterns and compare between case and control groups within an acceptable processing time and cost...

2008/11/06

Dr. María dM Vivanco, a CIC bioGUNE researcher, has been awarded a research bursary...

Dr. María dM Vivanco, Group Leader of the Molecular Biology and Stem Cell Unit at CIC bioGUNE, has obtained a research bursary awarded by the Spanish Foundation for Senology and Mammary Pathology in recognition of her work "Stem cells and resistance to therapy in breast cancer". The award was presented by Dr. Carlos Vázquez, chairman of the Foundation, during the closing ceremony of the 27th...

2008/10/31

Cryo-electron microscopy shows ribosomes on the move.

Researchers from the Structural Biology Unit of CICbioGUNE have captured the structure of ribosomes during the movement of...

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2008/10/22

CIC bioGUNE is to take part in the NANOTHER European Cancer Research Project

CIC bioGUNE is one of 18 entities which are going to be taking part in NANOTHER: a European research project in which advances in nanotechnology will be applied to cancer therapy and diagnosis. To be precise, the aim of this four-year project will be to develop nanoparticles capable of detecting the location of tumours and effecting controlled release of the medication which they contain so as to shrink the tumour.CIC bioGUNE's...

2008/10/15

Sumoylation in the synthesis of steroid hormones: smt3 is required for Drosophila melanogaster...

A group from CIC bioGUNE, in collaboration with groups from Barcelona and Stockholm...

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2008/10/08

CIC bioGUNE presents its Technology Platforms to CIBERehd

On 7th of October CIC bioGUNE presented its Technology Platforms to the Centre for Networked Biomedical Research, CIBERehd, during the workshop held in the Basque centre's headquarters. The seminar was organised by Mª Luz Martínez Chantar, Group Leader of CIC bioGUNE's Metabolomic Unit.The Centre for Networked Biomedical Research into Hepatic and Digestive Diseases (CIBERehd), which includes the best Spanish scientific groups working...

2008/10/08

Abnormal methionine metabolism leads to non-alcoholic fatty liver disease (NAFLD) and cancer.

Researchers at the CIC bioGUNE and the University of Southern California, Keck School...

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2008/09/22

CIC bioGUNE participates in two projects funded by NIH: liver injury and colon cancer pathogenesis....

The National Center for Complementary & Alternative Medicine (NCCAM), part of the US National Institutes of Health (NIH), has awarded two grants totaling US$ 2.57 million over a five-year period to the University of Southern California, Keck School of Medicine, in Los Angeles and CIC bioGUNE. The first grant is for the study of the role of S-adenosylmethionine (SAMe) in liver function and injury....

2008/09/19

Bilbao hosts the 31st Conference of the Spanish Biochemistry and Molecular Biology Society

From 10 to 13 September, Bilbao hosted the 31st Conference of the Spanish Biochemistry and Molecular Biology Society (SEBBM), organised, among others, by CIC bioGUNE. This prestigious meeting gathered together in the Vizcayan capital a large number of national and international experts who, over the course of the four days, analysed the very latest breakthroughs in the fields of biochemistry and molecular biology....

2008/09/19

CIC bioGUNE's Animal Unit receives the highest international accreditation for the use...

The Animal Unit of the CIC bioGUNE has been awarded the "Full Accreditation"...

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2008/09/03

The European network Inproteolys holds its first course on specialized methods of studying...

Between 1st and 5th September, at the premises of CIC bioGUNE, the European network for the study of intra-cellular proteolysis, Inproteolys, held its first course on specialized methods of studying the proteolysis performed by the ubiquitin/proteasome system. The destruction of proteins within the cell has implications in countless physiological and pathological processes such as neuro-degeneration, immune...

2008/09/03

International experts are to study the latest breakthroughs in genetic research into cancer...

The 11th European Workshop on Cytogenetics and Molecular Genetics of Solid Tumours, organized by Dr. Luis Antonio Parada, Group Head of the Cellular Biology and Stem Cells Unit of the Co-operative Bioscience Research Centre, CIC bioGUNE, will be held between 6 and 9 September in Bilbao and will feature a good number of internationally renowned scientists.These researchers will give talks and exchange the...

