Leire Moreno Cugnon
Leire Moreno Cugnon
Nerve Disorders Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Axon myelination is essential for rapid saltatory conduction of nerve impulses in the vertebrate nervous system. A central feature of several of these pathological conditions in the peripheral nervous system (PNS) is the destruction of myelin and the reprogramming of myelinating Schwann cells to a 'progenitor-like' state, a highly unusual feature in mammals.  This rests on the surprising plasticity of Schwann cells that allows them to switch between differentiation states. The work of in the laboratory addresses a set of interlocking issues in Schwann cell biology that deal with Schwann cell myelination, and the response of Schwann cells to pathological conditions. More specifically, we are focused on identifying the key mechanisms that drive Schwann cell reprogramming in different pathological conditions, including nerve injury, genetic disorders, immune cell attack and microbial infections. For these, we have been examining the role of autophagy, and the role of DNA methylation, histone modifications and non-coding RNAs in this process using high-throughput techniques. Another related ongoing project in the lab on is focused on the identification of therapeutical targets for neurofibromatosis type 1 and malignant peripheral nerve sheath tumours (MPNST)

Latest Publications

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.

Palomo-Irigoyen, Marta; Perez-Andres, Encarni; Iruarrizaga-Lejarreta, Marta; Barreira-Manrique, Adrian; Tamayo-Caro, Miguel; Vila-Vecilla, Laura; Moreno-Cugnon, Leire; Beitia, Nagore; Medrano, ...

journal of clinical investigation


The RNA-binding protein HuR/Elavl1 controls a core gene regulatory circuitry essential for MPNST growth and metastasis

Caro, MT (Tamayo Caro, M.); Irigoyen, MP (Palomo Irigoyen, M.); Andres, EP (Perez Andres, E.); Lejarreta, MI (Iruarrizaga Lejarreta, M.); Rey, MV (Varela Rey, M.); Woodhoo, A (Woodhoo, A.)



Analyzing Autophagic Flux in Nerve Cultures

Caro, MT(Tamayo Caro, Miguel);Irigoyen, MP(Palomo Irigoyen, Marta);Andres, EP(Perez Andres, Encarnacion);Manrique, AB(Barreira Manrique, Adrian);Rey, MV(Varela Rey, Marta);Woodhoo, A(Woodhoo, ...

Methods in molecular biology


Isolation and Purification of Primary Rodent Schwann Cells

Irigoyen, MP(Palomo Irigoyen, Marta);Caro, MT(Tamayo Caro, Miguel);Andres, EP(Perez Andres, Encarnacion);Manrique, AB(Barreira Manrique, Adrian);Rey, MV(Varela Rey, Marta);Woodhoo, A(Woodhoo, ...

Methods in molecular biology


Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

Zubiete-Franco, I(Zubiete-Franco, Imanol);Garcia-Rodriguez, JL(Garcia-Rodriguez, Juan Luis);Martinez-Una, M(Martinez-Una, Maite);Martinez-Lopez, N(Martinez-Lopez, Nuria);Woodhoo, A(Woodhoo, ...

Journal of hepatology


Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

Gomez-Sanchez, JA(Gomez-Sanchez, Jose A.);Carty, L(Carty, Lucy);Iruarrizaga-Lejarreta, M(Iruarrizaga-Lejarreta, Marta);Palomo-Irigoyen, M(Palomo-Irigoyen, Marta);Varela-Rey, M(Varela-Rey, Marta);Griffith, ...

The Journal of cell biology


Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance

Carrasco, Manuel; Rabaneda, Luis G.; Murillo-Carretero, Maribel; Ortega-Martinez, Sylvia; Martinez-Chantar, Maria L.; Woodhoo, Ashwin; Luka, Zigmund; Wagner, Conrad; Lu, Shelly C.; Mato, Jose ...



S-adenosylmethionine levels regulate the schwann cell DNA methylome.

Varela-Rey, Marta; Iruarrizaga-Lejarreta, Marta; Jose Lozano, Juan; Maria Aransay, Ana; Fernandez, Agustin F.; Luis Lavin, Jose; Mosen-Ansorena, David; Berdasco, Maria; Turmaine, Marc; Luka, ...



Calcineurin-nuclear factor of activated t cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP

Kipanyula, Maulilio J.; Woodhoo, Ashwin; Rahman, Mary; Payne, Donna; Jessen, Kristjan R.; Mirsky, Rhona

journal of neuroscience research


Human antigen R contributes to hepatic stellate cell activation and liver fibrosis

Woodhoo, Ashwin; Iruarrizaga-Lejarreta, Marta; Beraza, Naiara; Garcia-Rodriguez, Juan L.; Embade, Nieves; Fernandez-Ramos, David; Martinez-Lopez, Nuria; Gutierrez-De Juan, Virginia; Arteta, ...