2008/07/28

The "Asociación de Cáncer de Mama de Bizkaia" visited the Breast Cancer...

The "Asociación de Cáncer de Mama de Bizkaia" visited...

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2008/07/16

International experts in alcoholism and cirrhosis are to meet in Bilbao on 17 and 18 July

The third International Symposium on Alcoholic Liver and Pancreatic Diseases (ALPD) and Cirrhosis will be held in Bilbao on 17 and 18 July. This prestigious event is being organized by CIC bioGUNE, CIBERehd -Networked Bio-medical Research Centre for Hepatic and Digestive Diseases-, the ALPD Research Center of the University of Southern California/University of California, Los Angeles (USC/UCLA) and by the University...

2008/07/09

Researchers at the Structural Biology Unit and Genotyping Laboratory of CICbioGUNE are to participate...

Investigators from the CICbioGUNE's Structural Biology Unit will participate in the Consolider research project SICI (The Spanish Ionic Channel Initiative) included in the Ingenio 2010 programme, recently funded by the Ministry of Science and Innovation. Consolider projects constitute a new initiative that promotes high class research in fields of key interest....

2008/07/03

The dual face of PHDs

A team at CIC bioGUNE in collaboration with investigators at the CNRS-UMR 6543 in France has proved that the PHDs, which are immediately inactivated...

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2008/06/05

Professor Liang Tong gives a talk on the metabolism of fatty acids during the second Structural...

As part of the second Workshop organised by the Structural Biology Unit at CIC bioGUNE, on 29 May, Professor Liang Tong gave a talk entitled: 'Structural studies of fatty acid metabolism and relevance to the obesity epidemic'.Liang Tong is Professor and Co-Director of postgraduate studies at the Faculty of Biology at the University of Columbia, in New York. One of the key issues on which his current...

2008/05/30

Basic Course on Proteomics at CIC bioGUNE: 3th of July 2008

The course will focused mainly in mass spectrometry but will also cover different basic aspect as:Overview of proteomic experiments, sample preparation guides, introduction to mass spectrometry etc. It will also provide of the state of art of the latest techniques and methodologies in MALDI TOF/TOF and nLC MS/MS, giving special emphasis to data interpretation.

2008/05/20

PROTEOLYSIS COURSE.

 

CIC bioGUNE 1-7 SEP, 2008

http://www.inproteolys.eu/index.cfm

2008/05/20

2nd Structural Biology Workshop: Signal Transduction.
CIC bioGUNE, 29-30 May, 2008.

2008/05/20

Darwin and Wallace, 150 Years of Discovering Evolution: Lecture description and multimedia...

The lecture description and multimedia content is available courtesy of FBBVA, in Spanish or in English.

2008/04/30

Ginés Morata closes the 'Darwin and Wallace' cycle with a talk entitled 'Genes, development...

On 29 April, Ginés Morata, a researcher at the Supreme Council for Scientific...

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2008/04/23

Ana Talamillo and Jonatan Sánchez from the group of Rosa Barrio were awarded the 3rd...

Talamillo and co-workers showed that lack of sumoylation arrests larval development, probably due to the impairment of lipid droplets entrance into the gland responsible for steroid hormones synthesis from cholesterol. Based on the conservation of the steroid hormones mechanism throughout evolution, these experiments could provide insights into the physiological regulation by steroid hormones in higher organisms...

2008/04/21

Miguel Delibes de Castro talks about 'Evolutionism and nature conservation' in the 'Darwin...

Miguel Delibes de Castro, a research lecturer with the CSIC (Supreme Council for Scientific...

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2008/04/10

CIC bioGUNE researcher, Ana María Aransay, gave a talk on Personalised Medicine as part...

On 8 April in Bilbao, the head of the Genotyping Laboratory at the Functional Genomics...

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2008/04/08

Loss of GNMT induces liver cancer

A team at CIC bioGUNE, in collaboration with investigators at the University of Vanderbilt, the CNIO, and the Keck School of Medicine, have discovered...

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2008/03/14

Fern Elsdon-Baker analyses heredity theory in Darwin's thought

Fern Elsdon-Baker, lecturer in the History of Science at the University of Durham and member of the British Society...

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2008/03/12

In the series of lectures on Darwin and Wallace, Juan Uriagereka discourses on the evolution...

Juan Uriagereka, the linguist and Professor of the University of Maryland, delivered...

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2008/03/10

Markel Olano, Head of the Gipuzkoa Government, visits CIC biomaGUNE's facilities

On 5th March the Head of the Gipuzkoa Government, Markel Olano, visited CIC biomaGUNE's...

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2008/03/10

MD Renal, CIC biomaGUNE's first spin-off, gets under way

The Cooperative Biomaterials Research Centre, CIC biomaGUNE, has created its first spin-off, Donostia-based MD Renal...

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2008/03/04

The archaeologist Eudald Carbonell participated in the series of talks organised by CIC bioGUNE

On 28 February, Eudald Carbonell, professor of Prehistory at the Universitat...

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2008/03/03

Peter Bowler opens the cycle of talks entitled 'Darwin and Wallace. 150 years of discovering...

On 26 February, Peter Bowler, Professor in the History of Science at Queen's University...

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2008/02/19

The State Secretary for Universities and Research, Miguel Ángel Quintanilla, visits...

A delegation of the Ministry of Education and Science, made up by The State Secretary...

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2008/02/15

The General Secretary of the Socialist Party in the Basque Country, Patxi López, visits...

The General Secretary of the Socialist Party in the Basque Country, Patxi López,...

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2008/02/13

Edurne Berra, from CIC bioGUNE, is awarded the Íñigo Álvarez de Toledo...

Edurne Berra Ramírez (Donostia, 1967), a researcher at CIC bioGUNE, has been awarded the 19th Íñigo Álvarez de Toledo Basic Research Prize for her paper "The signalling cascade activated by hypoxia and the HIF (hypoxia inducible factor)", for which she was funded by the Bizkaia:xede Grant Programme 2006. Edurne Berra was presented with her prize - regarded as Spain's...

2008/02/12

Aitor Hierro joins CIC bioGUNE's Structural Biology Unit

Researcher Aitor Hierro has joined CIC bioGUNE's Structural Biology Unit, where he is continuing his work on protein trafficking. The philosophy of the research group which he is leading is to accomplish current biological questions through different perspectives and establishment of close collaborations with other disciplines. After graduating, Aitor Hierro went on to study for his doctorate in the Biochemistry and Molecular Biology...

2008/01/30

The researcher Francisco Blanco joins the Structural Biology Unit at CIC bioGUNE

The researcher Francisco Blanco has joined the Structural Biology Unit at CIC bioGUNE, where he has been working since December on the structural characterisation of proteins and on the protein-protein interactions involved in cellular adhesion, the remodelling of chromatin and DNA repair.Francisco Blanco has both an BSc and a PhD in chemistry from Madrid University and earned his doctorate under the supervision of J.L....

2008/01/29

The researcher Richard Finnell joins CIC bioGUNE on sabbatical, thanks to a chair provided...

Richard Finnell, director of the Texas Institute of Genomic Medicine (TIGM), has temporarily joined the team at CIC bioGUNE on a sabbatical made possible thanks to a Chair in Biomedicine established by the BBVA Foundation. Through these chairs, the BBVA Foundation aims to foster research and advanced training by enabling prominent international experts to join Spanish groups of excellence working at universities,...

2008/01/23

Antonio García Bellido gives a lecture on the occasion of CIC bioGUNE's third anniversary

To mark the third anniversary of CIC bioGUNE, Professor Antonio García...

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2008/01/15

First structures solved at the CICbioGUNE SBU

The first macromolecular structures emerge as the result of the research at the Structural Biology Unit of the CICbioGUNE. EM maps...

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